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| 1 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 2 | Rural E-commerce and New Model of Rural Development in China:A Comparative Study of 'Taobao Village' in Jiangsu Province显示文摘With the development of electronic commerce,there is a special phenomenon in rural areas of China that a lot of farmers in these areas depend on opening shops on Taobao online for a living. The products are made from the village workshop,and farmers become fullyfledged network businessmen. Electronic business platform mode of ' Taobao Village' is the result of integrated development of primary,secondary and tertiary industries. In this study,we take two kinds of typical Taobao villages( Dongfeng Village and Yanxia Village) as sample areas,and conduct comparative analysis of this new rural business model based on field survey data,case studies and theoretical research. We also probe into the problems in the development of Taobao villages,and set forth the recommendations for the new rural business model. | Changyu LIU Jiale LI Jing LIU | 2015 | Asian Agricultural Research2015，7，11： | 14 |
| 3 | The global oxygen budget and its future projection显示文摘Atmospheric oxygen (O_2 ) is the most crucial element on earth for the aerobic organisms that depend on it to release energy from carbon-based macromolecules. This is the first study to systematically analyze the global O_2 budget and its changes over the past 100 years. It is found that anthropogenic fossil fuel combustion is the largest contributor to the current O_2 deficit, which consumed 2.0 Gt/a in 1900 and has increased to 38.2 Gt/a by 2015. Under the Representative Concentration Pathways (RCPs) RCP8.5 scenario, approximately 100Gt (gigatonnes) of O_2 would be removed from the atmosphere per year until 2100,and the O_2 concentration will decrease from its current level of 20.946%to 20.825%. Human activities have caused irreversible decline of atmospheric O_2 . It is time to take actions to promote O_2 production and reduce O_2 consumption. | Jianping Huang Jiping Huang Xiaoyue Liu Changyu Li Lei Ding Haipeng Yu | 2018 | Science Bulletin2018，63，18： | 14 |
| 4 | Precise localization of small pulmonary nodules using Pre-VATS with Xper-CT in combination with real-time fluoroscopy-guided coil:report of 15 patients显示文摘Purpose: This study aimed to evaluate the value of precise localization of nodules using pre-video-assisted thoracic surgery(VATS) Xper–CT in combination with real-time fluoroscopy-guided coil in the resection of pulmonary nodules using VATS. Materials and Methods: Precise localization of nodules using Xper-CT in combination with real-time fluoroscopy-guided coil and wedge resection using VATS were conducted on 15 patients with 17 small pulmonary nodules(diameter 0.5–1.5 cm) from April 2015 to January 2016. The value of localization was evaluated in terms of procedure time, type of coils, associated complications of localization, and VATS success rate. Results: The success rate of coil localization was found to be 100% in the primary stage(as shown by the CT scan), and the average procedure time was 30–45 min(35.6 ± 3.05 min). No deaths or major complications occurred. Minor complications included five incidents of pneumothorax(the morbidity was 29.4%, 5/17; no patient required chest tube drainage). The dislocation of coil was found in one patient. The results of pathological examination of 17 small pulmonary nodules revealed 11 primary lung cancers, 1 mesenchymal tumor, 3 nonspecific chronic inflammations, 1 hamartoma, and 1 tuberculosis. Two patients with primary lung cancer underwent lobectomy with mediastinal lymph node dissection. Conclusion: The preoperative precise localization of small pulmonary nodules using Xper-CT-guided coil is an effective and safe technique. It helps in the resection of nodules using VATS. It increases the rate of lung wedge resection with few complications and allows for proper diagnosis with a low thoracotomy conversion rate. | Jiemin Cheng Changyu Li Liangwen Wang Jiting Liang Zhiping Yan Jiani Hu Huibing Shi | 2018 | Journal of Interventional Medicine2018，1，2： | 8 |
