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| 1 | Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis显示文摘Background:Due to the high prevalence and complex etiology,bovine mastitis(BM)is one of the most important diseases to compromise dairy cow health and milk quality.The shift in milk compositions has been widely investigated during mastitis,but recent studies suggested that gastrointestinal microorganism also has a crucial effect on the inflammation of other peripheral tissues and organs,including the mammary gland.However,research focused on the variation of rumen inner-environment during mastitis is still limited.Therefore,the ruminal microbial profiles,metabolites,and milk compositions in cows with different udder health conditions were compared in the present study.Furthermore,the correlations between udder health status and ruminal conditions were investigated.Based on the somatic cell counts(SCC),California mastitis test(CMT)parameters and clinical symptoms of mastitis,60 lactating Holstein dairy cows with similar body conditions(excepted for the udder health condition)were randomly divided into 3 groups(n=20 per group)including the healthy(H)group,the subclinical mastitis(SM)group and the clinical mastitis(CM)group.Lactation performance and rumen fermentation parameters were recorded.And rumen microbiota and metabolites were also analyzed via 16S rRNA amplicon sequencing and untargeted metabolomics,respectively.Results:As the degree of mastitis increased,rumen lactic acid(LA)(P<0.01),acetate,propionate,butyrate,valerate(P<0.001),and total volatile fatty acids(TVFAs)(P<0.01)concentrations were significantly decreased.In the rumen of CM cows,the significantly increased bacteria related to intestinal and oral inflammation,such as Lachnospiraceae(FDR-adjusted P=0.039),Moraxella(FDR-adjusted P=0.011)and Neisseriaceae(FDR-adjusted P=0.036),etc.,were accompanied by a significant increase in 12-oxo-20-dihydroxy-leukotriene B4(FDR-adjusted P=5.97×10^(−9))and 10beta-hydroxy-6beta-isobutyrylfuranoeremophilane(FDR-adjusted P=3.88×10^(−10)).Meanwhile,in the rumen of SM cows,the Ruminiclostridium_9(FDR-adjusted P=0.042)and Enterorhabdus(FDR-adjusted P=0.043)were increased along with increasing methenamine(FDR-adjusted P=6.95×10^(−6)),5-hydroxymethyl-2-furancarboxaldehyde(5-HMF)(FDR-adjusted P=2.02×10^(−6))and 6-methoxymellein(FDR-adjusted P=2.57×10^(−5)).The short-chain fatty acids(SCFAs)-producing bacteria and probiotics in rumen,including Prevoterotoella_1(FDRadjusted P=0.045)and Bifidobacterium(FDR-adjusted P=0.035),etc.,were significantly reduced,with decreasing 2-phenylbutyric acid(2-PBA)(FDR-adjusted P=4.37×10^(−6)).Conclusion:The results indicated that there was a significant shift in the ruminal microflora and metabolites associated with inflammation and immune responses during CM.Moreover,in the rumen of cows affected by SM,the relative abundance of several opportunistic pathogens and the level of metabolites which could produce antibacterial compounds or had a competitive inhibitory effect were all increased. | Yue Wang Xuemei Nan Yiguang Zhao Linshu Jiang Mengling Wang Hui Wang Fan Zhang Fuguang Xue Dengke Hua Jun Liu Junhu Yao Benhai Xiong | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 2 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 3 | Light-emitting diodes based on all-inorganic copper halide perovskite with self-trapped excitons显示文摘Light-emitting diodes based on lead halide perovskite have attracted great attention due to their outstanding performance.However,their application is plagued by the toxicity of Pb and the poor stability.Herein novel copper-based all inorganic perovskite CsCu2I3 with much enhanced stability has been reported with a potential photoluminescence quantum yield(PLQY)over 20%and self-trapped excitons(STE).By taking advantage of its extraordinary