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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 3 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 4 | A role for peroxisome proliferator‐activated receptor gamma in resveratrol‐induced colon cancer cell apoptosis显示文摘 | Virginie Aires Bertrand Brassart Annie Carlier Alessandra Scagliarini Stéphane Mandard Emeric Limagne Eric Solary Laurent Martiny Michel Tarpin Dominique Delmas | 2014 | Mol. Nutr. Food Res2014，，9： | 2 |
| 5 | Lessons from French national guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients显示文摘 | Dominique Farge Cecile Durant Stéphane Villiers Anne Long Alfred Mahr Michel Marty Philippe Debourdeau | 2010 | Thrombosis Research2010，，： | 2 |
| 6 | Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone显示文摘 | Dominique ST Christo IT Eric L | 2003 | Eur J Cardiothorac Surg2003，24，1： | 1 |
| 7 | Imaging aspects and non-surgical interventional treatment in human alveolar echinococcosis显示文摘 | Solange Bresson-Hadni Eric Delabrousse Oleg Blagosklonov Brigitte Bartholomot Stéphane Koch Jean-Philippe Miguet Georges André Mantion Dominique Angèle Vuitton | 2005 | Parasitology International2005，，： | 1 |
| 8 | Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone显示文摘 | Dominique ST Christo IT Eric L | 2003 | Eur J Cardio thorac Surg2003，24，1： | 1 |
| 9 | DRB4-Dependent TAS3 trans -Acting siRNAs Control Leaf Morphology through AGO7显示文摘 | Xavier Adenot Taline Elmayan Dominique Lauressergues Stéphanie Boutet Nicolas Bouché Virginie Gasciolli Hervé Vaucheret | 2006 | Current Biology2006，，9： | 1 |
| 10 | A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis显示文摘 | Line Claude David Pérol Chantal Ginestet Lionel Falchero Dominique Arpin Michel Vincent Isabelle Martel Stéphane Hominal Jean-Fran?ois Cordier Christian Carrie | 2004 | Radiotherapy and Oncology2004，，2： | 1 |
| 11 | Simultaneous determination of nine tyrosine kinase inhibitors by 96-well solid-phase extraction and ultra performance LC/MS-MS显示文摘 | Stéphane Bouchet Emmanuelle Chauzit Dominique Ducint Nadège Castaing Mireille Canal-Raffin Nicholas Moore Karine Titier Mathieu Molimard | 2010 | Clinica Chimica Acta2010，，11： | 1 |
| 12 | Excessive alcohol consumption after liver transplantation impacts on long-term survival, whatever the primary indication显示文摘 | Stéphanie Faure Astrid Herrero Boris Jung Yohan Duny Jean-Pierre Daures Thibaut Mura Eric Assenat Micha?l Bismuth Hassan Bouyabrine Hélène Donnadieu-Rigole Francis Navarro Samir Jaber Dominique Larrey Georges-Philippe Pageaux | 2012 | Journal of Hepatology2012，，2： | 1 |
| 13 | Do all patients with childhood-onset growth hormone deficiency (GHD) and ectopic neurohypophysis have persistent GHD in adulthood?显示文摘 | Juliane L Stéphanie D Dominique S | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 14 | Oceanic survival and movements of wild and captive-reared immature green turtles (Chelonia mydas) in the Indian Ocean显示文摘 | Dominique Pelletier David Roos Stéphane Ciccione | 2003 | Aquat Living Resour2003，16，： | 1 |
| 15 | Incidental focal solid liver lesions: diagnostic performance of contrast-enhanced ultrasound and MR imaging显示文摘 | Michael Soussan Christophe Aubé Stéphane Bahrami Jér?me Boursier Dominique Charles Valla Valérie Vilgrain | 2010 | European Radiology2010，，7： | 1 |
| 16 | Meta-Analysis of Ten Trials on the Effectiveness of the Radial Versus the Femoral Approach in Primary Percutaneous Coronary Intervention显示文摘 | Dominique Joyal Olivier F. Bertrand Stéphane Rinfret Avi Shimony Mark J. Eisenberg | 2012 | The American Journal of Cardiology2012，，6： | 1 |
| 17 | Herbal medicine hepatotoxicity: A new step with development of specific biomarkers显示文摘 | Dominique Larrey Stéphanie Faure | 2011 | Journal of Hepatology2011，，4： | 1 |
| 18 | Primary repair minimizing the use of conduits in neonates and infants with tetralogy or double-outlet right ventricle and anomalous coronary arteries 显示文摘 | Christo IT Marc PP Dominique ST | 2000 | J Thorac Cardiovasc Surg2000，119，： | 1 |
| 19 | Marrow stromal cells for cellular cardiomyoplasty: Feasibility and potential clinical advantages显示文摘 | Wang JS Dominique ST Jacques G | 2000 | J Thorac Cardiovasc Surg2000，120，5： | 1 |
| 20 | Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages 显示文摘 | Wang JS Dominique ST Galipeau J | 2000 | J Thorac Cardiovasc Surg2000，120，5： | 1 |
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