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| 1 | T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape显示文摘Bispecific chimeric antigen receptor T-cell(CAR-T)therapies have shown promising results in clinical trials for advanced B-cell malignancies.However,it is challenging to broaden the success of bispecific CAR-T therapies to treat refractory/relapse(r/r)T-cell leukemia/lymphoma because targeting multiple T-cell-expressing antigens leads to exacerbated CAR-T cell fratricide and potential safety concerns.Fully human heavy chain variable(FHVH)antibodies that specifically target CD5 or CD7 were screened and constructed to CD5/CD7 bispecific CARs.A truncated Epidermal growth factor receptor were integrated into CAR constructs to address safety concerns.To tackle the fratricidal issue of CAR-T cells targeting T-cell-pan marker(s),CRISPR/Cas9-based CD5 and CD7 genes knockout were performed before lentiviral transduction of bispecific CARs.Functional comparison between different bispecific CAR structures:tandem CARs and dual CAR were performed in vitro and in vivo to determine the optimal construct suitable for addressing T-cell malignancy antigen escape in clinical setting.Knockout of CD5 and CD7 prevents fratricide of CD5/CD7 bispecific CAR-T cells,and FHVH-derived CD5/CD7 bispecific CAR-T cells demonstrate potent antitumor activity in vitro and in vivo.The fratricide-resistant FHVH-derived CD5/CD7 bispecific CAR-T cells have potent antitumor activity against T-cell malignancies,and tandem CARs are more effective than dual CAR in preventing tumor escape in heterogeneous leukemic cells.The meaningful clinical efficacy and safety of tandem CD5/CD7 CAR-T cells deserve to be explored urgently. | Zhenyu Dai Wei Mu Ya Zhao Jiali Cheng Haolong Lin Kedong Ouyang Xiangyin Jia Jianwei Liu Qiaoe Wei Meng Wang Chaohong Liu Taochao Tan Jianfeng Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 3 |
| 2 | Chinese Bilateral Intra-Industry Trade: A Panel Data Study for 50 Countries in the 1992–2001 Period显示文摘 | Jianhong Zhang Arjen van Witteloostuijn Chaohong Zhou | 2005 | Review of World Economics2005，，3： | 1 |
| 3 | 'Chinese Bilateral Intra-lndustry Trade:A Panel Data Study for 50 Countries in the1992--2001 Period' 显示文摘 | Jianhong Zhang Arjen van Witteloostuijn and Chaohong Zhou | 2005 | Kiel Institute for World Economics2005，，5： | 1 |
| 4 | Experimental Study of Phase Change Material’s Application in Refuge Chamber of Coal Mine显示文摘 | Bing Wu Bowei Lei Chaohong Zhou Zhiyan Zhao | 2012 | Procedia Engineering2012，，： | 1 |
| 5 | Chinese Bilateral Intra-Industry Trade:A Panel Data Study for 50 Countries in the 1992-2001 Period显示文摘 | Jianhong Zhang Arjenvan Witteloostuijn Chaohong Zhou | 2005 | Review of World Economics2005，，03： | 1 |
| 6 | Preparation and properties of cotton fabrics treated with a novel guanidyl- and phosphorus-containing polysiloxane antimicrobial and flame retardant显示文摘 | Chaohong Dong Zhou Lu Fengjun Zhang | 2014 | Materials Letters2014，，： | 1 |
| 7 | Completion of Chinese Oversea Acquisitions:Institutional Perspective and Evidence显示文摘 | Jianhong Zhang Chaohong Zhou Haco ebbers | 2001 | International Business Review2001，，20： | 1 |
| 8 | Comple- tion of Chinese overseas acquisitions: Institutional perspectives and evidence显示文摘 | Zhang Jianhong Zhou Chaohong Ebbers Haico | 2011 | International Business Review2011，20，22： | 1 |
| 9 | Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells显示文摘Ubiquitin-specific peptidase 18(USP18)plays an important role in the development of CD11b^(+)dendritic cells(DCs)and Th17 cells,however,its role in the differentiation of other T cell subsets,especially in regulatory T(Treg)cells,is unknown.In our study,we used Usp18 K0 mice to study the loss of USP18 on the impact of Treg cell differentiation and function.We found that USP18 deficiency upregulates the differentiation of Treg cells,which may lead to disrupted homeostasis of peripheral T cells,and downregulates INF-y,IL-2,IL-17A producing CD4^(+)T cells and INF-γproducing CD8^(+)T cells.Mechanistically,we also found that the upre-gulation of Tregs is due to elevated expression of CD25 in Usp18 KO mice.Finally,we found that the suppressive function of Usp18 KO Tregs is downregulated.Altogether,our study was the first to identify the role of USP18 in Tregs differentiation and its suppressive function,which may provide a new reference for the treatment of Treg function in many autoimmune diseases,and USP18 can be used as a new therapeutic target for precise medical treatment. | Lu Yang Yukai Jing Danqing Kang Panpan Jiang Na Li Xinrong Zhou Yan Chen Lisa S.Westerberg Chaohong Liu | 2021 | Genes & Diseases2021，8，3： | 1 |