thermal stability,we successfully fabricate high-quality CsCu2I3 film through direct vacuum-based deposition(VBD)of CsCu2I3 powder.The resulting film shows almost the same PLQY with the synthesized powder,as well as excellent uniformity and stability.The perovskite light-emitting diodes(Pe-LED)based on the evaporated CsCu2I3 emitting layer achieve a luminescence of 10 cd/m2 and an external quantum efficiency(EQE)of 0.02%.To the best of our knowledge,this is the first CsCu2I3 Pe-LED fabricated by VBD with STE property,which offers a new avenue for lead-free Pe-LED. | Nian Liu Xue Zhao Mengling Xia Guangda Niu Qingxun Guo Liang Gao Jiang Tang | 2020 | Journal of Semiconductors2020，41，5： | 4 |
| 4 | E. coli and bacteriophage MS2 disinfection by UV, ozone and the combined UV and ozone processes显示文摘低剂量的臭氧与的联合紫外(紫外) 照耀应该是一种选择把利益给消毒和还原剂缺点紫外并且臭氧消毒。然而,少些对消毒表演被知道紫外并且臭氧(UV/ozone ) coexposure 和顺序的 UV-followed-by-ozone (紫外臭氧) 并且 ozone-followed-by-UV (臭氧 -- 紫外) 暴露。在这研究, E 的 inactivation。coli 和抗菌素 MS2 由紫外,臭氧, UV/ozone coexposure,并且顺序紫外臭氧并且臭氧 -- 紫外暴露被调查并且比较。E 上的 0.50.9 木头杀死的 Synergistic 效果。包括率和效率的增加, coli inactivation 在象 0.05 mg 潩 ? 慷 ? 捡畴污祬椠据敲獡摥愠瑦牥挠汨牯湩瑡潩一样低的臭氧集中在 UV/ozone coexposure 以后被观察吗? | Jingyun FANG Huiling LIU Chii SHANG Minzhen ZENG Mengling NI Wei LIU | 2014 | Frontiers of Environmental Science & Engineering2014，8，4： | 3 |
| 5 | Advances in Studies on Interaction between Selenium and Heavy Metal Cadmium显示文摘Selenium is an essential functional element of the human body,and the issue of selenium accompanying heavy metals is receiving much concern.This paper expounded the form of existence of selenium and cadmium in soil and influencing factors of their bioavailability,and further elaborated the interaction between selenium and cadmium.On the basis,it provided references for further studies on the interaction between selenium and cadmium,and provided basis for establishing selenium-enriched barrier technology for crops. | Liping PAN Yongxian LIU Yanfei HUANG Mengling NONG Shiyang LU Jinping CHEN Yuying ZHAO Liumei XIONG Xiu LAN Kebing LI | 2017 | Asian Agricultural Research2017，9，8： | 3 |
| 6 | Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection显示文摘Sensitive and fast detection of neutrons and gamma rays is vital for homeland security,high-energy physics,and proton therapy.Fast-neutron detectors rely on light organic scintillators,andγ-ray detectors use heavy inorganic scintillators and semiconductors.Efficient mixed-field detection using a single material is highly challenging due to their contradictory requirements.Here we report hybrid perovskites(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)that combine light organic cations and heavy inorganic skeletons at a molecular level to achieve unprecedented performance for mixed-field radiation detection.High neutron absorption due to a high density of hydrogen,strong radiative recombination within the highly confined[PbX_(6)]^(4-)layer,and sub-nanometer distance between absorption sites and radiative centers,enable a light yield of 41000 photons/MeV,detection pulse width of 2.97 ns and extraordinary linearity response toward both fast neutrons andγ-rays,outperforming commonly used fast-neutron scintillators.Neutron energy spectrum,time-of-flight based fast-neutron/γ-ray discrimination and neutron yield monitoring were all successfully achieved using(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)detectors.We further demonstrate the monitoring of reaction kinetics and total power of a nuclear fusion reaction.We envision that molecular hybridized scintillators open a new avenue for mixed-field radiation detection and imaging. | Mengling Xia Guangda Niu Linyue Liu Runlong Gao Tong Jin Pengying Wan Weicheng Pan Xianpeng Zhang Zuoxiang Xie Sam Teale Zenghua Cai Jiajun Luo Shan Zhao Haodi Wu Shiyou Chen Zhiping Zheng Qingguo Xie Xiaoping Ouyang Edward HSargent Jiang Tang | 2022 | InfoMat2022，4，9： | 2 |
