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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Research progress on silicon/carbon composite anode materials for lithium-ion battery显示文摘Silicon(Si) has been considered as one of the most promising anode material for the next generation lithium-ion batteries(LIBs) with high energy densities, due to its high theoretical capacity, abundant availability and environmental friendliness. However, silicon materials with low intrinsic electric and ionic conductivity suffer from huge volume variation during lithiation/delithiation processes leading to the pulverization of Si and subsequently resulting in severe capacity fading of the electrodes. Coupling of Si with carbon(C) realizes a favorable combination of the two materials properties, such as high lithiation capacity of Si and excellent mechanical and conductive properties of C, making silicon/carbon composite(Si/C) ideal candidates for LIBs anodes. In this review, recent progresses of Si/C materials utilized in LIBs are summarized in terms of structural design principles, material synthesis methods, morphological characteristics and electrochemical performances by highlighting the material structures. The mechanisms behind the performance enhancement are also discussed. Moreover, other factors that affect the performance of Si/C anodes, such as prelithiation, electrolyte additives, and binders, are also discussed. We aim to present a full scope of the Si/C-based anodes, and help understand and design future structures of Si/C anodes in LIBs. | Xiaohui Shen Zhanyuan Tian Ruijuan Fan Le Shao Dapeng Zhang Guolin Cao Liang Kou Yangzhi Bai | 2018 | Journal of Energy Chemistry2018，27，4： | 29 |
| 3 | Estimating Leaf Chlorophyll Content Using Red Edge Parameters显示文摘Hyperspectral remote sensing makes it possible to non-destructively monitor leaf chlorophyll content(LCC).This study characterized the geometric patterns of the first derivative reflectance spectra in the red edge region of rapeseed(Brassica napus L.) and wheat(Triticum aestivum L.) crops.The ratio of the red edge area less than 718 nm to the entire red edge area was negatively correlated with LCC.This finding allowed the construction of a new red edge parameter,defined as red edge symmetry(RES).Compared to the commonly used red edge parameters(red edge position,red edge amplitude,and red edge area),RES was a better predictor of LCC.Furthermore,RES was easily calculated using the reflectance of red edge boundary wavebands at 675 and 755 nm(R675 and R755) and reflectance of red edge center wavelength at 718 nm(R718),with the equation RES =(R718-R675)/(R755-R675).In addition,RES was simulated effectively with wide wavebands from the airborne hyperspectral sensor AVIRIS and satellite hyperspectral sensor Hyperion.The close relationships between the simulated RES and LCC indicated a high feasibility of estimating LCC with simulated RES from AVIRIS and Hyperion data.This made RES readily applicable to common airborne and satellite hyperspectral data derived from AVIRIS and Hyperion sources,as well as ground-based spectral reflectance data. | JU Chang-Hua TIAN Yong-Chao YAO Xia CAO Wei-Xing ZHU Yan D. HANNAWAY | 2010 | Pedosphere2010，20，5： | 26 |
| 4 | Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement显示文摘AIM: To study the effects of magnolol and honokiol on isolated smooth muscle of gastrointestinal tract and their relationship with Ca2+, and on the gastric emptying and the intestinal propulsive activity in mice.METHODS: Routine experimental methods using isolated gastric fundus strips of rats and isolated ileum segments of guinea pigs were adopted to measure the smooth muscle tension. The effects of magnolol 10-3, 10-4, 10-5 mol/L, and honokiol 10-4, 10-5, 10-6 mol/L on the contractility of gastric fundus strips of rats and ileum of guinea pigs induced by acetylcholine (Ach) and 5-hydroxytryptamine (5-HT)was