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| 1 | Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma显示文摘AIM: To assess serum cartilage oligomeric matrix protein(COMP) as a marker of cirrhosis and risk of progression to hepatocellular carcinoma(HCC). METHODS: A COMP enzyme-linked immunosorbentassay was used to test 187 patients with chronic liver diseases at the time point of first evaluation. The selected patients included 72 with chronic hepatitis B infection, 75 with chronic hepatitis C infection, 22 with primary biliary cirrhosis, 7 with autoimmune hepatitis type 1, and 11 with alcoholic liver disease. Demographic, biochemical, histological and clinical characteristics of the patients were recorded at the first evaluation. One hundred and forty-seven patients were followed for a median [interquartile range(IQR)] duration of 96.5(102) mo. The clinical, biochemical and histological data, as well as the development of cirrhosis, HCC according to internationally accepted criteria and in case of death, a liver-related cause during the follow-up period, were recorded at the electronic database of our clinic. COMP determination was also performed in 43 healthy individuals who served as the control study group.RESULTS: COMP positivity(> 15 U/L) was detected in 22%-36% among chronic liver disease groups. Strikingly, almost 83% of COMP-positive patients were cirrhotic at baseline, independently of cause of liver disease. Among the patients who developed HCC during follow-up, 73.7%(14/19) were COMP positive at baseline. COMP positivity was significantly associated with older age(P < 0.001), advanced fibrosis(P = 0.001) and necroinflammatory activity(P = 0.001), higher aspartate aminotransferase(P < 0.001), alanine aminotransferase(P < 0.02), γ-glutamyl transpeptidase(P = 0.003), alkaline phosphatase(P = 0.001), bilirubin(P < 0.05), international normalized ratio(P = 0.002) and alpha-fetoprotein levels(P < 0.02), and lower albumin(P < 0.001), and platelet count(P = 0.008). COMP levels [median(IQR)] were significantly higher in cirrhotics compared to non-cirrhotics [13.8(7.9) U/L vs 9.8(4.6) U/L, respectively; P < 0.001]. On multivariate logistic regression analysis, COMP-positivity was independently associated only with cirrhosis(OR = 4.40, 95%CI: 1.33-14.69, P = 0.015). Kaplan-Meier analysis showed that COMP positivity was significantly associated with HCC development(P = 0.007) and higher incidence of liver-related death(P < 0.001). CONCLUSION: Elevated COMP levels are strongly associated with cirrhosis and HCC progression. Serum COMP is a new promising non-invasive biomarker for HCC risk assessment in surveillance programs. | Gary L Norman Nikolaos K Gatselis Zakera Shums Christos Liaskos Dimitrios P Bogdanos George K Koukoulis George N Dalekos | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 2 | Circulating adiponectin levels are associated with better glycemic control,more favorable lipid profile,and reduced inflammation in women with type 2 diabetes显示文摘 | Christos SM Tricia L Joann E | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 3 | Pain management in trauma patients显示文摘 | Cohen SP Christo PJ Moroz L | 2004 | Am J Phys Med Rehabil2004，83，2： | 1 |
| 4 | Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone显示文摘 | Dominique ST Christo IT Eric L | 2003 | Eur J Cardiothorac Surg2003，24，1： | 1 |
| 5 | Defect/damage toler-ance of pressurized fiber composite shells显示文摘 | Christos C C Minnetyan L | 2001 | Com-posite Structures2001，51，： | 1 |
| 6 | Structurally tailored organic-inorganic perovskites: Optical properties and solution-processed channel material for thin-film transistors显示文摘 | David B Mitzi Christos D Dimitrakopoulos Laura L Kosbar | 2001 | Chem Mater2001，13，： | 1 |
| 7 | Retrograde nailing and compression bolts in the treatment of type C distal femoral fractures显示文摘 | CHRISTOS G PANAGIOTIS L NIKOLAOS G | 2012 | Injury2012，43，： | 1 |
| 8 | Reduced Connexin43 Expression Limits Neointima Formation After Balloon Distension Injury in Hypercholesterolemic Mice显示文摘 | Christos E. Chadjichristos Christian M. Matter Isabelle Roth Esther Sutter Graziano Pelli Thomas F. Lüscher Marc Chanson Brenda R. Kwak | 2006 | Circulation2006，，24： | 1 |
| 9 | Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone显示文摘 | Dominique ST Christo IT Eric L | 2003 | Eur J Cardio thorac Surg2003，24，1： | 1 |
| 10 | Single nucleotide polymorphisms in obesity-related genes and all-canse and cause-specific mortality : a prospective cohort study 显示文摘 | Gallicchio L Chang HH Christo DK | 2009 | BMC Medical Genetics2009，10，1： | 1 |
| 11 | Pain management intrauma patients显示文摘 | Cohen SP Christo PJ Moroz L | 2004 | Am J Phys Med Rehabil2004，83，2： | 1 |
| 12 | Deletion of PTENP1 pseu-dogene in human melanoma显示文摘 | Poliseno L Haimovic A Christos PJ | 2011 | J Invest Dermatol2011，131，12： | 1 |
| 13 | Spe eiation of phosphorus fractionation in river sedi ments by explanatory data analysis显示文摘 | Christos Z Katsaounos Dimosthenis L | 2007 | Water Re search2007，41，： | 1 |
| 14 | Slip-flow Heat Transfer in Circular Tubes显示文摘 | Francisco E L Christos H Yannis D | 2000 | International Journal of Heat and Mass Transfer2000，43，15： | 1 |
| 15 | The effect of negative pressure therapy on the femoral vein blood flow and wall structure 显示文摘 | Christos L Thomas K Calypso B | 2009 | Angiology2009，60，3： | 1 |
| 16 | 显示文摘 | Christos L Chochosa Giannis K Govarisa Fotini Kakali | 2005 | Polymer2005，46，13： | 1 |
| 17 | Synthesis of a solu- ble n-Type cyano substituted polythiophene derivative: A potential electron aceeptor in polymeric solar cells显示文摘 | Christos C L Economopoulos S P Deimede V | 2007 | J Phys Chem C2007，111，10： | 1 |
| 18 | Modeling, analysis, and optimal control of a class of hybrid systems显示文摘 | DAVID L P CHRISTOS G C | 1998 | Discrete Event Dy-namic Systems: Theory and Applications1998，7，2： | 1 |
| 19 | Exploiting mobility for efficient coverage in sparse wireless sensor networks显示文摘 | Theofanis L Christos P Santiago F | 2010 | Journal of Wireless Personal Communications2010，54，1： | 1 |
| 20 | Pain management in trauma patients显示文摘 | Cohen SP Christo PJ Moroz L | 2004 | Am J Phys Med Rehabil2004，83，2： | 1 |
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