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| 1 | NICE指南概要:共病状态的临床评估和管理显示文摘大多数慢性疾病患者患有一种或多种慢性疾病,共病状态在老年人中十分常见(图1和图2)。共病状态的重要性在于其与降低生活质量、高死亡率、多重用药、更高药物不良事件几率、更多计划外医疗服务耗费均相关。共病患者需要频繁前往初级医疗保健机构和各个专科就诊,这些机构的医师之间可能缺乏有效沟通交流。 | Caroline Farmer Elisabetta Fenu Norma O'Flynn Bruce Guthrie 符天旭 | 2017 | 中国医院院长2017，13，5： | 8 |
| 2 | Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses显示文摘 | Siobhain M. O’Mahony Julian R. Marchesi Paul Scully Caroline Codling Anne-Marie Ceolho Eamonn M.M. Quigley John F. Cryan Timothy G. Dinan | 2009 | Biological Psychiatry2009，，3： | 4 |
| 3 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 4 | Overview of screening methods for fatty liver disease in children显示文摘The prevalence of obesity and obesity related comorbidities including diabetes and nonalcoholic fatty liver disease (NAFLD) has been rising globally. Nonalcoholic fatty liver disease is emerging as a common liver disease among adults which can lead to the eventua development of complications including cirrhosis and hepatocellular carcinoma. With the rise of obesity in children, the development of detection methods for the presence of NAFLD is becoming imperative. Although the gold standard for diagnosis is liver biopsy, practica issues limit pediatric use and warrant development of noninvasive or minimally invasive screening tools for the detection and staging of NAFLD. A variety of diagnostic methods have been studied including use aminotransferases, imaging studies and serologic markers which have some population-based limitations. Additional factors such as gender and ethnicity may also play a role in the screening of NAFLD in pediatric population studies. | Caroline Anitha Devadason Ann O Scheimann | 2012 | World Journal of Hepatology2012，4，1： | 3 |
| 5 | A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome显示文摘 | Caroline Codling Liam O’Mahony Fergus Shanahan Eamonn M. M. Quigley Julian R. Marchesi | 2010 | Digestive Diseases and Sciences2010，，2： | 3 |
| 6 | Pericardial Fat, Visceral Abdominal Fat, Cardiovascular Disease Risk Factors, and Vascular Calcification in a Community-Based Sample: The Framingham Heart Study显示文摘 | Guido A. Rosito Joseph M. Massaro Udo Hoffmann Frederick L. Ruberg Amir A. Mahabadi Ramachandran S. Vasan Christopher J. O’Donnell Caroline S. Fox | 2008 | Circulation2008，，5： | 2 |
| 7 | The Accountable Care Organization results:Population health management and quality improvement programs associated with increased quality of care and decreased utilization and cost of care显示文摘Objective:The Accountable Care Organization(ACO)model of health care delivery is based on new payment models for general practice to reward improved quality and decreased cost of care.Methods:Banner Health Network(BHN)is one of the original CMS Pioneer ACO programs and implemented a comprehensive disease management program based on the collaborative care model.Key performance indicators for CMS reflected quality and cost of care.Results:BHN has demonstrated both improved quality and cost savings in the first two years of the pilot program.The disease management program based on the collaborative care model appears to have improved patient health outcomes based on quality improvement measures.In addition the program has reduced emergency department and hospital utilization,resulting in cost savings.Conclusions:The BHN quality improvement program is the platform for analyzing and improving on the BHN ACO model.This model appears to have excellent application to the China health care system that is also focused on prevention and improvement of chronic disease and cost-effectiveness. | Ronald O’Donnell Nishant Shaun Anand Caroline Ganser Nancy Wexler | 2015 | Family Medicine and Community Health2015，3，1： | 2 |
| 8 | Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study显示文摘 | Caroline S. Fox Joseph M. Massaro Udo Hoffmann Karla M. Pou Pal Maurovich-Horvat Chun-Yu Liu Ramachandran S. Vasan Joanne M. Murabito James B. Meigs L Adrienne Cupples Ralph B. D’Agostino Christopher J. O’Donnell | 2007 | Circulation2007，，1： | 2 |
| 9 | Relationship marketing in consunmer markets Rhetoric or reality?显示文摘 | LISA O CAROLINE T | 2000 | European Journal d Marketing2000，34，7： | 1 |
| 10 | Hepatic steatosis and cardiovascular disease outcomes: An analysis of the Framingham Heart Study显示文摘 | Jessica L. Mellinger Karol M. Pencina Joseph M. Massaro Udo Hoffmann Sudha Seshadri Caroline S. Fox Christopher J. O’Donnell Elizabeth K. Speliotes | 2015 | Journal of Hepatology2015，，2： | 1 |
| 11 | Physiologic cardiac hypertrophy during pregnancy involves a change in gene expression regulating cardiac metabolism 显示文摘 | JEFFREY G W CAROLINE O THOMAS H H | 2006 | FASEB J2006，20，8： | 1 |
| 12 | Pathogenic role of anti-neutrophil cytoplasmic antibodies in vasculitis显示文摘 | Tanya Pankhurst Caroline O S | | 0，，02： | 1 |
| 13 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 14 | Solid phase microextraction (SPME) combined with gas-chromatography and olfactometry-mass spectrometry for characterization of cheese aroma compounds显示文摘 | DAMIAN C F CAROLINE M O JOHN P | 2004 | LWT2004，37，2： | 1 |
| 15 | The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards显示文摘 | Caroline P Gavin O Alison E A | 2013 | Analytical Chemistry2013，85，15： | 1 |
| 16 | Evaluation of the microScan rapid neg ID3 panel for Identification of enterobacteriaceae and some common gram-negative nonfermenters 显示文摘 | Caroline Mohr O'Hara J Michael Miller | 2000 | Journal of Clinical Microbiology2000，38，： | 1 |
| 17 | Spatial regulation of pectic polysaecharides in relation to pit fields in cell walls of tomato fruit pericarp显示文摘 | CAROLINE O J PAUL K | 2000 | Plant Physiology2000，122，3： | 1 |
| 18 | Altered middle lamella homogalacturonan and disrupted deposition of (135)-a-L-Arabinan in the periearp of cnr,a ripening mutant of tomato显示文摘 | CAROLINE O GRAHAM B S WILLIAM GT | 2001 | Plant Physiology2001，126，3： | 1 |
| 19 | Probing a family GH11 endo-β-1,4-xylanase inhibition mechanism by phenolic compounds: Role of functional phenolic groups显示文摘 | Imen Boukari Michael O’Donohue Caroline Rémond Brigitte Chabbert | 2011 | Journal of Molecular Catalysis B Enzymatic2011，，3： | 1 |
| 20 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
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