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| 1 | Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO显示文摘The treatment of triple-negative breast cancer(TNBC)relies largely on chemotherapies.However,it is frequent that TNBC patients develop resistance to the chemotherapy drugs.Generation of drug-resistant cell lines facilitates the identification of drug resistance.Here,we established two paclitaxel(PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript(LINC-PINT)was significantly decreased in PTX-resistant cancer cells.Ectopic expression of LINC-PINT sensitized both PTX-resistant TNBC and wild-type TNBC to PTX.Moreover,RNA immunoprecipitation showed that LINC-PINT bound to RNA-binding protein NONO.Overexpression of LINC-PINT resulted in the degradation of NONO in a proteasome-dependent manner and vice versa.Knockdown of NONO with siRNA sensitized TNBC to PTX.We further analyzed the expression level of LINC-PINT and NONO in patient samples via online database and found that LINC-PINT and NONO may function antagonistically in all types of breast cancers.Taken together,our data illustrated a tumor suppressor role of LINC-PINT in sensitizing TNBC to chemotherapies via destabilizing NONO. | Jinghua Chen Meiqin Zhu Liqiu Zou Junxian Xia Jiacheng Huang Quantong Deng Ruilian Xu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 4 |
| 2 | New automatic tool for finding impossible differentials and zero-correlation linear approximations显示文摘Dear editor,Impossible differential cryptanalysis and zero-correlation linear cryptanalysis are two powerful methods in the block cipher field.Herein,we present an automatic tool to find impossible differentials(IDs)and zero-correlation linear approximations(ZCLAs)for both ARX and S-box-based ciphers.Similar to the idea of using mixed-integer linear programming(MILP)models for differential cryptanalysis in[1],we first use linear inequalities to describe all the target cipher's components exactly. | Tingting CUI Shiyao CHEN Kai FU Meiqin WANG Keting JIA | 2021 | Science China(Information Sciences)2021，64，2： | 3 |
| 3 | Strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome显示文摘Background:There is growing evidence indicating that the microbial communities that dwell on the human ocular surface are crucially important for ocular surface health and disease.Little is known about interspecies interactions,functional profiles,and strain heterogeneity across individuals in healthy ocular surface microbiomes.Methods:To comprehensively characterize the strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome,we performed shotgun metagenomics sequencing on ocular surface mucosal membrane swabs of 17 healthy volunteers.Results:The healthy ocular surface microbiome was classified into 12 phyla,70 genera,and 140 species.The number of species in each healthy ocular surface microbiome ranged from 6 to 47,indicating differences in microbial diversity among individuals.The species with high relative abundances and high positivity rates were Streptococcus pyogenes,Staphylococcus epidermidis,Propionibacterium acnes,Corynebacterium accolens,and Enhydrobacter aerosaccus.A correlation network analysis revealed a competitive interaction of Staphylococcus epidermidis with Streptococcus pyogenes in ocular surface microbial ecosystems.Staphylococcus epidermidis and Streptococcus pyogenes revealed phylogenetic diversity among different individuals.At the functional level,the pathways related to transcription were the most abundant.We also found that there were abundant lipid and amino acid metabolism pathways in the healthy ocular surface microbiome.Conclusion:This study explored the strain heterogeneity,cooccurrence network,taxonomic composition,and functional profile of the healthy ocular surface microbiome.These findings have important significance for the future development of probiotic-based eye therapeutic drugs. | Yutong Kang Shudan Lin Xueli Ma Yanlin Che Yiju Chen Tian Wan Die Zhang Jiao Shao Jie Xu Yi Xu Yongliang Lou Meiqin Zheng | 2021 | Eye and Vision2021，8，1： | 3 |
