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| 1 | Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells显示文摘Excessive fluoride exposure is known to contribute to reproductive system dysfunction,ultimately leading to pathological damage and apoptosis in cells. Although both oxidative and endoplasmic reticulum(ER) stresses have been implicated in fluorosis, the signaling pathways and their roles in sodium fluoride(Na F)-induced apoptosis of Sertoli cells have been sparsely described. In this study, oxidative damage, ER stress, and apoptosis were analyzed after Sertoli cells were treated with varying doses of Na F for 24 hr. Moreover, the antioxidant N-acetylcysteine(NAC) and pro-apoptotic transcription factor CHOP knockdown were used to clarify the precise interplay between reactive oxygen species(ROS), ER stress and their roles in NaF-induced apoptosis in Sertoli cells. The present study indicated that NaF significantly decreased cell viability and induced apoptosis in Sertoli cells. In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2-related factor 2(Nrf2) in Sertoli cells. Treatment with NAC caused remarkable recovery from these NaF-induced responses. Meanwhile, excessive NaF triggered ER stress as evidenced by up-regulated glucose-regulated protein 78 k Da(GRP78), PKR-like ER kinase(PERK), phosphorylation of eukaryotic translation initiation factor 2α(p-eI F2α) and CCAAT/enhancer-binding protein-homologous protein(CHOP), without affecting total eukaryotic translation initiation factor 2α(e IF2α). NAC effectively blocked the activation of ER stress, suggesting that Na F-induced ROS is an early event that triggers ER stress. Taken together, the results demonstrate that the ROS-mediated ER stress pathway is the crucial mechanistic event involved in NaF-induced apoptosis of Sertoli cells. | Yang Yang Xinwei Lin Hui Huang Demin Feng Yue Ba Xuemin Cheng Liuxin Cui | 2015 | Journal of Environmental Sciences2015，27，4： | 10 |
| 2 | 2.7 Ga Monzogranite on the Songnen Massif and Its Geological Implications显示文摘The formation and evolution of Songnen massif hasalways been a hot topic, and the presence of Precambrianbasement on the Songnen massif is still controversial: (1)Lacking of Pre-Paleozoic dating results, the Precambrianbasement on Songnen massif does not extend largelyaccording to the isotopic dating results of core frombasement, (2) the existence of gneiss from deep drill holesof the Songliao Basin makes some researchers considerthat Precambrian basement should exist on the Songnenmassif and another proof is that the geophysical featuresof gravity. | WU Xinwei ZHANG Chao ZHANG Yujin GUO Wei ZHANG Chao CUI Tianri YANG Yajun HU Jianfei SONG Wanbing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 8 |
| 3 | Randomized,multicenter,open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer:NCT01631357显示文摘Dear Editor,Cytokine-induced killer(CIK)cells have been recognized as a new type of anti-tumor effector cells.CIK cells are a mixture of T lymphocytes.Among them,CD3+/CD56+T cells,which are rare in uncultured peripheral blood,are the main effector cells.CIK cells can proliferate rapidly in vitro,with stronger antitumor activity,broader target tumor spectrum,and lower adverse effect than other reported antitumor effector cells.1 Their ease of production in vitro and antitumor potential have made them suitable candidates for cell therapy regimens in solid and hematopoietic tumor treatments.1,2 Our previous retrospective study showed that the median progression-free survival(PFS)and overall survival(OS)in untreated,advanced non-small-cell lung cancer(NSCLC)patients who received CIK cell immunotherapy plus chemotherapy(13 and 24 months,respectively)were significantly longer than in those who received chemotherapy alone(6 and 10 months,respectively).2 But so far,there is no prospective,multicenter clinical study in lung cancer.Based on our previous study,we designed this randomized,multicenter,open-label trial to further evaluate the clinical efficacy of CIK cell immunotherapy plus chemotherapy in patients with advanced squamous NSCLC(ClinicalTrials.gov number,NCT01631357). | Liang Liu Quanli Gao Jingting Jiang Junping Zhang Xin Song Jiuwei Cui Yunbin Ye Zhiyu Wang Xinwei Zhang Xiubao Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 4 | Precambrian Captured Zircon Ages in the Daheigou Formation, Xing’an Block显示文摘The Xing'an Block (XB) is located between the Erguna
Block (EB) and the Songnen Block (SB), which
topographically occupies the northeastern half of the Great
Xing'an Range (Liu et al., 2017). The XB was
traditionally considered to be composed of a Precambrian
metamorphic basement and post-Cambrian cover.
