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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Analysis of the factors affecting thermal evolution of hot rolled steel during coil cooling显示文摘The thermal evolution of steel coil during cooling was simulated and investigated by the use of in-house Q-CSP? software.The dependence of the thermal evolution of steel coil on cooling methods, temperature distribution of the strip before coiling, coil sizeand steel grades was also discussed. The study plays a significant role in helping steel makers to better understand and control thecooling process. | Jiefeng Cheng Zhengdong Liu Han Dong Yong Gan | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 3 |
| 3 | Cross-Modal Complementary Network with Hierarchical Fusion for Multimodal Sentiment Classification显示文摘Multimodal Sentiment Classification(MSC)uses multimodal data,such as images and texts,to identify the users'sentiment polarities from the information posted by users on the Internet.MSC has attracted considerable attention because of its wide applications in social computing and opinion mining.However,improper correlation strategies can cause erroneous fusion as the texts and the images that are unrelated to each other may integrate.Moreover,simply concatenating them modal by modal,even with true correlation,cannot fully capture the features within and between modals.To solve these problems,this paper proposes a Cross-Modal Complementary Network(CMCN)with hierarchical fusion for MSC.The CMCN is designed as a hierarchical structure with three key modules,namely,the feature extraction module to extract features from texts and images,the feature attention module to learn both text and image attention features generated by an image-text correlation generator,and the cross-modal hierarchical fusion module to fuse features within and between modals.Such a CMCN provides a hierarchical fusion framework that can fully integrate different modal features and helps reduce the risk of integrating unrelated modal features.Extensive experimental results on three public datasets show that the proposed approach significantly outperforms the state-of-the-art methods. | Cheng Peng Chunxia Zhang Xiaojun Xue Jiameng Gao Hongjian Liang Zhengdong Niu | 2022 | Tsinghua Science and Technology2022，27，4： | 2 |
| 4 | Topological design for vibrating structures 显示文摘 | Ma Zhengdong Noboru Kikuchi Hsien-Chie Cheng | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，： | 1 |
| 5 | Crystallization kinetics of thermosensitive colloids probed by transmission spectroscopy 显示文摘 | Tang Shijun Hu Zhibing Cheng Zhengdong | 2004 | Langmuir2004，20，20： | 1 |
| 6 | Topological design for vibrating structures显示文摘 | ZhengDong Ma Noboru Kikuchi Hsien Chie Cheng | 1995 | Computer methods in applied mechanics and engineering1995，121，： | 1 |
| 7 | Investigation on aging percipitates and strengthening mechanism of T122 boiler steel显示文摘 | Hansheng Bao Shichang Cheng Zhengdong Liu | 2010 | J Iron Steel Res2010，17，2： | 1 |
| 8 | Topological design for vibrating Structures 显示文摘 | MA Zhengdong Kikuchi Noboru CHENG Hsienchie | 1995 | Computer Methods in Applied Mechanics and Engineering(S0045-7825)1995，121，14： | 1 |
| 9 | Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer显示文摘 | Zhang Xiaoping Bai Zhibin Chen Baoan Feng Jifeng Yan Feng Jiang Zhi Zhong Yuejiao Wu Jianzhong Cheng Lu Lu Zuhong Tong Na Zhang Zhengdong | 2014 | Chinese Medical Journal2014，，20： | 1 |
| 10 | 不同种类碳源对TiC–TiB_2复合粉末合成的影响显示文摘以二氧化钛、硼酸和不同碳源(炭黑、蔗糖、葡萄糖)为原料,用碳热还原法合成了TiC–TiB_2复合粉末。研究了不同种类碳源及反应温度对TiC–TiB_2复合粉末的影响。用X-射线衍射仪、激光粒度分析仪和扫描电子显微镜对样品的物相组成、晶粒尺寸及颗粒形貌进行了分析。结果表明:以炭黑、葡萄糖为碳源合成TiC–TiB_2复合粉末的适宜宜条件为在1400℃保温2h;以蔗糖为碳源合成TiC–TiB_2复合粉末的适宜条件为在1350℃保温2h。在最适宜反应温度下,以炭黑为碳源合成的TiC–TiB_2复合粉末样品粒径最小,且颗粒之间相互团聚较少,大部分颗粒尺寸在100nm左右。 | 胡继林 彭红霞 田修营 胡传跃 CHENG Zhengdong | 2016 | 硅酸盐学报2016，44，3： | 0 |
| 11 | Pulse electrochemical synaptic transistor for supersensitive and ultrafast biosensors显示文摘High sensitivity and fast response are the figures of merit for benchmarking commercial sensors.Due to the advantages of intrinsic signal amplification,bionic ability,and mechanical flexibility,electrochemical transistors(ECTs)have recently gained increasing popularity in constructing various sensors.In the current work,we have proposed a pulse-driven synaptic ECT for supersensitive and ultrafast biosensors.By pulsing the presynaptic input(drain bias,VD)and setting the modulation potential(gate bias)near transconductance intersection(VG,i),the synaptic ECT-based pH sensor can achieve a record high sensitivity up to 124 mV pH^(-1)(almost twice the Nernstian limit,59.2 mV pH^(-1))and an ultrafast response time as low as 8.75 ms(7169 times faster than the potentiostatic sensors,62.73 s).The proposed synaptic sensing strategy can effectively eliminate the transconductance fluctuation issue during the calibration process of the pH sensor and significantly reduce power consumption.Besides,the most sensitive working point at VG,i has been elaborately figured out through a series of detailed mathematical derivations,which is of great significance to provide higher sensitivity with quasi-nonfluctuating amplification capability.The proposed electrochemical synaptic transistor paired with an optimized operating gate offers a new paradigm for standardizing and commercializing high-performance biosensors. | Jianlong Ji Zhenxing Wang Fan Zhang Bin Wang Yan Niu Xiaoning Jiang Zeng-ying Qiao Tian-ling Ren Wendong Zhang Shengbo Sang Zhengdong Cheng Qijun Sun | 2023 | InfoMat2023，5，11： | 0 |
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