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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?显示文摘Colorectal cancer(CRC),the third most commonly diagnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease,an observation sustained by the fact that histologically identical tumors may have different outcome,including various response to therapy.Therefore,particularly in early and intermediate stage(stages Ⅱ and Ⅲ,respectively) CRC,there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy.Histopathological examination shows that likely other solid tumors the development and progression of human CRC is not only determined by genetically abnormal cells,but also by intricate interactions between malignant cells and the surrounding microenvironment.This has led to reconsider the features of tumor microenvironment as potential predictive and prognostic biomarkers.Among the histopathological biomarkers,tumor budding(i.e.,the presence of individual cells and small clusters of tumor cells at the tumor invasive front) has received much recent attention,particularly in the setting of CRC.Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects,tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratification of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone,and also potentially guide treatment decisions,especially in T2-T3 N0(stage Ⅱ) CRCs. | Fabio Grizzi Giuseppe Celesti Gianluca Basso Luigi Laghi | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 3 | Application of the Eu^(3+) Ion for Site Symmetry Determination显示文摘ApplicationoftheEu^(3+)IonforSiteSymmetryDeterminationBinnemansK,Gorller-WalrandC(UniversityofLeuven,DepartmentofChemistry,Co?.. | Binnemans K Gorller-Walrand C (University of Leuven,Department of Chemistry, Coordnation Chemistry Division,Celesti jnenlaan 200F, B-3001 Heverlee, Belgium) | 1996 | Journal of Rare Earths1996，14，3： | 5 |
| 4 | Birthrates and delay times of Type Ia supernovae显示文摘Type Ia supernovae (SNe Ia) play an important role in diverse areas of astrophysics, from the chemical evolution of galaxies to observational cosmology. However, the nature of the progenitors of SNe Ia is still unclear. In this paper, according to a detailed binary population synthesis study, we obtained SN Ia birthrates and delay times from different progenitor models, and compared them with observations. We find that the Galactic SN Ia birthrate from the double-degenerate (DD) model is close to those inferred from observations, while the birthrate from the single-degenerate (SD) model accounts for only about 1/2-2/3 of the observations. If a single starburst is assumed, the distribution of the delay times of SNe Ia from the SD model is a weak bimodality, where the WD + He channel contributes to the SNe Ia with delay times shorter than 100 Myr, and the WD + MS and WD + RG channels to those with age longer than 1 Gyr. | WANG Bo1,2,3, LIU ZhengWei1,2,3, HAN YunKun1,2,3, LEI ZhenXin1,2,3, LUO YangPing1,2,3 & HAN ZhanWen1,2 1National Astronomical Observatories/Yunnan Observatory, Chinese Academy of Sciences, Kunming 650011, China 2Key Laboratory for the Structure and Evolution of Celestial Objects, Chinese Academy of Sciences, Kunming 650011, China 3Graduate University of Chinese Academy of Sciences, Beijing 100049, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 2 |
| 5 | Overview of priorities,threats,and challenges to biodiversity conservation in the southern Philippines显示文摘Human activities have severely impacted on many species and ecosystems.Thus,understanding the local biodiversity situation is crucial for implementing effective biodiversity conservation interventions.Mindanao in the southern Philippines is home to various unique species,particularly in its pristine ecosystems.However,the available biodiversity data for many terrestrial vertebrates and key areas remain incomplete.To address this issue,we synthesized published literature related to biodiversity from 2000 to 2022 in Mindanao.Moreover,this analysis used four key terrestrial vertebrates(amphibians,reptiles,birds,and mammals)in Mindanao as research objects.According to our findings,there was a