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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Subtalar dislocation without associated fractures: Case report and review of literature显示文摘Isolated subtalar dislocations are unusual injuries due to the inherent instability of the talus. Subtalar dislocations are frequently associated with fractures of the malleoli, the talus, the calcaneus or the fifth metatarsal. Four types of subtalar dislocation have been described according to the direction of the foot in relation to the talus: medial, lateral posterior and anterior. It has been shown that some of these dislocations may spontaneously reduce. A rare case of a 36-year-old male patient who sustained a closed medial subtalar dislocation without any associated fractures of the ankle is reported. The patient suffered a pure closed medial subtalar dislocation that is hardly reported in the literature. Six months after injury the patient did not report any pain, had a satisfactory range of motion, and no signs of residual instability or early posttraumatic osteoarthritis. The traumatic mechanism, the treatment options, and the importance of a stable and prompt closed reduction and early mobilization are discussed. | Dionisios Giannoulis Dimitrios V Papadopoulos Marios G Lykissas Panagiotis Koulouvaris Ioannis Gkiatas Alexandros Mavrodontidis | 2015 | World Journal of Orthopedics2015，6，3： | 4 |
| 3 | Use of a device that applies external kneading-like force on the abdomen for treatment of constipation显示文摘AIM: To evaluate the efficacy of a recently developed device that applies kneading-like motion on the abdomen in improving constipation in elderly long-term care patients.METHODS: Thirty constipated elderly patients were randomly selected from two nursing homes. They were instructed to use the device once daily for 20 min. Rate of bowel movements, volume and consistency of stool and the use of laxantia were all recorded during a 3-wk baseline period and for 12-wk treatment period. Colonic transit time (CTT) was measured in 13 patients by radiopaque markers during the baseline and at the end of treatment.RESULTS: Bowel movement rate (BM/week) increased from 1.4±0.4 BM/wk during baseline to 3.9±0.8 BM/wk during treatment (P<5.0×10-7). Stool amount that was 'low' in 30 patients during baseline increased in 21 patients at the end of the study period (χ2 = 19.048-P =1.3×10-5). Stool consistency, that was 'hard' in 25 patients and 'soft' in 5 patients during baseline, ameliorated in 23 patients at the end of the study (only 2 patients referred 'hard' stool) (χ2= 21.043-P = 4.0×10-6). The mean baseline CTT measured was 92.3±32.3 h at baseline and decreased to 49.4±31.3 h during the study period (P = 0.000208). No side effects were observed during the study period.CONCLUSION: External mechanical vibration of the abdomen reduced CTT and helped to relieve severe constipation in elderly constipated patients. | Konstantinos Mimidis David Galinsky Efraim Rimon Vassilios Papadopoulos Yehuda Zicherman Dimitrios Oreopoulos | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 4 | Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials显示文摘BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been published.AIM To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac arrhythmias.METHODS We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October 2020.We extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular death.We also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular tachycardia.RESULTS We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or placebo.DPP-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),while they were associated with a significant increase in the risk for atrial flutter,equal to 52%(RR=1.52,95%CI:1.03-2.24,I2=0%).DPP-4 inhibitors did not have a significant impact on the risk for any of the rest assessed cardiac arrhythmias.CONCLUSION DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM,while they do not seem to be associated with a significant risk for any major cardiac arrhythmias,except for atrial flutter.Therefore,this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors,except for those cases when newer antidiabetics(glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors)are not tolerated,contraindicated or not affordable for the patient. | Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos | 2021 | World Journal of Cardiology2021，13，10： | 2 |
