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| 1 | Interferon γ Induces Translocation of Commensal Escherichia coli Across Gut Epithelial Cells via a Lipid Raft--Mediated Process显示文摘 | Edwin Clark Catherine Hoare Jolanta Tanianis-Hughes Gordon L. Carlson Geoffrey Warhurst | 2005 | Gastroenterology2005，，5： | 2 |
| 2 | Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection显示文摘 | Rachael Barlow Patricia Price Thomas D. Reid Sarah Hunt Geoffrey W.B. Clark Timothy J. Havard Malcolm C.A. Puntis Wyn G. Lewis | 2011 | Clinical Nutrition2011，，5： | 2 |
| 3 | The RASSF1 A tumor suppressor 显示文摘 | Howard Donninger Michele D Vos Geoffrey J Clark | 2007 | J Cell Sci2007，120，： | 1 |
| 4 | Emulsion polymerization with 2-acrylamido - 2 - methylpropanesulphonic acid 显示文摘 | GEOFFREY P MARKA BELPER ALAN C CLARK | 1998 | Polymer Preprints1998，39，1： | 1 |
| 5 | Characterization of a soluble cytoplasmic antigen reac tive with sera from patients with systemic lupus eryth- matosus显示文摘 | Clark Geoffrey Reichlin Morris Thomas B | 1969 | J Immunol1969，102，11： | 1 |
| 6 | Is there a role for video-assisted thoracoscopy in the staging of non-small cell lung cancer?显示文摘 | David Waller Simon Clarke Geoffrey Tsang | 1997 | Eur J Cardiothorac Surg1997，12，： | 1 |
| 7 | Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection显示文摘 | Rachael Barlow Patricia Price Thomas D. Reid Sarah Hunt Geoffrey W.B. Clark Timothy J. Havard Malcolm C.A. Puntis Wyn G. Lewis | 2011 | Clinical Nutrition2011，，5： | 1 |
| 8 | The role of technology for achieving climate policy objectives: overview of the EMF 27 study on global technology and climate policy strategies显示文摘 | Elmar Kriegler John P. Weyant Geoffrey J. Blanford Volker Krey Leon Clarke Jae Edmonds Allen Fawcett Gunnar Luderer Keywan Riahi Richard Richels Steven K. Rose Massimo Tavoni Detlef P. Vuuren | 2014 | Climatic Change (-)2014，，3： | 1 |
| 9 | The antioxidant profiles of patients with recurrent acute and chronic pancreatitis显示文摘 | Gareth J Morris-Stiff David J Bowrey David Oleesky Mark Davies Geoffrey W.B Clark Malcolm C.A Puntis | 1999 | The American Journal of Gastroenterology1999，，： | 1 |
| 10 | Characterisation of Escherichia coli strains involved in transcytosis across gut epithelial cells exposed to metabolic and inflammatory stress显示文摘 | Christian Macutkiewicz Gordon Carlson Edwin Clark Ulrich Dobrindt Ian Roberts Geoffrey Warhurst | 2008 | Microbes and Infection2008，，4： | 1 |
| 11 | The Aldosteronoma Resolution Score: Predicting Complete Resolution of Hypertension After Adrenalectomy for Aldosteronoma显示文摘 | Rasa Zarnegar William F. Young James Lee Matthew P. Sweet Electron Kebebew David R. Farley Geoffrey B. Thompson Clive S. Grant Orlo H. Clark Quan-Yang Duh | 2008 | Annals of Surgery2008，，3： | 1 |
| 12 | 急性卒中影像学研究路径图Ⅱ显示文摘卒中影像学研究组(StrokeImagingResearchGroup,STIR)、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议,最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议(Stroke Treatment Academy Industry Roundtable,STAIR)期间举行。 | Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭 刘牧 张晶晶 柯开富 | 2014 | 国际脑血管病杂志2014，22，2： | 0 |
| 13 | MRI-Based Patient-Specific Left Ventricular Model to Determine the Effects of Trabeculae Carneae on the Diastolic and Systolic Functions显示文摘Introduction Trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles of human heart and account for a significant portion of the ventricular mass.However,the role of trabeculae carneae in left ventricular(LV)function is not well understood.Previous reports suggested that trabeculae help squeeze blood from the apical region during systole[1].Our recent study suggests that trabeculae carneae hypertrophy and fibrosis contribute to increased LV stiffness in patients with diastolic heart failure,and severing free-running trabeculae carneae may improve diastolic compliance of the LV[2].Objective To understand the role of trabeculae carneae in the left ventricular diastolic and systolic functions using anatomically detailed patient-specific finite element models of the human LV.Methods(1)Image acquisition An explanted human heart was collected from a 63 year old female donor with a history of stroke and congestive heart failure within 24 hours postmortem from South Texas Blood and Tissue Center(San Antonio,TX).The heart was de-identified in accordance with Institutional Review Board(IRB)requirements and informed consent for research was obtained from the donor’s family.Three-dimensional MRI scanning was conducted on a 3T(128 MHz)MRI system(TIM Trio,Siemens Medical Solutions),comprised of a superconducting magnet with a 60 cm diameter accessible bore,when the heart was submerged in a saline filled plastic container.