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| 1 | Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under highaltitude hypoxia显示文摘Background: Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pigs and have adapted well to the extreme conditions at high altitude.However, the genetic and epigenetic mechanisms of hypoxic adaptation in animals remain unclear.Methods: Whole-genome DNA methylation data were generated for heart tissues of Tibetan pigs grown in the highland(TH, n = 4) and lowland(TL, n = 4), as well as Yorkshire pigs grown in the highland(YH, n = 4) and lowland(YL, n = 4), using methylated DNA immunoprecipitation sequencing.Results: We obtained 480 million reads and detected 280679, 287224, 259066, and 332078 methylation enrichment peaks in TH, YH, TL, and YL, respectively. Pairwise TH vs. YH, TL vs. YL, TH vs. TL, and YH vs. YL comparisons revealed6829, 11997, 2828, and 1286 differentially methylated regions(DMRs), respectively. These DMRs contained 384, 619,192, and 92 differentially methylated genes(DMGs), respectively. DMGs that were enriched in the hypoxia-inducible factor 1 signaling pathway and pathways involved in cancer and hypoxia-related processes were considered to be important candidate genes for high-altitude adaptation in Tibetan pigs.Conclusions: This study elucidates the molecular and epigenetic mechanisms involved in hypoxic adaptation in pigs and may help further understand human hypoxia-related diseases. | Bo Zhang Dongmei Ban Xiao Gou Yawen Zhang Lin Yang Yangzom Chamba Hao Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 6 |
| 2 | Analysis of IGF2 mRNA expression and its methylation status between cattle yaks and their parents显示文摘Cattle yaks are an F1 hybrid between cattle and yaks and exhibit significant hybrid vigor. However, cattle yaks are sterile males. To study the epigenetic aspects of this reproductive isolation, IGF2 mRNA expression in cattle yaks and their parents and the patterns of the IGF2 differentially methylated regions (DMR) were examined in blood and testes. The results showed that IGF2 expression in cattle yaks' testes was lower than in their parents (P < 0.01). The IGF2 DMR was highly methylated (above 90%) in blood and testes of cattle yaks, yaks and cattle, with the highest level in cattle yaks (P > 0.05). Our study showed that IGF2 plays an important role in bovine spermato-genesis and might be involved in cattle-yak male sterility. The methylation level of the IGF2 DMR was irrelevant to the lower expression of IGF2 in cattle yaks; other factors perhaps play roles in its expression. | Zhenshan Liu Qifa Li Qingbo Zhang Xuguang Qu Liyan Dong Chamba Yang-zom Zhuang Xie Honglin Liu | 2009 | Progress in Natural Science:Materials International2009，19，9： | 5 |
| 3 | Close encounters of the monoamine kind: immune cells betray their nervous disposi- tion显示文摘 | Meredith EJ Chamba A Holder MJ | 2005 | Immunology2005，115，3： | 1 |
| 4 | Extracellular proteolysis of fibronectin by neutrophils: characterization and the effects of recombinant cytokines显示文摘 | Chamba A Afford SC Stockley RA | 1991 | Am J Respir Cell Mol Biol1991，4，4： | 1 |
| 5 | Close encounters of the monoamine kind: immune ceils betray their nervous disposition 显示文摘 | Meredith EJ Chamba A Holedr MJ | 2005 | Immunology2005，115，3： | 1 |
| 6 | Inhibition of Listeria monocytogenes by resident biofilms present on wooden shelves used for cheese ripening显示文摘 | MARIANI C OULAHAL N CHAMBA J F | 2011 | Food Control2011，22，8： | 1 |
| 7 | Close encounters of the monoamine kind: immune cells betray their nervous disposition 显示文摘 | Meredith E J Chamba A Holder M J | 2005 | Immunology2005，115，3： | 1 |
| 8 | Blood characteristics for high altitude adaptation in Tibetan chickens 显示文摘 | Zhang H C X Wu Y Chamba | 2007 | Poult Sci2007，86，： | 1 |
| 9 | Blond char- acteristics for high altitude adaptation in Tibetan chick- ens 显示文摘 | ZHANG H WU C X CHAMBA Y | 2007 | Pouhtw science2007，86，7： | 1 |
| 10 | Blood char- acteristics for high altitude adaptation in Tibetan chick- ens 显示文摘 | ZHANG H WU C X CHAMBA Y | 2007 | Poultry Science2007，86，： | 1 |
| 11 | Blood characteristics for high altitude adaptation in Tibetan chickens 显示文摘 | Zhang H Wu C X Chamba Y | 2007 | Poultry Science2007，86，： | 1 |
| 12 | Expression and function of thyroid hormone receptor variants in normal and chronically diseased human liver显示文摘 | Chamba A Neuberger J Strain A Hopkins J Sheppard M C Franklyn J A | | 0，，01： | 1 |
| 13 | Blood characteristics for high altitude adaptation in Tibetan chickens显示文摘 | Zhang H Wu C X Chamba Y | 2007 | Poultry Sci- ence2007，86，7： | 1 |
| 14 | Close encounters of the monoamine kind:immune cells betray their nervous disposition显示文摘 | Elizabeth J Meredith Anita Chamba | 2005 | Immunology2005，115，： | 1 |
| 15 | Contribution of propionic acid bacteria to lipolysis of Emmental cheese显示文摘 | CHAMBA J F PERREARD E | 2002 | Lait2002，82，： | 1 |
| 16 | A new insight on the roleof Mg in calcite 显示文摘 | Arvids Stashans Gaston Chamba | 2011 | Int J Quantum Chem2011，111，10： | 1 |
| 17 | 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cell reversal by selective serotonin reuptake inhibitors 显示文摘 | Serafeim A Grafton G Chamba A | 2002 | Blood2002，99，： | 1 |
| 18 | Close encounters of the monoamine kind: immune ceils betray their nervous disposition 显示文摘 | Meredith E J Chamba A Holder M J | 2005 | Immunology2005，115，3： | 1 |
| 19 | Oxidization and structural modifica- tion of full -fat and defatted flour based soy pro- tein isolates induced by natural and synthetic ex- traction chemicals 显示文摘 | Moses Vemonxious Madalitso Chamba Yufei Hua Wendy Katiyo | 2014 | Food Biophysics2014，，9： | 1 |
| 20 | Effect of milk urea content on characteristics of matured Reblochon cheeses显示文摘 | MARTIN B COULON J B CHAMBA J F | 1997 | Lait1997，77，4： | 1 |
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