|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The expression and clinical significance of CD44v in human gastric cancers显示文摘INTRODUCTIONCD44 was originally implicated as a'homing'receptor directing the migration of recirculatinglymphocytes.CD44 expression has beenconfirmed not only in lymphocytes but also in awide variety of epithelial tissues.It is considered asan important cell adhesion molecule for cell to cellinteractions.Molecular cloning and analysis | Chen GY Wang DR | 2000 | World Journal of Gastroenterology2000，6，1： | 22 |
| 2 | Primary 4-3-oxosteroid 5β-reductase deficiency:Two cases in China显示文摘Aldo-keto reductase 1D1(AKR1D1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-reductase.All of the coding exons and adjacent intronic sequence of the AKR1D1 gene were sequenced using peripheral lymphocyte genomic DNA of two patients and one of the patient's parents.One patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>A.Based on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be confirmed.With ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients. | Jing Zhao Ling-Juan Fang Kenneth DR Setchell Rui Chen Li-Ting Li Jian-She Wang | 2012 | World Journal of Gastroenterology2012，18，47： | 9 |
| 3 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 4 | Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes显示文摘BACKGROUND Disorders of primary bile acid synthesis may be life-threatening if undiagnosed,or not treated with primary bile acid replacement therapy. To date, there are few reports on the management and follow-up of patients with Δ4-3-oxosteroid 5β-reductase(AKR1 D1) deficiency. We hypothesized that a retrospective analysis of the responses to oral bile acid replacement therapy with chenodeoxycholic acid(CDCA) in patients with this bile acid synthesis disorder will increase our understanding of the disease progression and permit evaluation of this treatment regimen as an alternative to the Food and Drug Administration(FDA) approved drug cholic acid, which is currently unavailable in China.AIM To evaluate the therapeutic responses of patients with AKR1 D1 deficiency to oral bile acid therapy, specifically CDCA.METHODS Twelve patients with AKR1 D1 deficiency, confirmed by fast atom bombardment ionization-mass spectrometry analysis of urine and by gene sequencing for mutations in AKR1 D1, were treated with differing doses of CDCA or ursodeoxycholic acid(UDCA). The clinical and biochemical responses to therapy were monitored over a period ranging 0.5-6.4 years. Dose adjustment, to optimize the therapeutic dose, was based on changes in serum biochemistry parameters,notably liver function tests, and suppression of the urinary levels of atypical hepatotoxic 3-oxo-Δ4-bile acids measured by mass spectrometry.RESULTS Physical examination, serum biochemistry parameters, and sonographic findings improved in all 12 patients during bile acid therapy, except one who underwent liver transplantation. Urine bile acid analysis confirmed a significant reduction in atypical hepatotoxic 3-oxo-Δ4 bile acids concomitant with clinical and biochemical improvements in those patients treated with CDCA. UDCA was ineffective in down-regulating endogenous bile acid synthesis as evidenced from the inability to suppress the urinary excretion of atypical 3-oxo-Δ4-bile acids. The dose of CDCA required for optimal clinical and biochemical responses varied from 5.5-10 mg/kg per day among patients based on maximum suppression of the atypical bile acids and improvement in serum biochemistry parameters, and careful titration of the dose was necessary to avoid side effects from CDCA.CONCLUSION The primary bile acid CDCA is effective in treating AKR1 D1 deficiency but the therapeutic dose requires individualized optimization. UDCA is not recommended for long-term management. | Mei-Hong Zhang Kenneth DR Setchell Jing Zhao Jing-Yu Gong Yi Lu Jian-She Wang | 2019 | World Journal of Gastroenterology2019，25，7： | 7 |
