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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Effects of mulberry leaf flavonoid and resveratrol on methane emission and nutrient digestion in sheep显示文摘As a new type of methane control agent, natural plant extract has been widely studied in recent years,but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 different polyphenols on the methane(CH4) emission and digestion metabolism in sheep. Ten healthy crossbred sheep(Dorper(?)× small-tailed Han ♀; BW 60.0 ± 1.73 kg) were used in a change-over design.The sheep were fed the following 3 diets in the present study: the basal diet(CON) with no supplementation; the basal diet supplemented with 2 g mulberry leaf flavonoid(MLF) per day per sheep; the basal diet supplemented with 0.25 g resveratrol(RES) per day per sheep. Both MLF and RES reduced CH4 emission scaled to metabolic weight per kilogram of DMI and CO2 output scaled to metabolic weight, but the effect of RES was significant(P < 0.05). Both MLF and RES significantly improved apparent digestibility of DM, OM, NDF, ADF, and nitrogen, but the effect of RES was significant(P < 0.05). Both MLF and RES significantly improved ME(P < 0.05) and reduced energy losses in CH4 emission(P > 0.05). In conclusion, MLF and RES can improve the digestibility of nutrients, the utilization of nutrients and energy, and reduce CH4 emission, but they are not conducive to nitrogen retention. | Dandan Chen Xiaolin Chen Yan Tu Bo Wang Can Lou Tao Ma Qiyu Diao | 2015 | Animal Nutrition2015，，4： | 14 |
| 3 | Studies and advances on joint source-channel encoding/decoding techniques in flow media communications显示文摘Joint source-channel coding/decoding (JSCC/JSCD) techniques in flow media communications have become a state-of-the-art and one of the challenging research subjects in the spatial communication area. They have great application prospective and deep impact in various manned space flights, satellite missions, mobile radio communications and deep-space explorations. In the last few years, there have been influential achievements in JSCC/JSCD studies. This paper aims at an introduction to the basic principles of joint source-channel optimal design. A general summarization and classification for various existing JSCC/JSCD methods is addressed. Also presented is a JSCD scheme based on variable-length coding, capable of providing reliable resolutions for flow media data transmission in spatial communications. | TU GuoFang LIU JianJun ZHANG Can GAO ShaoShuai LI ShiDong | 2010 | Science China(Information Sciences)2010，53，1： | 8 |
| 4 | Distribution of cagG gene in Helicobacter pylori isolates from Chinese patients with different gastroduodenal diseases and its clinical and pathological significance显示文摘AIM: To determine the distribution of cagG gene of Helicobacter pylori(Hpylori) isolates cultured from patients with various digestive diseases and its relationship with gastroduodenal diseases.METHODS: cagG was amplified by polymerase chain reaction in 145 H pylori isolates cultured from patients with chronic gastritis (n=72), duodenal ulcer (n=48), gastric ulcer (n=17), or gastric and duodenal ulcer (n=8), and the relationship between cagGstatus and the grade of gastric mucosal inflammation was determined.RESULTS: cagG was present in 91.7% of the 145 H pylori isolates, with the rates were 90.3%, 93.8%, 88.2% and 100.0%, respectively, in those from patients with chronic gastritis, duodenal ulcer, gastric ulcer, and gastric and duodenal ulcer. There was no significant difference among the four groups (P>0.05). The average grade of gastric mucosal inflammation in the antrum and corpus was 1.819±0.325and 1.768±0.312, respectively in cagG positive patients,whereas the average inflammation grade was 1.649±0.297,1.598±0.278 respectively in cagG negative cases (P>0.05).CONCLUSION: cagG gene of H pylori was quite conservative,and most H pylori strains in Chinese patients were cagG positive.cagG status was not related to clinical outcome or the degree of gastric mucosal inflammation. Therefore, cagG can notbe used as a single marker for discrimination of H pylori strains with respect to a specific digestive disease. | Can Xu Zhao-Shen Li Zhen-Xing Tu Guo-Ming Xu Yan-Fang Gong Xiao-Hua Man, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 5 | Microstructure and dry sliding