assessed respectively. The method using nuclein and pigment methylene blue was adopted to measure the gastric retention rate of nuclein and the intestinal propulsive ratio of a nutritional semi-solid meal for assessing the effect of magnolol and honokiol (0.5, 2, 20 mg/kg) on gastric emptying and intestinal propulsion.RESULTS: Magnolol and honokiol significantly inhibited the contractility of isolated gastric fundus strips of rats treated with Ach or 5-HT and isolated ileum guinea pigs treated with Ach or CaCl2, and both of them behaved as non-competitive muscarinic antagonists. Magnolol and honokiol inhibited the contraction induced by Ach in Ca2+-free medium and extracellular Ca2+-dependent contraction induced by Ach. Each group of magnolol and honokiol experiments significantly decreased the residual rate of nuclein in the stomach and increased the intestinal propulsive ratio in mice.CONCLUSION: The inhibitory effect of magnolol and honokiol on contractility of the smooth muscles of isolated gastric fundus strips of rats and isolated ileum of guinea pigs is associated with a calcium-antagonistic effect.Magnolol and honokiol can improve the gastric emptying of a semi-solid meal and intestinal propulsive activity in mice. | Wei-Wei Zhang Yan Li Xue-Qing Wang Feng Tian Hong Cao Min-Wei Wang Qi-Shi Sun | 2005 | World Journal of Gastroenterology2005，11，28： | 22 |
| 5 | Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells显示文摘AIM:To investigate the apoptotic activities of casticin in hepatocellular carcinoma(HCC) cells and its molecular mechanisms.METHODS:PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolim bromide(MTT) assay.The apoptotic cell death was examined using the cell apoptosis enzyme linked immunosorbent assay(ELISA) detection kit,flow cytometry(FCM) after propidium iodide(PI) staining and DNA agarose gel electrophoresis.The caspase activities were measured using ELISA.Reactive oxygen species(ROS) production was evaluated by FCM after dichlorodihydrofluorescein diacetate(DCFH-DA) probe labeling.Intracellular glutathione(GSH) content was measured using a glutathione assay kit.The expression of death receptor(DR)4 and DR5 proteins was analyzed by Western blotting and FCM.RESULTS:Casticin significantly inhibited the growth of human HCC(PLC/PRF/5 and Hep G2) cells in a dosedependent manner(P < 0.05).Casticin increased the percentage of the sub-G1 population in HCC cells in a concentration-dependent manner.The potency of casticin to PLC/PRF/5 cells was higher than that of 5-flurouracil(26.8% ± 4.8% vs 17.4% ± 5.1%) at 10 μmol/L for 24 h.Casticin increased the levels of Histone/DNA fragmentation and the levels of active caspase-3,-8 and-9 in a concentration-dependent manner(P < 0.05).Treatment with 30 μmol/L casticin for 24 h resulted in the formation of a DNA ladder.Casticin reduced the GSH content(P < 0.05),but did not affect the level of intracellular ROS in PLC/PRF/5 and Hep G2 cells.The thiol antioxidants,acetylcysteine(NAC) and GSH restored GSH content and attenuated casticin-induced apoptosis.In contrast,the nonthiol antioxidants,butylated hydroxyanisole and mannitol failed to do so.In the HCC cells treated with casticin for 24 h,DR5 protein level was increased.The expression of DR5 protein induced by casticin was inhibited by NAC.Pretreatment with DR5/Fc chimera protein,a blocking antibody,effectively attenuated the induction of apoptosis by casticin.CONCLUSION:Casticin-induced apoptosis of HCC cells is involved in GSH depletion and DR5 upregulation. | Jun Yang Yun Yang Li Tian Xi-Feng Sheng Fei Liu Jian-Guo Cao | 2011 | World Journal of Gastroenterology2011，17，38： | 21 |