| 7 | The Pumilio RNA-binding protein APUM24 regulates seed maturation by fine-tuning the BPM-WRI1 module in Arabidopsis显示文摘Pumilio RNAbindingproteinsparticipateinmes-senger RNA(mRNA)degradation and t ranslational repression,but their roles in plant development are largely unclear.Here,we show that Arabidopsis PUMILIO PROTEIN24(APUM24),an atypical Pumiliohomology domaincontaining protein,plays an im-portant part in regulating seed maturation,a major stage of plant development.APUM24 is strongly expressed in maturing seeds.Reducing APUM24 expression resulted in abnormal seed maturation,wrinkled seeds,and lower seed oil contents,and APUM24 knockdown resulted in lower levels of WRINKLED 1(WRI1),a key transcription factor con-trolling seed oil accumulation,and lower expression of WRI1 target genes.APUM24 reduces the mRNA stability of BTB/POZMATH(BPM)family genes,thus decreasing BPM protein levels.BPM is responsible for the 26S proteasomemediated degradation of WRI1 and has important functions in plant growth and development.The 3′untranslated regions of BPM family genes contain putative Pumilio response elements(PREs),which are bound by APUM24.Re-duced BPM or increased WRI1 expression rescued the decient seed maturation of apum242 knock-down mutants,and APUM24 overexpression re-sulted in increased seed size and weight.Therefore,APUM24 is crucial to seed maturation through its action as a positive regulatornetuning the BPMWRI1 module,making APUM24 apromising target for breeding strategies to increase crop yields. | Ruihua Huang Mengling Liu Guanping Gong Pingzhi Wu Barunava Patra Ling Yuan Hongting Qin Xiaoxu Wang Guohe Wang Huimei Liao Lu Gao Chengwei Yang Hongqing Li Shengchun Zhang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 2 |
| 8 | Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays显示文摘 | William M. Huang David E. Seubert James G. Donnelly Mengling Liu Norman B. Javitt | 2007 | Journal of Perinatal Medicine2007，，： | 1 |
| 9 | Enhancing denitrification phosphorus removal with a novel nutrient removal process: Role of configuration显示文摘 | Hongbo Liu Mengling Zhu Saisai Gao | 2014 | Chemical Engineering Journal2014，240，15： | 1 |
| 10 | Effects of Amino Acid Selenium Foliar Fertilizer on Selenium Content and Quality of Mango显示文摘[Objectives]This study was conducted to explore the treatment methods of amino acid selenium fertilizer suitable for increasing the selenium content of mangoes and improving the quality of mangoes,so as to provide a theoretical basis for the production of selenium-enriched mangoes.[Methods]With Tainong mango as a test material,the amino acid selenium foliar fertilizer was applied by eight treatment methods to investigate the changes of selenium,soluble solid,vitamin C,and titratable acid contents in mango flesh and peel.[Results]Spraying amino acid selenium foliar fertilizer increased the selenium content of mango flesh.The selenium contents of the treatment groups T2,T3,T4 and T5 reached the selenium-enriched standard,and the T2 treatment group had the highest selenium content(0.020 mg/kg).The selenium contents in the peel of all treatment groups were greater than the corresponding selenium content in the flesh.Except for T1,the vitamin C contents of other treatment groups sprayed with amino acid selenium fertilizer increased compared with the control,and that of the T2 treatment group increased significantly(P<0.05).Compared with the control,the soluble solids of the treatment groups sprayed with amino acid selenium fertilizer once also increased.The treatment method of spraying amino acid selenium fertilizer with a dosage of 12000 ml/hm2 once(T2)achieved the best effect of increasing the selenium content and improving the quality of mangoes.[Conclusions]This study provides a scientific basis for increasing the selenium content of mangoes and improving the current situation of insufficient selenium intake. | Mengling NONG Jinping CHEN Weicong Gan Liping PAN Ying XING Yongxian LIU | 2020 | Agricultural Biotechnology2020，9，6： | 1 |
