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| 1 | Get effective polyclonal antisera in one month显示文摘According to the traditional immunization procedure, after the first injection of the sample A (emulsion of aimed antigen and Freund's complete adjuvant) to immunize rabbit, successive injections of the sample B (emulsion of aimed antigen and Freund's incomplete adjuvant) were followed every 2-4 weeks. In general,high titer of the corresponding polyclonal antisera will be observed after 4-5 injections of sample B in 3-4months. This report presents a simply modified procedure that was able to stimulate the antisera formation in one month and achieve enough avidity to satisfy either Western blot or immunohistochemistry analysis.It just applied an additional injection of the sample A to the rabbit at the 3rd day after the primary immunization injection. You could gain the high titer of the antisera right after the first sample B injection in one month. This method has produced the desired results in three different recombinant antigens with different molecular weight (5.9 KD-55 KD) expressed from prokaryotic or eukaryotic cells. | YUAN XIN HU, Ju YUAN QUO, Lu SHEN, YAN CHEN, Zu CHUAN ZHANG, YONG LIAN ZHANGState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, | 2002 | Cell Research2002，12，2： | 45 |
| 2 | Visualization of the complex structure and stress field inside rock by means of 3D printing technology显示文摘Accurate characterization and visualization of the complex inner structure and stress distribution of rocks are of vital significance to solve a variety of underground engineering problems. In this paper, we incorporate several advanced technologies, such as CT scan, three-dimensional(3D) reconstruction, and 3D printing, to produce a physical model representing the natural coal rock that inherently contains complex fractures or joints. We employ 3D frozen stress and photoelastic technologies to characterize and visualize the stress distribution within the fractured rock under uniaxial compression. The 3D printed model presents the fracture structures identical to those of the natural prototype. The mechanical properties of the printed model,including uniaxial compression strength, elastic modulus,and Poisson's ratio, are testified to be similar to those of the prototype coal rock. The frozen stress and photoelastic tests show that the location of stress concentration and the stress gradient around the discontinuous fractures are in good agreement with the numerical predictions of the real coalsample. The proposed method appears to be capable of visually quantifying the influences of discontinuous,irregular fractures on the strength, deformation, and stress concentration of coal rock. The method of incorporating3 D printing and frozen stress technologies shows a promising way to quantify and visualize the complex fracture structures and their influences on 3D stress distribution of underground rocks, which can also be used to verify numerical simulations. | Yang Ju Heping Xie Zemin Zheng Jinbo Lu Lingtao Mao Feng Gao Ruidong Peng | 2014 | Chinese Science Bulletin2014，59，36： | 41 |
| 3 | Energy analysis and criteria for structural failure of rocks显示文摘The intrinsic relationships between energy dissipation,energy release,strength and abrupt structural failure are key to understanding the evolution of deformational processes in rocks.Theoretical and experimental studies confirm that energy plays an important role in rock deformation and failure.Dissipated energy from external forces produces damage and irreversible deformation within rock and decreases rock strength over time.Structural failure of rocks is caused by an abrupt release of strain energy that manifests as a catastrophic breakdown of the rock under certain conditions.The strain energy released in the rock volume plays a pivotal role in generating this abrupt structural failure in the rocks.In this paper,we propose criteria governing(1) the deterioration of rock strength based on energy dissipation and(2) the abrupt structural failure of rocks based on energy release.The critical stresses at the time of abrupt structural failure under various stress states can be determined by these criteria.As an example,the criteria have been used to analyze the failure conditions of surrounding rock of a circular tunnel. | Heping Xie Liyun Li Ruidong Peng Yang Ju | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 39 |
| 4 | Effect of in-hospital medical complications on case fatality post-acute ischemic stroke: data from the China National Stroke Registry显示文摘 | WANG Peng-lian ZHAO Xing-quan YANG Zhong-hua WANG An-xin WANG Chun-xue LIU Li-ping WANGYi-long WANG Xin-gao JU Yi CHEN Sheng-yun CHEN Qi-dong QU Hui LU Jing-jing ZHANG Jing MA Rui-hua ZHANG Yu-mei WANG Yong-jun | 2012 | Chinese Medical Journal2012，，14： | 37 |
