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| 1 | 1995-2005年青海省棘球蚴病流行病学调查分析显示文摘目的分析1995-2005年青海省人与动物棘球蚴病的流行病学调查结果。方法人群棘球蚴病感染情况以Bu-ELISA、EM18-ELISA和B超、X线进行检查和评价。动物棘球蚴病/棘球绦虫感染调查采用解剖学方法和寄生虫学方法。结果①女性人群的血清阳性率和患病率显著高于男性人群(14.41%和4.81%、10.22%和3.25%);随年龄增长,人群血清阳性率和患病率升高(见表5);以牧民、喇嘛的血清阳性率和患病率最高(17.73%和9.33%、18.56%和10.0%)。②青海省人与动物棘球蚴病/棘球绦虫的血清阳性率和感染/患病率以青南高原的果洛、玉树、黄南三州最高(见表1、7、8),祁连山地和河湟谷地的海南、海北两州次之,海东地区、西宁及柴达木盆地的海西州较低。③青海省是以囊型棘球蚴病/细粒棘球绦虫为主的囊型和泡型棘球蚴病的混合流行区,并在其南部发现存在石渠棘球绦虫的动物感染。结论青海省棘球绦虫的生活史循环链十分复杂,家养动物相互之间、野生动物相互之间、家养动物和野生动物之间均参与其中。 | 王虎 张静宵 Schantz P M Akira Ito P S craig 吴献洪 韩秀敏 | 2006 | 中国人兽共患病学报2006,22,12: | 37 |
| 2 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014,3,1: | 35 |
| 3 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019,7,3: | 33 |
| 4 | Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China显示文摘背景过度放牧被假定增加是包虫 multilocularis 的中间的主人的小哺乳动物的人口密度,在 Qinghai 西藏高原的牙槽的包虫病的病原体。这研究测试了过度放牧可能支持的假设通过增加小哺乳动物的人口的包虫 multilocularis 传播,在擦伤惯例的西藏的牧剧 communities.Methods 的中间的主人,小哺乳动物索引和狗包虫 rnultilocularis 感染数据被收集分析在用的 nonpararnetric 测试和多重逐步的逻辑 regression.Results 过度放牧和包虫 rnultilocularis 传播之间的关系调查一公社的牧场存在,可得到的牧草为放牧是缺乏的。开(普通) 牧场被过度放牧并且与附近的 fenced 相比有小哺乳动物的更高的洞穴密度(私人) 牧场;由附近的 fenced 区域测量的开的牧场上的这个高过度放牧压力在开的牧场导致了小哺乳动物的更高的洞穴密度。在开的牧场的小哺乳动物的中部的洞穴密度独立地与附近犬的包虫 multilocularis 感染被联系(P=0.003, OR=1.048 ) 过度放牧的 .Conclusion 可以通过增加小哺乳动物的人口密度支持包虫 multilocularis 的传播。 | WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux | 2007 | Chinese Medical Journal2007,,3: | 20 |
| 5 | Management of distal humeral coronal shear fractures显示文摘Coronal shear fractures of the distal humerus are rare,complex fractures that can be technically challenging to manage. They usually result from a low-energy fall and direct compression of the distal humerus by the radial head in a hyper-extended or semi-flexed elbow or from spontaneous reduction of a posterolateral subluxation or dislocation. Due to the small number of soft tissue attachments at this site, almost all of these fractures are displaced. The incidence of distal humeral coronal shear fractures is higher among women because of the higher rate of osteoporosis in women and the difference in carrying angle between men and women. Distal humeral coronal shear fractures may occur in isolation, may be part of a complex elbow injury, or may be associated with injuries proximal or distal to the elbow. An associated lateral collateral ligament injury is seen in up to 40% and an associated radial head fracture is seen in up to 30% of these fractures. Given the complex nature of distal humeral coronal shear fractures, there is preference for operative management. Operative fixation leads to stable anatomic reduction, restores articular congruity, and allows initiation of early range-of-motion movements in the majority of cases. Several surgical exposure and fixation techniques are available to reconstruct the articular surface fol owing distal humeral coronal shear fractures. The lateral extensile approach and fixation with countersunk headless compression screws placed in an anterior-to-posterior fashion are commonly used. We have found a two-incision approach(direct anterior and lateral) that results in less soft tissue dissection and better outcomes than the lateral extensile approach in our experience. Stiffness, pain, articular incongruity, arthritis, and ulnohumeral instability may result if reduction is non-anatomic or if fixation fails. | Shahram S Yari Nathan L Bowers Miguel A Craig Lee M Reichel | 2015 | World Journal of Clinical Cases2015,3,5: | 15 |
| 6 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018,3,1: | 10 |
| 7 | 包虫病手术患者1312例流行病学资料分析显示文摘目的了解青藏高原包虫病的分布特点。方法对1992-2006年的1312例包虫病手术患者的相关资料进行分析。结果囊型和泡型包虫病均有分布。患者主要集中于21~50岁,20岁以下的患者相对较少,以藏族为主。囊型包虫病分布于四川省甘孜州和阿坝州的17个县以及青海省果洛州的5个县,而泡型包虫病同时分布于其中的大部分地区。结论囊型和泡型包虫病同时流行于四川省的西北部和青海省的东南部。 | 仁真 李调英 廖万明 陈兴旺 赵晓东 肖宁 喻晓慧 张西春 Akira Ito 邱加闽 Patrick Giraudoux Philip S Craig | 2008 | 寄生虫病与感染性疾病2008,6,3: | 8 |
