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| 1 | Stem cell-based bone and dental regeneration: a view of microenvironmental modulation显示文摘In modern medicine,bone and dental loss and defects are common and widespread morbidities,for which regenerative therapy has shown great promise.Mesenchymal stem cells,obtained from various sources and playing an essential role in organ development and postnatal repair,have exhibited enormous potential for regenerating bone and dental tissue.Currently,mesenchymal stem cells (MSCs)-based bone and dental regeneration mainly includes two strategies: the rescue or mobilization of endogenous MSCs and the application of exogenous MSCs in cytotherapy or tissue engineering.Nevertheless,the efficacy of MSCbased regeneration is not always fulfilled,especially in diseased microenvironments.Specifically,the diseased microenvironment not only impairs the regenerative potential of resident MSCs but also controls the therapeutic efficacy of exogenous MSCs,both as donors and recipients.Accordingly,approaches targeting a diseased microenvironment have been established,including improving the diseased niche to restore endogenous MSCs,enhancing MSC resistance to a diseased microenvironment and renormalizing the microenvironment to guarantee MSC-mediated therapies.Moreover,the application of extracellular vesicles (EVs) as cell-free therapy has emerged as a promising therapeutic strategy.In this review,we summarize current knowledge regarding the tactics of MSC-based bone and dental regeneration and the decisive role of the microenvironment,emphasizing the therapeutic potential of microenvironment-targeting strategies in bone and dental regenerative medicine. | Chenxi Zheng Ji Chen Shiyu Liu Yan Jin | 2019 | International Journal of Oral Science2019，11，3： | 18 |
| 2 | ZIF-8/LiFePO4 derived Fe-N-P Co-doped carbon nanotube encapsulated Fe2P nanoparticles for efficient oxygen reduction and Zn-air batteries显示文摘Iron-based oxygen reduction reaction(ORR)catalysts have been the focus of research,and iron sources play an important role for the preparation of efficient ORR catalysts.Here,we successfully use LiFePO4 as ideal sources of Fe and P to construct the heteroatom doped Fe-based carbon materials.The obtained Fe-N-P co-doped coral-like carbon nanotube arrays encapsulated Fe2P catalyst(C-ZIF/LFP)shows very high half-wave potential of 0.88 V in alkaline electrolytes toward ORR,superior to Pt/C(0.85 V),and also presents a high half-wave potential of 0.74 V in acidic electrolytes,comparable to Pt/C(0.8 V).When further applied into a home-made Zn-air battery as cathode,a peak power density of 140 mW·cm^-2 is reached,exceeds commercial Pt/C(110 mW·cm^-2).Besides,it also presents exceptional durability and methanol resistance compared with Pt/C.Noticeably,the preparation method of such a high-performance catalyst is simple and easy to optimize,suitable for the large-scale production.What’s more,it opens up a more sustainable development scenario to reduce the hazardous wastes such as LiFePO4 by directly using them for preparing high-performance ORR catalysts. | Huihui Jin Huang Zhou Pengxia Ji Chengtian Zhang Jiahuan Luo Weihao Zeng Chenxi Hu Daping He Shichun Mu | 2020 | Nano Research2020，13，3： | 8 |
| 3 | Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury显示文摘It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials.Therefore,we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology.The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia.After reperfusion for 30–180 minutes,the amplitude and latency began to gradually recover;at 360 minutes of reperfusion,the latency showed no significant difference compared with the pre-ischemic value,while the somatosensory evoked potential amplitude increased,and severe hindlimb motor dysfunctions were detected.Experimental findings suggest that changes in somatosensory evoked potential latency can reflect the degree of spinal cord ischemic injury,while the amplitude variations are indicators of the late spinal cord reperfusion injury,which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury. | Yiming Ji Bin Meng Chenxi Yuan Huilin Yang Jun Zou | 2013 | Neural Regeneration Research2013，8，33： | 5 |
