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| 1 | The expression and clinical significance of CD44v in human gastric cancers显示文摘INTRODUCTIONCD44 was originally implicated as a'homing'receptor directing the migration of recirculatinglymphocytes.CD44 expression has beenconfirmed not only in lymphocytes but also in awide variety of epithelial tissues.It is considered asan important cell adhesion molecule for cell to cellinteractions.Molecular cloning and analysis | Chen GY Wang DR | 2000 | World Journal of Gastroenterology2000，6，1： | 22 |
| 2 | Primary 4-3-oxosteroid 5β-reductase deficiency:Two cases in China显示文摘Aldo-keto reductase 1D1(AKR1D1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-reductase.All of the coding exons and adjacent intronic sequence of the AKR1D1 gene were sequenced using peripheral lymphocyte genomic DNA of two patients and one of the patient's parents.One patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>A.Based on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be confirmed.With ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients. | Jing Zhao Ling-Juan Fang Kenneth DR Setchell Rui Chen Li-Ting Li Jian-She Wang | 2012 | World Journal of Gastroenterology2012，18，47： | 9 |
| 3 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 4 | Prevalence of fatty liver in Japanese children and relationship to obesity显示文摘 | Kunihiko Tominaga MD Dr Ph John H. Kurata PhD Dr. Yang K. Chen MD Edward Fujimoto DHSc MPH Shouhei Miyagawa Ichiro Abe MSA Yoshimasa Kusano BS | | Digestive Diseases and Sciences0，，： | 5 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Loss of heterozygosity and p53 gene mutations in breast cancer 显示文摘 | Chen LC Schott DR | 1994 | Cancer Res1994，54，： | 1 |
| 7 | Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes显示文摘 | Haudenschild DR Nguyen B Chen J | 2008 | Arthritis Rheum2008，58，9： | 1 |
| 8 | Three-Dimensional ultrasound in margin evaluation for breast tumor excision using mammotome显示文摘 | Chen DR Chang RF Chen CJ | 2004 | Ultrasound Med Biol2004，30，2： | 1 |
| 9 | Mucosal immunization withpurified ClpP could elicit protective efficacy against pneumo-coccal pneumonia and sepsis in mice显示文摘 | Cao J Chen TM Li DR | 2008 | Microbes Infect2008，10，1415： | 1 |
| 10 | Colorectal cancerin the young patient显示文摘 | Leff DR Chen A Roberts D | 2007 | Am Surg2007，73，1： | 1 |
| 11 | EORTC QLQ-BM22 quality oflife evaluation and pain outcome in patients with bone metastasesfrom breast cancer treated with zoledronic acid显示文摘 | Yeh DC Chen DR Chao TY | 2014 | In Vivo2014，28，5： | 1 |
| 12 | Current trends in and indications for endoscopy-assisted breast surgery for breast cancer: results from a six-year study conducted by the taiwan endoscopic breast surgery cooperative group显示文摘 | Lai HW Chen ST Chen DR | 2016 | PLoS One2016，11，01： | 1 |
| 13 | Differentiation of serum levels of trace elements in normal and malignant breast patients显示文摘 | Wu HD Chou SY Chen DR | 2006 | Biol Trace Elem Res2006，113，1： | 1 |
| 14 | Consequences of telomerase inhibition and combination treatments for the proliferation of cancer cells显示文摘 | Chen Z Koeneman KS Corey DR | 2003 | Cancer Res2003，63，18： | 1 |
| 15 | Magnetic resonance imaging of cystic meningiomas and its surgical implications显示文摘 | Zee CS Chen T Hinton DR | 1995 | Neurosurgery1995，36，3： | 1 |
| 16 | Biosynthesis of modified peptide antibiotic nosiheptide in Streptomyces actuosus显示文摘 | Houck DR Chen LC Keller PJ | 1988 | Am Chem Soc1988，110，170： | 1 |
| 17 | Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes 显示文摘 | Haudenschild DR Nguyen B Chen J | 2008 | Arthritis Rheum2008，58，9： | 1 |
| 18 | Recurrent Proliferative Glomer- ulonephritis With Monoclonal IgG Deposits After a Renal Trans- plant Which Was Insensitive to Pulse Therapy Remitted by Double Filtration Plasmapheresis显示文摘 | Wu D Chen JS Cheng DR | 2015 | Exp Clin Transplant2015，13，5： | 1 |
| 19 | Measurement of Atlanta aerosol size distributions:observations of ultrafine particle events显示文摘 | Woo KS Chen DR Pui DYH McMurry PH | 2001 | Aerosol Sci Technol2001，34，： | 1 |
| 20 | Myocardial cell death and apoptesisin hibernating myocardium显示文摘 | Chen C Ma L Linfert DR | 1997 | J Am Coil Cardiol1997，30，5： | 1 |
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