(2)Finite element analysis Three distinct LV models were derived from the MR images.The first model was the intact trabeculated model(TM)which contained all trabeculae carneae and papillary muscles.This high-resolution anatomically detailed 3D model of the LV was segmented from 2D MR images in DICOM format using Mimics(Materialise NV,Leuven,Belgium).The second model was the papillary model(PM),in which the papillary muscles remain intact but most of the trabeculae carneae were excluded in the smoothing process.The third model was the smooth model(SM)in which the trabeculae carneae and papillary muscles were excluded during image segmentation.Finite element(FE)models of the TM,PM and SM were created by meshing 3D reconstructions of the acquired MR images using tetrahedral elements(ICEM,Ansys Inc.,Canonsburg,PA).The mesh size was selected after a pilot study on mesh sensitivity.The passive cardiac muscle was characterized as a hyperelastic,incompressible,transversely isotropic material with a Fung exponential strain energy function.The material constants were determined by matching the end-diastolic pressure-volume relationship with the empirical Klotz relation[3].A rule-based myocardial fiber algorithm was adopted to generate the myofiber directions [4].The active contraction(i.e.,systolic contraction)was modeled by the time varying'Elastance'active contraction model.The contractile parameter Tmax was determined and calibrated so that the FE predicted ejection fraction(EF)of TM matched the EF of a normal human heart at the specified end-systolic pressure[3].The analysis of the TM,PM,and SM models were implemented using the open-source finite element package FEBio(www.febio.org).In all models,the rigid body motion was suppressed by constraining the base from moving in all directions.The end-diastolic and end-systolic pressure-volume relationships(EDPVR and ESPVR)were obtained and characterized by an exponential function and the slope,respectively.Results Our simulation results showed that independent of the material model,the EDPVR curve shifts to the right in PM and SM compared to TM.However,the ESPVR curve may shift to the right or left in PM compared to TM,while shifting tothe right in SM for all material models.EDPVR was steeper in TM compared to PM and SM;however,ESPVR was found to be steeper in PM than in TM and SM.The predicted parameters of EDPVR and ESPVR showed lower average exponential term in PM and SM compared to TM,indicating a significant improvement in the compliance and global diastolic function of less trabeculated LV models(P<0.01).Similarly,the higher average elastance EEs and lower volume intersect in PM compared to TM,suggests that mild cutting of trabeculae carneae slightly improves the global systolic function of the LV(P=0.89).However,cutting all trabeculae carneae and papillary muscles in SM had a significant adverse effect on the global systolic function(P<0.01).Discussion and conclusions Most patient-specific LV studies in the literature have used smoothed ventricular geometries.We used high resolution MRI to capture the endocardial details of the LV.Though reproducing very fine trabeculae carneae was restricted by the MRI resolution,our results demonstrated the importance of considering endocardial structures,i.e.papillary muscles and trabeculae carneae,in the assessment of LV global function in patient-specific computational LV models.The present work is consistent with the observation that diastolic performance improved after severing trabeculae carneae due to a reduction in LV stiffness[2].Furthermore,our results also suggest that severing trabeculae carneae(without affecting papillary muscle)may improve LV systolic function.Our model results are consistent with experimental measurements using ex vivo rabbit heart perfusion [5].This improvement would be greater in hypertrophic hearts because trabeculae carneae are also hypertrophic and more fibrotic.Left ventricular hypertrophy is often associated with heart failure with preserved ejection fraction(HFpEF).There is no effective treatment for HFpEF,which is characterized by impaired diastolic relaxation due to increased LV stiffness.Our results indicate that trabecular cutting could be an effective treatment for HFpEF. | Fatemeh Fatemifar Marc Feldman Geoffrey Clarke Ender Finol Haichao Han | 2019 | 医用生物力学2019，34，A01： | 0 |
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