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| 1 | Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice显示文摘Refined-JQ(JQ-R) is a mixture of refined extracts from Coptis chinensis(Ranunculaceae),Astragalus membranaceus(Leguminosae) and Lonicera japonica(Caprifoliaceae), the three major herbs of Jin Qi-Jiang Tang tablet, a traditional Chinese medicine(TCM) formula. The mechanisms by which JQ-R regulates glucose metabolism and improves insulin sensitivity were studied in type 2 diabetic KK^(Ay)mice and insulin-resistant L6 myotubes. To investigate the mechanisms by which JQ-R improves insulin sensitivity, a model of insulin-resistant cells induced with palmitic acid(PA) was established in L6 myotubes. Glucose uptake and expression of factors involved in insulin signaling, stress, and inflammatory pathways were detected by immunoblotting. JQ-R showed beneficial effects on glucose homeostasis and insulin resistance in a euglycemic clamp experiment and decreased fasting insulin levels in diabetic KK^(Ay)mice. JQ-R also improved the plasma lipid profiles. JQ-R directly increased the activity of superoxide dismutase(SOD) and decreased malondialdehyde(MDA) as well as inducible nitric oxide synthase(iNOS) levels in insulin-resistant L6 cells, and elevated the insulin-stimulated glucose uptake with upregulated phosphorylation of AKT. The phosphorylation levels of nuclear factor kappa B(NF-κB p65), inhibitor of NF-κB(IκBα), c-Jun N-terminal kinase(JNK1/2) and extracellular-signal-regulated kinases(ERK1/2) were also changed after JQ-R treatment compared with the control group. Together these findings suggest that JQ-R improved glucose and lipid metabolism in diabetic KK^(Ay)mice. JQ-R directly enhanced insulin-stimulated glucose uptake in insulin-resistant myotubes with improved insulin signalling and inflammatory response and oxidative stress. JQ-R could be a candidate to achieve improved glucose metabolism and insulin sensitivity in type 2 diabetes mellitus. | Quan Liu Shuainan Liu Lihui Gao Sujuan Sun Yi Huan Caina Li Yue Wang Nan Guo Zhufang Shen | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 11 |
| 2 | Characteristics of Biogenic Silica and Its Effect on Reservoir in Wufeng-Longmaxi Shales,Sichuan Basin显示文摘Further researches of shale petrology indicate that clay minerals are not the dominant mineral in most shale reservoirs.Depending on the reservoir,shales are typically dominated by quartz,calcite,or mixtures of these minerals and the quartz content is usually more than 30%.Besides the detrital quartz,biogenic silica is also an important part of shale reservoir.In order to analyze the genesis of quartz in gas shale and its effect on the reservoir quality。 | ZHAO Jianhua JIN Zhijun JIN Zhenkui WEN Xin GENG Yikai YAN Caina | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 3 |
| 3 | Characterization of homoepitaxial β-Ga 2 O 3 films prepared by metal–organic chemical vapor deposition显示文摘 | Xuejian Du Wei Mi Caina Luan Zhao Li Changtai Xia Jin Ma | 2014 | Journal of Crystal Growth2014，，： | 2 |
| 4 | Recent progress in cationic polymeric gene carriers for cancer therapy显示文摘In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety.In particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy.Herein,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine(PEI),polyamidoamine(PAMAM) dendrimers,polylysine(PLL),chitosan and modified cationic polymers.And recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were summarized.Finally,the future perspectives in the development of novel polymeric carriers for delivery gene were presented. | Caina Xu Huayu Tian Xuesi Chen | 2017 | Science China Chemistry2017，60，3： | 2 |
| 5 | Resonance Scattering Effect of Dopamine Product Particle and Its Application to Polyphenoloxidase Activity Assay显示文摘在 pH 7.2 Na2HPO4-NaH2PO4 缓冲区答案, polyphenoloxidase (PPO ) 能催化多巴胺(DA ) 的氧化在黑暗红的颜色形成聚合物粒子,它展出了散布的强壮的回声(RS ) 在 780 nm 的山峰。处于选择条件,当 PPO 活动增加了,在 780 nm 的 RS 紧张线性地增加了。增加的 RS 紧张(I780 nm ) 对在 0.106.0 U 的范围的 PPO | Jiang, Caina Ling, Shaoming Liang, Aihui Ouyang, Huixiang Wang, Pengfei Jiang, Zhiliang | 2011 | Chinese Journal of Chemistry2011，29，3： | 2 |
