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| 1 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 2 | 大数据为企业创造巨大价值显示文摘你需要一个系统来管理如今大规模的数据流,它需具备智能性以提供不问断的运行报告。 | 夏晓婷 Simon Clark | 2014 | 中国物流与采购2014，，6： | 2 |
| 3 | DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein显示文摘 | Simon BE Cornell KA Clark TR | 2003 | Infect Immun2003，71，11： | 1 |
| 4 | Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice显示文摘 | Simons J P McClenaghan M Clark A J | 1987 | Nature1987，328，： | 1 |
| 5 | Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases显示文摘 | Edward G. McIver Justin Bryans Kristian Birchall Jasveen Chugh Thomas Drake Stephen J. Lewis Joanne Osborne Ela Smiljanic-Hurley William Tsang Ahmad Kamal Alison Levy Michelle Newman Debra Taylor J. Simon C. Arthur Kristopher Clark Philip Cohen | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，23： | 1 |
| 6 | Pharmaceuticals from transgenic live-stock显示文摘 | Clark A J Simons P Wilmut I | 1987 | Trends in Biotechnology1987，1，5： | 1 |
| 7 | Thermal barrier coating materials显示文摘 | David R. Clarke Simon R. Phillpot | 2005 | Materials Today2005，，6： | 1 |
| 8 | Thermal Barrier Coating Materials显示文摘 | CLARKE D R SIMON P R | | 0，，6： | 1 |
| 9 | Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mouse显示文摘 | Simons J P McClenagban M Clark A J | 1987 | Nature1987，328，： | 1 |
| 10 | Thermal barrier coating materials显示文摘 | David R. Clarke Simon R. Phillpot | 2005 | Materials Today2005，，6： | 1 |
| 11 | Stable Partnerships, Matching and Local Public Goods 显示文摘 | Simon Clark Ravi Kanbur | 2004 | European Economic Review2004，，48： | 1 |
| 12 | Reduced anisotropy of water diffusion in structural cerebral abnormalities demonstrated with diffusion tensor imaging显示文摘 | Udo C Wieshmann Chris A Clark Mark R Symms Florence Franconi Gareth J Barker Simon D Shorvon | 1999 | Magnetic Resonance Imaging1999，，9： | 1 |
| 13 | Thermal barrier coating materials显示文摘 | David R. Clarke Simon R. Phillpot | 2005 | Materials Today2005，，6： | 1 |
| 14 | Strain and deformation in ultra-hard nanocomposites nc-TiN/a-BN under hydrostatic pressure显示文摘 | Prillimana Stephen G Clark Simon M Paul Alivisatosa A | | 0，，： | 1 |
| 15 | The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4 + T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs显示文摘 | Susanna Commandeur Susan J.F. van den Eeden Karin Dijkman Simon O. Clark Krista E. van Meijgaarden Louis Wilson Kees L.M.C. Franken Ann Williams Dennis Christensen Tom H.M. Ottenhoff Annemieke Geluk | 2014 | Vaccine2014，，： | 1 |
| 16 | Collective Consulta- tion and Industrial Relations in China 显示文摘 | Clarke Simon Chang -Hee Lee and Qi Li | 2004 | British Journal of In- dustrial Relations2004，42，2： | 1 |
| 17 | Estimating a nucleotide substitution rate for maize from polymorphism at a major domestication locus显示文摘 | Clark R M Simon T Doebley J | 2005 | Molecular Biology and Evolution2005，22，11： | 1 |
| 18 | Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice 显示文摘 | Simons J P McClenaghan M Clark A J | 1987 | Nature1987，328，6130： | 1 |
| 19 | Thermal barrier coating materials显示文摘 | David R. Clarke Simon R. Phillpot | 2005 | Materials Today2005，，6： | 1 |
| 20 | Defective Counterregulation and Hypoglycemia Unawareness in Diabetes显示文摘 | Candace M. Reno Marina Litvin Amy L. Clark Simon J. Fisher | 2013 | Endocrinology and Metabolism Clinics of North America2013，，： | 1 |
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