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| 1 | Finite difference numerical simulation of guided wave propagation in the full grouted rock bolt显示文摘Based on guided wave theory and considering the grouted rock bolt as waveguide medium, we have constructed a three dimensional model of grouted rock bolt with the dynamics of finite difference numerical simulation software FLAC3D4.0, and simulated the propagation behavior of the guided wave in the full grouted rock bolt. The simulated waveform and wave velocity matched well with the experimental results. We have made a more in-depth and comprehensive study of the wave velocity, wave component and attenuation characteristics of the guided wave propagating in rock bolt, and found some new characteristics and phenomena. In addition, some phenomena that haven’t been explained in the previous researches have also been discussed in this paper. The result showed that when guided wave propagates in grouted rock bolt, after the body wave decays, there is still the interface wave-Stoneley wave that does not decay in the axial direction of the bolt. The findings can provide some reference for rock bolt testing and the selection of the optimal excitation wave of testing. | YAN ZhiXin CAI HanCheng WANG QunMin CAO XiaoHong ZHANG LiuPing | 2011 | Science China(Technological Sciences)2011，54，5： | 10 |
| 2 | Dense ceramics with complex shape fabricated by 3D printing:A review显示文摘Three-dimensional(3D)printing technology is becoming a promising method for fabricating highly complex ceramics owing to the arbitrary design and the infinite combination of materials.Insufficient density is one of the main problems with 3D printed ceramics,but concentrated descriptions of making dense ceramics are scarce.This review specifically introduces the principles of the four 3D printing technologies and focuses on the parameters of each technology that affect the densification of 3D printed ceramics,such as the performance of raw materials and the interaction between energy and materials.The technical challenges and suggestions about how to achieve higher ceramic density are presented subsequently.The goal of the presented work is to comprehend the roles of critical parameters in the subsequent 3D printing process to prepare dense ceramics that can meet the practical applications. | Zhe Chen Xiaohong Sun Yunpeng Shang Kunzhou Xiong Zhongkai Xu Ruisong Guo Shu Cai Chunming Zheng | 2021 | Journal of Advanced Ceramics2021，10，2： | 10 |
| 3 | A MULTI-ATTRIBUTE LARGE GROUP EMERGENCY DECISION MAKING METHOD BASED ON GROUP PREFERENCE CONSISTENCY OF GENERALIZED INTERVAL-VALUED TRAPEZOIDAL FUZZY NUMBERS显示文摘In this paper,a new decision making approach is proposed for the multi-attribute large group emergency decision-making problem that attribute weights are unknown and expert preference information is expressed by generalized interval-valued trapezoidal fuzzy numbers(GITFNs).Firstly,a degree of similarity formula between GITFNs is presented.Secondly,expert preference information on different alternatives is clustered into several aggregations via the fuzzy clustering method.As the clustering proceeds,an index of group preference consistency is introduced to ensure the clustering effect,and then the group preference information on different alternatives is obtained.Thirdly,the TOPSIS method is used to rank the alternatives.Finally,an example is taken to show the feasibility and effectiveness of this approach.These method can ensure the consistency degree of group preference,thus decision efficiency of emergency response activities can be improved. | Xuanhua Xu Chenguang Cai Xiaohong Chen Yanju Zhou | 2015 | Journal of Systems Science and Systems Engineering2015，24，2： | 7 |
