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| 1 | Variation of activation energy determined by a modified Arrhenius approach:Roles of dynamic recrystallization on the hot deformation of Ni-based superalloy显示文摘The hot deformation behaviors of Ni18 Cr9 Co9 Fe5 Nb3 Mo superalloy were explored in the formation temperature range free ofγ’phase with various strain rates applied.The hot deformation behaviors are initially modeled with Arrhenius equation which gives an average activation energy of 581.1 kJ mol^(-1).A modified Arrhenius approach,including the updated Zener-Hollomon parameter is proposed to consider the change of activation ene rgy under different deformation conditions which turns out a relatively accurate computation for activation energy of hot deformation,i.e.,the standard variance for modified model calculated in the covered deformation condition is just 35.4%of that for Arrhenius equation.The modified model also proposes a map for activation ene rgy which ranges from 571.5-589.0 kJ mol^(-1)for various deformation conditions.Microstructural features of the representative superalloy specimens were characterized by electron backscattered diffraction(EBSD)techniques in order to clarify the influence of activation energy on the microstructural formation.It is found that the Ni-based superalloy samples with higher activation energy are promoted by the degree of dynamic recrystallization which suggests that the rise in activation energy gives either a better recrystallization rate or finer grains. | Peiru Yang Chenxi Liu Qianying Guo Yongchang Liu | 2021 | Journal of Materials Science & Technology2021，，13： | 8 |
| 2 | Controlled synthesis of high-quality W-Y2O3 composite powder precursor by ascertaining the synthesis mechanism behind the wet chemical method显示文摘As an emerging preparation technology,wet chemical method has been employed widely to produce lots of alloy materials such as W and Mo based alloys,owing to its unique technical advantages.Ascertaining the synthesis mechanism behind wet chemical method is indispensable for controlled synthesis of highquality W-Y2 O3 composite powder precursor.The co-deposition mechanism of yttrium and tungsten component behind the wet chemical method of preparing yttrium-doped tungsten composite nanopowder was investigated systematically in this work.A series of co-deposited composite powders fabricated under different acidity conditions were used as research targets for investigating the effect of surface composition and structure on co-deposition efficiency.It was found that white tungstic acid has more W-OH bonds and much higher co-deposition efficiency with Y^3+ions than yellow tungstic acid.It is illustrated that the coordination reaction between W-OH bonds on tungstic acid particles and Y^3+ions brings the co-deposition of yttrium and tungsten component into being.Through displacing H^+ions in W-OH bonds,Y^3+ions can be adsorbed on the surface of or incorporated into tungstic acid particles in form of ligand.Consequently,to control and regulate Y2 O3 content in powder precursor accurately,H^+ion concentration in wet chemical reaction should be in range of 0.55-2.82 mol L^-1 to obtain white tungstic acid.Besides,H^+ion concentration also has prominent effect on the grain size and morphology of reduced powder precursor.The optimal value should be around 1.58 mol L^-1,which can lead to minimum W grain size(about 17 nm) without bimodal structure.The chemical mechanism proposed in this work could produce great sense to preparation of high-quality precursor for sintering high-performance Y2 O3 dispersion strengthened W based alloys.Our work may also shed light on the approach to exploit analogous synthesis mechanism in other alloy systems. | Zhi Dong Nan Liu Weiqiang Hu Zongqing Ma Chong Li Chenxi Liu Qianying Guo Yongchang Liu | 2020 | Journal of Materials Science & Technology2020，36，1： | 7 |
| 3 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 4 | Defect detection in atomic-resolution images via unsupervised learning with translational invariance显示文摘Crystallographic defects can now be routinely imaged at atomic resolution with aberration-corrected scanning transmission electron microscopy(STEM)at high speed,with the potential for vast volumes of data to be acquired in relatively short times or through autonomous experiments that can continue over very long periods.Automatic detection and classification of defects in the STEM images are needed in order to handle the data in an efficient way.However,like many other tasks related to object detection and identification in artificial intelligence,it is challenging to detect and identify defects from STEM images.Furthermore,it is difficult to deal with crystal structures that have many atoms and low symmetries.Previous methods used for defect detection and classification were based on supervised learning,which requires human-labeled data.In this work,we develop an approach for defect detection with unsupervised machine learning based on a one-class support vector machine(OCSVM).We introduce two schemes of image segmentation and data preprocessing,both of which involve taking the Patterson function of each segment as inputs.We demonstrate that this method can be applied to various defects,such as point and line defects in 2D materials and twin boundaries in 3D nanocrystals. | Yueming Guo Sergei V.Kalinin Hui Cai Kai Xiao Sergiy Krylyuk Albert V.Davydov Qianying Guo Andrew R.Lupini | 2021 | npj Computational Materials2021，，1： | 2 |