| 5 | Estimation of Gridded Atmospheric Oxygen Consumption from 1975 to 2018显示文摘Atmospheric Oxygen(O2)is one of the dominating features that allow the earth to be a habitable planet with advanced civilization and diverse biology.However,since the late 1980 s,observational data have indicated a steady decline in O2 content on the scale of parts-per-million level.The current scientific consensus is that the decline is caused by the fossil-fuel combustion;however,few works have been done to quantitatively evaluate the response of O2 cycle under the anthropogenic impact,at both the global and regional scales.This paper manages to quantify the land O2 flux and makes the initial step to quantificationally describe the anthropogenic impacts on the global O2 budget.Our estimation reveals that the global O2 consumption has experienced an increase from 33.69±1.11 to47.63±0.80 Gt(gigaton,109 t)O2yr^-1 between 2000 and 2018,while the land production of O2(totaling 11.34±13.48 Gt O2yr^-1 averaged over the same period)increased only slightly.In 2018,the combustion of fossil-fuel and industrial activities(38.45±0.61 Gt O2yr^-1)contributed the most to consumption,followed by wildfires(4.97±0.48 Gt O2yr^-1)as well as livestock and human respiration processes(2.48±0.16 and 1.73±0.13 Gt O2yr^-1,respectively).Burning of fossil-fuel that causes large O2 fluxes occurs in East Asia,India,North America,and Europe,while wildfires that cause large fluxes in comparable magnitude are mainly distributed in central Africa. | Xiaoyue LIU Jianping HUANG Jiping HUANG Changyu LI Lei DING Wenjun MENG | 2020 | Journal of Meteorological Research2020，34，3： | 8 |
| 6 | The oxygen cycle and a habitable Earth显示文摘As an important contributor to the habitability of our planet, the oxygen cycle is interconnected with the emergence and evolution of complex life and is also the basis to establish Earth system science. Investigating the global oxygen cycle provides valuable information on the evolution of the Earth system, the habitability of our planet in the geologic past, and the future of human life. Numerous investigations have expanded our knowledge of the oxygen cycle in the fields of geology,geochemistry, geobiology, and atmospheric science. However, these studies were conducted separately, which has led to onesided understandings of this critical scientific issue and an incomplete synthesis of the interactions between the different spheres of the Earth system. This review presents a five-sphere coupled model of the Earth system and clarifies the core position of the oxygen cycle in Earth system science. Based on previous research, this review comprehensively summarizes the evolution of the oxygen cycle in geological time, with a special focus on the Great Oxidation Event(GOE) and the mass extinctions, as well as the possible connections between the oxygen content and biological evolution. The possible links between the oxygen cycle and biodiversity in geologic history have profound implications for exploring the habitability of Earth in history and guiding the future of humanity. Since the Anthropocene, anthropogenic activities have gradually steered the Earth system away from its established trajectory and had a powerful impact on the oxygen cycle. The human-induced disturbance of the global oxygen cycle, if not controlled, could greatly reduce the habitability of our planet. | Jianping HUANG Xiaoyue LIU Yongsheng HE Shuzhong SHEN Zengqian HOU Shuguang LI Changyu LI Lijie YAO Jiping HUANG | 2021 | Science China Earth Sciences2021，64，4： | 5 |
| 7 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 8 | Effects of cerium precursors on surface properties of mesoporous CeMnO_x catalysts for toluene combustion显示文摘Mesoporous CeMnOx composite oxides catalysts were prepared by surfactant-assisted co-precipitation method and used for the catalytic oxidation of toluene.The effect of different cerium precursors[Ce(NO3)3 and(NH4)2 Ce(NO3)6] on catalyst structure,surface properties and toluene combustion activities of mesoporous CeMnOx catalysts were investigated.The Ce(Ⅲ)MnOx catalyst prepared from Ce(NO3)3 precursor shows higher catalytic activity,with a 90% conversion temperature of 240℃,which is better than the Ce(Ⅳ)MnOx catalyst derived from[(NH4)2 Ce(NO3)6] precursor.On the basis of characterizations,it reveals that abundant surface content of Mn4+,better redox behavior and larger concentration of surface active oxygen species are responsible for the excellent catalytic performance. | Changyu Zhang Wei Chu Feng Chen Lei Li Ruiyu Jiang Jinlong Yan | 2020 | Journal of Rare Earths2020，38，1： | 4 |
