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| 1 | Pollution characteristics of ambient PM_(2.5)-bound PAHs and NPAHs in a typical winter time period in Taiyuan显示文摘The pollution characteristics of ambient fine particulate matter(PM2.5) containing polycyclic aromatic hydrocarbons(PAHs) and nitrated PAHs(NPAHs) in samples collected during a typical winter time period in Taiyuan of China were investigated.The obtained results revealed that the mean mass concentrations of PM2.5,SPAHs(sum of 16 PAHs) and SNPAHs(sum of 3 NPAHs) on PM2.5were161.4 mg/m3,119.8 ng/m3and 0.446 ng/m3,respectively.Diagnostic ratios of PAHs and NPAHs implied that coal consumption might be the main source of the PM2.5pollution.The measured PM2.5mass concentrations,BaP equivalent toxicity(28.632 ng/m3) and individual carcinogenicity index(3.14 10 5) were much higher than those of the recommended safety standards. | Rui-Jin Li Xiao-Jing Kou Hong Geng Chuan Dong Zong-Wei Cai | 2014 | Chinese Chemical Letters2014，25，5： | 17 |
| 2 | LARGE EDDY SIMULATION OF OPEN CHANNEL FLOWS WITH NONSUBMERGED VEGETATION显示文摘Results of several Large Eddy Simulations (LES) of open channel flows with non-submerged vegetation are presented in this article. It is shown that the vegetation can make the flow structure in the mainstream direction uniform for both supercritical and subcritical flows. For subcritical flows, the LES results of the ensemble-average of time-averaged velocity distributions at four vertical sections around a single plant are in good agreement with measurements. The velocity sees double peaks at the upper and lower positions of flows. For supercritical flows, the ensemble-average velocities see some discrepancy between LES and measurement results. Some secondary flow eddies appear near the single plant, and they just locate in the positions of the double peaks in stream-wise velocity profiles. It is also found that the vegetation drag coefficient deceases as the Froude number increases. | HUAI Wen-xin WU Zhen-lei QIAN Zhong-dong GENG Chuan | 2011 | Journal of Hydrodynamics2011，23，2： | 11 |
| 3 | Facile synthesis of Li3V2(PO4)3/C cathode material for lithium-ion battery via freeze-drying显示文摘In this work, we report a facile route for the synthesis of Li3V2(PO4)3/C cathode material via freezedrying and then calcination. The effect of calcination temperature on the electrochemical properties of the Li3V2(PO4)3/C is also investigated. When used as a lithium-ion battery cathode, the optimized Li3V2(PO4)3/C (LVP-800) through calcination at 800 ℃ exhibits a high initial charge and discharge capacity. The excellent electrochemical performance of LVP-800 is attributed to the good crystallinity and uniform morphology of the electrode material. In addition, the residual carbon can also improve the conductivity and buffer the volume expansion during the Li-ion extraction/reinsertion. Meanwhile, charge compensation also plays an important role in excellent electrochemical performance. | Shuainan Guo Ying Bai Zhenfeng Geng Feng Wu Chuan Wu | 2019 | Journal of Energy Chemistry2019，28，5： | 8 |
| 4 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 5 | Circulating MicroRNAs as Novel Diagnostic Biomarkers for Very Early-onset(≤40 years) Coronary Artery Disease显示文摘Objective Very early-onset coronary artery disease(CAD) is a great challenge in cardiovascular medicine throughout the world,especially regarding its early diagnosis.This study explored whether circulating micro RNAs(mi RNAs) could be used as potential biomarkers for patients with very early-onset CAD.Methods We performed an initial screening of mi RNA expression using RNA isolated from 20 patients with angiographically documented very early-onset CAD and 20 age-and sex-matched normal controls.For further confirmation,we prospectively examined the mi RNAs selected from 40 patients with very early-onset CAD and 40 angiography-normal controls.Results A total of 22 overexpressed mi RNAs and 22 underexpressed mi RNAs were detected in the initial screening.RT-q