| 5 | Effects of Olanzapine–Fluoxetine Combination Treatment of Major Depressive Disorders on the Quality of Life During Acute Treatment Period显示文摘 | Wei Qu Shanshan Gu Han Luo Qianying Tang Junwei Guo | 2014 | Cell Biochemistry and Biophysics2014，，3： | 1 |
| 6 | A new type-γ'/γ''coprecipitation behavior and its evolution mechanism in wrought Ni-based ATI 718Plus superalloy显示文摘In the precipitation-hardened Ni-based superalloy,typified by ATI 718 Plus,the nano-scaleγandγphase in duplet or triple coprecipitate morphology can provide superior high-temperature strength.Thus,it is of great sense to study the evolution ofγ’/γ’’coprecipitate during long term service at elevated temperature.In this study,the new-typeγ’/γ’’coprecipitates with a sandwich or compact configuration were found firstly in wrought ATI 718 Plus superalloy during long term thermal exposure at 705℃.These co-structure of theγ’/γ’’precipitates evidently inhibit the coarsening ofγ’phase.The increase of thermal exposure time evidently leads to the increase of the volume fraction ofγ’/γ’’coprecipitate and transformation of sandwich-typeγ’/γ’’coprecipitate to compact-typeγ’/γ’’coprecipitate,which is characterized asγphase precipitate at several faces of theγphase.The main evolution mechanism ofγ’/γ’’coprecipitates is element segregation,especially the composition variations of Al+Ti and Nb and their ratio of Al+Ti/Nb.In addition,the interfacial energy betweenγ’’phase andγmatrix also plays a key role on theγ’/γ’’coprecipitates evolution.The calculated results show that the longer thermal exposure time leads to the higher interfacial energy,which is beneficial for nucleation and precipitation ofγ’’phase on the faces ofγ’phase. | Qianying Guo Zongqing Ma Zhixia Qiao Chong Li Teng Zhang Jun Li Chenxi Liu Yongchang Liu | 2022 | Journal of Materials Science & Technology2022，，24： | 1 |
| 7 | 显示文摘 | Liu Hongquan Zheng Tiantian Guo Qianying | 2012 | Rare Metal Materials and Engineering2012，41，4： | 1 |
| 8 | Exploring the role of autophagy during early human embryonic development through single-cell transcriptome and methylome analyses显示文摘Early human embryogenesis is a very sophisticated process due to its unique gene regulatory network.Autophagy has been suggested to play an important role in mediating the development of early embryonic cells in mammals.However,evidence showing how autophagy regulates early human embryogenesis remains to be further explored.In this study,we systematically investigated the human transcriptome and methylome patterns of autophagy-related(ATG)genes in early embryonic cells at single-cell resolution.We analyzed the transcriptomic data of 365 cells and methylome data of 265 cells.The results showed that most ATG genes remained epigenetically active and were expressed stably throughout early embryogenesis,whereas the dynamics varied among different developmental stages.This evidence indicated that the autophagy pathway was constitutively activated and exerted a fundamental role in early human embryo development.Our work,for the first time,comprehensively reveals the features of autophagy during early human embryo development. | Shi Song Qianying Guo Yiru Zhu Peng Yuan Zhiqiang Yan Liying Yan Jie Qiao | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 9 | The proteome of IVF-induced aberrant embryo-maternal crosstalk by implantation stage in ewes显示文摘Background:Implantation failure limits the success of in vitro fertilization and embryo transfer(IVF-ET).Wellorganized embryo-maternal crosstalk is essential for successful implantation.Previous studies mainly focused on the aberrant development of in vitro fertilized(IVF)embryos.In contrast,the mechanism of IVF-induced aberrant embryo-maternal crosstalk is not well defined.Results:In the present study,using ewes as the model,we profiled the proteome that features aberrant IVF embryo-maternal crosstalk following IVF-ET.By comparing in vivo(IVO)and IVF conceptuses,as well as matched endometrial caruncular(C)and intercaruncular(IC)areas,we filtered out 207,295,and 403 differentially expressed proteins(DEPs)in each comparison.Proteome functional analysis showed that the IVF conceptuses were characterized by the increased abundance of energy metabolism and proliferation-related proteins,and the decreased abundance of methyl metabolism-related proteins.In addition,IVF endometrial C areas showed the decreased abundance of endometrial remodeling and redox homeostasis-related proteins;while IC areas displayed the aberrant abundance of protein homeostasis and extracellular matrix(ECM)interaction-related proteins.Based on these observations,we propose a model depicting the disrupted embryo-maternal crosstalk following IVF-ET:Aberrant energy metabolism and redox homeostasis of IVF embryos,might lead to an aberrant endometrial response to conceptus-derived pregnancy signals,thus impairing maternal receptivity.In turn,the suboptimal uterine environment might stimulate a compensation effect of the IVF conceptuses,which was revealed as enhanced energy metabolism and over-proliferation.Conclusion:Systematic proteomic profiling provides insights to understand the mechanisms that underlie the aberrant IVF embryo-maternal crosstalk.This might be helpful to develop practical strategies to prevent implantation failure following IVF-ET. | Qianying Yang Wei Fu Yue Wang Kai Miao Haichao Zhao Rui Wang Min Guo Zhilong Wang Jianhui Tian Lei An | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 0 |