However, the recent geochronological studies show that
the so-called 'Precambrian metamorphic rocks^^ are much
younger in age and considered to be formed in the Early
Paleozoic, indicating no existence of the Precambrian
metamorphic basement. | SONG Wanbing CUI Fanghua YANG Hongzhi ZHANG Li WU Xinwei SHI Jianmin ZHANG Chao | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 1 |
| 5 | Characteristics of porosity and permeability layer of fossil Halimeda reef mineral rock of Miocene in the Xisha Islands and its genetic model显示文摘Halimeda is one of the major reef-building algas in the middle Miocene of Xisha, and one of the significant reefbuilding algas in the algal reef oil and gas field of the South China Sea. However, there have been few reports regarding the characteristics of mineral rocks, reservoir porosity and permeability layers, and sedimentationdiagenetic-evolution of fossil Halimeda systems. The present paper briefly introduces the relevant studies on chlorophyta Halimeda and the research status of oil and gas exploration. Through the 1 043 m core of the Xichen-1 well, we studied the characteristics of the mineral rocks and porosity and permeability of the middle Miocene Halimeda of the Yongle Atoll, identified and described the segments of fossil Halimeda, and pointed out that most of the segment slides are vertical sections in ovular, irregular or long strips. The overwhelming majority of these fossil Halimeda found and studied are vertical sections instead of cross sections. In this paper, knowledge regarding the cross sections of fossil Halimeda is reported and proven to be similar with the microscopic characteristics of modern living Halimeda; fossil Halimeda are buried in superposition; it is shown that there are different structures present, including typical bio-segment structure, and due to its feature of coexisting with red alga, tying structure, twining structure and encrusting structure are all present; and finally, it is suggested to classify the fossil Halimeda into segment algal reef dolomites. In addition, all of the studied intervals are moderately dolomitized. Secondary microcrystalline-dolosparite dominates the original aragonite raphide zones,and aphanitic-micrite dolomite plays the leading role in the cortexes and medullas; in the aragonite raphide zones between medulla and cysts, secondary dissolved pores and intercrystalline pores are formed inside the segments, and algal frame holes are formed between segments; therefore, a pore space network system(dissolved pores + intragranular dissolved pores—intercrystalline pores + algal frame holes) is established. Segment Halimeda dolomite has a porosity of 16.2%–46.1%, a permeability of 0.203×10–3–2 641×10–3 μm2, and a throatradius of 23.42–90.43 μm, therefore it is shown to be a good oil and gas reservoir. For the reasons mentioned above, we suggest building the neogene organic reef-modern reef sedimentation-diagenetic-evolution models for the Xisha Islands. | XU Hong ZHU Yurui EBERLI G.P. LUO Wei ZHAO Xinwei CAI Ying LIU Xinyu YAN Guijing ZHANG Bolin WEI Kai CUI Ruyong | 2015 | Acta Oceanologica Sinica2015，34，4： | 1 |
| 6 | Full-length sequence analysis of hepatitis E virus isolates: showing potential determinants of virus genotype and identity显示文摘 | Dong Yang Mei Jiang Min Jin Zhigang Qiu Weihong Cui Zhiqiang Shen Bo Li Lianfeng Gong Zhaoli Chen Xinwei Wang Jun-Wen Li | 2013 | Virus Genes2013，，3： | 1 |
| 7 | Electrochemical cyclability mechanism for MnO2 electrodes utilized as electrochemical supercapacitors显示文摘 | WEI Weifeng CUI Xinwei DOUGLAS G I | 2009 | Power Sources2009，186，： | 1 |
| 8 | Auxin signaling module OsSK41-OsIAA10-OsARF regulates grain yield traits in rice显示文摘Auxin is an important phytohormone in plants, and auxin signaling pathways in rice play key roles in regulating its growth, development, and productivity. To investigate how rice grain yield traits are regulated by auxin signaling pathways and to facilitate their application in rice improvement, we validated the functional relationships among regulatory genes such as OsIAA10, OsSK41, and OsARF21 that are involved in one of the auxin(OsIAA10) signaling pathways. We assessed the phenotypic effects of these genes on several grain yield traits across two environments using knockout and/or overexpression transgenic lines.Based on the