| 5 | New trends in fixation of proximal humeral fractures: A review显示文摘 | Dimitrios Karataglis Stavros I. Stavridis George Petsatodis Pericles Papadopoulos Anastasios Christodoulou | 2010 | Injury2010，，4： | 2 |
| 6 | Association between plasma homocysteine levels and coronary artery disease: a population-based study in northern Greece显示文摘 | Amalia I. Boufidou Areti D. Makedou Dimitrios N. Adamidis Haralampos I. Karvounis John T. Gourassas Haralampos T. Kesidis Kali G. Makedou Christodoulos E. Papadopoulos Georgios E. Parharidis Georgios E. Louridas | 2004 | Current Medical Research and Opinion?2004，，2： | 1 |
| 7 | The Culture Site of the Gallbladder Affects Recovery of Bacteria in Symptomatic Cholelithiasis 显示文摘 | Evangelos N Manolis Dimitrios K Filippou Vassilios P Papadopoulos ct al | 2008 | Journal of Gastrointestinal and Liver Diseases2008，17，2： | 1 |
| 8 | Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: a phase I/II study conducted by the Hellenic Cooperative Oncology Group显示文摘 | George Fountzilas Dimitrios Pectasides Anna Kalogera-Fountzila Dimosthenis Skarlos Haralambos P. Kalofonos Christos Papadimitriou Dimitrios Bafaloukos Stefanos Lambropoulos Savvas Papadopoulos Helen Kourea Christos Markopoulos Helen Linardou Dimitrios Mav | 2005 | Breast Cancer Research and Treatment2005，，1： | 1 |
| 9 | Long Head of the Biceps Pathology Combined with Rotator Cuff Tears显示文摘 | Konstantinos Ditsios Filon Agathangelidis Achilleas Boutsiadis Dimitrios Karataglis Pericles Papadopoulos Robert Gillespie | 2012 | Advances in Orthopedics2012，，： | 1 |
| 10 | Advances in Liver Echinococcosis: Diagnosis and Treatment显示文摘 | Dimitrios Filippou Dimitrios Tselepis Georgios Filippou Vassilios Papadopoulos | 2007 | Clinical Gastroenterology and Hepatology2007，，2： | 1 |
| 11 | All about KRAS for clinical oncology practice: Gene profile, clinical implications and laboratory recommendations for somatic mutational testing in colorectal cancer显示文摘 | Helena Linardou Evangelos Briasoulis Issa J. Dahabreh Giannis Mountzios Christos Papadimitriou Savvas Papadopoulos Dimitrios Bafaloukos Paris Kosmidis Samuel Murray | 2010 | Cancer Treatment Reviews2010，，3： | 1 |
| 12 | Green synthesis and characterization of silver nanoparticles produced using Arbutus Unedo leaf extract显示文摘 | Pantelis Kouvaris Andreas Delimitis Vassilis Zaspalis Dimitrios Papadopoulos Sofia A. Tsipas Nikolaos Michailidis | 2012 | Materials Letters2012，，： | 1 |
| 13 | All about KRAS for clinical oncology practice: Gene profile, clinical implications and laboratory recommendations for somatic mutational testing in colorectal cancer显示文摘 | Helena Linardou Evangelos Briasoulis Issa J. Dahabreh Giannis Mountzios Christos Papadimitriou Savvas Papadopoulos Dimitrios Bafaloukos Paris Kosmidis Samuel Murray | 2010 | Cancer Treatment Reviews2010，，3： | 1 |
| 14 | The culture site of the gallbladder affects recovery of bacteria in symptomatic cholelithiasis 显示文摘 | Evangelos N Manolis Dimitrios K Filippou Vassilios P Papadopoulos | 2008 | Journal of Gastrointestinal and Liver Diseases2008，17，2： | 1 |
| 15 | Locally adaptive metrics for clustering high dimensional data显示文摘 | Carlotta Domeniconi Dimitrios Gunopulos Sheng Ma Bojun Yan Muna Al-Razgan Dimitris Papadopoulos | 2007 | Data Mining and Knowledge Discovery2007，，1： | 1 |
| 16 | Dynamics of telomere’s length and telomerase activity in Philadelphia chromosome negative myeloproliferative neoplasms显示文摘 | Emmanouil Spanoudakis Ioanna Bazdiara Despoina Pantelidou Ioannis Kotsianidis Vasilios Papadopoulos Dimitrios Margaritis George Xanthopoulidis Eleftherios Moustakidis Stamatia Mantzourani George Bourikas Costas Tsatalas | 2010 | Leukemia Research2010，，4： | 1 |
| 17 | Increasing frequency of gram‐positive cocci and gram‐negative multidrug‐resistant bacteria in spontaneous bacterial peritonitis显示文摘 | Alexandra Alexopoulou Nikolaos Papadopoulos Dimitrios G. Eliopoulos Apostolia Alexaki Athanasia Tsiriga Marina Toutouza Dimitrios Pectasides | 2013 | Liver Int2013，，7： | 1 |