| 4 | Clinical Analysis of 240 Patients with HLA-B27 Associated Acute Anterior Uveitis显示文摘Purpose: To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features. Methods: A total of 240 patients with HLA-B27 associated acute anterior uveitis,who were admitted to Zhejiang Ophthalmologic Hospital between December 2006 and October 2012, were retrospectively analyzed.The age of onset,sex,affected eyes,HLA-B27 antigen detection,recurrence,joint involvement, and surgical complications were investigated. Results:The average age of onset was 37.0 ±12.0 years and the ratio of male to female patients was 2.4:1. Most cases had alternate unilateral or bilateral involvement. Among all participants, 234 cases (97.5%) were HLA-B27 positive, and 124 cases (51.7%) had spondyloarthropathies (SpA), dominated by 108 cases with ankylosing spondylitis. (AS,45.0%),and mostly seen in male subjects(P<0.05).Six patients were HLA-B27 negative(2.5%)and on statistical significance was noted between male and female patients (P >0.05).A total of 193 cases (80.4%) presented with complications, mainly fibrinous exudation, posterior synechia, and vitreous opacity. Conclusion: HLA-B27 that is associated acute anterior uveitis with a relatively high incidence and recurrence presents with more severe clinical features than does idiopathic acute anterior uveitis,and it often accompanies systemic arthritic diseases. HLA-B27 antibody detection is associated with the diagnosis and treatment of acute anterior uveitis. | Yuqin Wang Xiaoya Lu Yulin Wang Liping Mao Yunfeng Gu Pengfei Chen Meiqin Zheng | 2012 | Eye Science2012，27，4： | 3 |
| 5 | Automatic search method for multiple differentials and its application on MANTIS显示文摘Multiple differential cryptanalysis is one of the extensions of classic differential cryptanalysis. In this paper, we present a generic automatic search method for clustering multiple differentials on a target block cipher. Our search method has two steps. Firstly, the sets of input and output differences will be determined.With these sets, we get different multiple differentials. Then for each one of these multiple differentials, we enumerate and record all satisfied differential trails, which leads to a more accurate evaluation of the multiple differentials distinguisher. Among these different multiple differentials distinguishers, we can choose the best one for key recovery attack. We demonstrate our search method by applying it on the part of differentials of the block cipher MANTIS. As a result, we find a new 10-round multiple differentials distinguisher with probability 2^(-55.98) and an 11-round multiple differentials distinguisher with probability 2^(-63.71), which is the longest distinguisher for MANTIS so far as we know. This new 10-round distinguisher can lead to a better signal-to-noise ratio, so we derive an improved key recovery attack on MANTIS-6 with the complexity of about 2^(51.79) chosen-plaintext queries, 2^(51.91) encryptions and data-time product 2^(103.70), which is better than the previous best one with data-time product 2^(110.61). Aiming at exploring the gap between the performance of multiple differential attack and the security margin on MANTIS, we also use the 11-round distinguisher to derive a key recovery attack on MANTIS-7 with the complexity of about 2^(61.86) chosen-plaintext queries,2^(102.92) encryptions and data-time product 2^(164.78). It does not threat the security of full version MANTIS(MANTIS-7) since the security bound of data-time product claimed by the designers is 2^(126). | Shiyao CHEN Ru LIU Tingting CUI Meiqin WANG | 2019 | Science China(Information Sciences)2019，62，3： | 2 |
| 6 | Robust adaptive H_(∞) control for networked uncertain semi-Markov jump nonlinear systems with input quantization显示文摘Dear editor,Markov jump systems(MJSs),as one kind of switched systems,are a good candidate for modeling physical systems subject to abrupt variation in their structures or parameters caused by many reasons such as subsystem interconnection change and environmental disturbance[1,2]. | Shanling DONG Guanrong CHEN Meiqin LIU Zheng-Guang WU | 2022 | Science China(Information Sciences)2022，65，8： | 2 |
| 7 | Electrodeposition in organic system and properties of NiO electrochromic films显示文摘By electrodeposition in organic system,NiO films with reversible electrochromic property were fabricated.Fluorine-doped tin oxide glass slices were used as substrates,i.e.cathodes.Cyclic voltammetry and ultraviolet-visible transmission spectroscopy were adopted to study the electrochromic properties of the films.High resolution transmission electron microscopy(HRTEM) was employed to analyze the composition and structure of the films.It is found that the films are composed of fine NiO crystal grains of a few nanometers in diameter,endowing them with large visible light transmittance variation,rapid switch rate(i.e.rapid response time) between the bleached and colored states.Their cycling durability reached 6000 cycles. | SU Ge SONG MeiQin SUN WuZhu CAO LiXin LIU Wei MA DeWen CHEN Na ZHAO LiLi WANG Jing LIU XiaoYun | 2012 | Science China(Technological Sciences)2012，55，6： | 1 |