| 10 | Chinese Bilateral Intra-Industry Trade:A Panel Data Study for 50 Countries in the 1992–2001 Period显示文摘 | Jianhong Zhang Arjen van Witteloostuijn Chaohong Zhou | 2005 | Review of World Economics2005，，3： | 1 |
| 11 | Additive Manufacturing of Large-scale Metal Mesh with Core-shell Composite Structure for Transparent Electromagnetic Shielding/glass Heater显示文摘Transparent electromagnetic(EM)shielding glass with a metal mesh has significant potential for application in different fields of EM radiation and anti-EM interference light-transmitting observation windows.In particular,a transparent EM-shielding glass with a large-aspect-ratio metal mesh can effectively alleviate the contradictory problems of shielding effectiveness and light-transmission performance constraints.However,the fabrication of high-aspect-ratio metal meshes on glass substrates has problems such as high cost,complex processes,low efficiency,small area,and easy damage issues,which limit their application in the field of high-performance,transparent EM-shielding glass.Therefore,this paper proposes a composite additive manufacturing process based on electric-field-driven microjet 3D printing and electroplating.By fabricating metal meshes with an Ag-Cu core-shell structure on a glass substrate,EM-shielding glass with high shielding efficiency and light transmission can be manufactured without increasing the aspect ratio of the metal meshes.The prepared Ag-Cu composite metal mesh has excellent optoelectronic properties(period 250��m,line width 10��m,90.1%transmission at 550 nm visible light,square resistance 0.21Ω/sq),efficient electrothermal effect(3 V DC voltage can reach 189°C steady-state temperature),stable EM-shielding effectiveness(average shielding effectiveness 23 dB at X-band),and acceptable mechanical and environmental stability(less than 3%change in square resistance after 150-times adhesion test and less than 6%and 0.6%change in resistance after 72 h in acid and alkali environments,respectively).This method provides a new solution for the mass production of high-performance large-area transparent electric heating/EM-shielding glass. | Yuping Tai Junyi Zhou Xiaoyang Zhu Houchao Zhang Hongke Li Zhenghao Li Rui Wang Fan Zhang Guangming Zhang Chaohong Liu Hongbo Lan | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，3： | 0 |
| 12 | A Fractional Order Fast Repetitive Control Paradigm of Vienna Rectifier for Power Quality Improvement显示文摘Due to attractive features,including high efficiency,low device stress,and ability to boost voltage,a Vienna rectifier is commonly employed as a battery charger in an electric vehicle(EV).However,the 6k±1 harmonics in the acside current of the Vienna rectifier deteriorate theTHDof the ac current,thus lowering the power factor.Therefore,the current closed-loop for suppressing 6k±1 harmonics is essential tomeet the desired total harmonic distortion(THD).Fast repetitive control(FRC)is generally adopted;however,the deviation of power grid frequency causes delay link in the six frequency fast repetitive control to become non-integer and the tracking performance to deteriorate.This paper presents the detailed parameter design and calculation of fractional order fast repetitive controller(FOFRC)for the non-integer delay link.The finite polynomial approximates the non-integer delay link through the Lagrange interpolation method.By comparing the frequency characteristics of traditional repetitive control,the effectiveness of the FOFRC strategy is verified.Finally,simulation and experiment validate the steadystate performance and harmonics suppression ability of FOFRC. | Sue Wang Xintao Luo Saleem Riaz Haider Zaman Chaohong Zhou Pengfei Hao | 2023 | Computer Modeling in Engineering & Sciences2023，，2： | 0 |