wear behavior of laser clad AlCrNiSiTi multi-principal element alloy coatings显示文摘The approximately equimolar ratio AlCrNiSiTi multi-principal element alloy(MPEA) coatings were fabricated by laser cladding on Ti-6A1-4V(Ti64) alloy.Scanning electron microscopy(SEM),equipped with an energy-dispersive spectroscopy(EDS),and X-ray diffraction(XRD) were used to characterize the microstructure and composition.Investigations show that the coatings consist of(Ti,Cr)_5Si_3 and NiAl phases,formed by in situ reaction.The phase composition is initially explicated according to obtainable binary and ternary phase diagrams,and the formation Gibbs energy of Ti_5Si_3,V_5Si_3 and Cr_5Si_3.Dry sliding reciprocating friction and wear tests of the AlCrNiSiTi coating and Ti64 alloy substrate without coating were evaluated.A surface mapping profiler was used to evaluate the wear volume.The worn surface was characterized by SEM-EDS.The hardness and wear resistance of the AlCrNiSiTi coating are well compared with that of the basal material(Ti64).The main wear mechanism of the AlCrNiSiTi coating is slightly adhesive transfer from GCr15 counterpart,and a mixed layer composed of transferred materials and oxide is formed. | Can Huang Yi-Zhou Tang Yong-Zhong Zhang An-Ping Dong Jian Tu Lin-Jiang Chai Zhi-Ming Zhou | 2017 | Rare Metals2017，36，7： | 5 |
| 6 | Joint source-channel coded multidimensional modulation for variable-length codes显示文摘Resource-constrained networks such as deep space communications and mobile communications have the phenomena such us large-scale path loss,small-scale fading,and multipath effect,which are very hostile for information transmission.Combining Shannon’s source-channel coding theory with multidimensional modulation,an en/decoding method is proposed in this article called variable-length symbol-level joint sourcechannel and multidimensional modulation.Utilizing symbol-level source a priori information,an optimized symbol-level L-dimensional M-ary phase shift keying(LD-MPSK)constellation mapping function has been derived,which can increase free Euclidean distance between modulated symbols and enhance the decoding performance.It has been shown in the simulation results that the proposed scheme can achieve more than 2 dB signal-to-noise ratio gains compared with the conventional bit-level schemes under the condition of the same error rate. | CHENG Chen TU GuoFang ZHANG Can | 2014 | Science China(Information Sciences)2014，57，6： | 3 |
| 7 | A New PCR/LDR-Based Multiplex Functional Molecular Marker for Marker-Assisted Breeding in Rice显示文摘Marker-assisted selection or marker-aided selection(MAS)provides an effective complementary approach for conventional rice breeding with precise and speedy mobilization of target genes into elite genetic backgrounds.The targeted genes,however,may not be selected in the course of MAS due to the occasional recombination between the marker and the target gene/QTL during the many cycles of meiosis involved in breeding programs.This leads to failure in the selection of target traits(Gopalakrishnan et al,2008). | Chu Huangwei Tu Rongjian Niu Fuan Zhou Jihua Sun Bin Luo Zhongyong Cheng Can Cao Liming | 2021 | Rice science2021，28，1： | 3 |
| 8 | Joint Source-Channel En/Decoding Based on a New Symbol-Level Joint Trellis显示文摘 | TU Guofang LIU Jianjun ZHANG Can WANG Qiang | 2011 | Chinese Journal of Electronics2011，20，1： | 2 |
| 9 | Joint source channel VL coding/decoding for deep space communication networks based on a space trellis显示文摘This paper presents joint source channel variable length (VL) coding/decoding based on a space trellis.Through constructing a joint decoding plane trellis,better decoding performance can be achieved than by using the bit-level decoding algorithm.However,the plane trellis is complicated,which results in high decoding complexity for decoding VL turbo codes.To solve this problem,we construct a space trellis and design a low-complexity joint decoding algorithm with a variable length symbol-a posteriori probability (VLS-APP) algorithm in resource constrained deep space communication networks.Simulation results show that the proposed approach reduces the decoding complexity by 10% compared with the plane trellis,and the gain of Eb/N0 is about 0.2 dB at SER=10-4.Furthermore,it provides substantial error protection for variable-length encoded image data. | WU WeiRen TU Juan TU GuoFang GAO ShaoShuai ZHANG Can | 2011 | Science China(Information Sciences)2011，54，9： | 2 |
