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| 1 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 2 | ZNF411, a novel KRAB-containing zinc-finger protein, suppresses MAP kinase signaling pathway显示文摘 | Hui Liu Chuanbing Zhu Jian Luo Yuequn Wang Dali Li Yongqing Li Junmei Zhou Wuzhou Yuan Ying Ou Mingyao Liu Xiushan Wu | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 3 | A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways显示文摘 | Junmei Zhou Yongqing Li Pei Liang Wuzhou Yuan Xiangli Ye Chuanbing Zhu Yingduan Cheng Yuequn Wang Guan Li Xiushan Wu Mingyao Liu | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 4 | ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway显示文摘 | Yongqing Li Dan Yang Yan Bai Xiaoyang Mo Wen Huang Wuzhou Yuan Zhaochu Yin Yun Deng Oleg Murashko Yuequn Wang Xiongwei Fan Chuanbing Zhu Karen Ocorr Rolf Bodmer Xiushan Wu | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 5 | Three Practical Methods for Analyzing Slope Stability显示文摘自从环境能力并且象陆地实际上联系了的居民一样可耕全部的平衡,斜坡为各种各样的工程构造正在成为越来越重要的选择。因为斜坡的地质的复杂性,设计和基于斜坡的设计的决策仍然不是实际的完全依靠理论分析和数字计算,但是主要在专家的经验上。因此,它有重要实际意义把一些成功的经验变成数学方程。在在云南设计构造盒子的丰富的典型斜坡之上基于,西南的中国,为分析斜坡稳定性的 3 个方法在这篇论文被开发了。首先,为分析斜坡稳定性的通信类似的数学方程通过案例研究被建立了。然后,当 7 个主要影响因素被采用时,人工的神经网络和 multivariate 回归分析也被建立了。 | XU Shiguang ZHANG Shitao ZHU Chuanbing Y1N Ying | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 1 |
| 6 | Mapping the transcription repressive domain in the highly conserved human gene hnulp1显示文摘HNULP1,a new member of the basic helixloop-helix transcription factors,contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae,yeast,zebrafish to mouse.The function of this motif,however,is currently unknown.In this research,we fused five deletion fragments of the DUF654 domain to the GAL4 DNA-binding domain and then co-transfected with plasmids L8G5-Luc and VP-16.The analysis of the GAL4 luciferase reporter gene indicated that fragments from 228 to 407 amino acids in the DUF654 domain had a strong transcription repression activity.Therefore,this study lays a solid foundation for research on the mechanism of hnulp1 transcriptional regulation and the function of the DUF654 domain. | Yuequn WANG Lian LIU Zhenyu CAI Yongqing LI Wuzhou YUAN Chuanbing ZHU Yun DENG Xiaoyang MO Xiushan WU | 2008 | Frontiers in Biology2008，3，2： | 0 |
| 7 | Role of the domains of human gene ZNF569 in MAPK pathway显示文摘Mitogen-activated protein kinase(MAPK)signal pathways are important components in signal transduction connecting cell-surface receptors to critical regulatory targets within cells,mediating multiple intracellular signal cascades and phosphorylating their target proteins,such as transcriptional factors ELK-1,SRE and AP-1,and finally activating the expression of intracellular functional genes.Zinc finger genes are some of the largest gene families in humans,and Zinc finger proteins play an essential role in altering gene expression by acting as transcription factors.Zinc finger proteins are also involved in multiple cell processes,including proliferation,differentiation and development,by interacting with DNA.Here,we reported the transcriptional activities of the domains of zinc finger gene ZNF569 taking advantage of MAPK pathway.Overexpression of ZNF569 in COS-7 cells dramatically inhibited the transcriptional repressor activities of SRE and AP-1,which was also confirmed by subcellular localization analysis.Report assays indicated that the potent repression domains of ZNF569 were the KRAB and ZNF motifs.The results suggested that ZNF569 protein might act as a transcriptional repressor in MAPK signaling pathway to regulate cellular processes. | YUAN Wuzhou HUANG Xinqiong ZHU Chuanbing WANG Yuequn LI Yongqing WU Xiushan | 2006 | Frontiers in Biology2006，1，4： | 0 |
| 8 | Advanced studies on human gene ZNF322显示文摘The human novel gene of ZNF322 is cloned from human fetal cDNA library using the primers on the basis of the ZNF322 sequence analyzed with computer.The gene is located on Chromosome 6p22.1,and encodes a protein con-sisting of 402 amino acid residues and containing nine tandem C_(2)H_(2)-type zinc-finger motifs.Northern blot result shows that the gene is expressed in all examined adult tissues.Sub-cellular location study indicates that ZNF322-EGFP fusion protein is distributed in the nucleus and cytoplasm.Reporter gene assays show that ZNF322 is a potential transcriptional activator. | LI Yongqing WANG Yuequn YUAN Wuzhou DENG Yun ZHU Chuanbing WU Xiushan | 2007 | Frontiers in Biology2007，2，4： | 0 |
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