PCR analysis of the mi RNAs obtained from the initial screening revealed that four mi RNAs including mi R-196-5p,mi R-3163-3p,mi R-145-3p,and mi R-190a-5p exhibited significantly decreased expression in patients compared with that in controls(P<0.05).The areas under the receiver operating characteristic curve for these mi RNAs were 0.824(95% CI,0.731-0.917;P<0.001),0.758(95% CI,0.651-0.864;P<0.001),0.753(95% CI,0.643-0.863;P<0.001),and 0.782(95% CI,0.680-0.884;P<0.001),respectively,in the validation set.Conclusion To our knowledge,this is an advanced study to report about four serum mi RNAs(mi R-196-5p,mi R-3163-3p,mi R-145-3p,and mi R-190a-5p) that could be used as novel biomarkers for the diagnosis of very early-onset CAD. | DU Ying YANG Sheng Hua LI Sha CUI Chuan Jue ZHANG Yan ZHU Cheng Gang GUO Yuan Lin WU Na Qiong GAO Ying SUN Jing DONG Qian LIU Geng LI Jian Jun | 2016 | Biomedical and Environmental Sciences2016，29，8： | 5 |
| 6 | Formation blockage risk analysis of geothermal water reinjection:Rock property analysis,pumping and reinjection tests,and long-term reinjection prediction显示文摘The blockage induced by particle migration and deposition is one of the main reasons for the decrease of reinjection capacity in the porous geothermal reservoir with a low and medium temperature.In this paper,a new drilled geothermal well in Xining basin China is taken as an example to investigate the formation blockage risk due to the movable clay and sand particles in pores.The physical properties of the reservoir rocks were analyzed,a series of pumping and reinjection tests were conducted,and the longterm reinjection performance of the well was predicted by numerical simulation based on the test fitting.The results show that the geothermal reservoir rocks are argillaceous and weakly cemented sandstones with a content of movable clay and sand particles up to 0.18–23.42 wt.%.The well presented a high productivity of 935–2186 m3?d-1 at a pressure difference of 0.7–1.62 MPa in the pumping tests associated with a large amount of clay and sand particles produced out,while in the reinjection test,only a low injectivity of 240–480 m3?d-1 was observed at an injection pressure of 0.2–0.6 MPa with the clay and sand particles near the wellbore move into deep.According to the prediction,under conditions of a blockage risk,the injectivity of the well will start to decline after 100 days of injection,and in the third year,it will decrease by 59.00%–77.09%.The influence of invasion of pretreated suspended particles and scale particles can be neglected.Under conditions of a high blockage risk,the injectivity of the well will decrease significantly in the first 20–30 days,with a decline of 75.39%–78.96%.Generally,the higher the injection pressure or rate,the greater the decrease in injectivity of the well caused by particle blockage.Pump lifting is an effective measure to remove the well blockage which can be used regularly. | Liang Zhang Songhe Geng Linchao Yang Ronghua Wen Chuan He Zhen Zhao Guangxiong Qin | 2022 | Geoscience Frontiers2022，13，1： | 3 |
| 7 | Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts显示文摘The aim of this study was to investigate the chemical compositions of chalk dust and examine the adverse effects of fine chalk particle matters(PM_(2.5)) on rat alveolar macrophages(AMs) in vitro.Morphologies and element concentrations of chalk particles were analyzed using quantitative energydispersive electron probe X-ray microanalysis(ED-EPMA).The oxidative response of AMs exposed to chalk PM_(2.5) was measured by luminol-dependent chemiluminescence(CL).The results showed that(1)Chalk dust was mainly composed of gypsum(CaSO_4),calcite(CaCO_3)/dolomite(CaMg(CO_3)_2),and organic adhesives;(2) Fine chalk particles induced the AM production of CL,which was inhibited by about 90%by diphenyleneiodonium chloride(DPI).Based on these results,we showed that cytotoxicity of chalk PM_(2.5) may be related to the reactive oxygen species(ROS) generation. | Yue-Xia Zhang Zhen-Hua Yang Quan-Xi Zhang Rui-Jin Li Hong Geng Chuan Dong | 2015 | Chinese Chemical Letters2015，26，1： | 2 |
