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| 1 | New insights to occult gastrointestinal bleeding: From pathophysiology to therapeutics显示文摘Obscure gastrointestinal bleeding is still a clinical challenge for gastroenterologists. The recent development of novel technologies for the diagnosis and treatment of different bleeding causes has allowed a better management of patients, but it also determines the need of a deeper comprehension of pathophysiology and the analysis of local expertise in order to develop a rational management algorithm. Obscure gastrointestinal bleeding can be divided in occult, when a positive occult blood fecal test is the main manifestation, and overt, when external sings of bleeding are visible. In this paper we are going to focus on overt gastrointestinal bleeding, describing the physiopathology of the most usual causes, analyzing the diagnostic procedures available, from the most classical to the novel ones, and establishing a standard algorithm which can be adapted depending on the local expertise or availability. Finally, we will review the main therapeutic options for this complex and not so uncommon clinical problem. | Antonio Damián Sánchez-Capilla Paloma De La Torre-Rubio Eduardo Redondo-Cerezo | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 7 |
| 2 | Emerging treatments for complex perianal fistula in Crohn's disease显示文摘Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated.Correct diagnosis,characterization and classification of the fistulas are essential to optimize treatment.Nevertheless, in the case of patients whose fistulas are associated with Crohn's disease,complete closure is particularly difficult to achieve.Systemic medical treatments(antibiotics, thiopurines and other immunomodulatory agents,and, more recently,anti-tumor necrosis factor-αagents such as infliximab)have been tried with varying degrees of success.Combined medical(including infliximab)and less aggressive surgical therapy(drainage and seton placement)offer the best outcomes in complex Crohn's fistulas while more aggressive surgical procedures such as fistulotomy or fistulectomy may increase the risk of incontinence.This review will focus on emerging novel treatments for perianal disease in Crohn's patients. These include locally applied infliximab or tacrolimus, fistula plugs,instillation of fibrin glue and the use of adult expanded adipose-derived stem cell injection.More welldesigned controlled studies are required to confirm the effectiveness of these emerging treatments. | Carlos Taxonera David A Schwartz Damián García-Olmo | 2009 | World Journal of Gastroenterology2009，15，34： | 6 |
| 3 | Further the liquid biopsy:Gathering pieces of the puzzle of genometastasis theory显示文摘Metastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism,not yet fully understood.What is almost beyond doubt is that circulatory system is crucial for cancer propagation.Regarding this system,much attention has been recently paid to liquid biopsy.This technique is aimed to detect circulating tumor cells (CTCs) and circulating nucleic acids so it can be used as a tool for diagnostic,prognostic and follow-up of patients.Whereas CTCs tend to be scarce in serum and plasma from cancer patient,abundant circulating nucleic acids can be detected in the same location.This fact,together with the genetic origin of cancer,stands out the relevance of circulating nucleic acids and shed light into the role of nucleic acids as drivers of metastasis,a recently discovered phenomenon called Genometastasis.This innovative theory supports the transfer of oncogenes from cancer cells to normal and susceptible cells located in distant target organs through circulatory system.What is more,many biological processes haven been described to deliver and secrete circulating nucleic acids into the circulation which can allow such horizontal transfer of oncogenes.In this review,we focus not only on these mechanisms but also we demonstrate its putative role in cancer propagation and give insights about possible therapeutic strategies based on this theory.Our objective is to demonstrate how findings about cell-to-cell communications and previous results can agree with this unprecedented theory. | Ana García-Casas Dolores C García-Olmo Damián García-Olmo | 2017 | World Journal of Clinical Oncology2017，8，5： | 5 |