| 11 | A Meaningful Image Encryption Algorithm Based on Prediction Error and Wavelet Transform显示文摘Image encryption(IE)is a very useful and popular technology to protect the privacy of users.Most algorithms usually encrypt the original image into an image similar to texture or noise,but texture and noise are an obvious visual indication that the image has been encrypted,which is more likely to cause the attacks of enemy.To overcome this shortcoming,many image encryption systems,which convert the original image into a carrier image with visual significance have been proposed.However,the generated cryptographic image still has texture features.In line with the idea of improving the visual quality of the final password images,we proposed a meaningful image hiding algorithm based on prediction error and discrete wavelet transform.Lots of experimental results and safety analysis show that the proposed algorithm can achieve high visual quality and ensure the security at the same time. | Mengling Zou Zhengxuan Liu Xianyi Chen | 2019 | Journal on Big Data2019，1，3： | 1 |
| 12 | Global Weak Solution to the Chemotaxis-Fluid System显示文摘We investigate the existence of the global weak solution to the coupled Chemotaxisfluid system ■in a bounded smooth domain ??R^2. Here, r≥0 and μ > 0 are given constants,?Φ∈L~∞(?) and g∈L^2((0, T); L_σ~2(?)) are prescribed functions. We obtain the local existence of the weak solution of the system by using the Schauder fixed point theorem. Furthermore, we study the regularity estimate of this system. Utilizing the regularity estimates, we obtain that the coupled Chemotaxis-fluid system with the initial-boundary value problem possesses a global weak solution. | Mei LIU Mengling YU Hong LUO | 2019 | Journal of Mathematical Research with Applications2019，39，2： | 1 |
| 13 | β-Cyclodextrin carbon-based nanoparticles with a core-shell-shell structure for efficient adsorption of crystal violet and bisphenol A显示文摘Textile wastewater contains highly toxic,nondegradable,carcinogenic organic pollutants,causing severe damage to the ecological environment.In this work,β-cyclodextrin carbon-sphere-based nanocomposite(CS/SiO_(2)@β-CD)with a core-shell-shell configuration was prepared by hydrothermal synthesis and subsequent sedimentation-azeotropic distillation with SiO_(2)as intermediate layer for the removal of crystal violet(CV)and bisphenol A(BPA).The chemical structure and morphology of the CS/SiO_(2)@β-CD were characterized by FT-IR,SEM and TEM.The effects of contact time,pH,temperature and initial concentration of the absorbates on the adsorption property were explored.The CS/SiO_(2)@β-CD showed excellent adsorption capacity on CV and BPA,and the maximum adsorption capacity was 87.873 mg g^(-1)and 165.095 mg g^(-1),respectively.Their adsorption process was in line with the pseudo-second-order and pseudo-first-order kinetic models,respectively.The adsorption thermodynamics could be better fitted by Langmuir model than by Freundlich model.The calculated thermodynamic parameters(-ΔG0,ΔS0 andΔH0)illustrated the adsorption of CV was endothermic,in contrast,the adsorption of BPA was exothermic process.Furthermore,the CS/SiO_(2)@β-CD showed excellent recovery performance,making it a potential adsorbent for the practical treatment of textile wastewater. | Tian Tian Mengling Liu Yinhui Li Jian Han Liang Ren Heike Lorenz Qing Wu Jianxin Chen | 2022 | Particuology2022，20，3： | 1 |
| 14 | Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects显示文摘 | Ruocco Maria Grazia Pilones Karsten A Kawashima Noriko Cammer Michael Huang Julie Babb James S Liu Mengling Formenti Silvia C Dustin Michael L Demaria Sandra | 2012 | EN2012，，10： | 1 |