results, we constructed a model that showed how grain yield traits were regulated by OsIAA10 and OsTIR1, OsAFB2, and OsSK41 and OsmiR393 in the OsSK41-OsIAA10-OsARF module and by OsARF21 in the transcriptional regulation of downstream auxin response genes in the OsSK41-OsIAA10-OsARF module. The population genomic analyses revealed rich genetic diversity and the presence of major functional alleles at most of these loci in rice populations. The strong differentiation of many major alleles between Xian/indica and Geng/japonica subspecies and/or among modern varieties and landraces suggested that they contributed to improved productivity during evolution and breeding. We identified several important aspects associated with the genetic and molecular bases of rice grain and yield traits that were regulated by auxin signaling pathways.We also suggested rice auxin response factor(OsARF) activators as candidate target genes for improving specific target traits by overexpression and/or editing subspecies-specific alleles and by searching and pyramiding the ‘best' gene allelic combinations at multiple regulatory genes in auxin signaling pathways in rice breeding programs. | Fuying Ma Fan Zhang Yu Zhu Dengyong Lan Peiwen Yan Ying Wang Zejun Hu Xinwei Zhang Jian Hu Fuan Niu Mingyu Liu Shicong He Jinhao Cui Xinyu Yuan Ying Yan Shujun Wu Liming Cao Hongwu Bian Jinshui Yang Zhikang Li Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 9 | Effect of CeO2 on High Temperature Carburization Behavior of Mn-Cr-O Spinel and Chromium Oxide 显示文摘 | Li Hao Cui Xinwei Chen Weixing | 2010 | J Electrochem Soc2010，157，10： | 1 |
| 10 | Improved electrochemical impedance response induced by morphological and structural evolution in nanocrystalline MnO2 electrodes 显示文摘 | Weifeng Wei Xinwei Cui Weixing Chen | 2009 | Electrochimica Acta2009，54，8： | 1 |
| 11 | Morphology Evolution in Anodically Electrodeposited Manganese Oxide Nanostructures for Electrochemical Supercapacitor Applications-Effect of Supersaturation Ratio显示文摘 | WEI Weifeng CUI Xinwei MAO Xuhui | 2011 | Electrochimica Acta2011，56，3： | 1 |
| 12 | Improved electrochemical impedance response induced by morphological and structural evolution in nanocrystalline MnO 2 electrodes显示文摘 | Weifeng Wei Xinwei Cui Weixing Chen Douglas G. Ivey | 2008 | Electrochimica Acta2008，，8： | 1 |
| 13 | J Cryst Growth显示文摘 | Cui Yanjie Wang Xinwei Zhou You | 2012 | 338(1):962012，338，1： | 1 |
| 14 | LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury显示文摘Dear Editor,ATP-binding cassette(ABC)-ATPase(RAD50),together with meiotic recombination 11 homolog 1(MRE11)subunits,to form MRE11-RAD50 complex,plays important roles in recognition of double-stranded DNA(dsDNA)and initiation of consequent inflammatory cascade1.Acute lung injury(ALI)and acute respiratory destress syndrome(ARDS)are systemic uncontrolled inflammation and life-threatening.However,the function of the DNA sensor in ALI/ARDS remains poorly defined.Here we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide(LPS)-induced lung injury model. | Xueqin Zhan Rui Cui Xinwei Geng Jiaqian Li Yunlian Zhou Lulu He Chao Cao Chao Zhang Zhimin Chen Songmin Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 15 | A homogenization-planning-tracking method to solve cooperative autonomous motion control for heterogeneous carrier dispatch systems显示文摘Taxiing aircraft and towed aircraft with drawbar are two typical dispatch modes on the flight deck of aircraft carriers. In this paper, a novel hierarchical solution strategy, named as the Homogenization-Planning-Tracking(HPT) method, to solve cooperative autonomous motion control for heterogeneous carrier dispatch systems is developed. In the homogenization layer, any towed aircraft system involved in the sortie task is abstracted into a virtual taxiing aircraft. This layer transforms the heterogeneous systems into a homogeneous configuration. Then in the planning layer, a centralized optimal control problem is formulated for the homogeneous system. Compared with conducting the path planning directly with the original heterogeneous system, the homogenization layer contributes to reduce the dimension and nonlinearity of the formulated optimal control problem in the planning layer and consequently improves the robustness and efficiency of the solution process. Finally, in the tracking