| 6 | Kinematic analysis and experiment of planetary five-bar planting mechanism for zero-speed transplanting on mulch film显示文摘A novel seedling transplanting mechanism with planetary five-bar was developed in order to solve some problems when transplanting seedlings on mulch film,such as a large cave diameter,a low proportion of upright seedlings,and inconsistent planting depths,which seriously restrict the development of transplanting equipment used in dryland agriculture.The planetary five-bar structure of transplanting mechanism was designed based on analysis of the seedling transplanter on mulch film.The kinematics model of the transplanting mechanism was established and the optimal parameters of the transplanting mechanism were obtained by satisfying the motion trajectory conditions.Subsequently,the virtual prototype of transplanting mechanism was developed,and the simulation of motion trajectory was illustrated.Finally,the physical prototype of the transplanting mechanism was assembled and tested with the high-speed photography.The simulation results indicated that the desired“spindle”trajectory for the duckbill can be obtained,of which the height was 350 mm,and the diameter of the planting cave was 32 mm.The experimental results showed that the diameter of the planting cave was less than 70 mm,the seedling perpendicularity qualification rate reached 96%,the film injury rate was less than 0.5%,and the hanging membrane phenomenon was avoided.Therefore,the proposed transplanting mechanism can meet the requirements for a mulch-film transplanting machine. | Liu Jiaodi Cao Weibin Tian Dongyang Tang Haiyang Zhao Hongzheng | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 20 |
| 7 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 8 | Reply to the Comment by Tan Mingxuan et al.(2017), on “A new Discovery of the Early Cretaceous Supercritical Hyperpycnal Flow Deposits on the Lingshan Island, East China”显示文摘We thank Tan Mingxuan et al.(2017)for their comments stimulated by our short paper in the recent Acta Geologica Sinica(English edition).We are grateful for the opportunity to expand on the model of the supercritical hyperpycnal flow deposits in the Beilaishi section on the Lingshan Island,and to explain why the model proposed by Tan Mingxuan et al.(2017)cannot explain the bulk | YANG Tian CAO Yingchang WANG Yanzhong | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 19 |
| 9 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 10 | Status and Trends in Research on Deep-Water Gravity Flow Deposits显示文摘Deep-water gravity flows are one of the most important sediment transport mechanisms on Earth. After 60 years of study,significant achievements have been made in terms of classification schemes,genetic mechanisms,and depositional models of deep-water gravity flows. The research history of deep-water gravity flows can be divided into five stages: incipience of turbidity current theory; formation of turbidity current theory; development of deep-water gravity flow theory; improvement and perfection of deep-water gravity flow theory; and comprehensive development of deep-water gravity flow theory. Currently,three primary classification schemes based on the sediment support mechanism,the rheology and transportation process,and the integration of sediment support mechanisms,rheology,sedimentary characteristics,and flow state are commonly used.Different types of deep-water gravity flow events form different types of gravity flow deposits. Sediment slump retransportation mainly forms muddy debris flows,sandy debris flows,and surge-like turbidity currents. Resuspension of deposits by storms leads to quasi-steady hyperpycnal turbidity currents(hyperpycnal flows). Sustainable sediment supplies mainly generate muddy debris flows,sandy debris flows,and hyperpycnal flows. Deep-water fans,which are commonly controlled by debris flows and hyperpycnal flows,are triggered by sustainable sediment supply; in contrast,deep-water slope sedimentary deposits consist mainly of debris flows that are triggered by the retransportation of sediment slumps and deep-water fine-grained sedimentary deposits are derived primarily from finegrained hyperpycnal flows that are triggered by the resuspension of storm deposits. Harmonization of classification schemes,transformation between different types of gravity flow deposit,and monitoring and reproduction of the sedimentary processes of deep-water gravity flows as well as a source-to-sink approach to document the evolution and deposition of deep-water gravity flows are the most important research aspects for future studies of deep-water gravity flows study in the future. | YANG Tian CAO Yingchang WANG Yanzhong LI Ya ZHANG Shao Min | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 18 |