significant and positive correlation between the number of biodiversity studies and species recorded.In terms of species richness,birds were the most recorded group(n=334 spp.),followed by reptiles(n=108 spp.),mammals(n=70 spp.),and amphibians(n=52 spp.).We also found that the number of endemic and threatened species varies geographically and across taxonomic groups.Yet,we discovered a significant disparity in the information available on biodiversity in different provinces of Mindanao.For example,the western provinces of Mindanao have had no record of biodiversity for more than two decades.Furthermore,we found that the changes in tree cover loss were consistent with biodiversity records,but this correlation is only significant for birds.Finally,we highlighted some critical threats and challenges to biodiversity,including deforestation,agricultural expansion,mining,and their impact on biodiversity conservation in Mindanao.Our findings suggested that biodiversity conservation should focus not only on areas with high levels of biodiversity but also on areas lacking biodiversity information.To do this,we call for strengthening collaboration among various institutions and digitizing and centralizing of information related to biodiversity.By gaining a deeper understanding of biodiversity in Mindanao,we can better and sustainably protect critical ecosystems in this region from the increasing threats posed by human activities. | Angelo Rellama AGDUMA Francisco Gil GARCIA Ma.Teodora CABASAN Jonald PIMENTEL Renee Jane ELE Meriam RUBIO Sedra MURRAY Bona Abigail HILARIO-HUSAIN Kier Celestial Dela CRUZ Sumaira ABDULLAH Shiela Mae BALASE Krizler Cejuela TANALGO | 2023 | Regional Sustainability2023，4，2： | 1 |
| 6 | A statistical study of the relation between soft X-ray excess and accretion disk显示文摘To study the origin of the soft X-ray excess,we compile a sample of 94 unobscured,radio-quiet QSOs and Seyfert galaxies with available data from GALEX and ROSAT.We find that 50 sources show strong soft X-ray excess and the other 44 show weak/no soft X-ray excess.Systematic analyses of the data indicate that the difference in soft X-rays is mainly but not only resulting from different accretion rates(in units of Eddington rate).The statistical study of the sources with soft X-ray excess shows that the strength of soft X-ray excess weakly and positively correlates with the Eddington ratio and increases with the increase of the strength of UV radiations relative to the X-rays.Provided that the UV emissions are from the thin disk,the correlations imply that the origin of soft X-ray excess is associated with the thin disk,either by means of Comptonization of the disk photons or in some other ways. | LIU JieYing1,2,3 & QIAO ErLin1,2 1 National Astronomical Observatories/Yunnan Observatory,Chinese Academy of Science,Kunming 650011,China 2 Key Laboratory for the Structure and Evolution of Celestial Objects,Chinese Academy of Sciences,Kunming 650011,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 1 |
| 7 | Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis 显示文摘 | Celesti G Erreni M Siddiqui I | 2013 | Br J Cancer2013，109，9： | 1 |
| 8 | Presence of twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors显示文摘 | Celesti G Di Caro G Bianchi P | 2013 | Gastroenterology2013，143，5： | 1 |
| 9 | The motility of glioblastoma tumour cells is modulated by intracellular coffin expression in a concentration dependent manner 显示文摘 | Celestial T Yap Tlan Simpson | 2005 | Cell Motil Cytoskeleton2005，60，3： | 1 |