| 9 | Drag reduction and shear resistance properties of ionomer and hydrogen bond systems based on lauryl methacrylate显示文摘Based on molecular dynamics simulation results,a lauryl methacrylate polymer with drag reduction and shear resistance properties was designed,and synthesized by emulsion polymerization using 2-vinyl pyridine and methyl methacrylate as the polar polymerization monomer.After ionization of lauryl methacrylate polymer,an ion-dipole interaction based drag reduction agent (DRA) was obtained.The existence of ion-dipole interaction was proven through characterization of the drag-reducing agent from its infrared (IR) spectrum.The pilot-scale reaction yield of the DRA under optimum conditions was investigated,and the drag reduction and shear resistance properties were measured.The results show that:1) The ion-dipole or hydrogen bonding interaction can form ladder-shaped chains,therefore the synthesized DRA has shear resistance properties;2) The larger the molecular weight (MW) and more concentrated the distribution of MW,the better the drag reduction efficiency and the performance of the ionomer system was superior to that of the hydrogen bonding system;3) With increasing shear frequency,the drag-reduction rates of both the DRAs decreased,and the drag reduction rate of the ionomer system decreased more slowly than of the corresponding hydrogen bonding system.From the point of view of drag reduction rate and shear resistance property,the ionomer system is more promising than the hydrogen bonding | Yu Ping Li Changyu Zhang Changqiao Chen Shiwei Fang Shu Sun Hui | 2011 | Petroleum Science2011，8，3： | 3 |
| 10 | The interference characteristics of platform and towed body noise in shallow water for active/passive towed array sonar显示文摘拖引的站台噪音的干扰特征源于推进器并且拖引身体因为活跃 / 被动的拖引的数组被分析。在浅水环境,反映的直接波浪和底部 / 海表面飘动,这被显示出将严重影响声纳系统的性能。为以各种各样的参数计算干扰的到达( DOA )的方向的公式例如数组深度,一些拖引电缆线,是干扰噪音的 derived.The 效果因为声纳系统的察觉性能是系统模拟的 described.The 结果为减少这些种干扰的效果提供方法。 | LI Qihu LI Shuqiu SUN Changyu YU Huabing | 2007 | Chinese Journal of Acoustics2007，26，3： | 3 |
| 11 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 12 | Applying DNA Barcoding to Identify Actinidia in the Northeast of China显示文摘Identification of kiwifruit germplasm materials is the basis of protecting and utilizing these resources. However,identifying Actinidia arguta varieties based on morphology is difficult,especially for non-specialists. In this study,we collected 180 specimens comprising 60 varieties of three species( A. arguta,A. kolomikta,and A. polygama) from the Northeast of China. The emphasis of our study was on the feasibility of identifying A. arguta varieties. Here,we used common analysis methods( genetic distance,phylogenetic analysis and the DNA barcoding gap) and SNPs analysis to evaluate the discriminatory power of different DNA barcoding markers. The results revealed that common methods were insufficient to identify A. arguta varieties but SNPs analysis based on DNA barcoden was the potential method for identifying A. arguta varieties. Besides,Our study agree that DNA barcoding could be used to analysis the evaluation genetic relationship of the Actinidia plants. | haishuang liu hongyan qin jun ai huifang song yiming yang shutian fan peilei xu guangli shi changyu li | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 13 | Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: Results from a meta-analysis of cohort studies显示文摘 | Qingbing Wang Yi Chen Xiaolin Wang Gaoquan Gong Guoping Li Changyu Li | 2014 | European Journal of Cancer2014，，： | 2 |
| 14 | Design Aspects of Hybrid HVDC System显示文摘Hybrid high voltage direct current transmission(Hybrid HVDC)is a new type of HVDC technology developed in recent years.It combines the characteristics of large-capacity and low cost of the line commutated converters(LCC)and non-commutation failure and dynamic reactive power support of the voltage sourced converters(VSCs)in one HVDC system.It has technical advantages in the fields of unidirectional power transmission and in the application of improving the stability of multi-infeed HVDCs,giving it broad application prospects.This paper defines the basic form of hybrid HVDC first and discusses the characteristics and challenges of different hybrid HVDCs.Then,it analyzes the matching characteristics between LCC and VSC in the station-station hybrid HVDC,studies the key technologies,such as VSC topologies and control strategies for clearing the DC overhead line faults,and introduces the key technologies for analyzing and suppressing the high-frequency resonances between VSC and the power grid.In this paper,using the Wudongde UHV multi-terminal HVDC as an example,the proposed key technologies are analyzed and verified. | Hong Rao Yuebin Zhou Changyue Zou Shukai Xu Yan Li Liu Yang Weihuang Huang | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 2 |
