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| 1 | Frontiers in circularly polarized luminescence:molecular design,self-assembly,nanomaterials,and applications显示文摘The research in circularly polarized luminescence has attracted wide interest in recent years.Efforts on one side are directed toward the development of chiral materials with both high luminescence efficiency and dissymmetry factors,and on the other side,are focused on the exploitations of these materials in optoelectronic applications.This review summarizes the recent frontiers(mostly within five years)in the research in circularly polarized luminescence,including the development of chiral emissive materials based on organic small molecules,compounds with aggregation-induced emissions,supramolecular assemblies,liquid crystals and liquids,polymers,metal-ligand coordination complexes and assemblies,metal clusters,inorganic nanomaterials,and photon upconversion systems.In addition,recent applications of related materials in organic light-emitting devices,circularly polarized light detectors,and organic lasers and displays are also discussed. | Zhong-Liang Gong Xuefeng Zhu Zhonghao Zhou Si-Wei Zhang Dong Yang Biao Zhao Yi-Pin Zhang Jianping Deng Yixiang Cheng You-Xuan Zheng Shuang-Quan Zang Hua Kuang Pengfei Duan Mingjian Yuan Chuan-Feng Chen Yong Sheng Zhao Yu-Wu Zhong Ben Zhong Tang Minghua Liu | 2021 | Science China Chemistry2021，64，12： | 3 |
| 2 | Trace Ir(Ⅲ)complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media显示文摘Trace Ir(Ⅲ)complex enhanced aggregation-induced electrochemiluminescence(AIECL)of poly-tetraphenylethene(p TPE)in aqueous media was investigated for the first time.The poly-TPE end-capped by Ir(Ⅲ)complex(Ir@p TPE)and its corresponding model polymer poly-TPE(Ph@pTPE)could be synthesized by Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)-1,2-diphenylethene(M-1)with 1,2-diphenyl-1,2-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethene(M-2)and the continuous Suzuki coupling end-capped reaction of poly-TPE-pinacol boronate with(pq)2 Ir(pico)Br and bromobenzene,respectively.Subsequently,the corresponding Ir@p TPE Pdots and Ph@p TPE Pdots encapsulated with poly(styrene-co-maleicanhydride)(PSMA)could be obtained by nanoprecipitation method.Compared with Ph@p TPE Pdots,the Ir@p TPE Pdots with a trace amount of Ir(Ⅲ)complex(1.34‰of Ir(Ⅲ)content,wt)could exhibit 9.9-fold enhancement of the electrochemiluminescence(ECL)signal for visual emission.This work provided a novel strategy on designing highly efficient ECL materials based on trace Ir(Ⅲ)-end capping AIE-active polymer dots. | Hang Gao Nan Zhang Yang Li Wei Zhao Yiwu Quan Yixiang Cheng Hong-Yuan Chen Jing-Juan Xu | 2020 | Science China Chemistry2020，63，5： | 2 |
| 3 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 4 | A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes显示文摘Type 2 diabetes(T2D)is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field(SMF)and electric field.We systematically compared four types of SMFs and found that a downward SMF of100 mT could effectively reduce the development of hyperglycemia,fatty liver,weight gain,and tissue injury in high-fat-diet(HFD)/streptozocin-induced T2D mice,but not the upward SMF.The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota,and reduced iron deposition in the pancreas.SMF also reduced the labile iron and reactive oxygen species level in pancreatic Min6 cells in vitro and prevented palmitate-induced Min6 cell number reduction.Therefore,this simple SMF setting could partially prevent HFD-induced T2D development and ameliorate related symptoms,which could provide a low-cost and non-invasive physical method to prevent and/or treat T2D in the future. | Biao Yu Juanjuan Liu Jing Cheng Lei Zhang Chao Song Xiaofei Tian Yixiang Fan Yue Lv Xin Zhang | 2021 | The Innovation2021，2，1： | 1 |
| 5 | Multi-level simulation platform of SOFC-GT hybrid generation system 显示文摘 | BAO Cheng SHI Yixiang LIChen | 2010 | International Journal of Hydrogen Energy2010，35，7： | 1 |
| 6 | 显示文摘 | Cheng Yixiang Chen Lingwu Zou Xiaowei | 2006 | Polymer2006，47，1： | 1 |
| 7 | 显示文摘 | Song Jinfeng Cheng Yixiang Chen Lingwu | 2006 | European Polymer Journal2006，42，3： | 1 |
| 8 | A Highly Sensitive and Selective Fluorescence Chemosensor for Cu^2+ and Zn^2+ Based on Solvent Effect显示文摘1 能基于(R)-binaphthyl-salen 展出的新奇荧光 chemosensor 向由“转弯”的 Cu2+ 的高度敏感、选择的识别回答荧光由“刺激”在 THF/H2O,和 Zn2+ 熄灭类型在 CHCl3/CH3CN 的荧光改进类型分别地,建议溶剂能戏剧性地影响基于 salen 的 chemosensor 的应答的性质。另外,没有溶剂的影响, Cu2+ 能导致 CD 系列的最显著的变化,它显示这客气的 chemosensor 能也基于 CD 系列被用作一根唯一的 Cu2+ 探针。 | Xiaobo Huang Qian Miao Lu Wang Jieming Jiao Xianjing He Yixiang Cheng | 2013 | Chinese Journal of Chemistry2013，31，2： | 0 |
