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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | Sensors deployment optimization in multi-dimensional space based on improved particle swarm optimization algorithm显示文摘Sensors deployment optimization has become one of the most attractive fields in recent years. However, most of the previous work focused on the deployment problem in 2 D space.Compared to the traditional form, sensors deployment in multidimensional space has greater research significance and practical potential to satisfy the detecting needs in complex environment.Aiming at solving this issue, a multi-dimensional space sensor network model is established, and the radar system is selected as an example. Considering the possible working mode of the radar system(e.g., searching and tracking), two distinctive deployment models are proposed based on maximum coverage area and maximum target detection probability in the attack direction respectively. The latter one is usually ignored in the previous literature.For uncovering the optimal deployment of the sensor network, the particle swarm optimization(PSO) algorithm is improved using the proposed weights determination scheme, in which the linear decreasing, the pooling strategy and the cloud theory are combined for weights updating. Experimental results illustrate the effectiveness of the proposed method. | TANG Mingnan CHEN Shijun ZHENG Xuehe WANG Tianshu CAO Hui | 2018 | Journal of Systems Engineering and Electronics2018，29，5： | 6 |
| 3 | Arbuscular mycorrhizal fungi differ in affecting the flowering of a host plant under two soil phosphorus conditions显示文摘Aims Studies have showed that arbuscular mycorrhizal fungi(AMF)can greatly promote the growth of host plants,but how AMF affect flow-ering phenology of host plants is not well known.Here,we con-ducted a pot experiment to test whether life cycle and flowering phenology traits of host plant Medicago truncatula Gaertn can be altered by AMF under low and high soil phosphorus(P)levels.Methods the experiment was conducted in a greenhouse at Zhejiang University in China(120°19′E,30°26′N)and had a completely ran-domized design with two factors:AMF treatments and soil P levels.Six AMF species(Acaulospora scrobiculata,As;Gigaspora marga-rita,Gma;Funneliformis geosporum,Fg;Rhizophagus intraradices,Ri;Funneliformis mosseae,Fmo and Glomus tortuosum,Gt.)were used,and two soil P levels(24.0 and 5.7 mg kg−1 Olsen-soluble P)were designed.the six AMF species were separately inoculated or in a mixture(Mix),and a non-AMF control(NAMF)was included.When plants began to flower,the number of flowers in each pot was recorded daily.During fruit ripening,the number of mature fruits was also recorded daily.After~4 months,the biomass,bio-mass P content and AMF colonization of host plant were measured.Correlation between root colonization and first flowering time,or P content and first flowering time was analyzed.Important Findings Under the low P level,first flowering time negatively correlated with root colonization and biomass P.Only host plants with AMF spe-cies As,Fg,Ri,or Mix were able to complete their life cycle within 112 days after sowing.And treatment with AMF species Fg,Gt,or As resulted in two periods of rapid flower production while other fungi treatments resulted in only one within 112 days after sowing.the cumulative number of flowers produced and biomass P content were highest with species Fg.Host biomass allocation significantly differed depending on the species of AMF.Under both soil P levels,the host plant tended to allocate more biomass to fruits in the Mix treatment than in the other treatments.these results indicated that the effects of AMF on host flowering phenology and biomass allocation differed depending on AMF species and soil P levels. | Shijun Liu Hanling Guo Jing Xu Zeyuan Song Shurui Song Jianjun Tang Xin Chen | 2018 | Journal of Plant Ecology2018，11，4： | 3 |
| 4 | A review of Behcet's disease from the perspectives of both Western and Chinese Medicine显示文摘Behcet's disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet's disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet's disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East.This article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet's disease. Furthermore, the etiology of Behcet's disease will be evaluated from the aspect of Traditional Chinese Medicine(TCM) syndrome differentiation. As Behcet's disease is complex and intractable, its treatment warrants further research.Traditionally, Behcet's disease is treated with Western Medicine(WM) via medications that act locally and systemically; this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet's disease via a combination of WM and TCM.Recent studies have indicated that such a combination of Chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet's disease, and to outline its possible pathogenesis in terms of both TCM and WM. Based on these findings, the present review proposes a Behcet's disease treatment protocol composed of a combination of Chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication. | Zhang Jing Tang Yuping Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 3 |
