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| 1 | 不同人工泪液对体外培养的人角结膜上皮细胞的毒性作用比较显示文摘干眼是泪液分泌量不足、泪膜稳定性受损所致的眼部疾病[1-2].流行病学研究表明,在世界范围内,干眼发病率很高,与老龄、妇女围绝经期、配戴隐形眼镜及自身免疫性疾病等有关[3-5],其中亚洲人群中发病率约为17% ~ 33% [6-9],而白种人发病率相对较低,约为7%~14.6%[3,10].目前,干眼最常用的治疗方法是眼表滴用人工泪液,由于干眼是慢性疾患,大部分患者需长期用药,因此其长期疗效和安全性值得关注.本研究比较了不同成分的人工泪液对体外培养的人角膜和结膜上皮细胞的毒性作用,以期为临床用药提供试验依据. | Malik Kahook Cullen T. Vogelson Usha Sivaprasad David A. Ammar | 2012 | 中华眼科杂志2012，48，2： | 11 |
| 2 | Acute drivers of neuroinflammation in traumatic brain injury显示文摘Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the pathological consequences over time.Importantly,the mechanism(s)of injury,the location of the immune cells within the brain,and the animal species all contribute to immune cell behavior following traumatic brain injury.Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration.Within this paper,we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury. | Kathryn L.Wofford David J.Loane D.Kacy Cullen | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 3 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 4 | Phase I Trial of Intravesical Recombinant Adenovirus Mediated Interferon-α2b Formulated in Syn3 for Bacillus Calmette-Guérin Failures in Nonmuscle Invasive Bladder Cancer显示文摘 | Colin P.N. Dinney Mark B. Fisher Neema Navai Michael A. O’Donnell David Cutler Alice Abraham Sophia Young Beth Hutchins Maria Caceres Narendra Kishnani George Sode Constance Cullen Guangcheng Zhang H. Barton Grossman Ashish M. Kamat Marshall Gonzales Mich | 2013 | The Journal of Urology2013，，： | 1 |
| 5 | Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers显示文摘 | David Mataix-Cols Sarah Cullen Kezia Lange Fernando Zelaya Christopher Andrew Edson Amaro Michael J Brammer Steven C.R Williams Anne Speckens Mary L Phillips | 2003 | Biological Psychiatry2003，，6： | 1 |
| 6 | Lowe Covalent coupling of immunoglobulin G to self-assembled monolayers as a method for immobilizing the interfacialrecognitionlayer of a surface plasmon resonance immunosensor显示文摘 | Darren M Disley David C Cullen Hong-Xing You | 1998 | Biosensors & Bioelectronics1998，13，11： | 1 |
| 7 | Therapeutic intervention scoring system:Update 1983显示文摘 | Roberta AK David J Cullen MD | 1983 | Critical Care Medicine1983，11，1： | 1 |
| 8 | Surgical Management of Meckel?s Diverticulum An Epidemiologic, Population-Based Study显示文摘 | Joseph J. Cullen Keith A. Kelly Christopher R. Moir David O. Hodge Alan R. Zinsmeister L. Joseph Melton | 1994 | Annals of Surgery1994，，4： | 1 |
| 9 | Comparison of novel tools with traditional cognitive tests in detecting delirium in elderly medical patients显示文摘BACKGROUND Efficient detection of delirium and comorbid delirium-dementia is a key diagnostic challenge.Development of new,efficient delirium-focused methods of cognitive assessment is a key challenge for improved detection of neurocognitive disorders in everyday clinical practice.AIM To compare the accuracy of two novel bedside tests of attention,vigilance and visuospatial function with conventional bedside cognitive tests in identifying delirium in older hospitalized patients.METHODS 180 consecutive elderly medical inpatients(mean age 79.6±7.2;51%female)referred to a psychiatry for later life consultation-liaison service with delirium,dementia,comorbid delirium-dementia and cognitively intact controls.Participants were assessed cross-sectionally with conventional bedside cognitive tests[WORLD,Months Backward test(MBT),Spatial span,Vigilance A and B,Clock Drawing test and Interlocking Pentagons test]and two novel cognitive tests[Lighthouse test,Letter and Shape Drawing test(LSD)-4].RESULTS Neurocognitive diagnoses were delirium(n=44),dementia(n=30),comorbid delirium-dementia(n=60)and no neurocognitive disorder(n=46).All conventional tests had sensitivity of>70%for delirium,with best overall