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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Calculation of viscous EHL traction for squalane using molecular simulation and rheometry显示文摘 | Bair S McCabe C Cummings P T | 2002 | Tribology Letters2002，13，4： | 1 |
| 3 | Dis-tribution Functions of a Simple Fluid under Shear:LowShear Rates显示文摘 | Kalyuzhnyi Y V Cui S T Cummings P T | 1999 | Phys Rev E1999，60，2： | 1 |
| 4 | The current and future applications of microorganism in the bioremediation of cyanide contamination 显示文摘 | BAXTER J CUMMINGS S P | 2006 | Antonie van Leeuwenhoek2006，90，1： | 1 |
| 5 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 6 | Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats显示文摘 | Marenco T Bernstein S Cumming P | 2000 | Br J Pharmacol2000，129，1： | 1 |
| 7 | Fabrication of 3 nm wires using 100 keV electron beam lithography and poly(methyl methacrylate)resit显示文摘 | Thoms S Beaumont S P | 1996 | Appl Phys Lett1996，68，： | 1 |
| 8 | Once-yearly zoledronic acid for treatment of post-menopausal osteoporosis显示文摘 | Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Krasnow J Hue TF Sellmeyer D Eriksen EF Cummings SR HORIZON Pivotal Fracture Trial | | 0，，： | 1 |
| 9 | The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis:a randomized extension to the HORIZON-Pivotal Fracture Trial(PFT)显示文摘 | Black DM Reid IR Boonen S Bucci-Rechtweg C Cauley JA Cosman F Cummings SR Hue TF Lippuner K Lakatos P Leung PC Man Z Martinez RL Tan M Ruzycky ME Su G Eastell R | | 0，，： | 1 |
| 10 | Generation of a recombinant bacteriophage antibody library to mycobacterium tuberculosis显示文摘 | Cummings P J Hooper N E Rowland S S | 1998 | Hybridoma1998，17，2： | 1 |
| 11 | The current and future appli- cations of microorganism in the bioremediation of cya- nide contamination 显示文摘 | Baxter J Cummings S P | 2006 | Antonie Van Leeuwenhoek2006，90，1： | 1 |
| 12 | BMDand risk of hip and nonvertebral fractures in older men:aprospec-tive study and comparison with older women显示文摘 | CUMMINGS S R CAWTHON P M ENSRUD K E | 2006 | J Bone MinerRes2006，21，10： | 1 |
| 13 | The current and future applications of microorganism in the bioremediation of cyanide contamination显示文摘 | Baxter J Cummings S P | 2006 | Antonie van Leeuwenhoek2006，90，1： | 1 |
| 14 | A comparison of reviewers selected by editors and reviewers suggested by authors显示文摘 | Rivara F P Cummings P Ringold S | 2007 | J Pediatr2007，151，2： | 1 |
| 15 | Perceived orgnaizational support,discretionary treatment,and job satisfaction显示文摘 | Eisenberger R Cummings J Armeli S Lynch P | | 0，，05： | 1 |
| 16 | Habitat use and life history as predictors of bird responses to habitat change 显示文摘 | Okes N C Hockey P A R Cumming G S | 2008 | Conservation Biology2008，22，1： | 1 |
| 17 | The use of deuterium oxide as a mobile phase for structural elucidation by HPLC/UV/ESI/MS显示文摘 | OLSEN M A CUMMINGS P G KENNDY-GABB S | 2000 | Anal Chem2000，72，20： | 1 |
| 18 | Is winning everything?The relative contributions of motivational climate and won-lost percentage in youth sports显示文摘 | Cumming S P Smoll F L Smith R E | 2007 | Journal of Applied Sport Psychology2007，19，： | 1 |
| 19 | Congeni- tal club foot 显示文摘 | Cummings K J Davidson R S Armstrong P F | 2002 | Bone Joint Surg2002，，2： | 1 |
| 20 | Towards a familyprocess model of maternal and paternal depressive symptoms: exploring multiple relations with child and family functioning显示文摘 | Cummings E M Keller P S Davies P T | 2005 | J Child Psychol Psychiatry2005，46，5： | 1 |
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