| 6 | Depositional environment of shale in Wufeng and Longmaxi Formations, Sichuan Basin显示文摘Formation of organic-rich shale was controlled by depositional processes and environment condition.According to petrology,mineralogy,fossil composition and sedimentary structure,seven lithofacies of shale were identified in the Wufeng Formation to Longmaxi Formation,e.g.,siliceous shale,silty shale,argillaceous shale,calcareous shale,shell-bearing argillaceous limestone/calcareous mudstone,siltstonefine sandstone and bentonite.For shale in the Wufeng and Longmaxi Formations,the depositional mode was not only the suspension deposition under the low-energy hydrodynamic condition,but also the biogenic deposition,the storm deposition and the bottom current deposition indicated by large amount of siliceous biological fossils,biological detritus with size graded structure,silt laminations,lenticular bedding,ripple cross-bedding and other sedimentary structures.Trace element analysis suggested that the siliceous shale in theWufeng Formation and the lower part of Longmaxi Formation was developed in the oxygen-dysoxic/anoxic depositional environment,which was rich in organic matters;then due to influence of the sea level gradually decline and bottom current,the silty and argillaceous shales were formed,and the oxygen-dysoxic/anoxic depositional environment was destroyed,gradually leading to the worse preservation condition of organic matter. | Jianhua Zhao Zhijun Jin Zhenkui Jin Xin Wen Yikai Geng Caina Yan Haikuan Nie | 2017 | Petroleum Research2017，2，3： | 2 |
| 7 | Biomolecular analysis of elastic fibre molecules 显示文摘 | Stuart A Caina Bertrand Raynala Nigel Hodsona | 2008 | Methods ExtracellMatr Res2008，45，1： | 1 |
| 8 | Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment显示文摘肺的药和基因交货系统与最小的药损失,精确量子化,高本地的药集中和低副作用的优点在肺疾病的处理成为了一条吸引人的途径。然而,特殊注意应该对肺的生物障碍被给予。交货系统需要小心地被设计以便克服这些生物障碍并且最大化药和基因免职到肺。肺的药和基因交货系统能提供为把药和基因送到肺鼓励结果的一些。明确地,一些基于类脂化合物、基于聚合物的交货系统能与最小或可以忽略的毒性控制并且支撑药和基因的版本。这评论为各种各样的肺疾病的处理集中于药和基因的肺的交货的最近的发展。对肺,交货设备,管理的线路和为药和基因的交货系统的障碍肺的交货被描述。基于临床的要求的快速的开发,用为肺的交货药和基因的交货系统的新奇途径需要被构造,它被相信以后在肺疾病的治疗起一个重要作用。 | Caina Xu Huayu Tian Xuesi Chen | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 9 | Epitaxial relation- ships and optical properties of SnO2 films deposited on sap- phire substrates显示文摘 | Zhu Zhen Ma Jin Luan Caina | 2011 | Appl Surf Sci2011，257，7： | 1 |
| 10 | Epitaxial relationships and optical properties of SnOz films deposited on sap- phire substrates显示文摘 | Zhu Zhen Ma Jin Luan Caina | 2011 | Appl Surf Sci2011，257，20： | 1 |
| 11 | Isolation of high-purlty anthocyanin mixtures and monomers from blueberries using combined chromatographic techniques显示文摘 | Erlei Wang Yongguang Yin Caina Xu | 2014 | Journal of ChromatograpHy A2014，13，27： | 1 |
| 12 | Phosphopeptides (PPPs) from hen egg yolk phosvitin exert anti-inflammatory activity via modulation of cytokine expression显示文摘 | Xu Caina Yang Chengbo Yin Yongguang | 2012 | Journal of functional foods2012，4，4： | 1 |
| 13 | New Application of bond Function Basis Sets──ab initio Calculations of Nonlinear Optical Properties 显示文摘NewApplicationofbondFunctionBasisSets──abinitioCalculationsofNonlinearOpticalPropertiesofCh_(4-n)F_n(n=1,2,3)LiZhi-ru,TAOFu-mi... | Li Zhi-ru, TAO Fu-ming, PAN Yuh-kang., FENG Ji-kang, WU Di., HUANG Xu-rid , SUN Ghia-Chung.(Department of Chemistry, Jilin University, Changchun, 130023 , CAina b $$Department of Chemistry, Harvard University, Chmberidge,MA 02138 , USA/Department of Chem | 1997 | Chemical Research in Chinese Universities1997，13，3： | 1 |
| 14 | A new atomic absorption spectral assay for the determination of trace IgG using immunonanogold显示文摘 | Yafang Tang Caina Jiang Aihui Liang | | 0，，： | 1 |
| 15 | Highly selective resonance scattering detection of trace thrombin using aptamer-modifiedAuRe nanoprobe显示文摘 | Aihui Liang Jishun Li Caina Jiang | | 0，，： | 1 |
| 16 | Determination of norfloxacin in human urine by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Biyang Deng Caina Su Yanhui Kang | 2006 | Analytical and Bioanalytical Chemistry2006，，7： | 1 |