| 15 | Cetus:an efficient symmetric searchable encryption against file-injection attack with SGX显示文摘Symmetric searchable encryption(SSE)allows the users to store and query their private data in the encrypted database.Many SSE schemes for different scenarios have been proposed in the past few years,however,most of these schemes still face more or fewer security issues.Using these security leakages,many attacks against the SSE scheme have been proposed,and especially the non-adaptive file injection attack is the most serious.Non-adaptive file injection attack(NAFA)can effectively recover some extremely important private information such as keyword plaintext.As of now,there is no scheme that can effectively defend against such attacks.We first propose the new security attribute called toward privacy to resist nonadaptive file injection attacks.We then present an efficient SSE construction called Cetus to achieve toward privacy.By setting up a buffer and designing the efficient oblivious reading algorithm based on software guard extensions(SGX),we propose the efficient one-time oblivious writing mechanism.Oblivious writing protects the update pattern and allows search operations to be performed directly on the data.The experiment results show that Cetus achieves O(aw)search time and O(1)update communication.The practical search time,communication,and computation overheads incurred by Cetus are lower than those of state-of-the-art. | Yanyu HUANG Siyi LV Zheli LIU Xiangfu SONG Jin LI Yali YUAN Changyu Dong | 2021 | Science China(Information Sciences)2021，64，8： | 2 |
| 16 | Atmospheric Warming Slowdown during 1998-2013 Associated with Increasing Ocean Heat Content显示文摘Although atmospheric greenhouse gas concentrations continuously increased, there was relatively little change in global-averaged surface temperatures from 1998 to 2013, which is known as atmospheric warming slowdown. For further understanding the mechanism involved, we explored the energy redistribution between the atmosphere and ocean in different latitudes and depths by using data analysis as well as simulations of a coupled atmosphere–ocean box model. The results revealed that, compared with observational changes of ocean heat content (OHC) associated with rapid warming, the OHC changes related to warming slowdown are relatively larger in multiple ocean basins, particularly in the deeper layer of the Atlantic. The coupled box model also showed that there is a larger increasing trend of OHC under the warming slowdown scenario than the rapid warming scenario. Particularly, during the warming slowdown period, the heat storage in the deeper ocean increases faster than the ocean heat uptake in the surface ocean. The simulations indicated that the warming patterns under the two scenarios are accompanied by distinct outgoing longwave radiation and atmospheric meridional heat transport, as well as other related processes, thus leading to different characteristics of ocean heat uptake. Due to the global energy balance, we suggest this slowdown has a tight relationship with the accelerated heat transport into the global ocean. | Changyu LI Jianping HUANG Yongli HE Dongdong LI Lei DING | 2019 | Advances in Atmospheric Sciences2019，36，11： | 2 |
| 17 | Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidrug-resistant bacteria显示文摘Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants. | LI ShuiHong WU ChangYu LV XiaYi TANG Xiao ZHAO XinQing YAN Hong JIANG Hui WANG XueMei | 2012 | Science China Chemistry2012，55，11： | 2 |
| 18 | Superior activity of MnOx-CeO2/TiO2 catalysts for catalytic oxidation of elemental mercury in low flue gas temperatures显示文摘 | Li Hailong Wu Changyu Li Ying | 2012 | Appl Catal B:Environ2012，112，： | 1 |
| 19 | A New Cognitive Model: Cloud Model 显示文摘 | Li Deyi Liu Changyu Gan Wenyan | 2009 | International Journal of Intelligent Systems2009，24，4： | 1 |
| 20 | Organic–inorganic hybrid material for the cells immobilization: Long-term viability mechanism and application in BOD sensors显示文摘 | Ling Liu Li Shang Shaojun Guo Dan Li Changyu Liu Li Qi Shaojun Dong | 2009 | Biosensors and Bioelectronics2009，，2： | 1 |
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