| 10 | Precipitates evolution and tensile behavior of wrought Ni-based ATI 718Plus superalloy during long-term thermal exposure显示文摘In this paper,the microstructure evolution and tensile behavior of wrought ATI 718 Plus superalloy during long-term thermal exposure(LTTE) were investigated.The γ’ phase evolves from spherical morphology to cuboidal morphology at 800℃,which is related to increasing γ’/γ misfit because of the increase of elastic energy.The amounts of η phase obviously increased and γ’ precipitate free zones(PFZs) were found in 800-LTTE samples due to the increase of η phase amount by consuming Al,Ti,and Nb.According to the formula of “MC+γ→M_(23)C_(6)+η”,η phase is also related to the decomposition of MC carbide,which involves the diffusion and segregation of Nb and Ti.In addition,some short rod-like and irregular Cr,Mo-rich σ phases were prone to precipitate near η phases after LTTE at 800℃ for 500 and 1000 h.σ phase has a crystallographic relationship with ηphase as(002)_(σ)//(10■0)_(η),[0■0]_(σ)//[01■0]_(η).The deteriorated tensile strength after LTTE is mainly attributed to that:(1) the evident coarsening of γ’ phase results in that the deformation mechanism transforms from stacking faults(SFs) shearing to Orowan looping,which is also convinced by calculated critical resolved shear stress(CRSS);(2) the noticeable increasing number of η phase contributes to stress concentration,resulting in micro-cracks formation;and (3) the apparently increasing number of η phase promotes the PFZs formation. | GUO QianYing JI KangKang ZHANG Teng QIAO ZhiXia LI Chong LI Jun LIU ChenXi LIU YongChang | 2022 | Science China(Technological Sciences)2022，65，6： | 0 |
| 11 | Olefin-linked covalent organic frameworks with twisted tertiary amine knots for enhanced ultraviolet detection显示文摘Though Olefin-linked covalent organic frameworks(oCOFs)possess excellentπ-electron delocalization,the barely reversible olefin linkage brings challenges for oCOFs’synthesis and functionalization.Here,we synthesize new oCOFs with tertiary amine knots which have twisted configuration and electron-donating nature.Investigation into the structural variation and photoelectric performance shows that the twisted configuration of oCOF-TFPA could favor to the intramolecular charge transfer process and reduce the pos-sibility of aggregation-caused quenching.Photoelectrical measurements and electric band structure cal-culation both verify the superiority of this oCOFs’structure in photoelectric sensing. | Qianying Guo Hongyan Ji Lei Yang Daizong Ji Zhaolin Ai Shi Luo Jiatao Sun Yunqi Liu Dacheng Wei | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 12 | Strong Anisotropic Order Parameters at All-Nitride Ferromagnet/Superconductor Interfaces显示文摘Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Cooper pairs and ferromagnetic exchange interactions.The proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM interfaces.We fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined interfaces.The magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external perturbations.Moreover,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)N.We observe the intriguing competition of interfacial spin orientations near��T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices. | Qiao Jin Meng Yang Guozhu Song Nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang Yiyan Fan Chen Ge Can Wang Jiachang Bi Yanwei Cao Liusuo Wu Shanmin Wang Kui-Juan Jin Zhi-Gang Cheng Er-Jia Guo | 2024 | Chinese Physics Letters2024，41，2： | 0 |
| 13 | Precipitation sequences in rapidly solidified Allvac 718Plus alloy during solution treatment显示文摘Allvac 718Plus alloy is a compromising Ni-based superalloy at elevated-temperature of 704℃,due to its combination of good mechanical properties and excellent structure stability.The precipitation behaviors during heat treatment in Allvac 718Plus alloy processed by rapid solidification technique were systematically investigated in this work.The evolution of secondary phases in rapidly solidified(RS)718Plus alloy during annealing at 960℃is:η+MC in 1 h,η+MC+Laves(C14)in 6 h,and MC+Laves(C14)in longer duration.The growth and dissolution behaviors ofηphase are evidenced in RS samples and different types of dislocations at theη/γinterface are characterized.Based on these experimental observations,we examine the transformation mechanisms ofγ→ηandη→γ,which are related to the formation of stacking faults(SFs)with a1/6[211]γShockley partial dislocation and the climbing of14[0001]ηedge dislocations at theη/γinterface,respectively.Both MC and Laves(C14)phases are enriched in Nb and Mo,with a higher level of Ti in MC carbides and Cr in the Laves(C14)phase.The precipitation of MC carbides is driven by the high concentration of C atoms inγ-matrix,while the Cr segregation promotes the later nucleation of Laves(C14)phase inγ-matrix around MC carbides,which is due to the Cr atoms rejection from MC carbides into the matrix. | Liting Tang Qianying Guo Chong Li Chenxi Liu Yongchang Liu | 2022 | Journal of Materials Science & Technology2022，，33： | 0 |
| 14 | Advance and Economic Benefit Made in PetroleumIntegrated Exploration of CNPC显示文摘AdvanceandEconomicBenefitMadeinPetroleumIntegratedExplorationofCNPC￥DengLongwuandGuoQianie(ExplorationBureauofchinaNationalPe... | Deng Longwu and Guo Qianie(Exploration Bureau of china National Petroleum Corporation) | 1996 | China Oil & Gas1996，3，2： | 0 |
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