| 4 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 5 | Toward a high resolution 2-DE profile of the normal human liver proteome using ultra-zoom gels显示文摘The human liver is the largest organ in the body and has many important physiological functions. A global analysis of human liver proteins is essential for a better understanding of the molecular basis of the normal functions of the liver and of its diseases. As part of the Human Liver Proteome Project (HLPP), the goal of the present study was to visualize and detect as many proteins as possible in normal human livers using two-dimensional gel electrophoresis (2-DE). We have constructed a reference map of the proteins of human normal liver that can be used for the comprehensive analysis of the human liver proteome and other related research. To improve the resolution and enhance the detection of low abundance proteins, we developed and optimized narrow pH range ultra-zoom 2-DE gels. High resolution patterns of human liver in pH gradients 4.5-5.5, 5-6, 5.5-6.7, 6-9 and 6-11 are presented. To improve the poor resolution in the alkaline pH range of 2-DE gels, we optimized the isoelectric focusing protocol by including sample application using cup loading at the anode and incorporating 1.2% hydroxyethyl disulfide, 15% 2-propanol and 5% glycerol in the rehydration buffer. Using the optimized protocol, we obtained reproducibly better resolution in both analytical and preparative 2-DE gels. Compared with the 2386 and 1878 protein spots resolved in the wide range 3-10 and 4-7 pH gradients respectively, we obtained 5481 protein spots from the multiple (overlapping) narrow pH range ultra-zoom gels in the range of pH 4.5-9. The visualized reference map of normal human liver proteins presented in this paper will be valuable for comparative proteomic research of the liver proteome. | MI Wei LIU Xin JIA Wei LI Lei CAI Yun YING WanTao QIAN XiaoHong | 2011 | Science China(Life Sciences)2011，54，1： | 4 |
| 6 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 7 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 8 | Spatial Analysis of People Living with HIV/AIDS Transmitted Through Commercial Heterosexual Contact or Non-Marital Non-Commercial Heterosexual Contact—China,2018显示文摘Summary What is already known about this topic?Significant changes in human immunodeficiency virus(HIV)transmission modes have occurred in China,and the proportion of heterosexual transmission increased in recent years.What is added by this report?The proportions of diverse transmission routes and subgroups of heterosexual transmission were analyzed by provincial-level administrative divisions(PLADs). | Zhilong Dong Xiaohong Pan Chang Cai Qianqian Qin George F.Gao Fan Lyu | 2021 | China CDC weekly2021，3，15： | 3 |
| 9 | A four-gene signature-derived risk score for glioblastoma:prospects for prognostic and response predictive analyses显示文摘Objective: Glioblastoma(GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy.Therefore, a robust, multi-gene signature-derived model is required to predict the prognosis and treatment response in GBM.Methods: Gene expression data of GBM from TCGA and GEO datasets were used to identify differentially expressed genes(DEGs)through DESeq2 or LIMMA methods.The DEGs were then overlapped and used for survival analysis by univariate and multivariate COX regression.Based on the gene signature of multiple survival-associated DEGs, a risk score model was established,and its prognostic and predictive role was estimated through Kaplan–Meier analysis and log-rank test.Gene set enrichment analysis(GSEA) was conducted to explore high-risk score-associated pathways.Western blot was used for protein detection.Results: Four survival-associated DEGs of GBM were identified: OSMR, HOXC10, SCARA3, and SLC39A10.The four-gene signature-derived risk score was higher in GBM than in normal brain tissues.GBM patients with a high-risk score had poor survival outcomes.The high-risk group treated with temozolomide chemotherapy or radiotherapy survived for a shorter duration than the low-risk group.GSEA showed that the high-risk score was enriched with pathways such as vasculature development and cell adhesion.Western blot confirmed that the proteins of these four genes were