| 17 | Delay-dependent passive control of linear systems with nonlinear perturbation显示文摘The problem of delay-dependent passive control of a class of linear systems with nonlinear perturbation and time-varying delay in states is studied. The main idea aims at designing a state-feedback controller such that for a time-varying delay in states, the linear system with nonlinear perturbation remains robustly stable and passive. In the system, the delay is time-varying. And the derivation of delay has the maximum and minimum value. The time-varying nonlinear perturbation is allowed to be norm-bounded. Using the effective linear matrix inequality methodology, the sufficient condition is primarily obtained for the system to have robust stability and passivity. Subsequently the existent condition of a state feedback controller is given, and the explicit expression of the controller is obtained by means of the solution of linear matrix inequalities (LMIs). In the end, a numerical example is given to demonstrate the validity and applicability of the proposed approach. | Li Caina Cui Baotong | 2008 | Journal of Systems Engineering and Electronics2008，19，2： | 1 |
| 18 | Establishment of a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins显示文摘Dipeptidyl peptidase 4(DPP4)is recognised as an attractive anti-diabetic drug target,and several DPP4 inhibitors are already on the market.As members of the same gene family,dipeptidyl peptidase 8(DPP8)and dipeptidyl peptidase 9(DPP9)share high sequence and structural homology as well as functional activity with DPP4.However,the inhibition of their activities was reported to cause severe toxicities.Thus,the development of DPP4 inhibitors that do not have DPP8 and DPP9 inhibitory activity is critical for safe anti-diabetic therapy.To achieve this goal,we established a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins expressed by Rosetta cells.In this method,we used purified recombinant 120 kDa DPP8 or DPP9 protein from the Rosetta expression system.The optimum concentrations of the recombinant DPP8 and DPP9 proteins were 30 ng/mL and 20 ng/mL,respectively,and the corresponding concentrations of their substrates were both 0.2 mmol/L.This method was highly reproducible and reliable for the evaluation of the DPP8 and DPP9 selectivity for DPP4 inhibitor candidates,which would provide valuable guidance in the development of safe DPP4 inhibitors. | Jinglong Liu Yi Huan Caina Li Minzhi Liu Zhufang Shen | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 1 |
| 19 | FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect显示文摘African swine fever(ASF)is a highly pathogenic swine infectious disease that affects domestic pigs and wild boar,which is caused by the African swine fever virus(ASFV).ASF has caused huge economic losses to the pig industry and seriously threatens global food security and livestock health.To date,there is no safe and effective commercial vaccine against ASF.Unveiling the underlying mechanisms of ASFV-host interplay is critical for developing effective vaccines and drugs against ASFV.In the present study,RNA-sequencing,RT-qPCR and Western blotting analysis revealed that the transcriptional and protein levels of the host factor FoxJ1 were significantly down-regulated in primary porcine alveolar macrophages(PAMs)infected by ASFV.RT-qPCR analysis showed that overexpression of FoxJ1 upregulated the transcription of type I interferon and interferon stimulating genes(ISGs)induced by poly(dA:dT).FoxJ1 revealed a function to positively regulate innate immune response,therefore,suppressing the replication of ASFV.In addition,Western blotting analysis indicated that FoxJ1 degraded ASFV MGF505-2R and E165R proteins through autophagy pathway.Meanwhile,RT-qPCR and Western blotting analysis showed that ASFV S273R inhibited the expression of FoxJ1.Altogether,we determined that FoxJ1 plays an antiviral role against ASFV replication,and ASFV protein impairs FoxJ1-mediated antiviral effect by degradation of FoxJ1.Our findings provide new insights into the antiviral function of FoxJ1,which might help design antiviral drugs or vaccines against ASFV infection. | Caina Ma Shasha Li Fan Yang Weijun Cao Huisheng Liu Tao Feng Keshan Zhang Zixiang Zhu Xiangtao Liu Yonghao Hu Haixue Zheng | 2022 | Virologica Sinica2022，37，3： | 1 |
| 20 | Beyond Gene Expression:The Impact of Protein Post-translational Modifications in Bacteria显示文摘 | Joel A Caina N S Stuart J Cordwella | | 0，，： | 1 |
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