| 13 | Microwear analysis of a bone-handled microblade excavated at Shangzhai site in Beijing: Evidences from ESEM显示文摘The conventional wisdom has been challenged recently that microblades with handles are only tools for hunting and gathering in the Neolithic Age. Some scholars argued that microblades actually played an important part in the early agricultural development in the Neolithic. However, both of these opinions lacked direct evidence. Environmental scanning electron microscopy (ESEM) is used to analyze the residues of the bone-handled microblade excavated at the Shangzhai site in Pinggu, Beijing. The ESEM observation and EDX analysis show that at the edge of this bone-handled microblade are Ca, P, C, O or C, N, O, etc, which provide direct evidence for determining its function, namely that this microblade may have been dealt with animals. In addition, there was a layer of glue at the back of the microblade with barium and zinc salt distributed evenly in it, this new discovery sheds new light on adhesive technology in ancient China. | CUI TianXing YANG Qin YU JinCheng ZHOU ShuangLin ZHAO ChaoHong | 2010 | Science China Earth Sciences2010，53，9： | 0 |
| 14 | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism显示文摘The SARS-CoV-2 infection causes severe immune disruption.However,it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients.In our study,we have characterized the immunephe no type of B cells from 15 recovered COVID-19 patients,and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation,but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation.However,the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation.Interestingly,we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients.Moreover,the BCR signaling and early B-cell response were disrupted upon BCR stimulation.Mechanistically,we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism.In conclusion,we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhandng B-cell metabolism,which may provide a new intervention target to cure COVID-19. | Yukai Jing Li Luo Ying Chen Lisa S.Westerberg Peng Zhou Zhiping Xu Andres A.Herrada Chan-Sik Park Masato Kubo Heng Mei Yu Hu Pamela Pui-Wah Lee Bing Zheng Zhiwei Sui Wei Xiao Quan Gong Zhongxin Lu Chaohong Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 15 | Spatial variability and driving factors of soil multifunctionality in drylands of China显示文摘Drylands are highly vulnerable to climate change and human activities.The drylands of China account for approximately 10.8%of global drylands,and China is the country most severely affected by aridity in Asia.Therefore,studying the spatial variation characteristics in soil multifunctionality(SMF)and investigating the driving factors are critical for elucidating and managing the functions of dryland ecosystems in China.Based on the environmental factors(mean annual precipitation(MAP),mean annual temperature(MAT),solar radiation(Srad),soil acidity(pH),enhanced vegetation index(EVI),and cation exchange capacity(CEC))and aridity from the“dataset of soil properties for land surface modeling over China”,we used non-linear regression,ordinary least square(OLS)regression,structural equation model(SEM),and other analytical methods to investigate the relationships of SMF with environmental factors across different aridity levels in China.SMF in different dryland regions varied significantly and showed a patchy distribution,with SMF index values ranging from–1.21 to 2.42.Regions with SMF index values from–0.20 to 0.51 accounting for 63.0%of dryland area in China.OLS regression results revealed that environmental factors like MAP,MAT,Srad,pH,EVI,and CEC were significantly related to SMF(P<0.05).MAP and MAT were correlated to SMF at the whole aridity level(P<0.05).SEM results showed that the driving factors of SMF differed depending on the aridity level.Soil pH was the strongest driving factor of SMF when the aridity was less than 0.80(P<0.001).Both soil CEC and EVI had a positive effect on SMF when aridity was greater than 0.80(P<0.01),with soil CEC being the strongest driving factor.The importance ranking revealed that the relative importance contribution of soil pH to SMF was greatest when aridity was less than 0.80(66.9%).When aridity was set to greater than 0.80,the relative importance contributions of CEC and EVI to SMF increased(45.1%and 31.9%,respectively).Our findings indicated that SMF had high spatial heterogeneity in drylands of China.The aridity threshold controlled the impact of environmental factors on SMF. | ZHANG Shihang CHEN Yusen LU Yongxing GUO Hao GUO Xing LIU Chaohong ZHOU Xiaobing ZHANG Yuanming | 2022 | Regional Sustainability2022，3，3： | 0 |
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