| 8 | Priorities for research and control of cestode zoonoses in Asia显示文摘Globally,cestode zoonoses cause serious public health problems,particularly in Asia.Among all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)lost.An international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these zoonoses.It brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian region.Key objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses. | Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira Ito | 2013 | Infectious Diseases of Poverty2013,2,1: | 6 |
| 9 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009,19,3: | 5 |
| 10 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008,,5: | 4 |
| 11 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012,,: | 3 |
| 12 | Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Jonathan C Craig Anthony S McLean | 2007 | The Lancet Infectious Diseases2007,,3: | 3 |
| 13 | Flip the switch: BTG2–PRMT1 protein complexes antagonize pre-B-cell proliferation to promote B-cell development显示文摘B lymphocytes are vital components of vertebrate adaptive immune systems.However,B-cell dysfunction can promote autoimmunity and immunodefi-ciency,and errors in development can cause B-lineage lymphoid malignancies.B-cell development requires RAG1/RAG2(RAG)endonuclease-mediated assembly of immunoglobulin(Ig)genes.The assembly of Ig heavy chain(IgH)genes in G1-phase pro-B cells produces IgH proteins that pair with VpreB/λ5 to form pre-B-cell receptor(pre-BCR)complexes.In pro-B cells,pre-BCR signaling inhibits Rag1/Rag2 transcription,stabilizes Cyclin D3 to drive cellular proliferation and promotes differentiation of large pre-B cells. | Glendon S Wu Craig H Bassing | 2018 | Cellular & Molecular Immunology2018,15,9: | 3 |
| 14 | MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice显示文摘 | Callis Thomas E Pandya Kumar Seok Hee Young Tang Ru-Hang Tatsuguchi Mariko Huang Zhan-Peng Chen Jian-Fu Deng Zhongliang Gunn Bronwyn Shumate Janelle Willis Monte S Selzman Craig H Wang Da-Zhi | 2009 | Journal of Clinical Investigation2009,,9: | 3 |
| 15 | Evolution of Siderian juvenile crust to Rhyacian high Ba-Sr magmatism in the Mineiro Belt, southern S?o Francisco Craton显示文摘Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally 'Ⅰ-type',meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite. | Hugo Moreira Luís Seixas Craig Storey Mike Fowler Stephanie Lasalle Ross Stevenson Cristiano Lana | 2018 | Geoscience Frontiers2018,9,4: | 3 |
| 16 | Effectiveness of intravenous r- tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study显示文摘Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://gffzzd5593dd32ed44506hpqo5fubp5buv6k6k.ffgz.tsg.suse.edu.cn identifier:NCT02854592. | Xinhong Wang Xiaoqiu Li Yuming Xu Runhui Li Qingcheng Yang Yong Zhao Fengyun Wang Baoying Sheng Runqing Wang Shaoyuan Chen Lihua Wang Liying Shen Xiaowen Hou Yu Cui Duolao Wang Bin Peng Craig S Anderson Huisheng Chen On behalf of INTRECIS Investigators | 2021 | Stroke & Vascular Neurology2021,6,4: | 2 |
| 17 | A comparison of different in vitro methods for measuring mucoadhesive performance显示文摘 | Tamburic S Craig DQM | 1997 | Eur J Pharm Biopharm1997,44,: | 2 |
| 18 | Epidemiological investigation of infectious hematopoietic necrosis virus in salt water net-pen reared Atlantic salmon in British Columbia, Canada显示文摘 | Sophie St-Hilaire Carl S Ribble Craig Stephen Eric Anderson Gael Kurath Michael L Kent | 2002 | Aquaculture2002,,1: | 2 |
| 19 | Robotic partial nephrectomy: the real benefit显示文摘 | Craig Rogers Shyam Sukumar Inderbir S Gill | 2011 | Current Opinion in Urology2011,,1: | 2 |
| 20 | Protein folding and its implications for the production of recombinant proteins 显示文摘 | Hlodan R Craig S Pain RH | 1991 | Biotech Genet Eng Rev1991,9,: | 2 |