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| 1 | Development of Overpressure in the Tertiary Damintun Depression, Liaohe Basin, Northern China显示文摘The Damintun depression is one of the four depressions in the Liaohe basin in northern China, and is a rift basin developed in the Paleogene. This paper discusses in detail the characteristics of pressure and fluid potential of the Damintun depression based on a synthesis of the data from boreholes, well tests and seismic surveys. Data from sonic logs, well tests and seismic velocity measurements are used to study the pressure characteristics of the areas. From the sonic log data, shales can be characterized as normally pressured, slightly overpressured or highly overpressured; from the well test data, the pressure-depth gradient in oil-producing intervals implies hydrostatic pressure in general. Most seismic profiles in the Damintun depression are of sufficiently high quality for seismic velocities to be measured. The fluid pressures, excess pressures and pressure coefficients in 47 representative seismic profiles are predicted using formula calculation methods, and further transformed to fluid potentials. The resultant pressure profiles show normal pressure, moderate overpressure and intense overpressure increasing with depth. The pressure evolution can be divided into three stages as initial generation, partial dissipation and re-accumulation. Fluid potential is the principal factor controlling hydrocarbon migration in a reservoir. Its distribution varies with depth; above the T4 interface a gravity-flow dominates, whereas beneath it a compaction flow dominates. The development of overpressure in the Damintun depression has a crucial influence on the distribution of fluid potentials, which agrees with that of overpressure in general. The results of the fluid potential analysis indicate that the areas of Dongshenpu-Xinglongpu and the southwestern part of the depression are most favorable for hydrocarbon migration and accumulation. | YE Jiaren, HAO Fang and CHEN JianyuFaculty of Earth Resources, China University of Geosciences, Wuhan, Hubei 430074 E-mail: jrye@cug.edu.cn Ren Xifei and Zhu Xiling | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 7 |
| 2 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 3 | Fast hydrogenation kinetics of acridine as a candidate of liquid organic hydrogen carrier family with high capacity显示文摘Hydrogen has been deemed as one of the most efficient energy carriers for a broad variety of industrial applications[1,2].Large-scale,low-cost hydrogen production,safe storage and delivery represent a tremendous technological challenge and have become a subject of intense research and development activities in the past few decades[3–5]. | Ming Yang Xile Xing Ting Zhu Xuedi Chen Yuan Dong Hansong Cheng | 2020 | Journal of Energy Chemistry2020，29，2： | 4 |
| 4 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 5 | A new transparent conductive thin film In203 :Mo显示文摘 | MENG Yang YANG Xiling CHEN Huaxian | 2001 | Thin Solid Film2001，394，12： | 1 |
| 6 | Preparation of lowersulfur content and expandable graphite 显示文摘 | Chen Xiling Song Kemin Li Jihui | 1996 | Carbon1996，34，12： | 1 |
| 7 | Preparation of lower - sulfur content and expandable graphite 显示文摘 | Xiling Chen Kemin Song Jihui Li | 1996 | Carbon1996，，12： | 1 |
| 8 | A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells显示文摘 | Pengcheng Bu Kai-Yuan Chen Joyce Huan Chen Lihua Wang Jewell Walters Yong Jun Shin Julian P. Goerger Jian Sun Mavee Witherspoon Nikolai Rakhilin Jiahe Li Herman Yang Jeff Milsom Sang Lee Warren Zipfel Moonsoo M. Jin Zeynep H. Gümü? Steven M. Lipkin Xiling | 2013 | Cell Stem Cell2013，，： | 1 |
| 9 | The nature of the potentiostatic current oscillations at iron/sulfuric acid solution interfaces 显示文摘 | Chao Wang Shenhao Chen Xiling Yu | 1994 | Electrochimica Acta1994，39，4： | 1 |
| 10 | Preparation of lower sulfuric expandable graphite显示文摘 | Chen Xiling | 1996 | Carbon1996，34，12： | 1 |
| 11 | Chromosome-level genome assemblies of five Prunus species and genome-wide association studies for key agronomic traits in peach显示文摘Prunus species include many important perennial fruit crops,such as peach,plum,apricot,and related wild species.Here,we report de novo genome assemblies for five species,including the cultivated species peach(Prunus persica),plum(Prunus salicina),and apricot(Prunus armeniaca),and the wild peach species Tibetan peach(Prunus mira)and Chinese wild peach(Prunus davidiana).The genomes ranged from 240 to 276 Mb in size,with contig N50 values of 2.27−8.30Mb and 25,333−27,826 protein-coding gene models.As the phylogenetic tree shows,plum diverged from its common ancestor with peach,wild peach species,and apricot~7 million years ago(MYA).We analyzed whole-genome resequencing data of 417 peach accessions,called 3,749,618 high-quality SNPs,577,154 small indels,31,800 deletions,duplications,and inversions,and 32,338 insertions,and performed a structural variant-based genome-wide association study(GWAS)of key agricultural traits.From our GWAS data,we identified a locus associated with a fruit shape corresponding to the OVATE transcription factor,where a large inversion event correlates with higher OVATE expression in flat-shaped accessions.Furthermore,a GWAS revealed a NAC transcription factor associated with fruit developmental timing that is linked to a tandem repeat variant and elevated NAC expression in early-ripening accessions.We also identified a locus encoding microRNA172d,where insertion of a transposable element into its promoter was found in