accuracy for the Vigilance-B(78.3%),Vigilance-A(77.8%)and MBT(76.7%)tests.The sustained attention component of the Lighthouse test was the most distinguishing of delirium(sensitivity 84.6%;overall accuracy 75.6%).The LSD-4 had sensitivity of 74.0%and overall accuracy 74.4%for delirium identification.Combining tests allowed for enhanced sensitivity(>90%)and overall accuracy(≥75%)with the highest overall accuracy for the combination of MBT-Vigilance A and the combined Vigilance A and B tests(both 78.3%).When analyses were repeated for those with dementia,there were similar findings with the MBTVigilance A the most accurate overall combination(80.0%).Combining the Lighthouse-SA with the LSD-4,a fail in either test had sensitivity for delirium of 91.4 with overall accuracy of 74.4%.CONCLUSION Bedside tests of attention,vigilance and visuospatial ability can help to distinguish neurocognitive disorders,including delirium,from other presentations.The Lighthouse test and the LSD-4 are novel tests with high accuracy for detecting delirium. | David J Meagher Henry O’Connell Maeve Leonard Olugbenga Williams Fahad Awan Chris Exton Michael Tenorio Margaret O’Connor Colum P Dunne Walter Cullen John McFarland Dimitrios Adamis | 2020 | World Journal of Psychiatry2020，10，4： | 1 |
| 10 | Submerged electric motor pumps for marine liquefied gas cargo显示文摘 | Loughman David Cullen David | 1996 | World Pumps1996，，9： | 1 |
| 11 | 查看详情显示文摘 | S Waleed Haddad David Cullen Johndale C | | 0，，： | 1 |
| 12 | Fourier-transform holographic microscope显示文摘 | Haddad Waleed S Cullen David Solem Johndale C | 1992 | Appl Opt1992，31，24： | 1 |
| 13 | Fourier-transform holographic microscope显示文摘 | Haddad Waleed S Cullen David Solem Johndale C etal | 1992 | Appl Opt1992，31，24： | 1 |
| 14 | Therapeutic Intervention Scoring System: Update 1983显示文摘 | A. ROBERTA KEENE DAVID J. CULLEN | 1983 | Critical Care Medicine1983，，1： | 1 |
| 15 | Therapeutic intervention scoring system: a method for quantitative comparison of patient care显示文摘 | DAVID J. CULLEN JOSEPH M. CIVETTA BURTON A. BRIGGS LINDA C. FERRARA | 1974 | Critical Care Medicine1974，，2： | 1 |
| 16 | LipL21 is a novel surface-exposed lipoprotein of pathogenic leptospira species显示文摘 | Paul A Cullen David A Haake Ben Adler | 2003 | Infect and Immun2003，75，2： | 1 |
| 17 | β受体阻滞剂(普萘洛尔)治疗复杂的面部血管瘤显示文摘【结论】为检测β受体阻滞剂治疗血管瘤远期效果的安全性和有效性,将其与其他药物进行前瞻性对照研究显然是有必要的。采用皮质类固醇治疗复杂的血管瘤,可能无反应或产生有害后遗症,因此,需要把注意力放到非传统疗法上。然而,这并不是对已报道的采用传统治疗标准的成功案例的否定。口服皮质类固醇仍是目前可以接受的药物治疗标准;然而,此类药物既不是完全良性,也不是普遍有效。 | Jugpal S. Arneja Peggy N. Pappas Tor A. Shwayder Marc L. Cullen Cristie J. Becker Fasahat H. Hamzavi John D. Roarty David N. Madgy John D. Baker 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，3： | 0 |
| 18 | Months backward test:A review of its use in clinical studies显示文摘AIM: To review the use of the Months Backwards Test(MBT) in clinical and research contexts.METHODS: We conducted a systematic review of reports relating to the MBT based upon a search of Psych INFO and MEDLINE between January 1980 and December 2014. Only reports that specifically described findings pertaining to the MBT were included. Findings were considered in terms of rating procedures, testing performance, psychometric properties, neuropsychological studies and use in clinical populations.RESULTS: We identified 22 data reports. The MBT is administered and rated in a variety of ways with very little consistency across studies. It has been used to assess various cognitive functions including focused and sustained attention as well as central processingspeed. Performance can be assessed in terms of the ability to accurately complete the test without errors('MB accuracy'), and time taken to complete the test('MB duration'). Completion time in cognitively intact subjects is usually < 20 s with upper limits of 60-90 s