| 5 | PERFORMANCE OF ULTRA-LOW FREQUENCY PASSIVE VERTICAL VIBRATION ISOLATION SYSTEM WITH REVERSE PENDULUM显示文摘A novel long period passive vertical vibration isolator constructed by mounting reverse pendu-lums on two pairs of torsion springs is presented.By theoretical analysis and nmnerical calculation,it isshown that the isolator can achieve much longer resonant period due to gravitational positive feedback and issmaller in size than the current torsion spring isolators with the same geometric parameters. | Zhao Pengfei Huang Yuying Tang Mengxi Sun Shijun | 2002 | Acta Mechanica Solida Sinica2002，15，1： | 2 |
| 6 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 7 | Characterization of mesoporous activated carbons prepared by pyrolysis of sewage sludge with pyrolusite显示文摘 | Chen Liu Zhengguang Tang Yao Chen Shijun Su Wenju Jiang | 2009 | Bioresource Technology2009，，3： | 1 |
| 8 | Crystallization kinetics of thermosensitive colloids probed by transmission spectroscopy 显示文摘 | Tang Shijun Hu Zhibing Cheng Zhengdong | 2004 | Langmuir2004，20，20： | 1 |
| 9 | Detection of Patulin in Dairy Products by ELISA显示文摘The content of patulin in dairy products was detected by rapid ELISA assay.The pretreatment of samples was simple,with wide range of application.The standard product showed good linear relationship with the range of 0-5.4 μg/kg,and the linear relationship reached 0.999 3,with high sensitivity.It took shorter time,with a total time-consumption of 1 h.Moreover,it had good repeatability for analytical requirements. | Tang Shiyun Shen Zhiqiang Fu Shijun Wu Yuxiang Li Jinlin | 2018 | Animal Husbandry and Feed Science2018，10，2： | 1 |
| 10 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 11 | Simultaneous Determination of Sulfamonomethoxine Sodium and Trimethoprim in Compound Sulfamonomethoxine Sodium Propolis Solution by High Performance Liquid Chromatography(HPLC)显示文摘[Objective] The paper aimed to provide a basis for quality control of compound sulfamonomethoxine sodium propolis solution. [Method] High performance liquid chromatography( HPLC) method was used to determine the contents of sulfamonomethoxine sodium and trimethoprim simultaneously in compound sulfamonomethoxine sodium propolis solution. [Result]Sulfamonomethoxine sodium and trimethoprim showed a linear relationship within the concentration of 10-500 μg / m L under the following chromatographic conditions: Kromasil C18column( 250 mm × 4. 6 mm,5 μm),mobile phase 0. 02 mol / L phosphoric acid solutionmethanol( 80∶20,V / V),detection wavelength 270 nm,flow rate 1. 0 m L / min,and column temperature 30℃. The average recoveries were 99. 3% and 99. 4%,respectively. [Conclusion] The method is accurate and feasible,and can determine sulfamonomethoxine sodium and trimethoprim simultaneously in compound sulfamonomethoxine sodium propolis solution. | Guo Shijin Zhang Zhimei Fu Shijun Tang Shiyun Shen Zhiqiang | 2015 | Animal Husbandry and Feed Science2015，7，4： | 1 |
| 12 | A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis显示文摘 | Jianchang Wang Yongqiang Wang Jue Liu Lin Ding Quanhong Zhang Xiaoqi Li Hong Cao Jun Tang Shijun J. Zheng | 2012 | Virus Research (-)2012，，1： | 1 |
| 13 | Ablation behaviors of ultra-high temperature ceramic composites显示文摘 | Sufang Tang Jingyi Deng Shijun Wang Wenchuan Liu Ke Yang | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 14 | Formation and volume phase transition of hydroxypropyl cellulose micro- gels in salt solution 显示文摘 | Xia Xiaohu Tang Shijun Lu Xihua | 2003 | Macromolecules2003，36，10： | 1 |
| 15 | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin显示文摘 | Xin Zhao Yong Wang Shijun Yang Wentong Zhang Chengzhe Zu Taotao Zhang Binghua Tang Baochun Zhang Guozhang Li Bo Deng Dayong Cai Bhushan Patwardhan | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 16 | Ablation behaviors of ultra-high temperature ceramic composites显示文摘 | Sufang Tang Jingyi Deng Shijun Wang Wenchuan Liu Ke Yang | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 17 | Construction of immobilized films photocatalysts with CdS clusters decorated by metal Cd and BiOCl for photocatalytic degradation of tetracycline antibiotics显示文摘A kind of CdS/Cd-BiOCl immobilized films photocatalyst was prepared.The optical and physicochemical properties of