differentially expressed in GBM cells.Conclusions: The four-gene signature-derived risk score functions well in predicting the prognosis and treatment response in GBM and will be useful for guiding therapeutic strategies for GBM patients. | Mianfu Cao Juan Cai Ye Yuan Yu Shi Hong Wu Qing Liu Yueliang Yao Lu Chen Weiqi Dang XiangZhang Jingfang Xiao Kaidi Yang Zhicheng He Xiaohong Yao Yonghong Cui Xia Zhang Xiuwu Bian | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 10 | Chemical vapor deposition growth of phase-selective inorganic lead halide perovskite films for sensitive photodetectors显示文摘Inorganic lead halide perovskites are attractive optoelectronic materials owing to their relative stability compared to organic cation alternatives.The chemical vapor deposition(CVD) method offers potential for high quality perovskite film growth.The deposition temperature is a critical parameter determining the film quality owing to the melting difference between the precursors.Here,perovskite films were deposited by the CVD method at various temperatures between 500-800℃.The perovskite phase converts from CsPb_(2)Br_(5) to CsPbBr_(3) gradually as the deposition temperature is increased.The grain size of the perovskite films also increases with temperature.The phase transition mechanism was clarified.The photoexcited state dynamics were investigated by spatially and temporally resolved fluorescence measurements.The perovskite film deposited under 750℃ condition is of the CsPbBr_(3) phase,showing low trap-state density and large crystalline grain size.A photodetector based on perovskite films shows high photocurrent and an on/off ratio of ~2.5×10^(4). | Weilong Xu Mengsi Niu Xiaoyu Yang Haiyue Chen Xiaohong Cai Trevor A.Smith Kenneth PGhiggino Xiaotao Hao | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 11 | Sparse representation of global features of visual images in human primary visual cortex: Evidence from fMRI显示文摘In fMRI experiments on object representation in visual cortex, we designed two types of stimuli: one is the gray face image and its line drawing, and the other is the illusion and its corresponding completed illusion. Both of them have the same global features with different minute details so that the results of fMRI experiments can be compared with each other. The first kind of visual stimuli was used in a block design fMRI experiment, and the second was used in an event-related fMRI experiment. Comparing and analyzing interesting visual cortex activity patterns and blood oxygenation level dependent (BOLD)- fMRI signal, we obtained results to show some invariance of global features of visual images. A plau- sible explanation about the invariant mechanism is related with the cooperation of synchronized re- sponse to the global features of the visual image with a feedback of shape perception from higher cortex to cortex V1, namely the integration of global features and embodiment of sparse representation and distributed population code. | ZHAO SongNian YAO Li JIN Zhen XIONG XiaoYun WU Xia ZOU Qi YAO GuoZheng CAI XiaoHong LIU YiJun | 2008 | Chinese Science Bulletin2008，53，14： | 2 |
| 12 | Comparison of the diagnostic performances of circulating tumor cells and the serum tumor markers CEA,CA125,and CA15-3 for breast cancer:a retrospective case-control study显示文摘Objective:Serum tumor markers are seldom considered as diagnostic biomarkers for breast cancer because they lack good sensitivity or specificity.This study aimed to evaluate whether a combination of circulating tumor cells(CTCs)and the serum tumor markers carcinoembryonic antigen(CEA),cancer antigen(CA)125,and CA15-3 might improve their diagnostic performance.Methods:We performed a retrospective case-control study of patients with breast cancer or benign breast diseases(BBD)and healthy female donors(HDs)who underwent preoperative CTC detection and serum tumor marker tests between December 2017 and November 2018.CTC detection and serum tumor marker test results were collected from 177 breast cancer patients,64 patients with BBD,and 20 HDs.Correlations between CTC,CEA,CA125,or CA15-3 and participants’clinical characteristics were then analyzed.The diagnostic performances of CTC,CEA,CA125,and CA15-3 were estimated using the area under the receiver operating characteristic curve(AUC).This study was approved by the Institutional Review Board of Sun Yat-sen Memorial Hospital of Sun Yat-sen University,China(approval No.