| 10 | Scalable video object coding & QoS control for next generation space internet显示文摘The next generation space internet (NGSI) is based on all-IP-based mobile network that merges land-based network, sea-based network, sky-based network, spacebased network, deep space-based network together using existing assess network technologies. There are high signal propagation delays, high error rate, bandwidth variation and time-variety in NGSI. In order to adapt to various space communication environment constraints and bandwidth variation, we propose a reduced dimension scalable video coding scheme based on CCSDS IDCS algorithm and quality of service (QoS) control method by cross layer design (CLD). The experimental result shows that this new method has better performance than that of existing algorithms, and can be adaptive to the bandwidth variation dynamically. | TU GuoFang ZHANG Can HEINRICH Nimann XU Jie WU WeiRen | 2008 | Science in China(Series F)2008，51，5： | 2 |
| 11 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 12 | Effects of Ausforming Procedure and Following Annealing Treatment on Microstructural Characteristics in Cobalt显示文摘The effects of ausforming procedure and subsequent annealing treatments on microstructures of cobalt(Co)samples are investigated by electron channeling contrast and electron backscatter diffraction techniques. Results show that the ausformed Co samples consist of coarsen blocky laths(single ε phase) with the irregular morphology and the ultra-fine acicular laths(dual phase: γ and ε) with the slender and rectangular morphologies. As compared to the slight reduction sample, the much denser acicular laths are observed in the heavily ausformed sample. In addition, recrystallization behavior and annealing-induced γ→ε transformation have occurred in ausformed Co samples during the annealing treatment. | Jian Tu Kun-Feng Zhou Zhi-Ming Zhou Can Huang Zhi-Gang Chen | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，4： | 1 |
| 13 | FimH alleles direct preferential binding of Salmonella to distinct mammalian cells or to avian cells 显示文摘 | Guo Ai-zhen Can Sha Tu Ling-ling | 2009 | Microbiology2009，155，5： | 1 |
| 14 | Application of Livelihood Vulnerability Index to Assess Risks from Flood Vulnerability and Climate VariabilitymA Case Study in the Mekong Delta of Vietnam显示文摘 | Nguyen Duy Can Vo Hong Tu Chu Thai Hoanh | 2013 | Journal of Environmental Science and Engineering(A)2013，2，8： | 1 |
| 15 | Predictive parameters on CT scan for dysthyroid optic neuropathy显示文摘AIM:To evaluate the value of parameters on CT scan in predicting dysthyroid optic neuropathy(DON)and to provide guidance for early diagnosis of DON accordingly.METHODS:A total of 67 eyes of 35 patients with thyroid-associated ophthalmopathy(TAO)were included in this study.Patients were divided into 2 groups(DON group and non-DON group).Parameters were measured on high resolution CT,including muscle index(MI),superior ophthalmic vein(SOV)dilatation,extraocular muscle volume/orbit volume(MV/OV),and intracranial fat prolapsed,and be compared between these 2 groups.The relation between those parameters and visual function[visual acuity(VA)and visual field defect(VF defect)]were also evaluated.RESULTS:MI and MV/OV were significantly higher in DON group(P=0.00035 and P=0.00026).No significant difference was detected regarding intracranial fat prolapse existence and SOV dilatation(P=0.37 and P=0.15).MV/OV was found to have significant negative correlation with both VF defect(R=-0.332,P=0.0273)and VA(R=-0.635,P=0.00)while MI was found to have negative linear correlation with VA only(R=-0.456,P=0.00017).The area under receiver operating characteristic curves was 0.82 for MV/OV and 0.75 for MI.The best performance in detecting DON was achieved when MV/OV is set at 0.20 with 72%sensitivity and 87%specificity and MI is set at 0.52 with 64%sensitivity and 80%specificity.CONCLUSION:MI and MV/OV are predictive parameters for DON.Together with clinical manifestations,MV/OV≥0.2 can be used as a good indicator for DON in TAO patients. | Bo Yu Can Gong Yuan-Fei Ji Yu Xia Yun-Hai Tu Wen-Can Wu | 2020 | International Journal of Ophthalmology(English edition)2020，13，8： | 1 |
