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| 1 | Activated graphene with tailored pore structure parameters for long cycle-life lithium-sulfur batteries显示文摘 | Mingbo Zheng Songtao Zhang Shuangqiang Chen Zixia Lin Huan Pang Yan Yu | 2017 | Nano Research2017，10，12： | 4 |
| 2 | Design and analysis of multi-level physical-layer network coding for gaussian two-way relay channels显示文摘 | Chen Zhiyong Xia Bin Hu Zixia | 2014 | IEEE Transactions on Communications2014，62，6： | 1 |
| 3 | Design and analysis of multi-level physical-layer network coding for gaussian two-way relay channels显示文摘 | CHEN Zhiyong XIA Bin HU Zixia | 2014 | IEEE Transactions on Communications2014，62，6： | 1 |
| 4 | Research on distribution centers location problem显示文摘 | Chen Zixia Wang Yeqing | 2008 | MultiMedia and Infor- mation Technology2008，，3： | 1 |
| 5 | PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-κB pathway activity and DNA damage response induced by Idarubicin显示文摘Idarubicin(IDA),an anthracycline antineoplastic drug,is commonly used in the treatment of acute myeloid leukemia(AML)with reasonable response rates and clinical benefits.However,some patients still relapse,or do not respond,and suffer high fatality rates.Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients.The aim of the present study was to determine the underlying molecular mechanisms by which the PARP-1 inhibitor Olaparib enhances the chemosensitivity of the leukemia cell line K562 and THP1 to IDA.Our data demonstrated that PARP-1 is upregulated in AML patients as well as in K562 and THP1 cells,and that the suppression of PARP-1 activity by Olaparib enhances the inhibitory effect of IDA.A mechanistic study revealed that Olaparib decreases the expressions of p-ATM,p-IκBα,XIAP and p65,and upregulates Bax,cleaved-Caspase-3 andγ-H2AX.Olaparib can enhance the induction of DNA damage by IDA,probably mediated by the inhibition of the ATM-related DNA damage response.Moreover,we also found that the nuclear translocation of p65 and the nuclear export of NEMO are inhibited when IDA and Olaparib are combined.Our results suggest that Olaparib attenuates the activity of the NF-κB pathway and decreases the DNA damage response induced by IDA.Therefore,we conclude that Olaparib is a potentially valuable chemosensitizer for leukemia patients. | Bo Ke Anna Li Huan Fu Chunfang Kong Tingting Liu Qingqing Zhu Yue Zhang Zixia Zhang Chen Chen Chenghao Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 6 | Yishen Huoxue decoction(益肾活血方) attenuates unilateral ureteric obstruction-induced renal fibrosis and hypoxia-induced reactive oxygen species generation via adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor coa显示文摘OBJECTIVE:To investigate the effeicacy of Yishen Huoxue decoction(YSHX)on renal fibrosis induced by unilateral ureteric obstruction(UUO),and on reactive oxygen species(ROS)homeostasis in human umbilical vein endothelial cells(HUVECs).METHODS:Forty male mice were randomly divided into six groups,sham group,UUO group,UUO+resveratrol(RSV)(15 mg/kg)group,UUO+YSHX20 mg/kg group(UUO+YSHX-L),UUO+YSHX 40 mg/kg group(UUO+YSHX-M),UUO+YSHX 80 mg/kg group(UUO+YSHX-H).Western blotting was used to measure protein expression levels.Reverse transcription-quantitative polymerase chain reaction was used to measure the m RNA expression.Immunohistochemistry was used to examine the histopathological changes of kidney tissue sample.Cell apoptosis was measured by Annexin V/PI staining.Cell viability was measured using CCK-8/WST-8 assay.RESULTS:YSHX treatment reducedα-SMA and Col-4 expressions,and increased CD31 and VE-cadherin expressions in UUO model mice.In vitro,YSHX increased cell viability and decreased apoptosis of HUVECs under hypoxic conditions.YSHX inhibited ROS generation by activating adenosine monophosphate-activated protein kinase(AMPK)/peroxisome proliferator-activated receptor coactivator-1α(PGC-1α)/silent mating-type information regulation2 homolog 3(Sirt3)signaling.CONCLUSION:YSHX treatment reduced 109 KJ UUO-induced renal injury and fibrosis.Furthermore,YSHX treatment attenuated hypoxia-induced oxidative stress by regulating AMPK/PGC-1α/Sirt3 signaling. | ZHONG Jian FANG Guiyu WANG Zixia CHEN Ping LU Dengyong SHI Xiaodong | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 0 |
| 7 | An Improved Ant Algorithm for VRP with the Shortest Delivery Time in Distribution Center显示文摘 | Zixia Chen | 2007 | Journal of Systems Science and Information2007，5，3： | 0 |
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