| 11 | Postponed and reduced basal nitrogen application improves nitrogen use efficiency and plant growth of winter wheat显示文摘Excessive nitrogen(N) fertilization with a high basal N ratio in wheat can result in lower N use efficiency(NUE) and has led to environmental problems in the Yangtze River Basin, China. However, wheat requires less N fertilizer at seedling growth stage, and its basal N fertilizer utilization efficiency is relatively low; therefore, reducing the N application rate at the seedling stage and postponing the N fertilization period may be effective for reducing N application and increasing wheat yield and NUE. A 4-year field experiment was conducted with two cultivars under four N rates(240 kg N ha–1(N240), 180 kg N ha–1(N180), 150 kg N ha–1(N150), and 0 kg N ha–1(N0)) and three basal N application stages(seeding(L0), fourleaf stage(L4), and six-leaf stage(L6)) to investigate the effects of reducing the basal N application rate and postponing the basal N fertilization period on grain yield, NUE, and N balance in a soil-wheat system. There was no significant difference in grain yield between the N180 L4 and N240 L0(control) treatments, and the maximum N recovery efficiency and N agronomy efficiency were observed in the N180 L4 treatment. Grain yield and NUE were the highest in the L4 treatment. The leaf area index, flag leaf photosynthesis rate, flag leaf nitrate reductase and glutamine synthase activities, dry matter accumulation, and N uptake post-jointing under N180 L4 did not differ significantly from those under N240 L0. Reduced N application decreased the inorganic N content in the 0–60-cm soil layer, and the inorganic N content of the L6 treatment was higher than those of the L0 and L4 treatments at the same N level. Surplus N was low under the reduced N rates and delayed basal N application treatments. Therefore, postponing and reducing basal N fertilization could maintain a high yield and improve NUE by improving the photosynthetic production capacity, promoting N uptake and assimilation, and reducing surplus N in soil-wheat systems. | TIAN Zhong-wei LIU Xiao-xue GU Shi-lu YU Jin-hong ZHANG Lei ZHANG Wei-wei JIANG Dong CAO Wei-xing DAI Ting-bo | 2018 | Journal of Integrative Agriculture2018，17，12： | 18 |
| 12 | Characteristics and origin of abnormally high porosity zones in buried Paleogene clastic reservoirs in the Shengtuo area, Dongying Sag, East China显示文摘There are three abnormally high porosity zones developed in buried Paleogene nearshore subaqueous fan and sublacustrine fan clastic reservoirs at 2,800-3,200 m, 3,250-3,700 m and 3,900-4,400 m, respectively, within the Shengtuo area of the Dongying Sag. Here the porosity of reservoirs buried deeper than 4,000 m can still be greater than 20%. Investigation of these three abnormally high porosity(AHP) zones in the 3rd to 4th member of the Paleogene Shahejie Formation in the Shengtuo area was carried out with utilization of core observation, thin section identification, SEM observation, image analysis, core physical property testing and other technical methods. The results show that, the AHP zones in 2,800-3,200 m and 3,250-3,700 m are visible pores primary AHP zones dominated by significant primary intergranular pores(more than 50% of the total porosity), while secondary pores and micropores in authigenic clays may develop in some