layer, a receding horizon controller is developed to track the reference trajectory obtained in the planning layer. To improve the tracking performance,multi-objective optimization techniques are implemented offline in advance to determine optimal weight parameters used in the tracking layer. Simulations demonstrate that smooth and collision-free cooperative trajectory can be generated efficiently in the planning phase. And robust trajectory tracking can be realized in the presence of external disturbances in the tracking phase.The developed HPT method provides a promising solution to the autonomous deck dispatch for unmanned carrier aircraft in the future. | Jie LIU Xianzhou DONG Xinwei WANG Kaikai CUI Xiwang QIE Jun JIA | 2022 | Chinese Journal of Aeronautics2022，35，9： | 0 |
| 16 | A neuropsin-based optogenetic tool for precise control of Gq signaling显示文摘G_(q)-coupled receptors regulate numerous physiological processes by activating enzymes and inducing intracellular Ca^(2+)signals.There is a strong need for an optogenetic tool that enables powerful experimental control over G_(q) signaling.Here,we present chicken opsin 5(cOpn5)as the long sought-after,single-component optogenetic tool that mediates ultra-sensitive optical control of intracellular G_(q) signaling with high temporal and spatial resolution.Expressing cOpn5 in HEK 293T cells and primary mouse astrocytes enables blue light-triggered,G_(q)-dependent Ca^(2+) release from intracellular stores and protein kinase C activation.Strong Ca^(2+) transients were evoked by brief light pulses of merely 10 ms duration and at 3 orders lower light intensity of that for common optogenetic tools.Photostimulation of cOpn5-expressing cells at the subcellular and single-cell levels generated fast intracellular Ca^(2+)transition,thus demonstrating the high spatial precision of cOpn5 optogenetics.The cOpn5-mediated optogenetics could also be applied to activate neurons and control animal behavior in a circuit-dependent manner.cOpn5 optogenetics may find broad applications in studying the mechanisms and functional relevance of G_(q) signaling in both non-excitable cells and excitable cells in all major organ systems. | Ruicheng Dai Tao Yu Danwei Weng Heng Li Yuting Cui Zhaofa Wu Qingchun Guo Haiyue Zou Wenting Wu Xinwei Gao Zhongyang Qi Yuqi Ren Shu Wang Yulong Li Minmin Luo | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 17 | 4-Dimethylaminopyridine-catalyzed Cascade Reaction for Efficient Synthesis of Naphthofurans显示文摘 | FAN Chenli HE Xinwei LIAO Kaisheng WANG Cui'e SHANG Yongjia | 2016 | Chemical Research in Chinese Universities2016，32，1： | 0 |
| 18 | Ethylene Copolymerization with Linear and End-Cyclized Olefins via a Metallocene Catalyst:Polymerization Behavior and Thermal Properties of Copolymers显示文摘Olefin solution polymerization can be used to obtain high-performance polyolefin materials that cannot be obtained via other polymerization processes.Polyolefin elastomers(POE)are a typical example.Due to cost,only a few linear a-olefins(e.g.,1-butene,1-hexene,and 1-octene)are used as comonomers in solution polymerization in industry.However,a-olefin comonomers with other structures may have different effects on polymerization in comparison with common linear ones.Moreover,the properties of the corresponding materials may differ significantly.In this work,copolymers of ethylene with linear and endcyclized a-olefins are synthesized using a metallocene catalyst.The copolymerization of ethylene with linear a-olefins results in a higher turn-over frequency(TOF)and lower incorporation than copolymerization with end-cyclized a-olefins,which may indicate that end-cyclized a-olefins have a higher coordination probability and lower insertion rate.In this reaction,the comonomer is distributed randomly in the polymer chain and efficiently destroys crystallization.End-cyclized a-olefins exhibit a much stronger crystallization destructive capacity(CDC)in the copolymer than linear a-olefins,possibly because linear a-olefins act mainly in the radial direction of the main chain of the polymer,while end-cyclized a-olefins act mainly in the axial direction of the main chain. | Changjiang Wu Minqiao Ren Liping Hou Shuzhang Qu Xinwei Li Cui Zheng Jian Chen Wei Wang | 2023 | Engineering2023，，11： | 0 |
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