| 8 | Cooperative neural-adaptive fault-tolerant output regulation for heterogeneous nonlinear uncertain multiagent systems with disturbance显示文摘This paper investigates the cooperative output regulation problem for heterogeneous nonlinear uncertain multiagent networked systems subject to actuator failure,bounded matched or mismatched disturbances or disturbances produced by a given linear exosystem.Accurate information about nonlinearity,actuator failure and disturbance may be completely unknown.First,a distributed finite-time observer is designed to estimate the dynamics of the exosystem on a finite-time interval over a communication digraph.Then,a neural-adaptive control protocol is proposed.It is shown that(i)closed-loop multiagent systems are asymptotically stable,with output synchronization errors that tend to zero in the absence of mismatched disturbance,and(ii)the states of the closed-loop multiagent systems and the output synchronization errors are bounded in the presence of mismatched disturbance.Finally,a simulation example is given to demonstrate the effectiveness of the proposed control strategy. | Shanling DONG Guanrong CHEN Meiqin LIU Zheng-Guang WU | 2021 | Science China(Information Sciences)2021，64，7： | 1 |
| 9 | Multidimensional zero-correlation attacks on lightweight block cipher HIGHT: Improved cryptanalysis of an ISO standard显示文摘 | Long Wen Meiqin Wang Andrey Bogdanov Huaifeng Chen | 2014 | Information Processing Letters2014，，6： | 1 |
| 10 | Highly active pd/WO2-CNTs catalysts for formic acid electro-oxidation and study of the kinetics显示文摘 | Chun'an Ma* Yanxian Jin Meiqin Shi Youqun Chu Yinghua Xu Wenping Jia Qiaohua Yuan Jiabin Chen Huiling Pan Qiuwei Dai | 2014 | Ionics2014，20，： | 1 |
| 11 | Isolation and Identification of an Exopolysaccharide‐Producing Lactic Acid Bacterium Strain from Chinese Paocai and Biosorption of Pb(II) by Its Exopolysaccharide显示文摘 | Meiqin Feng Xiaohong Chen Chengcheng Li Rahman Nurgul Mingsheng Dong | 2012 | Journal of Food Science2012，，6： | 1 |
| 12 | Isolation and identification of an exopolysaccharide-producing lactic acid bacterium strain from Chinese paocai and biosorption of Pb(II) by its exopolysaccharide显示文摘 | Feng Meiqin Chen Xiaohong Li Chengcheng | 2012 | Journal of Food Science2012，77，6： | 1 |
| 13 | H∞ output tracking control of discrete-time nonlinear systems via stand- ard neural network models显示文摘 | LIU Meiqin CHEN Haiyang SHENG Weihua | 2014 | IEEE transactions on neural networks and learning systems2014，25，10： | 1 |
| 14 | BIBO stability of the discrete bilinear system显示文摘 | Bose Tamal Chen Meiqin | 1995 | Digital Signal Processing1995，5，： | 1 |
| 15 | DETERMINING THE STRUCTURES AND PARAMETERS OF RADIAL BASIS FUNCTION NEURAL NETWORKS USING IMPROVED GENETIC ALGORITHMS显示文摘Powelproposedradialbasisfunction(RBF)methodforstrictmultivariablefunctioninterpola-tion[1].BroomheadandLowefirstlyappliedRBFw... | Meiqin Liu Jida Chen | 1998 | Journal of Central South University1998，10，2： | 1 |
| 16 | Catalyticperformance of bi- functional WC/HZSM- 5 catalysts forhexane aromatization显示文摘 | Shi Meiqin Chen Ningning Ma Chun'an | 2012 | Chin J of catal2012，33，3： | 1 |
| 17 | Testosterone improves spatial cognitive dysfunction via androgen non-genomic effeet in Tfm mice显示文摘The non-genomic actions of androgen on cognitive function have been extensively studied.However,the underlying mechanisms remain controversial.In this study,we used testicular feminized(Tfm)mouse as a cell research model,which had androgen receptor deficiency and low circulating testosterone level,to investigate whether testosterone improves spatial cognitive dysfunction via its androgen non-genomic actions.We found that testosterone supplementation can improve the spatial cognitive function,hippocampal neuron danage and dendritic spine density in Tfm mice,but no statistical difference was found in fear memory function. | Chen Meiqin Li Sha Zhang Yizhou Mi Shixiong Du Juan Wang Chang Ma Min Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | Systematic study of the transfer of amino acids across the water/1,2-dichloroethane interface facilitated by dibenzo-18-crown-6显示文摘Facilitated ion transfer reactions of 20 amino acids with dibenzo-18-crown-6 (DB18C6) at the water/1,2-dichloroethane (W/DCE) interfaces supported at the tips of micro- and nano-pipets were investigated systematically using cyclic voltammetry. It was found that there were only 10 amino acids, that is, Leu, Val, Ile, Phe, Trp, Met, Ala, Gly, Cys, Gln (in brief), whose protonated forms as cations can give well-defined facilitated ion transfer voltammograms within the potential window, and the reaction pathway was proven to be consistent with the transfer by interfacial complexation/dissociation (TIC/TID) mechanisms. The association constants of DB 18C6 with different amino acids in the DCE (β0), and the kinetic parameters of reaction were evaluated based on the steady-state voltammetry of micro- or nano-pipets, respectively. The