| 15 | Study on Extraction Method of Selenium-enriched Rice显示文摘[Objectives] The aims were to optimize the extraction process of selenoproteins from selenium-enriched rice in Guangxi and provide references for the intensive processing and comprehensive utilization of selenium protein resources. [Methods]Selenium-enriched rice was used as materials to extract selenoproteins by phosphate buffer extraction method and to optimize the extraction process of selenoproteins by using the orthogonal experiment. Proteins and selenium content was measured by Coomassie Brilliant Blue G-250 reagent and AFS( atomic fluorescence spectrometry) respectively. [Results] The most significant factor affecting extraction of rice Selenoproteins was extraction NaO H concentration,followed by the ratio of solid-liquid,temperature and then extraction time. The optimum extraction conditions of selenoproteins from rice were extraction temperature of 50 ℃,NaO H concentration of 0. 14 mol/L,extraction time of 5 h,and solid-liquid ratio of 1∶ 30. [Conclusions]The alkali extraction process optimized by orthogonal test could effectively improve the extraction rate of selenoproteins,and the optimized process parameters could be popularized and applied in practical production. | Panxia LIANG Xiu LAN Yongxian LIU Liping PAN Mengling NONG Ying XING Qing LIAO Shiyang LU Jinping CHEN | 2018 | Agricultural Biotechnology2018，7，3： | 1 |
| 16 | Enhancing denitrifica- tion phosphorus removal with a novel nutrient removal process : Role of configuration 显示文摘 | Liu Hongbo Zhu Mengling Gao Saisai | 2014 | Chemical Engineering Journal2014，240，： | 1 |
| 17 | PAM4 enzyme immunoassay alone and in combination with CA 19‐9 for the detection of pancreatic adenocarcinoma显示文摘 | David V. Gold Jochen Gaedcke B. Michael Ghadimi Michael Goggins Ralph H. Hruban Mengling Liu Guy Newsome David M. Goldenberg | 2012 | Cancer2012，，3： | 1 |
| 18 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 19 | Enhancing denitrification phosphorus removal with a novel nutrient removal process: role of configuration 显示文摘 | LIU Hongbo ZHU Mengling GAO Saisai | 2014 | Chemical Engineering Journal2014，240，15： | 1 |
| 20 | A model for aircraft cabin evacuation considering passenger type显示文摘Pedestrian safety evacuation in aircraft cabins has been a challenging problem because of the aircraft’s unique characteristics,such as the diversity of passengers and the restricted evacuation environment.It is difficult to reproduce evacuation activities in aircraft cabin due to safety concerns and cost constraints.To fill this gap,an improved cellular automaton model of crowd evacuation for aircraft cabin is established by incorporating the characteristics of cabin space structures and passenger attributes.Passengers are divided into healthy individual passengers and disabled-healthy group passengers,whose movement mechanisms are quantified.Based on the constructed model,simulation experiments are conducted using the configuration cabin layout of B737-800 as an example.The results show that the evacuation time is prolonged with increased passenger density and the number of disabled passengers.Moreover,the overall evacuation time is insignificantly affected by whether disabled-healthy group passengers’seats are close to the aisle or window,and the evacuation efficiency is best when their seats are evenly distributed in the cabin.The evacuation time is the shortest when all cabin doors are open,and pedestrians are evacuated the slowest when the central emergency doors are closed.This study pro-vides valuable insights into effective strategies for pedestrian evacuation and crowd emergency management of civil aircraft. | Yaping Ma Jinfeng Yuan Lingling Tan Quanyi Liu Mengling Li | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
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