typically applied in studies. The majority of cognitively intact adults can complete the test without error such that any errors of omission are strongly suggestive of cognitive dysfunction. Coverage of clinical populations, including those with significant cognitive difficulties is high with the majority of subjects able to engage with MBT procedures. Performance correlates highly with other cognitive tests, especially of attention, including the digit span backwards, trailmaking test B, serial threes and sevens, tests of simple and complex choice reaction time, delayed story recall and standardized list learning measures. Test-retest and inter-rater reliability are high(both > 0.90). Functional magnetic resonance imaging studies comparing the months forward test and MBT indicate greater involvement of more complex networks(bilateral middle and inferior frontal gyri, the posterior parietal cortex and the left anterior cingulate gyrus) for backwards cognitive processing. The MBT has been usefully applied to the study of a variety of clinical presentations, for both cognitive and functional assessment. In addition to the assessment of major neuropsychiatric conditions such as delirium, dementia and Mild Cognitive Impairment, the MBT has been used in the assessment of concussion, profiling of neurocognitive impairments in organic brain disorders and Parkinson's disease, prediction of delirium risk in surgical patients and medication compliance in diabetes. The reported sensitivity for acute neurocognitive disturbance/delirium in hospitalised patients is estimated at 83%-93%. Repeated testing can be used to identify deteriorating cognitive function over time.CONCLUSION: The MBT is a simple, versatile tool that is sensitive to significant cognitive impairment. Performance can be assessed according to accuracy and speed of performance. However, greater consistency in administration and rating is needed. We suggest two approaches to assessing performance- a simple(pass/fail) method as well as a ten point scale for rating test performance(467). | James Meagher Maeve Leonard Laura Donoghue Niamh O'Regan Suzanne Timmons Chris Exton Walter Cullen Colum Dunne Dimitrios Adamis Alasdair J Maclullich David Meagher | 2015 | World Journal of Psychiatry2015，5，3： | 0 |
| 19 | Multi-scale characterization and simulation of impact welding between immiscible Mg/steel alloys显示文摘Vaporizing foil actuator spot welding method is used in this paper to join magnesium alloy AZ31 and uncoated high-strength steel DP590,which are typically considered as un-weldable due to their high physical property disparities,low mutual solubility,and the lack of any intermetallic phases.Characterization results from scanning electron microscopy(SEM)and high-resolution transmission electron microscopy(HRTEM)of the weld interface indicate that the impact creates an Mg nanocrystalline interlayer with abundant Fe particles.The interlayer exhibits intact bonding with both DP590 and AZ31 substrates.To investigate the fundamental bond formation mechanisms at the interface,a finite element(FE)-based process simulation is first performed to calculate the local temperature and deformation at the interface under the given macroscopic experimental condition.Taking the FE results at the interface as inputs,molecular dynamics(MD)simulations are conducted to study the interlayer formation at the Mg/Fe interface during the impact and cooling.The results found a high velocity shearing-induced mechanical mixing mechanism that mixes Mg/Fe atoms at the interface and creates the interlayer,leading to the metallurgical bond between Mg/steel alloys. | Jiahao Cheng Xiaohua Hu Xin Sun Anupam Vivek Glenn Daehn David Cullen | 2020 | Journal of Materials Science & Technology2020，59，24： | 0 |
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