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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens显示文摘 | Sinead C. Corr Colin Hill Cormac G.M. Gahan | 2009 | Advances in Food and Nutrition Research2009，，： | 2 |
| 3 | Preinoculation enrichment procedure enhances the performance of bacteriocinogenic Lactocoocus lactic meat starter culture 显示文摘 | Amalia G M Scannell Gerhard Schwarz Colin Hill | 2001 | International Journal of Food Microbiology2001，64，： | 1 |
| 4 | Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast显示文摘 | Jeremy Allen Laurence Colleaux Duncan Davidson Elisabeth Graham Muriel Lee Robert Hill Cathy Abbott Colin Gordon | 1997 | Mammalian Genome1997，，5： | 1 |
| 5 | The interaction between bacteria and bile显示文摘 | Máire Begley Cormac G.M. Gahan Colin Hill | 2004 | FEMS Microbiology Reviews2004，，4： | 1 |
| 6 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 7 | Bacteriocins:developing innate immunity for food显示文摘 | Paul D Cotter Colin Hill Paul Ross R | 2005 | Nature2005，，3： | 1 |
| 8 | Bacteriocins:biological tools for bio-preservation and shelf-life extension显示文摘 | Lucy H Deegana Paul D Cottera Colin Hill | 2006 | International Dairy Journal2006，16，： | 1 |
| 9 | Accelerated carbona- tion treatment of industrial wastes 显示文摘 | Peter J Gunning Colin D Hills Paula J | 2010 | Waste Management2010，30，6： | 1 |
| 10 | Bacterio eins: biological tools for bio p reservation and shelf -lifeextension显示文摘 | Lucy H Deegan Paul D Cotter Colin Hill | 2006 | International Dairy Journal2006，16，： | 1 |
| 11 | Bile Salt Hydrolase Activity in Probiotics显示文摘 | Ma'ire Begley Colin Hill | 2006 | Applied and Environmental Micribiology2006，72，3： | 1 |
| 12 | Phage therapy in the food industry 显示文摘 | Lorraine Endersen Jim O'Mahony Colin Hill | 2014 | Annu Rev Food Sci Technol2014，5，： | 1 |
| 13 | Controlled Autolysis and Enzyme Release in a Recombinant Lactococcal Strain Expressing the Metalloendopeptidase Enterolysin A 显示文摘 | Rita M Hickey R Paul Ross Colin Hill | 2004 | Appl and Environmental Microbiology2004，70，： | 1 |
| 14 | Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease显示文摘 | Prue M. Pereira-Fantini Susan Lapthorne Susan A. Joyce Nicole L. Dellios Guineva Wilson Fiona Fouhy Sarah L. Thomas Michelle Scurr Colin Hill Cormac G.M. Gahan Paul D. Cotter Peter J. Fuller Winita Hardikar Julie E. Bines | 2014 | Journal of Hepatology2014，，5： | 1 |
| 15 | The interaction between bacteria and bile显示文摘 | Maire Begley Cormac G M Gahan Colin Hill | 2005 | Microbiology Reviews2005，29，4： | 1 |
| 16 | Surviving the acid test: responses of gram-positive bacteria to low pH显示文摘 | Paul D Cotter Colin Hill | 2003 | Microbiology and Molecular Biology Reviews2003，67，3： | 1 |
| 17 | Bile Salt Hydrolase Activity in Probiotics 显示文摘 | BEGLEY MAIRE HILL COLIN G M GAHAN CORMAC | 2006 | American Society for Microbiology2006，72，3： | 1 |
| 18 | Isolation and Analysis of Bacteria with Antimicrobial Activities from the Marine Sponge Haliclona simulans Collected from Irish Waters显示文摘 | Jonathan Kennedy Paul Baker Clare Piper Paul D. Cotter Marcella Walsh Marlies J. Mooij Marie B. Bourke Mary C. Rea Paula M. O’Connor R. Paul Ross Colin Hill Fergal O’Gara Julian R. Marchesi Alan D. W. Dobson | 2009 | Marine Biotechnology2009，，3： | 1 |
| 19 | Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats显示文摘 | Wang Lin Wang Xiangdong Xie Guanhua Wang Lei Hill Colin K DeLeve Laurie D | 2012 | EN2012，，4： | 1 |
| 20 | Exploiting gut bacteriophages for human health显示文摘 | Marion Dalmasso Colin Hill R. Paul Ross | 2014 | Trends in Microbiology2014，，： | 1 |
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