the CdS/Cd-BiOCl photocatalysts were analysed,and the detailed characterization revealed CdS/Cd-BiOCl films photocatalyst with good charge carrier separation effect.The reusabilities and photocatalytic properties of the samples were studied.The 15%Cd S/Cd-Bi OCl photocatalyst exhibited superior performance in photocatalytic degradation of tetracycline(TC)and favorable stability under visible light irradiation.As for the photodegradation rate of TC,15%CdS/Cd-BiOCl exhibited an excellent photodegradation activity,which is 4.06 and 9.53 times higher than that of Cd S/Cd and Bi OCl,respectively.The results showed that dominant active species are·O_(2)^(-)and·OH radicals during photodegradation.The charge transfer in Z-scheme CdS/Cd-BiOCl films photocatalyst could synchronously generate conduct band(CB)electrons in BiOCl and valence band(VB)holes in CdS,and metal Cd served as electron mediator.This work can be a reference for the design of film photocatalysts and new insight for photodegradating towards contaminants. | Jiajia Li Ziwei Zhao Zhuoning Li Huijuan Yang Shijun Yue Yuping Tang Qizhao Wang | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 18 | Detection of genomic signatures for pig hairlessness using high-density SNP data显示文摘Hair provides thermal regulation for mammals and protects the skin from wounds,bites and ultraviolet(UV)radiation,and is important in adaptation to volatile environments.Pigs in nature are divided into hairy and hairless,which provide a good model for deciphering the molecular mechanisms of hairlessness.We conducted a genomic scan for genetically differentiated regions between hairy and hairless pigs using 60K SNP data,with the aim to better understand the genetic basis for the hairless phenotype in pigs.A total of 38405 SNPs in 498 animals from 36 diverse breeds were used to detect genomic signatures for pig hairlessness by estimating between-population(FST)values.Seven diversifying signatures between Yucatan hairless pig and hairy pigs were identified on pig chromosomes(SSC)1,3,7,8,10,11 and 16,and the biological functions of two notable genes,RGS17 and RB1,were revealed.When Mexican hairless pigs were contrasted with hairypigs,strong signatures were detected on SSC1 and SSC10,which harbor two functionally plausible genes,REV3L and BAMBI.KEGG pathway analysis showed a subset of overrepresented genes involved in the T cell receptor signaling pathway,MAPK signaling pathway and the tight junction pathways.All of these pathways may be important in local adaptability of hairless pigs.The potential mechanisms underlying the hairless phenotype in pigs are reported for the first time.RB1 and BAMBI are interesting candidate genes for the hairless phenotype in Yucatan hairless and Mexico hairless pigs,respectively.RGS17,REV3L,ICOS and RASGRP1 as well as other genes involved in the MAPK and T cell receptor signaling pathways may be important in environmental adaption by improved tolerance to UV damage in hairless pigs.These findings improve our understanding of the genetic basis for inherited hairlessness in pigs. | Ying SU Yi LONG Xinjun LIAO Huashui AI Zhiyan ZHANG Bin YANG Shijun XIAO Jianhong TANG Wenshui XIN Lusheng HUANG Jun REN Nengshui DING | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 0 |
| 19 | Harms of Mycotoxins to Animals and Research Progress of Detection Methods显示文摘Mycotoxin is widely distributed in various feedstuffs and feeds of animals.Mycotoxin not only causes feed deterioration,but also leads to various diseases of animals,or even results in acute toxic death,causing great harm to the breeding industry.In this paper,the harm of mycotoxin to animals and its detection methods in feed and animals are summarized and analyzed,so as to provide the reference basis for further improving the detection methods of mycotoxin and reducing the harm of mycotoxin to breeding industry. | Guo Shijin Zhang Zhimei Tang Shiyun Fu Shijun Li Ling Shen Zhiqiang | 2022 | Animal Husbandry and Feed Science2022，14，4： | 0 |
| 20 | Application Research Progress of Amino Acid Chelated Iron in Pig Nutrition显示文摘As an essential trace element for pigs,iron is very important for pig production,and plays an important role in sow performance,growth and development of piglets,metabolic process and physiological defense[1-3].Iron is a cofactor of catalase in the body’s anti-oxidation system,which plays an important role in preventing lipid oxidation and maintaining meat flavor.Iron is an indispensable activator of enzymes involved in redox reaction,such as superoxide dismutase(SOD). | Guo Shijin Zhang Zhimei Fu Shijun Wang Jianjun Tang Shiyun Shen Zhiqiang | 2022 | Animal Husbandry and Feed Science2022，14，4： | 0 |
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