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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 3 | The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis:a randomized extension to the HORIZON-Pivotal Fracture Trial(PFT)显示文摘 | Black DM Reid IR Boonen S Bucci-Rechtweg C Cauley JA Cosman F Cummings SR Hue TF Lippuner K Lakatos P Leung PC Man Z Martinez RL Tan M Ruzycky ME Su G Eastell R | | 0，，： | 1 |
| 4 | Lung overexpansion increases pulmonary microvascular protein permeability in young lambs显示文摘 | Carkon D P Cummings J J Scheerer R G | 1990 | J Appl Physiol1990，69，2： | 1 |
| 5 | Influence of soil pH,sulfur, and sawdu st on rabbiteye blueberry survival, growth,andyield 显示文摘 | Cumming G A Mainland C M Lilly L P | 1981 | J Amer Hort Sci1981，106，： | 1 |
| 6 | Diabetes and risk fracture: The blue mountains eye study显示文摘 | Ivers R Q Cumming R G Mitchell P | 2001 | Diabetes Care2001，24，7： | 1 |
| 7 | Habitat use and life history as predictors of bird responses to habitat change 显示文摘 | Okes N C Hockey P A R Cumming G S | 2008 | Conservation Biology2008，22，1： | 1 |
| 8 | The use of deuterium oxide as a mobile phase for structural elucidation by HPLC/UV/ESI/MS显示文摘 | OLSEN M A CUMMINGS P G KENNDY-GABB S | 2000 | Anal Chem2000，72，20： | 1 |
| 9 | Changes in the proteome of Candida albicans in response to azole,polyene,and echinocandin antifungal agents显示文摘 | Hoehamer C F Cummings E D Hilliard G M Rogers P D | | 0，，： | 1 |
| 10 | Influence of soil pH,sulfur,and sawdust on rabbiteye blueberry survival,growth,and yield显示文摘 | CUMMING G A MAINLAND C M LILLY J P | 1981 | J Amer Hort Sci1981，，106： | 1 |
| 11 | Polymer hydrolysis a cold climate显示文摘 | Cummings S P Black G W | 1999 | Extremophiled1999，3，2： | 1 |
| 12 | The relation- ship between alexithymia and depressive symptoms in a sample of newly abstinent alcoholic inpatients显示文摘 | Haviland M G Mac Murray J P Cummings M A | 1988 | Psychother Psychosom1988，49，： | 1 |
| 13 | Evolution of the avocados as revealed by DNA restriction frag- ment variation显示文摘 | Furnier G R Cummings M P Clegg M T | 1990 | J Hered1990，81，4： | 1 |
| 14 | Re-Os geochronology of the lacustrine Green River Formation : Insights into direct depositional dating of lacustrine successions, Re-Os systematics and paleocon- tinental weathering显示文摘 | Cumming V M Selby D Lillis P G | 2012 | Earth and Planet Science Letters2012，359，1： | 1 |
| 15 | Decay of the ',(3 770) to light hadrons显示文摘 | Adams G S Anderson M Cummings J P | 2006 | Phys Rev D2006，73，01： | 1 |
| 16 | Process for claims on Foods(PASSCLAIM)--Phase One:Preparing the Way显示文摘 | ASP N G CUMMINGS J H MENSINK R P et aL | 2003 | Eur J Nutr2003，42，1： | 1 |
| 17 | Membrane potential depolarization of root cap cells precedes aluminum tolerance in soybean 显示文摘 | OLIVERTTI G P CUMMING J R ETHERTON B | 1995 | Plant Physiol1995，，109： | 1 |
| 18 | Substitution effects in CVM values显示文摘 | Cummings R G Ganderton P T Mcguckin T | 1994 | American Journal of Agricultural Economics1994，76，2： | 1 |
| 19 | Diabetes,fasting blood lucose and age-related cataract:the Blue Mountains Eye Study显示文摘 | ROWE N G MITCHELL P G CUMMING R G | 2000 | Ophthalmic Epidemiol2000，7，2： | 1 |
| 20 | Broader Incorporation of Bioinformatics in Education: opportunities and challenges 显示文摘 | Cummings M P Temple G G | 2010 | Briefings in Bioinformatics2010，11，6： | 1 |
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