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| 1 | 急性心肌梗死后凋亡和炎症及相关因子的动态变化显示文摘目的探讨实验大鼠急性心肌梗死(AMI)后心功能改变和心肌梗死(MI)范围、凋亡、炎症的病理演变规律及相关机制。方法雄性Wistar大鼠68只,随机分MI(结扎冠状动脉左前降支)组(n=40)及相应假手术(Sham,只挂线不结扎冠状动脉)组(n=28)。MI组(3 h内死亡12只)分MI后1、7、14和28 d组,分别于术后观察期满导管法检测血流动力学改变,并取心脏组织行苏木素伊红(HE)、氯化四唑(TTC)、Masson染色观察病理变化,末端脱氧核糖核苷酸转移酶介导的dUTP缺口末端标记法(TUNEL)染色检测凋亡,免疫组化检测炎症细胞密度及转化生长因子β1(TGF-β1)的表达。Western blot检测血管细胞黏附分子-1(VCAM-1)、TGF-β1的表达,实时PCR法检测VCAM-1、单核细胞趋化因子1(MCP-1)的表达。结果MI后1~14 d心功能明显下降,28 d未明显恶化。MI后1、7、14及28 d组梗死范围分别为(41±3)%、(37±3)%、(38±3)%和(28±3)%,凋亡率分别为(46.3±3.0)%、(3.8±2.1)%、(3.3±2.3)%和(1.4±1.0)%,炎症细胞密度分别为(630±72)个/mm2、(1360±102)个/mm2、(1000±98)个/mm2和(223±13)个/mm2,而相应Sham组各种指标均为正常。VCAM-1、MCP-1的表达在MI后1 d明显升高,14 d后下降。TGF-β1在MI后始终处于高表达。结论大鼠MI后其凋亡高峰在1 d,炎症反应高峰在7 d出现,28 d后基本完成MI后修复过程。 | 姚玉宇 马根山 刘乃丰 尹航 沈波 JULIE Chao LEE Chao | 2008 | 江苏医药2008，34，12： | 7 |
| 2 | 果糖诱导大鼠胰岛素抵抗和高血压的机制及人组织型激肽释放酶基因的治疗作用显示文摘目的 研究果糖诱导高血压合并高胰岛素血症、胰岛素抵抗时内皮素 1(ET -1)及其受体 (ETA)、血管紧张素Ⅱ受体 1(AT1)的变化和人组织型激肽释放酶 (HK )基因的治疗作用。方法雄性Sprague -Dawley (SD)大鼠饮用 10 %果糖水诱导形成高血压和胰岛素抵抗动物模型后 ,静脉注入含HKcDNA的重组质粒 (pcDNA HK )。监测血压 ,血清胰岛素及血糖等。 2周时处死动物 ,测定脏器中HK的表达及ET 1、ETA和AT1的表达情况。结果 饮高果糖水 2周后 ,动物血压、血胰岛素水平明显高于正常饮水组 ,静脉注射pcDNA HK后第 3天即可明显降低果糖诱导高血压大鼠的血压 ,最大降压效应在导入基因后第 14天 (达 15mmHg) ,其降压效应持续 3周以上。HK基因导入后第 2周 ,HK治疗组动物ET 1、ETA及AT1明显低于对照组 ,与正常组接近。并且在血压下降的同时 ,血胰岛素浓度亦明显降低。结论 动物高果糖饮水可导致高血压及高胰岛素血症 ,其机理可能与ET 1、ETA和AT1表达增加有关 ,HK基因的导入可能通过降低血管ET 1、ETA和AT1表达而降低血压 ,并纠正高血压伴随的高胰岛素血症 。 | 赵春霞 汪培华 李宏伟 Lee Chao Julie Chao 肖啸 汪道文 | 2003 | 中华心血管病杂志2003，31，10： | 7 |
| 3 | 组织激肽释放酶、缓激肽对心肌梗死后心力衰竭心室重构的作用显示文摘目的利用心肌梗死后心力衰竭模型研究组织激肽释放酶(TK)和缓激肽(BK)改善心功能、抑制心肌纤维化的机制。方法冠状动脉结扎后1周,纯化的TK及BK连续皮下渗透给药4周,5周后处死动物。导管法检测各组动物的心功能,天狼红染色检测胶原的沉积,银染法测量心肌细胞的面积,免疫组织化学法检测Ⅰ、Ⅲ型胶原,W estern b lot-ting检测TGF-β1、Sm ad 2和phosph-Sm ad 2的表达,化学发光法检测一氧化氮(NO)和过氧化物的含量。结果TK及BK能明显改善心功能,对梗死面积无影响。治疗组胶原的沉积明显减少,细胞肥大减轻,TGF-β1、Smad的表达和磷酸化减少,NO的合成增加,过氧化物蓄积减轻。结论TK及BK对心肌梗死后的心力衰竭有治疗作用,抑制TGF-β1活化及过氧化物形成是主要的机制。 | 姚玉宇 马根山 刘乃丰 尹航 Julie Chao Lee Chao | 2008 | 现代医学2008，36，6： | 3 |
| 4 | Study on topographic compensation model of the Okinawa Trough I. Calculation of theoretical isostatic response function显示文摘Based on regional compensation and experimental isostasy, the calculating formula of theoretical isostatic response function is deduced when the loads on top correlate with loads from below. A variety of curves of theoretical isostatic response function were calculated with different effective elastic thickness of the plate and by using different proportions between loads on top and loads from below. And preliminary discussion is made on shapes of the curves. | Liu Baohua Wu Jinlong Xin Baisen and Peng Chao 1. First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China 2. Ocean University of Qingdao, Qingdao 266003, China (Received October 12, 1997 accepted July 17, 1998) | 1999 | Acta Oceanologica Sinica1999，18，2： | 2 |
| 5 | Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad 14-3- 3γsignaling pathways 显示文摘 | Yin Hang Chao Lee Chao Julie | 2005 | J Biol Chem2005，280，： | 1 |
| 6 | Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis显示文摘 | Chun-Fang Xia Hang Yin Cesar V. Borlongan Lee Chao Julie Chao | 2004 | Hypertension: Journal of the American Heart Association ( Part )2004，，2： | 1 |
