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| 1 | Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China显示文摘Monoclonal gammopathies are characterized by the presence of monoclonal immunoglobulin in patients with or without evidence of multiple myeloma (MM),macroglobulinemia,amyloidosis (AL),or a related plasma cell proliferative disorder. This study aims to evaluate laboratory diagnostic characters of monoclonal gammopathies and investigates the correlation between monoclonal gammopathies and transforming growth factor β1 (TGFβ1). Immunofixation electrophoresis (IFE),serum protein electrophoresis (SPE),nephelometry and urine light chain ELISA were used for laboratory identification of monoclonal immunoglobulins. Plasma TGFβ1 was detected with double-antibodies ELISA. Lightcycler was used for single nucleotide polymorphism (SNP) analysis. Totally 2,007 cases of monoclonal immunoglobulin (M protein) were identified in 10,682 samples. The isotypes of M protein were IgG type 47.1%,IgA 23.0%,IgM 8.7%,IgD 5.3%,free light chain κ 6.1%,λ 9.8%. In reference to IFE,the coherency of diagnosis was serum light chain ratio (κ/λ) 94.4%,quantitation of Igs 83%,light chain quantitation 80.9%,and urine light chain ratio (κ/λ) 58.0%. Plasma TGFβ1 was elevated significantly compared to normal control. The allelic frequency of codon 10 (C > T) was neither associated with the existence of the M protein nor with the M protein isotype. Monoclonal gammopathies can be identified with the combination of IFE,SPE,Igs quantitaion and urine light chain determination. Although TGFβ1,an important cytokine in immune regulation,was elevated in monoclonal gammopathies,the SNPs in coding region of TGFβ1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study. | Hao Wang Chunfang Gao Lingling Xu Zaixing Yang Wenjing Zhao Xiantao Kong | 2008 | Cellular & Molecular Immunology2008，5，4： | 8 |
| 2 | Preparation and Characterization of Natural Rubber/Silica Nanocomposites using Rule of Similarity in Latex显示文摘Rule of similarity and latex compounding techniques were combined for the first time to prepare natural rubber/nanosilica(NR/SiO2) nanocomposite with core-shell nanosilica-poly(methyl methacrylate)(SiO2-PMMA) particles and PMMA-modified natural rubber matrix(NR-PMMA).The microstructure of SiO2 and nanocomposites with different SiO2 contents was characterized by fourier transform infrared spectroscopy(FTIR);the morphology of nanocomposites was investigated with scanning electron microscopy(SEM);the tensile strength was characterized by tensile testing machine and the thermal stability of composites was studied by thermal gravimetric analysis.Results showed that PMMA chains have successfully grafted onto the surface of SiO2,and the core-shell SiO2-PMMA nanoparticles and NR-PMMA latex have been perfectly incorporated.SiO2-PMMA nanoparticles are evenly distributed over the NR matrix with an average size in the range of 60-100 nm at the low content(SiO2 ≤ 3 wt%),while aggregations are apparently observed when 5 wt% SiO2 is loaded.In addition,NR/SiO2 composities possess a considerable improvement in ageing resistance compared with the pure NR.The tensile strength of composite increases from 6.99 to 12.72 MPa,reaching the highest value at a 0.5 wt% SiO2 loading,and then the figure decreases gradually because of the aggregation of SiO2 nanoparticles.It is anticipated that the reported process is to provide a simple and economic way for preparing NR composites. | 罗勇悦 FENG Chunfang WANG Qinghuang YI Zhifeng QIU Quanfang Kong LX 彭政 | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 1 |
| 3 | Triptolide prevents bone destruction in the collagen-induced arthritis model of rheumatoid arthritis by targeting RANKL/RANK/OPG signal pathway显示文摘 | CHUNFANG LIU YANQIONG ZHANG XIANGYING KONG | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 4 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang<.--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，： | 1 |
| 5 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang< !--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，24： | 1 |
| 6 | PARP-1 inhibitors enhance the chemosensitivity of leukemia cells by attenuating NF-κB pathway activity and DNA damage response induced by Idarubicin显示文摘Idarubicin(IDA),an anthracycline antineoplastic drug,is commonly used in the treatment of acute myeloid leukemia(AML)with reasonable response rates and clinical benefits.However,some patients still relapse,or do not respond,and suffer high fatality rates.Recent studies have shown that overexpression of PARP-1 may represent an important risk factor in AML patients.The aim of the present study was to determine the underlying molecular mechanisms by which the PARP-1 inhibitor Olaparib enhances the chemosensitivity of the leukemia cell line K562 and THP1 to IDA.Our data demonstrated that PARP-1 is upregulated in AML patients as well as in K562 and THP1 cells,and that the suppression of PARP-1 activity by Olaparib enhances the inhibitory effect of IDA.A mechanistic study revealed that Olaparib decreases the expressions of p-ATM,p-IκBα,XIAP and p65,and upregulates Bax,cleaved-Caspase-3 andγ-H2AX.Olaparib can enhance the induction of DNA damage by IDA,probably mediated by the inhibition of the ATM-related DNA damage response.Moreover,we also found that the nuclear translocation of p65 and the nuclear export of NEMO are inhibited when IDA and Olaparib are combined.Our results suggest that Olaparib attenuates the activity of the NF-κB pathway and decreases the DNA damage response induced by IDA.Therefore,we conclude that Olaparib is a potentially valuable chemosensitizer for leukemia patients. | Bo Ke Anna Li Huan Fu Chunfang Kong Tingting Liu Qingqing Zhu Yue Zhang Zixia Zhang Chen Chen Chenghao Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
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