| 5 | ON THE CONVERGENCE OF ASYNCHRONOUS NESTEDMATRIX MULTISPLITTING METHODS FOR LINEARSYSTEMS显示文摘1.IntroductionTherehasbeenalotofliterature(see[1]--[61and[12])ontheparalleliterativemethodsforthelarge--scalesystemoflinearequationsinthesenseofmatrixmultisplittingsincethepioneeringworkofO'LearyandWhite(see[l])waspublishedin1985.Oneofthemostrecentre... | Bai, ZZ Wang, DR Evans, DJ | 1999 | Journal of Computational Mathematics1999，17，6： | 3 |
| 6 | Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature显示文摘Steroid 5β-reductase [aldo-keto reductase family 1 member D1(AKR1D1)] is essential for bile acid biosynthesis. Bile acid deficiency caused by genetic defects in AKR1D1 leads to life-threatening neonatal hepatitis and cholestasis. There is still limited experience regarding the treatment of this disease. We describe an infant who presented with hyperbilirubinemia and coagulopathy but normal bile acid and γ-glutamyltransferase. Gene analysis was performed using genomic DNA from peripheral lymphocytes from the patient, his parents, and his elder brother. The patient was compound heterozygous for c.919C>T in exon 8 and exhibited a loss of heterozygosity of the AKR1D1 gene, which led to an amino acid substitution of arginine by cysteine at amino acid position 307(p.R307C). Based on these mutations, the patient was confirmed to have primary 5β-reductase deficiency. Ursodeoxycholic acid(UDCA) treatment did not have any effect on the patient. However, when we changed to chenodeoxycholic acid(CDCA) treatment, his symptoms and laboratory tests gradually improved. It is therefore crucial to supplement with an adequate dose of CDCA early to improve clinical symptoms and to normalize laboratory tests. | Hui-Hui Wang Fei-Qiu Wen Dong-Ling Dai Jian-She Wang Jing Zhao Kenneth DR Setchell Li-Na Shi Shao-Ming Zhou Si-Xi Liu Qing-Hua Yang | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 7 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 8 | Interleukin 18 in the heart 显示文摘 | Wang M Markel TA Meldrum DR | 2008 | Shock2008，30，1： | 1 |
| 9 | Coronary artery calcification and myocardial perfusion in asymptomatic adults显示文摘 | Wang L Jerosch- Herold M Jacobs DR | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 10 | Health care professionals' perceptions of hospital - based cardiac rehabilitation in mainland China: an exploratory study显示文摘 | Wang W Chair SY Thompson DR | 2009 | J Clin Nurs2009，18，24： | 1 |
| 11 | Forecasting cancellation rates for services booking revenue management using data mining显示文摘 | Morales DR Wang JB | 2010 | European Journal of Opera- tional Research2010，，202： | 1 |
| 12 | Benefit of single-leaf resection for horizontal meniscus tear显示文摘 | Haemer JM Wang M J Carter DR | 2007 | Clin Orthop Relat Res2007，457，： | 1 |
| 13 | Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatoeellular ear- einoma patients 显示文摘 | Zhao ZK Yu HF Wang DR | 2012 | World J Gastroenterol2012，18，45： | 1 |
| 14 | Modeling participation in an online travel community显示文摘 | Wang Y Fesenmaier DR | 2004 | Journal of Travel Research2004，42，： | 1 |
| 15 | Health care pro- fessionals'perceptions of hospital - based cardiac rehabilita- tion in mainland China: an exploratory study 显示文摘 | Wang W Chair SY Thompson DR | 2009 | J Clin Nurs2009，18，： | 1 |
| 16 | Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites 显示文摘 | Wang YH Jones DR Hall SD | 2004 | Drug Metab Dispos2004，32，： | 1 |
| 17 | A 2-D liquid sepa- rations/mass mapping method for interlysate comparison of o- varian cancers显示文摘 | Kachman MT Wang H Schwartz DR | 2002 | Anal Chem2002，74，8： | 1 |
| 18 | Calcitonin downregulated E-cadherin expression in rodent uterine epithelium during implantation显示文摘 | Li Q Wang Jun Armant DR | 2002 | Journal of Biological Chemistry2002，277，46： | 1 |
| 19 | The role of xanthine oxi- dase in thiopufine metabolism: a case report显示文摘 | Wang DR Derijks LJ den Dulk MO | 2007 | Ther Drug Monit2007，29，6： | 1 |
| 20 | Nomograms to predict risk of inhospital and post-discharge venous thromboembolism after abdominal and tho- racic surgery:An American College of Surgeons National Surgical Quali- ty Improvement Program analysis显示文摘 | Shah DR Wang H Bold R J | 2013 | JSurg Res2013，183，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员