| 8 | The strengthening effect of a static magnetic field on activated sludge activity at low temperature 显示文摘 | Niu Chuan Geng Jinju Ren Hongqiang | 2013 | Bioresource Technology2013，150，12： | 1 |
| 9 | An Efficient Preconditioning Technique for Numerical Simulation of Hydrodynamic Model Semiconductor Devices显示文摘 | YANG Geng WANG Shao di WANG Ru chuan | 2003 | International Journal on Numerical Simulation:Electronic Networks Devices Fields2003，16，8： | 1 |
| 10 | An adaptive remeshing technique based on hierarchical error estimates for simulation of semiconductor devices显示文摘 | YANG Geng WANG Ru chuan WANG Shao di | 2004 | International Journal on Numerical Simulation:Electronic Networks Devices Fields2004，17，1： | 1 |
| 11 | Immunological and metabolic characteristics of the Omicron variants infection显示文摘The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global pandemics.Here,we systemically examined immunological and metabolic characteristics of Omicron variants infection.We found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype SARS-CoV-2.Omicron could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta variant.Through mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with Delta.These epitopes could induce robust CD8+T cell responses.Moreover,we found booster vaccination increased the cross-memory CD8+T cell responses against Omicron.Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T cells.Consistently,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of Omicron.CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia.Taken together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron. | Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo Chen Zhi-Nan Chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui Chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping Zhu Huijie Bian Liang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 12 | Recombinant human vascular endostatin injection to synchronize craniospinal radiotherapy for the treatment of recurrent medulloblastoma in children:A retrospective clinical study显示文摘Objective Medulloblastoma(MB)is the most common primary central nervous system malignancy in children.Nonetheless,there is no standard treatment for recurrent MB.The purpose of this study was to investigate the clinical value and toxicity of recombinant human endostatin injection(Endostar~?)combined with craniospinal radiotherapy for the treatment of recurrent MB in children.Methods This study retrospectively analyzed 13 patients with recurrent MB aged 5–18 years.Endostar?7.5 mg/m~2/d was synchronized during craniospinal radiotherapy for 7 children with a portable micro uniform speed infusion pump.Endostar~?was applied 3 days prior to the initiation of radiotherapy.The drug was in continuous use for 7 days.Similarly,the withdrawal of the drug took place over 7 days.This represented a cycle.During radiotherapy,the application was repeated until the end of radiotherapy(experimental group).In the other 6 cases,only craniospinal radiotherapy was used(control group).Results The complete remission rate was 71.4%in the experimental group and 16.7%in the control group.The median progression-free survival(PFS)was 14 months(95%CI:0.0–29.60)and 19 months(95%CI:0.0–39.53)in the experimental and control groups,respectively.The median overall survival(OS)was 19 months(95%CI:0.0–38.20)and 23 months(95%CI:2.47–43.53)in the experimental and control groups,respectively.The most common adverse events included grade 1 thrombocytopenia(7.7%),grade 3 neutropenia(38.5%),and grade 1 anemia(30.8%).Conclusion Endostar~?synchronizing craniospinal radiotherapy significantly improved the complete response rate of children with recurrent MB.It did not increase the side effects of radiation therapy.However,it did not improve the PFS or OS. | Yang Song He Xiao Chuan Chen Ping Liang Wenyuan Ji Mingying Geng | 2021 | Oncology and Translational Medicine2021，7，3： | 0 |