reservoirs. AHP reservoirs in the AHP zone of 3,900-4,400 m are dominated by micropores in matrix, visible pores are mainly grain dissolution pores but with low absolute content(< 1%), so this zone belongs to the micropores primary AHP zone. The genesis of the three AHP zones was studied to distinguish between porosity enhancement and porosity preservation. Our research shows that, in deeply buried clastic reservoirs in the Shengtuo area, mineral dissolution occurred in a relatively closed diagenetic system with high temperature and high salinity. Reservoir rocks underwent extensive feldspar dissolution, while detrital carbonate grains and carbonate cements show no evidence of extensive dissolution. Although significant feldspar dissolution pores developed, feldspar dissolution enhanced porosity only a little due to the precipitation of almost isovolumetric dissolution products in the nearby primary intergranular pores in forms of authigenic clays and quartz cements. Net enhanced porosity originating from feldspar dissolution is generally less than 0.25%. Thus, the subsurface dissolution has little impact on the mid-deep buried high porosity reservoirs. Reservoirs in braided channels of middle fans in sublacustrine fans and reservoirs in the middle-front of fan bodies of nearshore subaqueous fans provide the basis for the development of AHP zones. The shallow development of fluid overpressure and early hydrocarbon emplacement have effectively retarded compaction and carbonate cementation, so that the high porosity in the superficial layers is preserved in the mid-deep layers. These are the main controlling factors in the development of AHP zones. | Cao Yingchang Yuan Guanghui Li Xiaoyan Wang Yanzhong Xi Kelai Wang Xiaoming Jia Zhenzhen Yang Tian | 2014 | Petroleum Science2014，11，3： | 18 |
| 13 | ESCRT-I Component VPS23A Affects ABA Signaling by Recognizing ABA Receptors for Endosomal Degradation显示文摘受体在过去的十年在植物科学成为了很重要的进展之一的 PYR/PYL/RCAR-type abscisic 酸(骆驼毛的织物) 的最近的发现。在哺乳动物,排序的 endosomal 充当一条重要小径到 downregulate 受体的不同类型,而是它在植物荷尔蒙发信号的角色糟糕被理解。这里,我们报导那 ubiquitin 象 E2 一样蛋白质, VPS23A,是 ESCRT-I 的一个关键部件,否定地调整骆驼毛的织物发信号。VPS23A 与 PYR/PYL/RCAR-type 骆驼毛的织物受体和提高的 VPS23A 的混乱有 epistatic 关系在在骆驼毛的织物处理下面表明小径的 ABA 的关键 kinase OST1 的活动。而且, VPS23A 与 PYR1/PYLs 交往,连接 K63 的 diubiquitin,和 PYL4 在 vivo 拥有连接 K63 的 ubiquitinated 修正。进一步的分析表明 VPS23A 影响 PYR1 和 PYL4 的稳定性的 subcellular 本地化。一起拿,我们的结果建议 VPS23A 经由调停液泡的降级影响 PYR1/PYL4,提供两个的先进理解在植物荷尔蒙发信号的骆驼毛的织物受体和 ESCRT 的周转。 | Feifei Yu Lijuan Lou Miaomiao Tian Qingliang Li Yanglin Ding Xiaoqiang Cao Yaorong Wu Borja Belda-Palazon Pedro L. Rodriguez Shuhua Yang Qi Xie | 2016 | Molecular Plant2016，9，12： | 17 |
| 14 | Minocycline attenuates bone cancer pain in rats by inhibiting NF-KB in spinal astrocytes显示文摘瞄准:调查在 rats.Methods 在骨头癌症疼痛(BCP ) 上位于 minocycline 的 anti-nociceptive 效果下面的机制:BCP 的一个老鼠模型被接种沃克建立 256 个乳房的癌房间进胫骨的髓的运河。二个星期以后,老鼠与 minocycline 被注射(50, 100 μ g intrathecally;或 40, 80 mg/kg, ip ) 为 3 连续的天两次每日。机械爪退却阀值(PWT ) 被用来估计疼痛行为。在老鼠是 euthanized 以后,针的绳索为 immunoblotting 分析被收获。NF-κ 上的 minocycline 的效果; B 激活也在与 IL-1β 刺激的主要老鼠星形细胞被检验;在 vitro.Results:BCP 老鼠标记骨头破坏,并且在 d 上显示出机械触觉的 allodynia 7 并且 d 14 在操作以后。minocycline 的 Intrathecal 注射(100 μ g ) 或 minocycline (80 mg/kg ) 的 intraperitoneal 注射颠倒了导致 BCP 的机械触觉的 allodynia。而且, minocycline (80 mg/kg ) 的 intraperitoneal 注射在针的绳索颠倒了 GFAP (星形细胞标记) 和 PSD95 的导致 BCP 的 upregulation。而且, minocycline (80 mg/kg ) 的 intraperitoneal 注射颠倒了 NF-κ 的导致 BCP 的 upregulation; B, p-IKKα并且 Iκ Bα在针的绳索。在 IL-1β刺激主要老鼠星形细胞,有 minocycline 的预告的处理(75, 100 μ mol/L ) 显著地禁止了 NF-κ 的 translocation; B 到 nucleus.Conclusion:Minocycline 有效地由禁止 NF-κ 减轻 BCP;在针的星形细胞的 B 发信号小径。 | Zhen-peng SONG Bing-rui XIONG Xue-hai GUAN Fei CAO Anne MANYANDE Ya-qun ZHOU Hua ZHENG Yu-ke TIAN | 2016 | Acta Pharmacologica Sinica2016，37，6： | 17 |