| 5 | Numerical simulation of mechanisms of deformation,failure and energy dissipation in porous rock media subjected to wave stresses显示文摘The pore characteristics,mineral compositions,physical and mechanical properties of the subarkose sandstones were acquired by means of CT scan,X-ray diffraction and physical tests.A few physical models possessing the same pore characteristics and matrix properties but different porosities compared to the natural sandstones were developed.The 3D finite element models of the rock media with varied porosities were established based on the CT image processing of the physical models and the MIMICS software platform.The failure processes of the porous rock media loaded by the split Hopkinson pressure bar(SHPB) were simulated by satisfying the elastic wave propagation theory.The dynamic responses,stress transition,deformation and failure mechanisms of the porous rock media subjected to the wave stresses were analyzed.It is shown that an explicit and quantitative analysis of the stress,strain and deformation and failure mechanisms of porous rocks under the wave stresses can be achieved by using the developed 3D finite element models.With applied wave stresses of certain amplitude and velocity,no evident pore deformation was observed for the rock media with a porosity less than 15%.The deformation is dominantly the combination of microplasticity(shear strain),cracking(tensile strain) of matrix and coalescence of the cracked regions around pores.Shear stresses lead to microplasticity,while tensile stresses result in cracking of the matrix.Cracking and coalescence of the matrix elements in the neighborhood of pores resulted from the high transverse tensile stress or tensile strain which exceeded the threshold values.The simulation results of stress wave propagation,deformation and failure mechanisms and energy dissipation in porous rock media were in good agreement with the physical tests.The present study provides a reference for analyzing the intrinsic mechanisms of the complex dynamic response,stress transit mode,deformation and failure mechanisms and the disaster mechanisms of rock media. | JU Yang1,2,WANG HuiJie1,YANG YongMing1,HU QinAng3 & PENG RuiDong1 1 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rock and Concrete,China University of Mining and Technology,Beijing 100083,China 2 Department of Mechanical and Manufacturing Engineering,University of Calgary,Calgary,Alberta,T2N 1N4,Canada 3 School of Environment and Civil Engineering,College of Engineering,Oklahoma State University,Stillwater,OK 74078,USA | 2010 | Science China(Technological Sciences)2010，53，4： | 32 |
| 6 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 7 | Influence of pore structures on the mechanical behavior of low-permeability sandstones:numerical reconstruction and analysis显示文摘The research of rock properties based on its inherent microscopic to mesoscopic porous structure has drawn great attention for its potential in predicting the macroscopic behavior of rocks.An accurate reconstruction of the threedimensional porous structure is a premise for the related studies of hydraulic and mechanical properties of rocks,such as the transport properties and mechanical responses under pressures.In this paper,we present a computer procedure for reconstructing the 3D porous structure of low-permeability sandstone.Two large-size 3D models are reconstructed based on the information of a reference model which is established from computed tomography(CT)images.A self-developed finite element method is applied to analyze the nonlinear mechanical behavior of the sandstone based on its reconstructed model and to compare the results with those based on the reference model.The good consistency of the obtained mechanical responses indicates the potential of using reconstruction models to predict the influences of porous structure on the mechanical properties of low-permeability sandstone. | Jiangtao Zheng Yang Ju Xi Zhao | 2014 | International Journal of Coal Science & Technology2014，1，3： | 34 |