[2018]kuaishendi(75))on May 24,2018.Results:CTC,CEA,and CA15-3 were able to distinguish breast cancer patients from controls(BBD+HDs)(P<0.0001,P=0.0006,and P=0.0086,respectively).CTCs were associated with tumor size(P=0.0275)and lymph node involvement(P=0.0373),while CA15-3 was correlated with cancer stage(P=0.01)and lymph node involvement(P=0.001).The AUCs of CTCs,CEA,CA125,and CA15-3 were 0.845,0.623,0.477,and 0.58,respectively.CA125,with AUC<0.5,was not considered a biomarker for breast cancer.CEA and CA15-3 had low sensitivities(<10%)but high specificities(>98%).Combination with CTC improved the diagnostic performances of CEA and CA15-3 for breast cancer.CTC_CA15-3 had better diagnostic performance than CTC_CEA,with an AUC of 0.874,a sensitivity of 0.757,and a specificity of 0.905.Conclusion:CTCs,CEA,and CA15-3 are potential diagnostic biomarkers for breast cancer.The diagnostic performance of CEA and CA15-3 may be improved by combination with CTCs. | Yi Luan Jie Wei Ke Wang Donghao Cai Xiaohong Luo Wanhung Fan Haijiang Wang Chaohui Duan | 2021 | Journal of Bio-X Research2021，4，2： | 2 |
| 13 | New Study of Anshunsaurus huangnihensis Cheng,2007(Reptilia:Thalattosauria):Revealing its Transitional Position in Askeptosauridae显示文摘Anshunsaurus huangnihensis Cheng 的颅骨, 2007,特别颅骨房顶,在这份报纸详细被描述。比作 Askeptosauroidea 的另外的类和种, Anshunsaurus huangnihensis 从 Askeptosaurus italicus 有一些重要过渡人物到 Anshunsaurus huangguoshuensis:与在 Askeptosaurus italicus 和 Anshunsaurus huangguoshuensis 之间的颅骨长度有关的喙的长度;存在的 postfrontal 但是清楚地减少了;相关地短的 posterolateral 过程并且重叠顶骨。种系发生的分析微弱地从 Anshunsaurus huangnihensis 支持进化进步到 Anshunsaurus huangguoshuensis。骨胳的比率显示了在 Askeptosauridae 内集团之中的节点。Askeptosauridae 的进化方向应该从 Askeptosaurus italicus 到 Anshunsaurus huangguoshuensis。骨胳的比率显示进化进步是 Askeptosaurus italicus Anshunsaurus huangnihensis Anshunsaurus huangguoshuensis。在生物地理学省,从华南的 Askeptosauroidea taxa 从西方的 Tethys 与那些有一种靠近的关系;然而, Xinpusaurus 从晚三叠纪是与从东方太平洋的那些有关的更多。 | CHENG Long CHEN Xiaohong ZHANG Baomin CAI Yongjian | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 2 |
| 14 | Preoperative Serum C-Reactive Protein Levels and Early Breast Cancer by BMI and Menopausal Status显示文摘 | Tingting Hong Aining Liu Dongyan Cai Ying Zhang Dong Hua Xiaosheng Hang Xiaohong Wu | 2013 | Cancer Investigation2013，，4： | 1 |
| 15 | Assessment of pollutant loads discharged from aquaculture ponds around Taihu Lake, China显示文摘 | Chunfang Cai Xiaohong Gu Yuantu Ye Caigeng Yang Xiuying Dai Dongxing Chen Chao Yang | 2012 | Aquac Res2012，，5： | 1 |
| 16 | Extraction, purification, a- nd characterization of the polysaeeharides from Opuntia milpaaLta 显示文摘 | Cai Weirong Gu Xiaohong Tang Jian | 2008 | Carbohydrate Polymers2008，71，3： | 1 |
| 17 | 4 - 18 Shell Effect on Subsequent Stabilization of Multi-electron Transfer in Slow Arq +-Ar ( q = 6 - 9, 11 ) Collisions显示文摘 | Lu Rongchun Yu Deyang Shao Caojie Ruan Fangfang Xue Yingli Cai Xiaohong | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 18 | Function of selfforming dynamic membrane and biokinetic parameters' determination by microelectrode显示文摘 | Zhou Xiaohong Shi Hanchang Cai Qiang | | 0，，10： | 1 |
| 19 | Variable amplitude Fourier series with its application in gearbox diagnosis 显示文摘 | Yuan Xiaohong Cai Lilong | 2005 | Mechanical Systems and Signal Processing2005，19，5： | 1 |
| 20 | Ion chromatography in combination with ESI ion trap MS for the analysis of diphacinone in animal livers 显示文摘 | CAI Meiqiang CHEN Xiaohong YAN Yongqing | 2009 | Chromatographia2009，69，12： | 1 |
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