| 15 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 16 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 17 | Common Spectral Bands and Optimum Vegetation Indices for Monitoring Leaf Nitrogen Accumulation in Rice and Wheat显示文摘Real-time monitoring of nitrogen status in rice and wheat plant is of significant importance for nitrogen diagnosis, fertilization recommendation, and productivity prediction. With 11 field experiments involving different cultivars, nitrogen rates, and water regimes, time-course measurements were taken of canopy hyperspectral reflectance between 350-2 500 nm and leaf nitrogen accumulation (LNA) in rice and wheat. A new spectral analysis method through the consideration of characteristics of canopy components and plant growth status varied with phenological growth stages was designed to explore the common central bands in rice and wheat. Comprehensive analyses were made on the quantitative relationships of LNA to soil adjusted vegetation index (SAVI) and ratio vegetation index (RVI) composed of any two bands between 350-2 500 nm in rice and wheat. The results showed that the ranges of indicative spectral reflectance were largely located in 770-913 and 729-742 nm in both rice and wheat. The optimum spectral vegetation index for estimating LNA was SAVI (R822, R738) during the early-mid period (from jointing to booting), and it was RVI (R822, R738) during the mid-late period (from heading to filling) with the common central bands of 822 and 738 nm in rice and wheat. Comparison of the present spectral vegetation indices with previously reported vegetation indices gave a satisfactory performance in estimating LNA. It is concluded that the spectral bands of 822 and 738 nm can be used as common reflectance indicators for monitoring leaf nitrogen accumulation in rice and wheat. | WANG Wei YAO Xia TIAN Yong-chao LIU Xiao-jun NI Jun CAO Wei-xing ZHU Yan | 2012 | Journal of Integrative Agriculture2012，11，12： | 13 |
| 18 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 19 | Relative pollen productivities of typical steppe species in northern China and their potential in past vegetation reconstruction显示文摘The Relative Pollen Productivities(RPPs)of common steppe species are estimated using Extended R-value(ERV)model based on pollen analysis and vegetation survey of 30 surface soil samples from typical steppe area of northern China.Artemisia,Chenopodiaceae,Poaceae,Cyperaceae,and Asteraceae are the dominant pollen types in pollen assemblages,reflecting the typical steppe communities well.The five dominant pollen types and six common types(Thalictrum,Iridaceae,Potentilla,Ephedra,Brassicaceae,and Ulmus)have strong wind transport abilities;the estimated Relevant Source Area of Pollen(RSAP)is ca.1000 m when the sediment basin radius is set at 0.5 m.Ulmus,Artemisia,Brassicaceae,Chenopodiaceae,and Thalictrum have relative high RPPs;Poaceae,Cyperaceae,Potentilla,and Ephedra pollen have moderate RPPs;Asteraceae and Iridaceae have low RPPs.The reliability test of RPPs revealed that most of the RPPs are reliable in past vegetation reconstruction.However,the RPPs of Asteraceae and Iridaceae are obviously underestimated,and those of Poaceae,Chenopodiaceae,and Ephedra are either slightly underestimated or slightly overestimated,suggesting that those RPPs should be considered with caution.These RPPs were applied to estimating plant abundances for two fossil pollen spectra(from the Lake Bayanchagan and Lake Haoluku)covering the Holocene in typical steppe area,using the'Regional Estimates of Vegetation Abundance from Large Sites'(REVEALS)model.The RPPs-based vegetation reconstruction revealed that meadow-steppe dominated by Poaceae,Cyperaceae,and Artemisia plants flourished in this area before 6500–5600 cal yr BP,and then was replaced by present typical steppe. | XU QingHai CAO XianYong TIAN Fang ZHANG ShengRui LI YueCong LI ManYue LI Jie LIU YaoLiang LIANG Jian | 2014 | Science China Earth Sciences2014，57，6： | 13 |
| 20 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
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