|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | PeerSearch: Efficient Information Retrieval in Peer-to-Peer Networks 显示文摘 | Chunqiang Tang Zhichen Xu Mallik Mahalingam | 2003 | ACM SIGCOMM Computer Communication Review2003，33，1： | 1 |
| 3 | pSeareh : information retrieval in structured overlays显示文摘 | TANG Chunqiang XU Zhichen MAHLINGAM M | 2003 | Computer Communication Review2003，33，1： | 1 |
| 4 | Evolution of the ductile shear zone of the Paishanlou gold deposits,western Liaoning,China显示文摘The combination of field surveys with analysis of microstructure of tectonite and Electron Backscatter Diffraction(EBSD) on quartz fabric indicated that three periods of ductile shear events developed in the Paishanlou gold deposits and the E-W and NE-striking ductile shear zones were formed during each event.The E-W-striking ductile shear zone,accompanied by compressional and dextral shear slip,was shear-cut by the NE-striking shear zones,accompanied by compressional-sinistral shear slip and sinistral-normal shear slip,successively.An E-W-striking ductile shear zone developed at a deeper tectonic level and at middle- to high-temperatures,accompanied by abundant microstructures,including microlayering between a polycrystal quartz belt and mica,and quartz deformation was depended on cylinder(10-10) or glide.The development of an E-W-striking shear zone can be seen as a tectonic pattern in the region of the Paishanlou gold deposits of the collision between the Mongolian tectonic belt and the North Archean Craton from Suolun to the Linxi suture zone during the Indosinian.The NE-striking ductile shear zone developed approximately 160 Ma during the early Yianshanian at middle to shallow tectonic levels and at middle- to low-temperatures,accompanied by typical microstructures,including polycrystal quartz aggregation and quartz subgrain rotation recrystallization,etc.,and quartz deformation was depended on prismatic(1011) glide.The last ductile shear event around the NE-striking shear zone developed at low temperatures and shallow tectonic levels,yielding to a pre-existing NE-striking shear zone,accompanied by abundant microstructures,including low-temperature quartz grain boundary migration and bulging recrystallization.The last ductile shear movement may be related to lithosphere thinning and the destruction of the North China Craton from approximately 130-120 Ma,and this shear event resulted directly in the mineralization in the Paishanlou region. | NI JinLong LIU JunLai TANG XiaoLing ZHAO ChunQiang ZENG QingDong | 2014 | Science China Earth Sciences2014，57，4： | 1 |
| 5 | pSearch :information retrieval in structured overlays显示文摘 | Tang Chunqiang Xu Zhichen Mahalingam M | 2003 | Computer Communication Review2003，33，1： | 1 |
| 6 | Automatic Home Medical Product Recommendation显示文摘 | Gang Luo Selena Thomas Chunqiang Tang | 2012 | Journal of Medical Systems2012，，2： | 1 |
| 7 | Information retrieval in structured overlays显示文摘 | Tang Chunqiang Xu Zhichen Mahalingam M | 2002 | ACM SIGCOMM Computer Communication Review2002，33，1： | 1 |
| 8 | Towards a semantic aware file store显示文摘 | Zhichen Xu Magnus Karlsson Chunqiang Tang Christos Karamanolis | 2003 | HP laboratories palo Alto CA943042003，4，： | 1 |
| 9 | 细根与根系总质量比的相似性导致了共存的本土植物和入侵植物之间植物-土壤反馈的对比显示文摘土壤生物通过植物-土壤的反馈作用调控植物间相互作用和外来植物入侵。因此,探明植物-土壤反馈作用种间差异的形成原因,对于预测土壤生物在植物入侵过程中的作用具有重要价值。近期的研究发现,植物性状可以用于预测植物-土壤反馈作用。同时,研究发现植物入侵也与植物的一些性状相关联,暗示植物-土壤反馈作用通过植物性状与外来植物入侵之间存在关联,但尚缺乏实验证明。鉴于此,本研究选取了3对近缘入侵和本土植物为对象,比较了其植物-土壤反馈作用,探讨了植物-土壤反馈作用与植物根部性状的关联性。首先,通过种植实验植物3个月,驯化采自于田间的土壤。之后,将实验植物种植于对照和灭菌处理的同种或近缘(同科或同属)种驯化过的土壤中,评价同种或近缘种根际土壤生物对植物生长的净反馈作用(与灭菌土比较),并比较了两类土壤生物对植物的反馈作用。总体而言,同种或近缘种根际土壤生物对入侵与本土植物的净反馈作用无显著差异,两类土壤生物对入侵和本土植物的反馈作用亦无显著差异。土壤反馈作用的强度和种植于对照土壤中植物细根生物量比存在正相关关系,且入侵与本土植物细根生物量比无显著差异。这一发现表明:相似的细根生物量比可能是导致入侵与本土植物间土壤反馈作用无差异的一个重要原因。为提升人们对土壤生物在植物入侵过程中作用的认识,亟需选取更多入侵与本土植物(尤其是亲缘关系较远的物种)开展实验研究,进一步探明植物性状、土壤反馈作用和外来植物入侵之间的关联性。 | Xuefei Tang Chunqiang Wei Lunlun Gao Bingbing Jia Xinmin Lu | 2021 | Journal of Plant Ecology2021，14，1： | 0 |
| 10 | Cloning and Expression Analysis of THWRKY12 Gene from Tamarix hispida显示文摘[Objective]This study aimed to clone and analyze the expression of THWRKY12 gene in Tamarix hispida. [Method]T. hispida seedlings were treated with 400 mmol / L NaCl solution,20% PEG and 100 μmol / L ABA,respectively. The expression of THWRKY12 gene in different tissues was investigated by RT-PCR technology. [Result] Under treatments of NaCl and PEG,the expression of THWRKY12 gene in different tissues of T. hispida seedlings showed an overall upregulated trend,suggesting that THWRKY12 is related with the saline-alkali resistance and drought resistance of T. hispida. Under ABA treatment,THWRKY12 gene had approximately the same expression pattern with the former two,indicating that THWRKY12 gene may involve in the regulation and control of the saline-alkali resistance and drought resistance of T. hispida through the signal pathway regulated by ABA. [Conclusion] This study laid foundation for investigating the functions of WRKY gene in the stress resistance of T. hispida. | Jingxue WANG Yuekun TANG Qi LIU Chunqiang LIANG Yucheng WANG | 2013 | Agricultural Biotechnology2013，2，5： | 0 |
| 11 | High-frequency Noise-induced Hearing Loss Disrupts Functional Connectivity in Non-auditory Areas with Cognitive Disturbances显示文摘Dear Editor,Approximately 500 million individuals suffer from hearing loss worldwide. The number of hearing-impaired individuals is estimated to increase to 900 million by 2050. The etiology of hearing loss is complex. | Ying Luan Richard Salvi Lijie Liu Chunqiang Lu Yun Jiao Tianyu Tang Haiqing Liu Gao-Jun Teng | 2021 | Neuroscience Bulletin2021，37，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员