| 8 | Energy analysis for damage and catastrophic failure of rocks显示文摘The development history and current state of studies on the characteristics and mechanisms of deformation and failure of rock materials were briefly reviewed from the viewpoint of energy.The main scope and the achievable objectives of the energy-based research system were expatiated.It was validated by experiments that the damage process of rocks can be well described by the rock damage evolution equation established based on energy dissipation.It was found from the uniaxial compression and biaxial compression tests that only a small proportion of the total input energy in hard rocks is dissipated before peak load and a large proportion in soft rocks is dissipated before peak load.For both hard and soft rocks,the energy dissipated after peak load accounts for a greater proportion.More energy would be required for rock failure under equal biaxial compression than under unequal biaxial compression.The total absorbed energy is different for rock failure under high-rate loading and low-rate loading.More fragmented failure pattern usually corresponds to higher energy absorption.The mesoscopic analysis on the damage and failure of bedded salt rocks showed that the energy dissipation is prominent and the total absorbed energy for rock failure is low when cracks propagate in the weak mud interlayer while it is contrary when cracks propagate in the salt rock.The energy accumulation,transfer,dissipation and release during the failure process of tunnel with impending failure under disturbance were analyzed theoretically based on the elastoplastic mechanics theory.Furthermore,the spatial distribution of energy dissipation and energy release of fractured rocks under unloading was simulated numerically.It was demonstrated that energy is likely to be released from the weakest surface under compression,which triggers the global failure of rocks. | XIE HePing 1,2,LI LiYun 2,1,JU Yang 2,PENG RuiDong 2 & YANG YongMing 2 1 Sichuan University,Chengdu 610065,China 2 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rock and Concrete,China University of Mining and Technology,Beijing 100083,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 29 |
| 9 | Spatio-temporal dynamics of vegetation and its relationship with climate factors Mongolia, China coverage in Inner显示文摘The vegetation coverage dynamics and its relationship with climate factors on different spatial and temporal scales in Inner Mongolia during 2001-2010 were analyzed based on MODIS-NDVI data and climate data.The results indicated that vegetation coverage in Inner Mongolia showed obvious longitudinal zonality,increasing from west to east across the region with a change rate of 0.2/10°N.During 2001-2010,the mean vegetation coverage was 0.57,0.4 and 0.16 in forest,grassland and desert biome,respectively,exhibiting evident spatial heterogeneities.Totally,vegetation coverage had a slight increasing trend during the study period.Across Inner Mongolia,the area of which the vegetation coverage showed extremely significant and significant increase accounted for 11.25% and 29.13% of the area of whole region,respectively,while the area of which the vegetation coverage showed extremely significant and significant decrease accounted for 7.65% and 26.61%,respectively.On inter-annual time scale,precipitation was the dominant driving force of vegetation coverage for the whole region.On inter-monthly scale,the change of vegetation coverage was consistent with both the change of temperature and precipitation,implying that the vegetation growth within a year is more sensitive to the combined effects of water and heat rather than either single climate factor.The vegetation coverage in forest biome was mainly driven by temperature on both inter-annual and inter-monthly scales,while that in desert biome was mainly influenced by precipitation on both the two temporal scales.In grassland biome,the yearly vegetation coverage had a better correlation with precipitation,while the monthly vegetation coverage was influenced by both temperature and precipitation.In grassland biome,the impacts of precipitation on monthly vegetation coverage showed time-delay effects. | MU Shaojie YANG Hongfei LI Jianlong CHEN Yizhao GANG Chengcheng ZHOU Wei JU Weimin | 2013 | Journal of Geographical Sciences2013，23，2： | 28 |
| 10 | An experimental investigation on the mechanism of fluid flow through single rough fracture of rock显示文摘The structure of fractures in nature rock appears irregular and induces complicated seepage flow behavior.The mechanism and quantitative description of fluid flow through rock fractures is a difficult subject that has been greatly concerned in the fields of geotechnical,mining,geological,and petroleum engineering.In order to probe the mechanism of fluid flow and the effects of rough structures,we conducted a few laboratory tests of fluid flow through single rough fractures,in which the Weierstrass-Mandelbrot fractal function and PMMA material were employed to produce the fracture models with various fractal roughnesses.A high-speed video camera was employed to record the fluid flow through the entire single rough fracture with a constant hydraulic pressure.The properties of fluid flow varying with the fracture roughness and the influences of the rough structure were analyzed.The components of flow resistance of a single rough fracture were discussed.A fractal model was proposed to relate the fluid resistance to the fracture roughness.A fractal equivalent permeability coefficient of a single rough fracture was formulated.This study aims to provide an experimental basis and reference for better understanding and quantitatively relating the fluid flow properties to the structures of rock fractures. | JU Yang ZHANG QinGang YANG YongMing XIE HePing GAO Feng WANG HuiJie | 2013 | Science China(Technological Sciences)2013，56，8： | 28 |
