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| 1 | N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression,Plant Development, and Stress Responses显示文摘N6-Methyladenine (6mA)DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes,including the dioot modelArabidopsis thaliana.However,the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive.Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars,Nipponbare (Nip;Japonica)and 93-11 (Indica).Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis.We found that 6mA levels are positively correlated with the expression of key stressrelated genes,which may be responsible for the difference in stress tolerance between Nip and 93-11. Moreover,we showed that mutations in DDM1 cause defects in plant growth and decreased 6mA level. Our results reveal that 6mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants. | Qian Zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian Zhang Jingrong Liu Adeel Riaz Pu Yao Min Liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu | 2018 | Molecular Plant2018，11，12： | 18 |
| 2 | Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil显示文摘与化学疗法的药相结合的 Angiogenesis 禁止者在许多癌症的治疗有重要功效。金钱松属酸 B (PAB ) 是一个传统的终止怀孕的代理人,它以前被显示了减少肿瘤生长和 angiogenesis。在这研究,我们使用了高满意的屏蔽试金在人的脐的静脉 endothelial 房间(HUVEC ) 上检验 PAB 的效果。二个 hepatocarcinoma 22-transplanted 老鼠模型被用来与 5 氟尿嘧啶(5-Fu ) 在联合决定 PAB 功效。我们的结果建议没有明显的 cytotoxicity, PAB (0.1561.250 M ) 在 vitro 以一种集中依赖者方式禁止了 HUVEC 活动性。在 vivo, PAB (25 mg/kg/day ) 在联合治疗支持了 5-Fu (5 mg/kg/2 天) 的反肿瘤功效,导致显著地更高的肿瘤抑制率,更低的 microvessel 密度价值,和延长幸存时间。PAB 由在 G1/S 边界和 M 阶段堵住细胞周期行动了,这也被表明,脉管的 endothelial 生长因素的下面规定,组织缺氧可诱导的因素 1 并且 cdc2 的 cyclin E 表示,和起来规定表示。这些观察提供在有 5-Fu 的联合的 PAB 可能在癌症治疗是有用的第一条证据。 | Jingtao Liu Wei Guo Bo Xu Fuxiang Ran Mingming Chu HongzhengFu Jingrong Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 6 |
| 3 | Effects of CS-1 on A431 cell proliferation, cell cycle, and epidermal growth factor receptor signal transduction显示文摘CS-1,有 C21H20O8N2S 的一个分子的公式的新碱,从繁体中文药被提取。以前的研究证明了 CS-1 能在 vivo 并且在 vitro 禁止几个人的癌房间的增长。这研究的目的是在在人的 A431 细胞线表明小径的表皮的生长因素受体(EGFR ) 调查反肿瘤效果和 CS-1 的机制。通过 sulforhodamine B 试金,我们发现 CS-1 在集中依赖者和时间依赖者礼貌禁止了 A431 房间增长。禁止的率在孵化的 24 h 以后从 14.5% ~ 87.8%。高满意的屏蔽(HCS ) 多参数 cytotoxicity 分析证明在高集中的 CS-1 有从房间 permeabilization 和细微减小导致了全部的 mitochondrial 质量的细微 cytotoxicity,而在原子核尺寸 / 形态学和 lysosomal mass-pH 的变化都没被发现。CS-1 的 cytotoxicity 不是为它的 anti-proliferative 效果的一个主要原因。房间周期分析显示 CS-1 在一个时间依赖者在 A431 房间导致了 G1 阶段拘捕在高集中(2.5 M ) 的举止,和 S 阶段在低集中(0.625 M ) 逮捕。HCS 试金也证明 CS-1 能禁止 EGFR 成为主观,到原子核的 extracellular-signal-regulated kinase (英皇家空军之阶级最低之兵)/mitogen-activated 蛋白质 kinase translocation, phosphorylated 蛋白质 kinase B (Akt ) 的累积,信号变换器和抄写 3 的使活跃之物(STAT3 ) ,并且在原子核的 cyclin D1。这些结果被西方的污点分析证实。CS-1 可能禁止表皮的生长因素绑定到它的受体,导致 phosphorylated 的累积的抑制英皇家空军之阶级最低之兵和 Akt,和在原子核的 STAT3,并且在 G1/S 影响 cyclin D1 和细胞周期拘捕的抄写阶段。 | Haiyan Du Bo Xu Caixia WU Min Li Fuxiang Ran Shaoqing Cai Jingrong Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 1 |
| 4 | Synthesis and antitumor activity of iodo-bridged binuclear platinum complex显示文摘Iodo-bridged binuclear platinum(II) com- plex[Pt( -NH2)I2]2(BPA) has been synthesized and characterized by elemental analysis, conductivity, differential thermal analysis, IR, UV and 1HNMR spectra techniques. The cytotoxicity of the complex was tested by MTT and SRB assays. The results show that complex BPA demonstrates better cyto-toxicity than that of the clinically established cisplatin against EJ, HCT-8, BGC-823, HL-60 and MCF-7 cell lines. The complex BPA at concentrations of 1.00 and 2.00 μmol/L induces G1 cell