| 13 | Microstructure and Improved Thermal Shock Behaviour of an In Situ Formed Metal-Enamel Interlocking Coating显示文摘A novel metal-enamel interlocking coating was designed and prepared in situ by co-deposition of Ni-enamel composite layer and subsequent air spray of enamel with 10 wt% nanoscale Ni. During the firing process, the external enamel layer was melted and jointed with the enamel particles at the upper part of the Ni-plating layer to form the enamel pegs. Thermal shock tests of pure enamel, enamel with 10 wt% Ni composite and metal-enamel interlocking coatings were conducted at 600 °C in water and static air. The results indicated that the metal-enamel interlocking showed superior thermal shock resistance to both pure enamel and enamel with 10 wt% Ni composite coatings. The enhanced performance was mainly attributed to the advantageous effects of mechanical interlocking of the enamel pegs formed at the enamel/Ni-plating interface. Meanwhile, during thermal shock test, big clusters formed by nanoscale Ni agglomerations were oxidised to be a Ni/NiO core–shell structure while small single nanoscale Ni grains were oxidised completely, which both improved the thermal shock resistance of enamel coating significantly. | Hang Wang Chuan Zhang Chengyang Jiang Lijuan Zhu Lihong Han Minghui Chen Shujiang Geng Fuhui Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，8： | 0 |
| 14 | Dual precipitate simultaneous enhancement of tensile and fatigue strength in(FeCoNi)_(86)Al_(7)Ti_(7) high-entropy alloy fabricated using selective laser melting显示文摘Recent studies have indicated that precipitation-strengthened high-entropy alloys(HEAs)show superior mechanical performance and have been successfully fabricated by additive manufacturing.However,the lack of fatigue and fracture research has limited the engineering applications of additive manufacturing HEAs.This work explored a dual precipitation-strengthened(FeCoNi)_(86)Al_(7)Ti_(7) HEA with excellent tensile and fatigue strength,prepared through selective laser melting and heat treatment.Compared with the as-built samples,the tensile properties and fatigue endurance limit improved through aging by 48.7%and 30%,respectively.The strengthening mechanism and enhanced fatigue performance were clarified in detail.The improvement in fatigue strength was attributed to the improved resistance of the L1_(2) and L2_(1) precipitates.During deformation,the dislocation shear coherent L1_(2) precipitates reduced slip band energy and inhibited slip band expansion,while the L2_(1) particles acted as obstructions for further slip band propagation,severely limiting the rapid formation and propagation of crack growth.In-situ TEM cyclic tensile-tensile testing also clarified the fatigue crack growth behavior,demonstrating that crack deflection due to L2_(1) precipitate obstruction slowed down the crack growth rate and efficiently promoted the closure of the microcrack tips.This work offers im plications for a new strategy to develop additive manufacturing HEAs. | Long Xu Yandong Jia Zhenhui Wang Shiwei Wu Yuefei Jia Chuan Geng Jianchao Peng Xiaohua Tan Gang Wang | 2023 | Journal of Materials Science & Technology2023，，17： | 0 |
| 15 | TRIM72‑mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells显示文摘Dear Editor,Autophagy is an evolutionarily conserved catabolic process that involves the sequestration and transport of organelles,macromolecules,or invading microorganisms to lysosomes for degradation[1].Sequestosome 1(p62/SQSTM1)was the first protein shown to bind target-associated ubiquitin(Ub)and LC3 conjugated to the phagophore membrane,thus,acting as an important autophagy receptor for ubiquitinated targets[2]. | Cheng‑Cheng Wang Hong Peng Zi Wang Jiao Yang Rong‑Gui Hu Chuan‑Yin Li Wu‑Jun Geng | 2023 | Military Medical Research2023，10，4： | 0 |