| 16 | Protective effect of ulinastatin against murine models of sepsis : inhibition of TNF - ot and IL - 6 and augmen- tation of IL - 10 and IL - 13 显示文摘 | Can YZ Tu YY Chen X | 2012 | Experimental and Toxicologic Pa- thology2012，64，6： | 1 |
| 17 | Self-assembled pH-responsive MPEG- b -(PLA- co -PAE) block copolymer micelles for anticancer drug delivery显示文摘 | Can Yang Zhang You Qiang Yang Tu Xiong Huang Bin Zhao Xin Dong Guo Ju Fang Wang Li Juan Zhang | 2012 | Biomaterials2012，，26： | 1 |
| 18 | Microstructural Characterization of Pure Titanium Treated by Laser Surface Treatment Under Different Processing Parameters显示文摘Advanced characterization techniques are utilized to investigate the effect of laser surface treatment on microstructural evolution of pure titanium(Ti). The results show that there are three distinctly different types of microstructure from surface to substrate in Ti samples, including phase transformation and solidification microstructure in zone I(melting zone); insufficient recrystallization grains with residual a martensitic plates in zone II(heat-affected zone, HAZ); fully recrystallization microstructure in zone III(base metal, BM). The hardness evolution profiles under different laser treatment parameters are similar.The highest hardness in MZ is ascribed to a plate, while the lowest hardness value in HAZ is due to the insufficiently recrystallized grains. The metallurgical process on the laser-modified Ti samples is systematically discussed in this work. | Can Huang Jian Tu Yu-Ren Wen Zhi Hu Zhi-Ming Zhou An-Ping Dong Guo-Liang Zhu | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，3： | 1 |
| 19 | Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial显示文摘Background As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical expenses.Epidemiological evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is rising.Recent guidelines indicate a reduced role for medicines in the management of CNLBP.Objective The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of CNLBP.Design,setting,participants and interventions We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel groups.Diclofenac sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied externally.Patients in the test group were treated with cupping and scraping using a medical device and medicated balm.Main outcome measures Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment tools.Results Between baseline and postintervention,all changes in outcome metric scales were statistically significant(P<0.001).Compared to the control group,patients in the test group had a significantly greater treatment effect in all outcome variables,as indicated by lower VAS and TCMS scores and higher JOA scores,after the one-week intervention period(P<0.001).Further,according to the findings of multivariate linear regression analysis,the participants’pain(VAS score)was related to their marital status,age,smoking habits and body mass index.No adverse reactions were reported for any participants in this trial.Conclusion The effectiveness of TCM combined with the new physiotherapy tool is superior to that of NSAID combined with topical plasters,regarding to pain intensity,TCM symptoms and quality of life.The TCM plus physiotherapy also showed more stable and long-lasting therapeutic effects. | Jun-yan He Xiao-yu Tu Zi-fei Yin Hui Mu Ming-jun Luo Xing-yu Chen Wei-bin Cai Xue Zhao Can Peng Fan-fu Fang Can Lü Bai Li | 2024 | Journal of Integrative Medicine2024，22，1： | 0 |
| 20 | Distribution of Eight Blast-resistant Genes in Parents of Three-line Japonica Hybrid Rice显示文摘The distribution of rice blast-resistant genes Pi2, Pi5, Pi9, Pi54, Pia, Pib, Pit and Pita in 36 restoring lines and 42 sterile lines were detected using functional molecular markers. The results indicated that those eight blast-resistant genes distributed in the 78 tested lines at various frequencies. Six rice blast-resistant genes were detected in the sterile line Shen 11 A, containing the most rice blast-resistant genes among the 78 lines, whereas no rice blast-resistant gene was detected in the lines 8527 A, Xu1 A and 016 A. The genetic distance-based clustering analysis showed that those 78 lines could be divided into five groups. | Chu Huangwei Cheng Can Niu Fu’an Zhou Jihua Tu Rongjian Luo Zhongyong Wang Xinqi Cao Liming | 2018 | Plant Diseases and Pests2018，9，2： | 0 |
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