| 4 | Magnetic Fe_(2)O_(3)/biochar composite prepared in a molten salt medium for antibiotic removal in water显示文摘The large-scale use of antibiotics is causing serious water pollution problems,and it is of great significance to develop new technologies to remove antibiotics from water.As an environmentally friendly and economical adsorption material,carbon derived from biomass is a low-cost and feasible material for removing antibiotics in sewage,but the current removal efficiencies are not high enough for large-scale practical application.In this study,poplar wood chips are used as raw material,and a magnetic biochar is prepared by co-pyrolysis of poplar wood chips and FeCl_(3)/CaCl_(2)mixed molten salt.X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),N_(2)-isothermal adsorption and desorption,X-ray photoelectron spectroscopy(XPS)and scanning electron microscope(SEM)techniques showed the successful synthesis of Fe_(2)O_(3)/bioC composite.In-situ formed Fe_(2)O_(3)makes the biochar possess the characteristic of superparamagnetic,which is conducive to the recycling of biochar.Due to the etching effect of the molten salts,rough surface was formed on Fe_(2)O_(3)/bioC,result-ing in a maximum norfloxacin(NOR)adsorption ability up to 38.77 mg g^(−1)at pH 6.0.The NOR adsorption behavior on Fe_(2)O_(3)/bioC followed the pseudo second order kinetic model and the equilibrium data was best fitted the Langmuir model.In addition,the adsorption process of NOR on Fe_(2)O_(3)/bioC was thermodynamically spontaneous.The results show that this low-cost and reusable magnetic biochar has the potential for rapid and efficient removal of antibiotic from aqueous solution. | Huagen Liang Chenxi Zhu Shan Ji Palanisamy Kannan Fu Chen | 2022 | Biochar2022，4，1： | 4 |
| 5 | Investigation of the solute transportation coupled with heat transfer and fluid flow during twin-roll strip casting process显示文摘Mathematical model of solute [C] distribution in twin-roll strip casting process has been setup successfully with Calcosoft for the first time. Simulation result shows that in the center of the molten steel pool between the two rolls there is a vortex flow, which is a solute enriched area. But the highest solute concentration position is at the solidification front of the columnar grain zone near the cooling roll surface. Another solute enriched position is in the back flow above the nip point. Combined with the formation mechanism of microstructure in final as cast strip, analysis shows that solute enriched area is in the transitional area between columnar and equiaxed grain zone. | Yongsheng WANG Chenxi JI Jiongming ZHANG Xinhua WANG Wanjun WANG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，5： | 1 |
| 6 | Microstructure of AISI 304 stainless steel strips produced by a twin-roll caster显示文摘By optical inspection of macro-etched metallography and electron back-scattered diffraction (EBSD) mapping, this paper analyzed the microstructure of austenitic stainless steel strips produced with an equal-diameter twin-roll strip caster. The results in-dicate that the microstructure of the strips includes two columnar zones with highly compact dendrites and one equiaxed zone. The characteristics, such as grain size and growing direction of columnar grains and equiaxed grains, were investigated. An additional transitional area with many finer grains between the columnar zone and the equiaxed zone was found. As shown in EBSD analysis, small angle boundaries exist both in the columnar zone and the equiaxed zone, although they are especially more in the transitional area. Additionally, some <111> twin boundaries were found in the microstructure of the strips. | Chenxi Ji Jiongmmg Zhang Fuxiang Huang Xinhua Wang Yuan Fang Yan Yu | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 1 |
| 7 | LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma显示文摘 | Feng Yao Tiejun Zhao Chenxi Zhong Ji Zhu Heng Zhao | 2013 | Tumor Biology2013，，1： | 1 |