| 18 | Locally adaptive metrics for clustering high dimensional data显示文摘 | Carlotta Domeniconi Dimitrios Gunopulos Sheng Ma Bojun Yan Muna Al-Razgan Dimitris Papadopoulos | 2007 | Data Mining and Knowledge Discovery2007，，1： | 1 |
| 19 | Serum profiles of matrix metalloproteinases and their tissue inhibitor in patients with acute coronary syndromes. The effects of short-term atorvastatin administration显示文摘 | Dimitrios N. Tziakas Georgios K. Chalikias John T. Parissis Eleni I. Hatzinikolaou Elias D. Papadopoulos Grigorios A. Tripsiannis Evropi G. Papadopoulou Ioannis K. Tentes Spilios M. Karas Dimitrios I. Chatseras | 2003 | International Journal of Cardiology2003，，2： | 1 |
| 20 | Endothelial progenitor cells mobilization after maximal exercise according to heart failure severity显示文摘BACKGROUND Vascular endothelial dysfunction is an underlying pathophysiological feature of chronic heart failure(CHF).Patients with CHF are characterized by impaired vasodilation and inflammation of the vascular endothelium.They also have low levels of endothelial progenitor cells(EPCs).EPCs are bone marrow derived cells involved in endothelium regeneration,homeostasis,and neovascularization.Exercise has been shown to improve vasodilation and stimulate the mobilization of EPCs in healthy people and patients with cardiovascular comorbidities.However,the effects of exercise on EPCs in different stages of CHF remain under investigation.AIM To evaluate the effect of a symptom-limited maximal cardiopulmonary exercise testing(CPET)on EPCs in CHF patients of different severity.METHODS Forty-nine consecutive patients(41 males)with stable CHF[mean age(years):56±10,ejection fraction(EF,%):32±8,peak oxygen uptake(VO2,mL/kg/min):18.1±4.4]underwent a CPET on a cycle ergometer.Venous blood was sampled before and after CPET.Five circulating endothelial populations were quantified by flow cytometry:Three subgroups of EPCs[CD34+/CD45-/CD133+,CD34+/CD45-/CD133+/VEGFR2 and CD34+/CD133+/vascular endothelial growth factor receptor 2(VEGFR2)]and two subgroups of circulating endothelial cells(CD34+/CD45-/CD133-and CD34+/CD45-/CD133-/VEGFR2).Patients were divided in two groups of severity according to the median value of peak VO2(18.0 mL/kg/min),predicted peak VO2(65.5%),ventilation/carbon dioxide output slope(32.5)and EF(reduced and mid-ranged EF).EPCs values are expressed as median(25th-75th percentiles)in cells/106 enucleated cells.RESULTS Patients with lower peak VO2 increased the mobilization of CD34+/CD45-/CD133+[pre CPET:60(25-76)vs post CPET:90(70-103)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133+/VEGFR2[pre CPET:1(1-4)vs post CPET:5(3-8)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133-[pre CPET:186(141-361)vs post CPET:488(247-658)cells/106 enucleated cells,P<0.001]and CD34+/CD45-/CD133-/VEGFR2[pre CPET:2(1-2)vs post CPET:3(2-5)cells/106 enucleated cells,P<0.001],while patients with higher VO2 increased the mobilization of CD34+/CD45-/CD133+[pre CPET:42(19-73)vs post CPET:90(39-118)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133+/VEGFR2[pre CPET:2(1-3)vs post CPET:6(3-9)cells/106 enucleated cells,P<0.001],CD34+/CD133+/VEGFR2[pre CPET:10(7-18)vs post CPET:14(10-19)cells/106 enucleated cells,P<0.01],CD34+/CD45-/CD133-[pre CPET:218(158-247)vs post CPET:311(254-569)cells/106 enucleated cells,P<0.001]and CD34+/CD45-/CD133-/VEGFR2[pre CPET:1(1-2)vs post CPET:4(2-6)cells/106 enucleated cells,P<0.001].A similar increase in the mobilization of at least four out of five cellular populations was observed after maximal exercise within each severity group regarding predicted peak,ventilation/carbon dioxide output slope and EF as well(P<0.05).However,there were no statistically significant differences in the mobilization of endothelial cellular populations between severity groups in each comparison(P>0.05).CONCLUSION Our study has shown an increased EPCs and circulating endothelial cells mobilization after maximal exercise in CHF patients,but this increase was not associated with syndrome severity.Further investigation,however,is needed. | Christos Kourek Eleftherios Karatzanos Katherina Psarra Georgios Georgiopoulos Dimitrios Delis Vasiliki Linardatou Gerasimos Gavrielatos Costas Papadopoulos Serafim Nanas Stavros Dimopoulos | 2020 | World Journal of Cardiology2020，12，11： | 1 |
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