| 7 | Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis显示文摘 | Lee Chao Julie Chao | 2006 | Human Gene Therapy2006，17，1： | 1 |
| 8 | Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction显示文摘 | Robert S. Smith Jun Agata Chun-Fang Xia Lee Chao Julie Chao | 2005 | Life Sciences2005，，21： | 1 |
| 9 | Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia显示文摘 | Costanza Emanueli Alessandra Minasi Antonella Zacheo Julie Chao Lee Chao Maria Bonaria Salis Stefania Straino Maria Grazia Tozzi Robert Smith Leonardo Gaspa Giuseppe Bianchini Francesco Stillo Maurizio C. Capogrossi Paolo Madeddu | 2001 | Circulation: Journal of the American Heart Association2001，，1： | 1 |
| 10 | Rescue of Impaired Angiogenesis in Spontaneously Hypertensive Rats by Intramuscular Human Tissue Kallikrein Gene Transfer显示文摘 | Costanza Emanueli Maria Bonaria Salis Tiziana Stacca Leonardo Gaspa Julie Chao Lee Chao Andrea Piana Paolo Madeddu | 2001 | Hypertension: Journal of the American Heart Association2001，，1： | 1 |
| 11 | Salutary Effect of Kallistatin in Salt-Induced Renal Injury, Inflammation, and Fibrosis via Antioxidative Stress显示文摘 | Bo Shen Makoto Hagiwara Yu-Yu Yao Lee Chao Julie Chao | 2008 | Hypertension2008，，5： | 1 |
| 12 | Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A显示文摘 | Chao Cai Kemal Solakyildirim Bo Yang Julie M. Beaudet Amanda Weyers Robert J. Linhardt Fuming Zhang | 2011 | Carbohydrate Polymers2011，，1： | 1 |
| 13 | Atrial natrluretie peptide gene delively attenuates hypertension, cardiac hypertrophy, and renal injury in salt-sensetive rats显示文摘 | Kuei-Fu Julie Chao Lee Chao | 1998 | Human Gene Therapy1998，9，： | 1 |
| 14 | Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis 显示文摘 | Lee Chao Julie Chao | 2006 | Human gene therapy2006，17，： | 1 |
| 15 | Tissue kallikrein elicits cardioprotection by direct kinin B2 receptor activation independent of kinin formation显示文摘 | JULIE Chao HANG Yin LEE Chao | 2008 | Hypertension2008，52，4： | 1 |
| 16 | Tissue kallikrein infusion prevents cardiomyocyte apoptosis,inflammation and ventricular remodeling after myocardial infarction显示文摘 | YU-YU Yao HANG Yin JULIE Chao | 2007 | Regul Pept2007，140，12： | 1 |
| 17 | Purification,characterization and activation of fish muscle prokallikrein 显示文摘 | Gary P Richard Yu-mei Liang Julie Chao | 1997 | Comp Biochem Physiol1997，118，1： | 1 |
| 18 | Tissue kallikrein is related to the severity of coronary artery disease显示文摘 | Yu-yu Yao Cong Fu Gen-shan Ma Yi Feng Cheng-xing Shen Guo-qiu Wu Xiao-guo Zhang Jian-dong Ding Cheng-chun Tang Zhong Chen Qi-ming Dai Jia-yi Tong Dan Luo Jian Zhu Hong Zhi Yong-jun Li Cheng-wei Ju Jing Lu Julie Chao Lee Chao | 2013 | Clinica Chimica Acta2013，，： | 1 |
| 19 | Human atrial natriuretic peptide gene delivery reduces blood pressure in hypertensive rats显示文摘 | Julie Chao Lee Chao | 1995 | Hypertension1995，26，6： | 1 |
| 20 | Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing显示文摘 | Julie Chao Bo Shen Lin Gao Chun-Fang Xia Grant Bledsoe Lee Chao | 2010 | Biological Chemistry2010，，4： | 1 |
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