| 8 | Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress显示文摘Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient therapeutics.We discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on bone.Intriguingly,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress osteoclastogenesis.Collectively,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses. | Bingdong Sui Jin Liu Chenxi Zheng Lei Dang Ji Chen Yuan Cao Kaichao Zhang Lu Liu Minyan Dang Liqiang Zhang Nan Chen Tao He Kun Xuan Fang Jin Ge Zhang Yan Jin Chenghu Hu | 2022 | International Journal of Oral Science2022，14，4： | 1 |
| 9 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 10 | Bi-continuous Mg-Ti interpenetrating-phase composite as a partially degradable and bioactive implant material显示文摘Mg(and Mg alloys)and Ti(and Ti alloys)are two important classes of metallic implant materials which are respectively completely degradable and non-degradable after implantation.Making composites composed of them offers the promise for combining their property advantages for bone repair.Here,we present a Mg-Ti composite fabricated by pressureless infiltration of pure Mg melt into 3D printed Ti scaffold,and demonstrate a potential of the composite for use as new partially degradable and bioactive implant materials.The composite has such architecture that the Mg and Ti phases are topologically bicontinuous and mutually interspersed in 3D space,and exhibits several advantages over its constituents,such as higher strengths than as-cast pure Mg and Ti scaffold along with lower Young’s modulus than dense Ti.Additionally,the degradation of Mg phase may induce the formation and ingrowth of new bone tissues into the Ti scaffold to form mechanical interlocking between them;in this process,the Ti scaffold provides constant support and Young’s modulus adaptively decreases toward that of bone.Despite the accelerated corrosion than pure Mg,the composite remains non-cytotoxic and does not cause obvious adverse reactions after implantation as revealed by in vitro and in vivo experiments.This study may offer a new possibility for combining mechanical durability and bioactivity in implant materials,and allow for customized and targeted design of the implant. | Chenxi Dou Mingyang Zhang Dechun Ren Haibin Ji Zhe Yi Shaogang Wang Zengqian Liu Qiang Wang Yufeng Zheng Zhefeng Zhang Rui Yang | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 11 | Shaking table test study on performance and functionality of a typical telecommunication room after earthquakes显示文摘Large numbers of basic transceiver stations,where the telecommunication room is one of the main components,comprise an important part of the telecommunication system.After earthquakes,considerable economic loss from telecommunication systems is often associated with seismic damage and functional loss of the telecommunication room.However,research related to this has been limited.In this study,shaking table tests were conducted for a full-scale typical telecommunication room,including a light-steel house and the necessary communication and power supply equipment.The tests not only focused on the seismic damage to all the structures but also considered the functions of the communication and power supply of the equipment.The interactions between these facilities and their effects on communication function were also investigated.Compared with the damage to structures,the interruption of the power supply due to earthquakes is a weak link.Finally,the damage indexes,together with their threshold values of different damage states for the communication and power supply equipment,were derived from the test results.The results of this research can contribute to the literature gaps regarding seismic performance studies of telecommunication rooms,and can serve as a valuable reference for future research on its seismic fragility and economic losses evaluation. | Li Bo Guo Endong Sun Guoliang Ji Shuqiang Mao Chenxi Wang Tao Han Di Li Xiaofei | 2024 | Earthquake Engineering and Engineering Vibration2024，23，2： | 0 |
| 12 | Distribution of lightning spatial modes and climatic causes in China显示文摘本文利用中国气象局国家雷电监测网(CNLDN)的地闪观测数据集,分析了2010-2020年中国陆地区域地闪空间模态分布特征及其可能的气候成因.研究发现,夏季地闪第一模态的方差贡献率为32.86%,其分布从北到南呈现出“-+-”的经向跷跷板模式,当东太平洋和印度洋的海温异常增暖,西北太平洋的海温异常变冷时,在中国黄海,东海及热带西太平洋地区激发出气旋性环流,随着水汽南下至华南地区,与来自孟加拉湾的水汽汇合,上升运动在此加强,从而使得该地区的雷电活动增强.表明厄尔尼诺-南方涛动(ENSO)现象,是发生在中国陆地区域的地闪活动的气候驱动因子。 | Mingyi Xu Xiushu Qie Chenxi Zhao Shanfeng Yuan Ji Li Yuyu Tao Guangyu Shi Wenjing Pang Lijuan Shi | 2023 | Atmospheric and Oceanic Science Letters2023，16，2： | 0 |