| 9 | 2D materials for intelligent devices显示文摘Neuromorphic intelligent hardware technologies have undergone rapid advancement during the past decade,with the goal of building intelligent devices and systems capable of overcoming challenges associated with conventional hardware.Realization of neuromorphic intelligent hardware depends on major advances in materials science,condensed matter physics,device physics and engineering.As a revolutionary discovery,two-dimensional(2D)materials with atomically-thin thickness and exceptionally high tunability introduce a new physical paradigm and show great promise in the development of intelligent devices.Here,we give prominence to three categories of tunable properties(i.e.,charge carrier,band structure,lattice structure)that are inherent for 2D materials and review their superiorities in constructing intelligent devices particularly in electronics and optoelectronics.Furthermore,we provide insight into how the unique physical mechanisms emerging in 2D materials offer a fertile ground for the design of diverse intelligence devices. | Xuan Pan Yixiang Li Bin Cheng Shi-Jun Liang Feng Miao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，11： | 0 |
| 10 | Water Flow Characteristics and Related Effects in PEMFC显示文摘Water management in proton exchange membrane fuel cells(PEMFC)is a topic of great importance for the optimization of these systems.Effective proton conductivity calls for moderate moisture content in the membrane,while uneven water distribution can lead to instability of the whole flow field,thereby decreasing the performance of the fuel cell.In the present study,a simplified two-tier hybrid structure is used to investigate the impact of the dynamic behavior of liquid water on the current density of the PEMFC.Simulation results show that water droplets attached to wall sides tend to increase current density.Visualization experiments confirm the existence of liquid droplets and the enhancement of current density,while indicating that the best performance and stability of fuel cell are attained for a cathode air flow rate of 300 ml/min. | Mingge Wu Lei Wang Yixiang Wang Cheng Zhang Cheng Qiu | 2019 | Fluid Dynamics & Materials Processing2019，15，4： | 0 |
| 11 | Controllable CPL response driven by achiral UV-photosensitive dichroic dye through cholesteric liquid crystals显示文摘Versatile stimuli-responsive circularly polarized luminescent(CPL)materials have potential applications in information storage,security encryption,and intelligent displays.In this study,the Z/E isomerization of ultraviolet(UV)-photosensitive achiralα-cyanostilbene derivative was used as an achiral dichroic dye(Switch)to drive the controllable CPL-active response in cholesteric liquid crystals(CLCs).Under irradiation by 365 nm UV light,the resulting CLCs-Z-Switch underwent a Z-to-E configuration isomerization as CLCs-E-Switch,accompanied by a decrease in its dichroic order parameter(SFvalue)from 0.15to 0.07.Although the quantum yield(QY)of CLCs-E-Switch increased from 8.1%(CLCs-Z-Switch)to 16.8%,the corresponding glumvalues of CPL emission decreased from+0.55/-0.57 to+0.37/-0.39 due to a decrease in the order of helical arrangement of E-Switch in E7 media.This study enables photosensitive CLCs-Switch to be applied for optical information storage devices. | Yihan Chen Yang Li Hang Li Lulu Li Yiwu Quan Yixiang Cheng | 2024 | Science China Chemistry2024，67，4： | 0 |
| 12 | Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors have been reapproved for heart failure(HF)therapy in patients with and without diabetes.However,the initial glucose-lowering indication of SGLT2i has impeded their uses in cardiovascular clinical practice.A challenge of SGLT2i then becomes how to separate their anti-HF activity from glucose-lowering side-effect.To address this issue,we conducted structural repurposing of EMPA,a representative SGLT2 inhibitor,to strengthen anti-HF activity and reduce the SGLT2-inhibitory activity according to structural basis of inhibition of SGLT2.Compared to EMPA,the optimal derivative JX01,which was produced by methylation of C2—OH of the glucose ring,exhibited weaker SGLT2-inhibitory activity(IC_(50)>100 nmol/L),and lower glycosuria and glucose-lowering side-effect,better NHE1-inhibitory activity and cardioprotective effect in HF mice.Furthermore,JX01 showed good safety profiles in respect of single-dose/repeat-dose toxicity and hERG activity,and good pharmacokinetic properties in both mouse and rat species.Collectively,the present study provided a paradigm of drug repurposing to discover novel anti-HF drugs,and indirectly demonstrated that SGLT2-independent molecular mechanisms play an important role in cardioprotective effects of SGLT2 inhibitors. | Yixiang Xu Chao Zhang Kai Jiang Xinchun Yang Feng Chen Zhiyang Cheng Jinlong Zhao Jiaxing Cheng Xiaokang Li Xin Chen Luoyifan Zhou Hao Duan Yunyuan Huang Yaozu Xiang Jian Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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