| 10 | Multi-epoch X-ray observations of the narrow-line Seyfert 1 galaxy SDSS J160508.87+323921.4 with XMM-Newton显示文摘We present results of multi-epoch XMM-Newton observations separated by several years of the narrow-line Seyfert 1(NLS1) galaxy,SDSS J160508.87+323921.4.The NLS1 showed X-ray flux variations on timescales of years as well as low amplitude variations on timescales as short as hours,while the X-ray spectral shape remained essentially unchanged.The spectrum shows a significant soft X-ray excess.The model of reflection from an ionized disc,that is dominant in the whole XMM-Newton bandpass,provides the best description of the observed spectra for all the observations,though alternatives such as Compton scattering(T-0.25 keV) cannot be ruled out in a statistical sense.For the disc reflection model,the observed variations may originate either from the change in the reflection fraction,or from the variability of the intrinsic X-ray luminosity. | AI YanLi1,2,3,YUAN WeiMin1,2,ZHOU HongYan4,5 & WANG JianGuo1,2,3 1 National Astronomical Observatories/Yunnan Observatory,Chinese Academy of Sciences,Kunming 650011,China 2 Key Laboratory for the Structure and Evolution of Celestial Objects,Chinese Academy of Sciences,Kunming 650011,China 3 Graduate University of the Chinese Academy of Sciences,Beijing 100049,China 4 Center for Astrophysics,University of Science and Technology of China,Hefei 230026,China 5 Joint Institute of Galaxies and Cosmology,SHAO and USTC,Shanghai 200030,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 1 |
| 11 | Presence of Twist1-Positive Neoplastic Cells in the Stroma of Chromosome-Unstable Colorectal Tumors显示文摘 | Giuseppe Celesti Giuseppe Di Caro Paolo Bianchi Fabio Grizzi Gianluca Basso Federica Marchesi Andrea Doni Giancarlo Marra Massimo Roncalli Alberto Mantovani Alberto Malesci Luigi Laghi | 2013 | Gastroenterology2013，，3： | 1 |
| 12 | Sanctions for Infringements of Gambling Laws in Italy 显示文摘 | Stefano Sbordoni Stefano Maria Celesti Francesca Dionisi | 2007 | EAR Forum2007，，8： | 1 |
| 13 | 2004, Why is advantageous for animals to n the ultraviolet?, skylight polarization s strongest in the UV 显示文摘 | BARTA A HORVATH G detect celestial polarization under clouds and canopies Theoretical Biology | 2004 | Journal of 2262004，，： | 1 |
| 14 | Application of Derivative Resolution of UV Spectra to the Quality Control of Rifaumin and Its Possible Impurities显示文摘 | Corti P Savini L Celesti L | 1992 | Pharm Acta Helv1992，67，3： | 1 |
| 15 | Leaf morphology and macronutrients in broadleaved trees in central Italy显示文摘 | Filippo Bussotti Francesca Borghini Carlo Celesti Claudio Leonzio Piero Bruschi | 2000 | Trees2000，，7： | 1 |
| 16 | Variations in larval growth and metabolism of an estuarine shrimp,palaemonentspugio during toxicosis by an insect growth regulator 显示文摘 | MCKENNEY C L CELESTIAL D M | 1993 | Comparative Biochemistry Physiology1993，105，： | 1 |
| 17 | IoT-Based Wrist Band for Women Safety显示文摘In the modern world,women now have tremendous success in every field.They can play,learn,and earn as much as men.But what about safety?Do they have the same secure environment that men and boys do?The answer is“NO”.Women and girls have been subjected to numerous incidents,including acid throwing,rape,kidnapping,and harassment.It is common to read a lot of news like this in newspapers every day.These incidents make women feel unsafe in this society.Our freedom came a long time ago,but women still lack complete security in this society.All women cannot fight or shout all the time when some danger is happening to them.What can the physically challenged person and Children do?To make women feel safe,we designed“Wrist Band”using IoT for women safety.As the sensors sense information from the body,it will always update the information such as pulse,temperature,and vibration to the well-wishers through the Blynk app. | V.Ebenezer J.Uvaana Falicica M.Roshni Thanka Rithika Baskaran Agatha Celesty Sejal R.Eden | 2023 | Journal of Artificial Intelligence and Technology2023，3，2： | 0 |
| 18 | Avoided crossings between non-radial modes in low mass RGB stars显示文摘Non-radial p modes and g modes appear simultaneously in red giant stars. Their frequencies have different variation rates,causing their frequencies to become close during stellar evolution so that avoided crossings appear.The separation between regions where acoustic waves and gravity waves propagate for l=1,2 and 3 is different,which results in the coupling efficiency also being different.We present the results of numerical computations of the models we study.We find that the two kinds of modes for l=2 and 3 need to be closer in frequency in order for a complete exchange to occur,compared to the case for modes with l=1.Their scaled