| 13 | Precipitates evolution and tensile behavior of wrought Ni-based ATI 718Plus superalloy during long-term thermal exposure显示文摘In this paper,the microstructure evolution and tensile behavior of wrought ATI 718 Plus superalloy during long-term thermal exposure(LTTE) were investigated.The γ’ phase evolves from spherical morphology to cuboidal morphology at 800℃,which is related to increasing γ’/γ misfit because of the increase of elastic energy.The amounts of η phase obviously increased and γ’ precipitate free zones(PFZs) were found in 800-LTTE samples due to the increase of η phase amount by consuming Al,Ti,and Nb.According to the formula of “MC+γ→M_(23)C_(6)+η”,η phase is also related to the decomposition of MC carbide,which involves the diffusion and segregation of Nb and Ti.In addition,some short rod-like and irregular Cr,Mo-rich σ phases were prone to precipitate near η phases after LTTE at 800℃ for 500 and 1000 h.σ phase has a crystallographic relationship with ηphase as(002)_(σ)//(10■0)_(η),[0■0]_(σ)//[01■0]_(η).The deteriorated tensile strength after LTTE is mainly attributed to that:(1) the evident coarsening of γ’ phase results in that the deformation mechanism transforms from stacking faults(SFs) shearing to Orowan looping,which is also convinced by calculated critical resolved shear stress(CRSS);(2) the noticeable increasing number of η phase contributes to stress concentration,resulting in micro-cracks formation;and (3) the apparently increasing number of η phase promotes the PFZs formation. | GUO QianYing JI KangKang ZHANG Teng QIAO ZhiXia LI Chong LI Jun LIU ChenXi LIU YongChang | 2022 | Science China(Technological Sciences)2022，65，6： | 0 |
| 14 | Distribution pattern and driving factors of genetic diversity of passerine birds in the Mountains of Southwest China显示文摘Genetic diversity is one of the three dimensions of biodiversity and fundamental to various life forms on the Earth.Understanding the distribution pattern of genetic diversity and its driving forces has been an important topic in ecology,biogeography and conservation biology since the last decade.We investigated the genetic diversity pattern of passerine birds in the Mountains of Southwest China,a global biodiversity hotspot with the highest species richness of birds in the entire Eurasia,and explored the influencing forces of environmental variables on genetic diversity.We compiled 1189 Cytochrome b sequences of 27 passerine species from 152 geographic sites,covering the range of Mountains of Southwest China and its adjoining areas.We generated genetic diversity distribution maps using a grid-cell method based on nucleotide diversity and haplotype diversity indices.We further analyzed the variation pattern of the two indices along latitudinal,longitudinal,and elevational gradients.The correlations between the two indices and environmental variables were also evaluated.The nucleotide diversity hotspots were mostly located in the southern Hengduan Mountains,while for haplotype diversity,three hotspots were detected:the southeast edge of the Qinghai-Tibetan Plateau,the southern Hengduan Mountains and the Qinling Mountains.There was no monotonic increasing or decreasing pattern in nucleotide diversity or haplotype diversity along latitudinal,longitudinal or elevational gradients except for altitudinal range.Correlation and model selection analyses detected multiple environmental variables in driving genetic diversity patterns,including temperature,precipitation,vegetation,human influence,longitude and altitude range.Similar to the pattern of species richness,the nucleotide diversity pattern of passerine birds in the Mountains of Southwest China presents a decreasing trend from southwest to northeast,while the haplotype diversity pattern is more likely decreased from west to east.Our results indicate that the distribution pattern of genetic diversity may be derived from the complex topography and diverse microclimates in the Mountains of Southwest China. | Yongbin Chang Gang Song Dezhi Zhang Chenxi Jia Ping Fan Yan Hao Yanzhu Ji Fumin Lei | 2022 | Avian Research2022，13，3： | 0 |
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