| 11 | State-of-the-art of 3D printing technology of cementitious material—An emerging technique for construction显示文摘In recent few years, significant improvement has been made in developing largescale 3 D printer to accommodate the need of industrial-scale 3 D printing. Cementitious materials that are compatible with 3 D printing promote rapid application of this innovative technique in the construction field with advantages of cost effective, high efficiency, design flexibility and environmental friendly. This paper firstly reviews existing 3 D printing techniques that are currently being used in commercial3 D printers. It then summarizes three latest development of largescale 3 D printing systems and identifies their relationships and limiting factors. Thereafter, critical factors that are used to evaluate the workability and printable performance of cementitious materials are specified. Easy-extrusive, easy-flowing, well-buildable, and proper setting time are significant for cementitious material to meet the critical requirements of a freeform construction process. Finally, main advantages, potential applications and the prospects of future research of 3 D printing in construction technology are suggested. The objective of this work is to review current design methodologies and operational constraints of largescale 3 D printing system and provide references for optimizing the performance of cementitious material and promote its responsible use with largescale 3 D printing technology. | MA GuoWei WANG Li JU Yang | 2018 | Science China(Technological Sciences)2018，61，4： | 28 |
| 12 | Computation of fractal dimension of rock pores based on gray CT images显示文摘The characterization of pore structure in rocks is relevant in determining their various mechanical behaviors. Digital image processing methods integrated with fractal theory were applied to analyze images of rock slices obtained from industry CT, elucidating the characteristics of rock pore structure and the relationship between porosity and fractal dimensions. The gray values of pixels in CT images of rocks provide comprehensive results with respect to the attenuation coefficients of various materials in corresponding rock elements, and these values also reflect the effect of rock porosity at various scales. A segmentation threshold can be determined by inverse analysis based on the pore ratios that are measured experimentally, and subsequently binary images of rock pores can be obtained to study their topological structures. The fractal dimension of rock pore structure increases with an increase in rock pore ratio, and fractal dimensions might differ even if pore ratios are the same. The more complex the structure of a rock, the larger the fractal dimension becomes. The experimental studies have validated that fractal dimension calculated directly from gray CT images of rocks can give an effective complementary parameter to use alongside pore ratios and they can suitably represent the fractal characteristics of rock pores. | PENG RuiDong YANG YanCong JU Yang MAO LingTao YANG YongMing | 2011 | Chinese Science Bulletin2011，56，31： | 25 |
| 13 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 14 | Microwave photocatalytic degradation of Rhodamine B using TiO_2 supported on activated carbon:Mechanism implication显示文摘The photocatalytic degradation of Rhodamine B(RhB) was carried out using TiO2 supported on activated carbon(TiO2-AC) under microwave irradiation.Composite catalyst TiO2-AC was prepared and characterized using X-ray diffraction(XRD),transmission electron microscopy(TEM) and Brunauer-Emmett-Teller(BET).In the process of microwave-enhanced photocatalysis(MPC),RhB(30 mg/L) was almost completely decoloured in 10 min,and the mineralization effciency was 96.0% in 20 min.The reaction rate constant of RhB in MPC using TiO2-AC by pseudo first-order reaction kinetics was 4.16 times of that using Degussa P25.Additionally,according to gas chromatography/mass spectrometry(GC/MS) and liquid chromatography/mass spectrometry(LC/MS) identification,the major intermediates of RhB in MPC included two kinds of N-de-ethylation intermediates(N,N-diethyl-N'-ethyl-rhodamine(DER)),oxalic acid,malonic acid,succinic acid,and phthalic acid,maleic acid,3-nitrobenzoic acid,and so on.The degradation of RhB in MPC was mainly attributed to the destruction of the conjugated structure,and then the intermediates transformed to acid molecules which were mineralized to water and carbon dioxide. | HE Zhong,YANG Shaogui,JU Yongming,SUN Cheng State Key Laboratory of Pollution Control and Resource Reuse,School of the Environment,Nanjing University,Nanjing 210093,China. | 2009 | Journal of Environmental Sciences2009，21，2： | 22 |