| 16 | CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis显示文摘COVID‐19 patients can develop clinical and histopathological features associated with fibrosis,but the pathogenesis of fibrosis remains poorly understood.CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants,which could initiate COVID-19-related cytokine storm.Here,we systemically analyzed lung pathogenesis in SARS-CoV-2-and its delta variant-infected humanized CD147 transgenic mice.Histopathology and Transmission Electron Microscopy revealed inflammation,fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.Consistently,RNA-sequencing identified a set of fibrosis signature genes.Furthermore,we identified CD147 as a crucial regulator for fibroblast activation induced by SARS-CoV-2.We found conditional knockout of CD147 in fibroblast suppressed activation of fibroblasts,decreasing susceptibility to bleomycin-induced pulmonary fibrosis.Meplazumab,a CD147 antibody,was able to inhibit the accumulation of activated fibroblasts and the production of ECM proteins,thus alleviating the progression of pulmonary fibrosis caused by SARS-CoV-2.In conclusion,we demonstrated that CD147 contributed to SARS-CoV-2-triggered progressive pulmonary fibrosis and identified CD147 as a potential therapeutic target for treating patients with post-COVID-19 pulmonary fibrosis. | Jiao Wu Liang Chen Chuan Qin Fei Huo Xue Liang Xu Yang Kui Zhang Peng Lin Jiangning Liu Zhuan Feng Jiansheng Zhou Zhuo Pei Yatao Wang Xiu-Xuan Sun Ke Wang Jiejie Geng Zhaohui Zheng Xianghui Fu Man Liu Qingyi Wang Zheng Zhang Huijie Bian Ping Zhu Zhi-Nan Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 17 | Low-Cost and Scalable Platform with Multiplexed Microwell Array Biochip for Rapid Diagnosis of COVID-19显示文摘Sensitive detection of SARS-CoV-2 is of great importance for inhibiting the current pandemic of COVID-19.Here,we report a simple yet efficient platform integrating a portable and low-cost custom-made detector and a novel microwell array biochip for rapid and accurate detection of SARS-CoV-2.The instrument exhibits expedited amplification speed that enables colorimetric read-out within 25 minutes.A polymeric chip with a laser-engraved microwell array was developed to process the reaction between the primers and the respiratory swab RNA extracts,based on reverse transcriptase loop-mediated isothermal amplification(RT-LAMP).To achieve clinically acceptable performance,we synthesized a group of six primers to identify the conserved regions of the ORF1ab gene of SARS-CoV-2.Clinical trials were conducted with 87 PCR-positive and 43 PCRnegative patient samples.The platform demonstrated both high sensitivity(95.40%)and high specificity(95.35%),showing potentials for rapid and user-friendly diagnosis of COVID-19 among many other infectious pathogens. | Yang Wang Kaiju Li Gaolian Xu Chuan Chen Guiqin Song Zaizai Dong Long Lin Yu Wang Zhiyong Xu Mingxia Yu Xinge Yu Binwu Ying Yubo Fan Lingqian Chang Jia Geng | 2021 | Research2021，，1： | 0 |
| 18 | Synthesis and Optical Properties of Hyperbranched PAEKs Containing Porphyrin and Its Metal Derivatives显示文摘Novel functional hyperbranched poly(aryl ether ketone)s(HPAEKs) bonded with nonlinear optical chromophores(meso-tetrakis(4-hydroxyphenyl) porphyrin, THPP and its metal derivatives) were synthesized and characterized by 1H-NMR and UV-Vis absorption spectra. The incorporation of chromophores into HPAEKs endowed HPAEKs novel NLO and OL properties. Indeed, dendritic architecture allowed for maximum dispersion of the chromophores, avoided aggregation, more optical limiting property was obtained. Simultaneously, they retained the excellent properties of the materials, particularly in thermal stability. Their optical properties were evaluated by nonlinear optical analyses and optical limiting. The results showed that these polymers possessed good optical limiting(OL) property and large nonlinear optical(NLO) susceptibilities(ca. 10 12esu). All polymers containing chromophores presented excellent thermal stability(DT5 > 524.17 °C). | Xu Jiang Yin-long Du Chuan Liu Peng-fei Huo Zhi Geng Shu-ling Zhang 王贵宾 | 2014 | Chinese Journal of Polymer Science2014，32，1： | 0 |
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