| 4 | Stem cell therapy for faecal incontinence: Current state and future perspectives显示文摘Faecal continence is a complex function involving different organs and systems. Faecal incontinence is a common disorder with different pathogeneses, disabling consequences and high repercussions for quality of life. Current management modalities are not ideal, and the development of new treatments is needed. Since 2008, stem cell therapies have been validated, 36 publications have appeared(29 in preclinical models and seven in clinical settings), and six registered clinical trials are currently ongoing. Some publications have combined stem cells with bioengineering technologies. The aim of this review is to identify and summarise the existing published knowledge of stem cell utilization as a treatment for faecal incontinence. A narrative or descriptive review is presented. Preclinical studies have demonstrated that cellular therapy, mainly in the form of local injections of muscle-derived(muscle derived stem cells or myoblasts derived from them) or mesenchymal(bone-marrow-or adipose-derived) stem cells, is safe. Cellular therapy has also been shown to stimulate the repair of both acute and subacute anal sphincter injuries, and some encouraging functional results have been obtained. Stem cells combined with normal cells on bioengineered scaffolds have achieved the successful creation and implantation of intrinsically-innervated anal sphincter constructs. The clinical evidence, based on adipose-derived stem cells and myoblasts, is extremely limited yet has yielded some promising results, and appears to be safe. Further investigation in both animal models and clinical settings is necessary to drawing conclusions. Nevertheless, if the preliminary results are confirmed, stem cell therapy for faecal incontinence may well become a clinical reality in the near future. | Jacobo Trébol Ana Carabias-Orgaz Mariano García-Arranz Damián García-Olmo | 2018 | World Journal of Stem Cells2018，10，7： | 4 |
| 5 | Paclobutrazol and Its Use in Fruit Production:A Review显示文摘There are documentary records referring to paclobutrazol(PBZ)as a growth bioregulator that inhibits the gibberellin synthesis and its application increases yields in fruit and vegetable crop productions.Its agronomic management includes it as an emerging technology to reduce vigour,promote flower induction and flower development in fruit trees with increased economic returns.Its use is banned in some countries because of concerns about residues that can cause harmful effects on the environment.Therefore,the aim of this article was to collect,analyse and summarise relevant information on the use of PBZ in fruit tree production and its possible risks to the environment.The results obtained indicated that the application of PBZ can be effective in solving some problems related to flowering if it is applied in the right amount and at the right time.However,it is necessary to elucidate the physiological processes with which it is associated and its response to be taken into account to increase yield.PBZ is currently used in fruit trees such as mango,lime,apple and guava,increasing their productivity.However,some studies have shown its residual effect on the environment.Therefore,PBZ is a viable strategy,because it presents a series of advantages in the production of fruit trees.However,it is vital to generate protocols that seek its regulation with a rational and sustainable approach. | Laura Raquel Orozco-Meléndez Ofelia Adriana Hernández-Rodríguez Oscar Cruz-Álvarez Loreto Robles-Hernández Graciela Dolores Avila-Quezada Esteban Sánchez Chavez DamiánAarón Porras-Flores Dámaris Leopoldina Ojeda-Barrios | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 6 | Rat model of anal sphincter injury and two approaches for stem cell administration显示文摘AIM To establish a rat model of anal sphincter injury and test different systems to provide stem cells to injured area.METHODS Adipose-derived stem cells(ASCs) were isolated from BDIX rats and were transfected with green fluorescent protein(GFP) for cell tracking. Biosutures(sutures covered with ASCs) were prepared with 1.5 × 10~6 GFPASCs, and solutions of 10~6 GFP-ASCs in normal saline were prepared for injection. Anorectal normal anatomy was studied on Wistar and BDIX female rats. Then, we designed an anal sphincter injury model consisting of a 1-cm extra-mucosal miotomy beginning at the anal verge in the anterior middle line. The sphincter lesion was confirmed with conventional histology(hematoxylin and eosin) and immunofluorescence with 4', 6-diamidino-2-phenylindole(commonly known as DAPI), GFP and α-actin. Functional effect was assessed with basal anal manometry, prior to and after injury. After sphincter damage, 36 BDIX rats were randomized to three groups for:(1) Cell injection without repair;(2) biosuture repair; and(3) conventional suture repair and cell injection. Functional and safety studies were conducted on all the animals. Rats were sacrificed after 1, 4 or 7 d. Then, histological and immunofluorescence studies were performed on the surgical area.RESULTS With the described protocol, biosutures had been covered with at least 820000-860000 ASCs, with 100% viability. Our studies demonstrated that some ASCs remained adhered after suture passage through the muscle. Morphological assessment showed that the rat anal anatomy is comparable with human anatomy; two sphincters are present, but the external sphincter is poorly developed. Anal sphincter pressure data showed spontaneous, consistent, rhythmic anal contractions, taking the form of 'plateaus' with multiple twitches(peaks) in each pressure wave. These basal contractions were very heterogeneous; their