cycle arrest in HL-60 cells. The level of total platinum bound to DNA in HL-60 cells is significantly higher than that of cisplatin under the same experimental conditions. Acute tox-icity experimental results indiacte that LD50 of BPA is 815.3 mg/kg by intraperitoneal administration. BPA at dose of 12 mg/kg significantly inhibits the growth of nude mice implanted by human A2780 and HCT-116 carcinomas, and inhibition rate is similar to that of cisplatin at dose of 4 mg/kg by intraperitoneal admini-stration. BPA at dose of 20 mg/kg inhibits the growth of nude mice implanted by human A549 carcinomas, but there was no significant statistical difference. | ZHANG Jinchao GONG Yuqiu ZHENG Xiaoming YANG Mengsu CUI Jingrong | 2006 | Chinese Science Bulletin2006，51，8： | 1 |
| 5 | Interactions Between Thrombin with Flavonoids from Abelmoschus manihot (L.) Medicus by CZE显示文摘 | Yi Liu Xianyin Lai Xiaomei Ling Yuying Zhao Jingrong Cui | 2006 | Chromatographia (-)2006，，1： | 1 |
| 6 | Synthesis and biological activity of flavanone derivatives显示文摘 | Sill Lei FENG Xiue CUI Jingrong | 2010 | Bioorg MOd Chem Lett2010，20，18： | 1 |
| 7 | Synthesis, characterization, crystal structure and antitumor activities of a novel demethylcantharidato bridged copper(Ⅱ) phenanthroline complex显示文摘A new polymeric demethylcantharidato (DCA) bridged copper(Ⅱ) phenanthroline (phen) complex ([Cu(DCA)(phen)] n ·nH2O) has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measurement, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallographic data: a = 12.4537(4), b = 9.3897(5), c = 30.1264(10), and Z = 8. In the crystal structure, the octahedral coordinated copper(Ⅱ) ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the Cu···Cu separation of 6.1719, along with phen ligands attached to both sides of the chain alternatively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evaluation of the cytotoxic activity of the copper(Ⅱ) complex against HCT-8 (colorectal carcinoma), A549 (pulmonary carcinoma), HeLa (cervical cancer), HepG2 (hepatocarcinoma), BGC-823 (gastric carcinoma), and MCF-7 (breast adenocarcinoma) cell lines revealed that it is a potent cytotoxic agent, superior to Na2DCA and phen against HeLa, HepG2 and BGC-823 cells. | YIN FuLing ZHU JingJing HAO Jian CUI JingRong YANG JunJiao | 2013 | Science China Chemistry2013，56，4： | 0 |
| 8 | Retrospective Analysis of the Duration of Hospitalization of Imported Patients Infected with SARS-CoV-2 in Guangzhou, 2021显示文摘The pandemic of coronavirus disease 2019 is“not over,”in fact,the“dynamic clearing”policy for SARS-CoV-2 control and prevention in China has been firmly enforced.This study aimed to analyze the clinical symptoms and dynamic viral RNA changes in 2021 at Guangzhou Eighth People’s Hospital.This study showed that 31.4%of the patients(695/2212)tested negative for viral RNA from admission to the final release from quarantine.Of all negative cases,86.5%(601/695)remained in the hospital for no more than 5 days and were asymptomatic or mild.Among the remaining 402 patients who stayed for no more than 5 days,76.4%(307/402)were viral RNA retest positive during the isolation stage.However,96.4%of the peak viral RNA(296/307)was over Ct=33 cycles during the isolation stage. | Zhiwei Xie Guofang Tang Lu Li Jingrong Shi Qingxin Gan Xiaowen Zheng Jingyan Tang Huimin Zeng Chuyu Zhang Sisi Cheni Jianping Cui Zishi Lin Lihua Lin Youxia Li Jinxin Liu Feng Li Fengyu Hui Xiaoping Tang Xilong Deng | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
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