double-flower accessions.Thus,our efforts have suggested roles for OVATE,a NAC transcription factor,and microRNA172d in fruit shape,fruit development period,and floral morphology,respectively,that can be connected to traits in other crops,thereby demonstrating the importance of parallel evolution in the diversification of several commercially important domesticated species.In general,these genomic resources will facilitate functional genomics,evolutionary research,and agronomic improvement of these five and other Prunus species.We believe that structural variant-based GWASs can also be used in other plants,animal species,and humans and be combined with deep sequencing GWASs to precisely identify candidate genes and genetic architecture components. | Qiuping Tan Sen Li Yuzheng Zhang Min Chen Binbin Wen Shan Jiang Xiude Chen Xiling Fu Dongmei Li Hongyu Wu Yong Wang Wei Xiao Ling Li | 2021 | Horticulture Research2021，8，1： | 1 |
| 12 | Agrobacterium–mediated Transformation of Kalanchoe laxiflora显示文摘Plants with crassulacean acid metabolism(CAM) generally utilize water 20%–80% more efficiently than non-CAM plants. The whole genomes of several CAM plants have been sequenced or are being sequenced. For effective genome characterization and genome editing of CAM plants,an efficient transformation system is essential. In this study, we developed an Agrobacterium-mediated transformation protocol for Kalanchoe laxiflora, an obligate CAM plant,by optimizing several factors affecting the transformation efficiency. Agrobacterium strains AGL1, C58, EHA105,and GV3101 were all suitable for K. laxiflora transformation. Fifty-nine percent of the leaf explants yielded kanamycin-resistant and GUS-positive shoots. Polymerase chain reaction and quantitative real-time PCR(qRT-PCR) using gus A-, gus Plus-, npt II-and hpt-specific primers confirmed that the transgenes were integrated into K. laxiflora genome and expressed. This efficient transformation system will allow effective functional characterization of genes through over-or down-expression, knockout, or genome editing. | Xiling Wang Xinlu Chen Qunkang Cheng Kaikai Zhu Xiaohan Yang Zongming Cheng | 2019 | Horticultural Plant Journal2019，5，5： | 1 |
| 13 | Some consideration on the rece nt tectonic stress field of China显示文摘 | Cao Xiling Chen Jiagang | 1985 | Tectonophysics1985，117，： | 1 |
| 14 | The short isoform of the long‐type PML ‐ RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all‐trans‐retinoic acid显示文摘 | Yanhong Tan Sicheng Bian Zhifang Xu Xiuhua Chen Xiling Qi Fanggang Ren Li Li Haixiu Guo Aining Xu Linlin Zhang Hongwei Wang | 2013 | Br J Haematol2013，，1： | 1 |
| 15 | Preparation of Lower-Sulfur Content and Expandable Graphite显示文摘 | Chen XiLing | 1996 | Carbon1996，34，12： | 1 |
| 16 | Preparation of lower - sulfur content and expandable graphite显示文摘 | CHEN XILING | 1996 | Carbon1996，34，12： | 1 |
| 17 | Study of radioactive status in the Zhujiang Estuary and adjacent sea area in South China Sea (SCS)显示文摘Through the investigation on radioactive activities of water, sediment and some marine organismsin the Zhujiang Estuary, adjacent sea area and the distributary mouths of the Zhujiang River, activities of total α. radioactivity, total β radioactivity, artificial radioactive 90Srand 157Cs, and factors inflencing the distribution and the content of U in seawater are studied.The mainly radioactive pollution substances and their sources in the sea area are studied by γ spectra obtained from sediment in the sea area. The results show that the main radioactivity substances are natural radioactivity U,Th series and 40K. which were produced by the modern industry and transported into the sea through the main current of the Zhujiang River. | Liu Huai, Su Xiling, Chen Chi, Gou Min Liang Qianlin Environment Monitoring Center of South China Sea, SOA, Guangzhou, China | 1989 | Acta Oceanologica Sinica1989，8，2： | 1 |
| 18 | A “Seawater-in-Sludge” approach for capacitive biochar production via the alkaline and alkaline earth metals activation显示文摘Sewage sludge is a potential precursor for biochar production,but its effective utilization involves costly activation steps.To modify biochar properties while ensuring cost-effectiveness,we examined the feasibility of using seawater as an agent to activate biochar produced from sewage sludge.In our proof-of-concept study,seawater was proven to be an effective activation agent for biochar production,achieving a surface area of 480.3 m^(2)/g with hierarchical porosity distribution.Benefited from our design,the catalytic effect of seawater increased not only the surface area but also the graphitization degree of biochar when comparing the pyrolysis of sewage sludge without seawater.This leads to seawater activated biochar electrodes with lower resistance,higher capacitance of 113.9 F/g comparing with control groups without seawater.Leveraging the global increase in the salinity of groundwater,especially in coastal areas,these findings provide an opportunity for recovering a valuable carbon resource from sludge. | Xiling Li Tianwei Hao Yuxin Tang Guanghao Chen | 2021 | Frontiers of Environmental Science & Engineering2021，15，1： | 0 |
| 19 | Improvement of plant cryosection显示文摘因为比动物房间在植物房间包含的大量水,在植物的 Cryosection 通常是挑战性的。在植物房间以内的冰晶体的形成容易破坏 subcellular 详细在期间结冰处理。并且房间墙使结冰植物纸巾几乎没切并且以微妙的方法保存房间结构。在这研究,这种技术在注入上被改进,嵌入并且有冬季小麦变化 Aikang58 的 flatting 节是原料。 | Zhaopei ZHANG Liyuan N1U Xiling CHEN Xu XU Zhengang RU | 2012 | Frontiers in Biology2012，7，4： | 0 |
| 20 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
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