frequency was 0.91-4.17 per min(mean 1.6980, SD 0.57698), their mean duration was 26.67 s and mean number of peaks was 12.53. Our morphological assessment revealed that with the aforementioned surgical procedure, both sphincters were completely sectioned. In manometry, the described activity disappeared and was replaced by a gentle oscillation of basal line, without a recognizable pattern. Surprisingly, these findings appeared irrespective of injury repair or not. ASCs survived in this potentially septic area for 7 d, at least. We were able to identify them in 84% of animals, mainly in the muscular section area or in the tissue between the muscular endings. ASCs formed a kind of 'conglomerate' in rats treated with injections, while in the biosuture group, they wrapped the suture. ASCs were also able to migrate to the damaged zone. No relevant adverse events or mortality could be related to the stem cells in our study. We also did not find unexpected tissue growths. CONCLUSION The proposed procedure produces a consistent sphincter lesion. Biosutures and injections are suitable for cell delivery. ASCs survive and are completely safe in this clinical setting. | Jacobo Trébol Tihomir Georgiev-Hristov Luz Vega-Clemente Ignacio García-Gómez Ana Carabias-Orgaz Mariano García-Arranz Damián García-Olmo | 2018 | World Journal of Stem Cells2018，10，1： | 2 |
| 7 | Solid phase extraction of Pb(II) in water samples using a new hybrid inorganic-organic mesoporous silica prior to its determination by FAAS显示文摘 | Damián Pérez-Quintanilla Alfredo Sánchez Isabel del Hierro Mariano Fajardo Isabel Sierra | 2009 | Microchimica Acta (-)2009，，3： | 1 |
| 8 | Preparation, characterization, and Zn 2+ adsorption behavior of chemically modified MCM-41 with 5-mercapto-1-methyltetrazole显示文摘 | Damián Pérez-Quintanilla Alfredo Sánchez Isabel del Hierro Mariano Fajardo Isabel Sierra | 2007 | Journal of Colloid And Interface Science2007，，2： | 1 |
| 9 | Predictive ability of reconstructed human epidermis equivalents for the assessment of skin irritation of cosmetics 显示文摘 | Faller C Bracher M Dami N | 2002 | Toxicol In Vitro2002，16，5： | 1 |
| 10 | A Phase I Clinical Trial of the Treatment of Crohn’s Fistula by Adipose Mesenchymal Stem Cell Transplantation显示文摘 | Damián García-Olmo M.D. Mariano García-Arranz Ph.D. Dolores Herreros M.D. Isabel Pascual M.D. Concepción Peiro Ph.D. José Antonio Rodríguez-Montes M.D | 2005 | Diseases of the Colon & Rectum2005，，7： | 1 |
| 11 | Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics显示文摘 | Roberto Bravo Tomás Gutierrez Felipe Paredes Damián Gatica Andrea E. Rodriguez Zully Pedrozo Mario Chiong Valentina Parra Andrew F.G. Quest Beverly A. Rothermel Sergio Lavandero | 2011 | International Journal of Biochemistry and Cell Biology2011，，： | 1 |
| 12 | Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer:a randomised,double-blind study显示文摘 | Fizazi K Carducci M Smith M Dami?o R Brown J Karsh L Milecki P Shore N Rader M Wang H Jiang Q Tadros S Dansey R Goessl C | | 0，，： | 1 |
| 13 | Eye irritation of low-irritant cosmetic formulations : correlation of in vitro results with clinical data and product composition 显示文摘 | DEBBASCH C EBENHAHN C DAMI N | 2005 | Food Chem Toxicol2005，43，1： | 1 |
| 14 | New Diagnostic and Therapeutic Approaches to Treat Ventricular Tachycardias Originating at the Summit of the Left Ventricle: Role of Merged Hemodynamic–MRI and Alternative Ablation Sources显示文摘 | Felipe Atienza ángel Arenal Esther Pérez-David Jaime Elízaga Juan Enrique Ortu?o María Jesús Ledesma-Carbayo Damián Sánchez-Quintana Francisco Fernández-Avilés | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，6： | 1 |
| 15 | Mechanical and metabolic com- plications of, hysteroscopic surgery, report of a retrospective study of 351 procedures 显示文摘 | Castaning N DamiE Chuong T | 1999 | Contracept Fertil sex1999，27，3： | 1 |
| 16 | Preparation,characterization,and Zn 2+adsorption behav-ior of chemically modified MCM-41with5-mercapto-1-methyltetr azole显示文摘 | DAMIN PREZ-QUINTANILLA ALFREDO SNCHEZ ISABEL DELHIERRO | 2007 | J Colloid Interf Sci2007，313，2： | 1 |
| 17 | Diagnostic accuracy of tumour markers in serous effusions: a validation study显示文摘 | Jaume Trapé Rafael Molina Francesc Sant Jesús Montesinos Anna Arnau Josefina Franquesa Rosana Blavia Esperanza Martín Emili Marquilles Damià Perich Concepción Pérez Josep Maria Roca Montserrat Doménech Joan López Josep Miquel Badal | 2012 | Tumor Biology2012，，5： | 1 |
| 18 | Evaluation of eye irritation potential: statistical analysis and tier testing 显示文摘 | DESILVA O M COTHN M DAMI N | 1997 | Food Chem Toxicol1997，35，： | 1 |
| 19 | Anti-citrullinated peptide antibodies in lupus patients with or without deforming arthropathy显示文摘 | DAMI(A)N-ABREGO G N CABIEDES J CABRAL A R | 2008 | Lupus2008，17，4： | 1 |
| 20 | Load distribution in a four contact-point slewing bearing显示文摘 | Jose Ignacio Amasorrain Xabier Sagartzazu Jorge Damián | 2003 | Mechanism and Machine Theory2003，，6： | 1 |
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