oscillation frequencies also present better regularity with evolution than modes with l=1. In order to study the effect of the avoided crossings in detail,we set the mode which has the smallest mode inertia to be the p mode.We plot the two kinds of modes for l =1,2 and 3 in frequency and periodéchelle diagrams and find modes of l=2 and 3 fit the two relations better;they are more equally spaced in frequency and period than modes with l=1.Under careful observation of the two kinds oféchelle diagrams for l=2 and 3,we still find that some p modes shift a little from being equally spaced in frequency and some g modes,which are close to those p modes in period,shift a little from being equally spaced in period.Then,we study the relation between the deviation from period being equally spaced and the mode inertia of g modes for different l.The g modes of l=1 with a period closer to the p mode have less inertia and the deviation is bigger in the periodéchelle diagram.Their deviation is also obvious. However g modes of l=2 and 3 shift a little or have almost no deviation from being equally spaced in period,even though some of them may have strong coupling and close mode inertia like in the p modes.So,we suggest a possible method for measuring period spacing of g modes precisely using mixed g modes with l=2 and 3 that have fewer observed mixed g modes than for l=1. | Jun-Jun Guo1,2,3,Yan Li1,2 and Xiang-Jun Lai1,2 1 National Astronomical Observatories/Yunnan Observatory,Chinese Academy of Sciences, Kunming 650011,China 2 Key Laboratory for the Structure and Evolution of Celestial Objects,Chinese Academy of Sciences,Kunming 650011,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2012 | Research in Astronomy and Astrophysics2012，12，12： | 0 |
| 19 | A novel 2D-GO@WS2 electrochemical platform for the determination of thiram fungicide显示文摘In this paper,the determination of Thiram fungicide by a novel modified screen-printed carbon electrode(SPCE)fabricated modifying the working electrode(WE)with 2D-GO/WS2nanohybrid composites,is reported.Scanning electron microscopy(SEM),Raman spectroscopy,and fluorescence analysis(PL)were used to reveal the morphological and microstructural characteristics of the 2D-GO/WS2 nanohybrids with different graphene oxide:tungsten disulphide(GO:WS_(2))ratio.Electrochemical characterization demonstrated that the 2D-WS2/GO nanohybrids having a GO:WS_(2)ratio=2:1 shows the highest electrocatalytic activity towards oxidation of Thiram.The developed sensor permits the quantification of Thiram in the linear range 0.083-0.33μM with a limit of detection(LOD)of 0.02μM,which is below the legal limits for this fungicide in drinking water or foods. | Khouloud Abid Daniela Iannazzo Consuelo Celesti Amani Khaskhoussi Antonino Foti Ramzi Maalej Pietro Giuseppe Gucciardi Giovanni Neri | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 20 | A puzzle of the radio-quiet quasar PG 1407+265:Are optical and X-ray emissions produced from a relativistic jet?显示文摘PG 1407+265 is a radio quiet quasar that has a relativistic jet.In this report,we show some peculiar properties of its optical and X-ray emissions,which indicate possible non-thermal origins produced from the jet.We use a simple synchrotron + synchrotron self Compton (SSC) model to fit the emissions with different ratios of energy densities between the magnetic field and electrons (η≡U B/U e),which predicts a different γ-ray luminosity.The First LAT AGN Catalog (1LAC) did not include PG 1407+265,which indicates an upper limit of γ-ray luminosity.This upper limit constrains the ratio to be unreasonably large (η≥10 4-5).This inversely indicates that the optical and X-ray emissions may not be produced from the beaming jet.We discuss the physical implications of these results. | CHEN Liang 1,2,3 & BAI JinMing 1,2 1 National Astronomical Observatories/Yunnan Observatory,Chinese Academy of Sciences,Kunming 650011,China 2 Key Laboratory for the Structure and Evolution of Celestial Objects,Chinese Academy of Sciences,Kunming 650011,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 0 |
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