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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori显示文摘AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic group.METHODS: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial therapy.RESULTS: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P<0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains. | Mehmet Sarg■n OyaUygur-Bayramili Haluk Sarg■n Ekrem Orbay Dilek Yavuzer Ali Yayla | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 3 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 4 | Current concepts in volar fixed-angle of unstable distal radius fractures 显示文摘 | Orbay JL Touhami A | 2006 | Clin Orthop2006，445，： | 1 |
| 5 | Volar fixed - angle plate fixation for unstable distal radius fractures in the elderly patient 显示文摘 | Orbay JL Fernandez DL | 2004 | J Hand Surg (Am)2004，29，1： | 1 |
| 6 | Current concepts in volar fixed-angle fixation of unstable distal radius fractures显示文摘 | Orbay JL Touhami A | 2006 | Clin Orthop Relat Res2006，445，4： | 1 |
| 7 | Derivation and validation ofthe systemic lupus international collaborating clinics classificationcriteria for systemic lupus erythematosus显示文摘 | Petri M Orbai AM Alarcon GS | 2012 | Arthritis Rheum2012，64，8： | 1 |
| 8 | Adipose-derived stem cells for wound repair and regeneration显示文摘 | Shingyochi Y Orbay H Mizuno H | 2015 | Expert Opin Biol Ther2015，15，9： | 1 |
| 9 | On the computation of molecular auxiliary functions A n and B n显示文摘 | I I Guseinov B A Mamedov M Kara M Orbay | 2001 | Pramana2001，，5： | 1 |
| 10 | Volar plate fixation of distal radius fractures显示文摘 | Orbay J | | 0，，03： | 1 |
| 11 | Voltammetric determina tion of nitrite in meat products using polyvinylimidazole modified carbon paste electrode I显示文摘 | Yildiz G Oztekin N Orbay A | 2014 | Food Chemistry2014，152，： | 1 |
| 12 | Modified polyacrylamide hydrogels and their application in removal of heavy metal ions显示文摘 | Kasgoz H Ozgümüs S Orbay M | 2003 | Polymer2003，44，6： | 1 |
| 13 | Modified polyacrylamide hydrogels and their application in removal of heavy metal ions 显示文摘 | Hasine Kasgoz Saadet Zgumtus Murat Orbay | 2003 | Polymer2003，44，6： | 1 |
| 14 | Derivation and vali- dation of the Systemic Lupus International Collaborating Clin- ics classification criteria for systemic lupus erythematosus 显示文摘 | Petri M Orbai A M Alarc6n G S | 2012 | Arthritis & Rheumatism2012，64，8： | 1 |
| 15 | Volar fixed - angle plate fixation for unstable diatal radius fractures in the elderly patient显示文摘 | Orbay JL Fernandez DL | 2004 | J Hand Surg(Am)2004，29，： | 1 |
| 16 | Volar fixation for dorsally displaced fracmres of the distal radius: a preliminary report显示文摘 | Orbay JL Fernandez DL | 2002 | J hand Surg Am2002，27，2： | 1 |
| 17 | Volar plate fixation of distal radius fractures显示文摘 | Orbay J | 2005 | Hand Clin2005，21，3： | 1 |
| 18 | Volar fixtion for dorsally displaced fracture of the distal radius:a preliminary report显示文摘 | Orbay JL Fernandez DL | | 0，，： | 1 |
| 19 | Current concepts in volar fixed-an- gle fixation of unstable distal radius fractures显示文摘 | Orbay JL Touhami A | 2006 | Clin Or- thop Relat Res2006，445，： | 1 |
| 20 | The treatment of unstable metacarpal and phalangeal shaft fractures with flexible nonlokcing and locking in- tramedullar nails显示文摘 | Orbay JL Touhami A | 2006 | Hand Clin2006，22，3： | 1 |
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