experimental results demonstrated that the selectivity of complexation of protonated amino acid by DB18C6 compared with that of alkali metal cations was low, which can be attributed to the vicinal effect arising from steric hindrance introduced by their side group and the steric bulk effect by lipophilic stabilization. Moreover, the association constants and the standard rate constants for different amino acids showed good correlations with their hydrophobicity (π), except Gly and Met, which inferred that the selectivity of such heterogeneous complex reaction for different amino acids with DB18C6, was not only affected by discrimination in binding these ions to the crown ether macro-cycle, but also significantly modified by the ion transfer Gibbs energy which was closely related to the structure of the transferred ions, protonated amino acids. | CHEN Yong, YUAN Yi, ZHANG Meiqin, LI Fei, SUN Peng, GAO Zhao & SHAO YuanhuaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China | 2004 | Science China Chemistry2004，47，1： | 0 |
| 19 | Real-world outcomes of niraparib treatment in patients with ovarian cancer:amulticenter non-interventional study in China显示文摘Dear Editor,Ovarian cancer remains the deadliest among all gynecological cancers.Although most patients at advanced stage respond to initial treatment,the majority experience recurrence[1].It was estimated that 55,342 new cases and 37,519 deaths from ovarian cancer occurred in China annually[2].Contemporarily,the treatment landscape has changed rapidly since the role of poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)in ovarian cancer treatmentwas explored.Based on data from the PRIMA/ENGOT-OV26/GOG-3012[3]and ENGOTOV16/NOVA trials[4],niraparib has been approved globally as maintenance therapy for newly diagnosed and platinum-sensitive recurrent ovarian cancer.The indication of niraparib for salvage treatment was based on the results of the QUADRA(NCT02354586)trial[5].Although niraparib has been tested in prospective randomized clinical trials(RCTs),no multicenter study on its real-world application in China had been conducted.Considering the differences in population,accessibility and affordability of drugs,the results of the real-world settings may differ from those of RCTs.Therefore,we conducted this multicenter,non-interventional study at 8 hospitals. | Jin Li Jianhua Yang Huafeng Shou Lin Zhang Xiaohong Huang Xuedong Tang Fei Zheng Fang Liu Hao Wen Huijuan Yang Huaying Wang Ziting Li Xiaojun Chen Xingzhu Ju Xi Cheng Jie Tang Meiqin Zhang Xiaohua Wu | 2023 | Cancer Communications2023，43，6： | 0 |
| 20 | Non-escaping frost tolerant QTL linked genetic loci at reproductive stage in six wheat DH populations显示文摘Reproductive stage frost poses a major constraint for wheat production in countries such as Australia.However,little progress has been made in identifying key genes to overcome the constraint.In the present study,a severe frost event hit two large-scale field trials consisting of six doubled haploid(DH)wheat populations at reproductive stage(young microspore stage)in Western Australia,leading to the identification of 30 robust frost QTL on 17 chromosomes.The major 18 QTL with the phenotype variation over 9.5%were located on 13 chromosomes including 2 A,2 B,2 D,3 A,4 A,4 B,4 D,5 A,5 D,6 D,7 A,7 B and7 D.Most frost QTL were closely linked to the QTL of anthesis,maturity,Zadok stages as well as linked to anthesis related genes.Out of those,six QTL were repetitively detected on the homologous regions on 2 B,4 B,4 D,5 A,5 D,7 A in more than two populations.Results showed that the frost damage is associated with alleles of Vrn-A1 a,Vrn-D1 a,Rht-B1 b,Rht-D1 b,and the high copy number of Ppd-B1.However,anthesis QTL and anthesis related genes of Vrn-B1 a and Ta FT3-1 B on chromosomes 5 B and 1 B did not lead to frost damage,indicating that these early-flowering phenotype related genes are compatible with frost tolerance and thus can be utilised in breeding.Our results also indicate that wild-type alleles Rht-B1 a and Rht-D1 a can be used when breeding for frost-tolerant varieties without delaying flowering time. | Jingjuan Zhang MD Shahidul Islam Yun Zhao Masood Anwar Zaid Alhabbar Maoyun She Rongchang Yang Angela Juhasz Guixiang Tang Jiansheng Chen Hang Liu Yanjie Jiang Shengnan Zhai Xin Hu Junkang Rong Yingquan Zhang Yebo Qin Qier Liu Zitong Yu Yujuan Zhang Sadegh Balotf Mirza Dowla Sonia Afrin Nandita Roy Md Resad Mallik Md Atik Us Saieed Shanjida Rahman Nigarin Sultana Sarah Al-Sheikh Ahmed Chris Florides Kefei Chen Darshan Sharma Nathan Height Ben Biddulph Meiqin Lu Jorge EMayer Wujun Ma | 2022 | The Crop Journal2022，10，1： | 0 |
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