| 15 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 16 | Grain yield and water use efficiency of super rice under soil water deficit and alternate wetting and drying irrigation显示文摘This study investigated if super rice could better cope with soil water deficit and if it could have better yield performance and water use efficiency(WUE) under alternate wetting and drying(AWD) irrigation than check rice. Two super rice cultivars and two elite check rice cultivars were grown in pots with three soil moisture levels, well watered(WW), moderate water deficit(MWD) and severe water deficit(SWD). Two cultivars, each for super rice and check rice, were grown in field with three irrigation regimes, alternate wetting and moderate drying(AWMD), alternate wetting and severe drying(AWSD) and conventional irrigation(CI). Compared with that under WW, grain yield was significantly decreased under MWD and SWD treatments, with less reduction for super rice than for check rice. Super rice had higher percentage of productive tillers, deeper root distribution, higher root oxidation activity, and greater aboveground biomass production at mid and late growth stages than check rice, especially under WMD and WSD. Compared with CI, AWMD increased, whereas AWSD decreased grain yield, with more increase or less decrease for super rice than for check rice. Both MWD and SWD treatments and either AWMD or AWSD regime significantly increased WUE compared with WW treatment or CI regime, with more increase for super rice than for check rice. The results suggest that super rice has a stronger ability to cope with soil water deficit and holds greater promising to increase both grain yield and WUE by adoption of moderate AWD irrigation. | ZHOU Qun JU Cheng-xin WANG Zhi-qin ZHANG Hao LIU Li-jun YANG Jian-chang ZHANG Jian-hua | 2017 | Journal of Integrative Agriculture2017，16，5： | 22 |
| 17 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 18 | Visual representation and characterization of three-dimensional hydrofracturing cracks within heterogeneous rock through 3D printing and transparent models显示文摘 | Peng Liu Yang Ju Pathegama G. Ranjith Zemin Zheng Li Wang Ayai Wanniarachchi | 2016 | International Journal of Coal Science & Technology2016，3，3： | 21 |
| 19 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 20 | A statistical model for porous structure of rocks显示文摘The geometric features and the distribution properties of pores in rocks were in- vestigated by means of CT scanning tests of sandstones. The centroidal coordi- nates of pores, the statistic characterristics of pore distance, quantity, size and their probability density functions were formulated in this paper. The Monte Carlo method and the random number generating algorithm were employed to generate two series of random numbers with the desired statistic characteristics and prob- ability density functions upon which the random distribution of pore position, dis- tance and quantity were determined. A three-dimensional porous structural model of sandstone was constructed based on the FLAC3D program and the information of the pore position and distribution that the series of random numbers defined. On the basis of modelling, the Brazil split tests of rock discs were carried out to ex- amine the stress distribution, the pattern of element failure and the inosculation of failed elements. The simulation indicated that the proposed model was consistent with the realistic porous structure of rock in terms of their statistic properties of pores and geometric similarity. The built-up model disclosed the influence of pores on the stress distribution, failure mode of material elements and the inosculation of failed elements. | JU Yang1,2, YANG YongMing1, SONG ZhenDuo3 & XU WenJing4 1 State Key Laboratory of Coal Resources and Safe Mining, China University of Mining & Technology, Beijing 100083, China 2 Department of Mechanical and Manufacturing Engineering, The University of Calgary, 2500 University Drive NW Calgary, AB T2N 1N4, Canada 3 China National Coal Mining Equipment Co. Ltd, Beijing 100011, China 4 Department of Materials and Metallurgy, The University of Utah, Salt Lake City, Utah 84112, USA | 2008 | Science China(Technological Sciences)2008，51，11： | 21 |
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