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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer显示文摘 | David A. Lieberman Douglas K. Rex Sidney J. Winawer Francis M. Giardiello David A. Johnson Theodore R. Levin | 2012 | Gastroenterology2012，，3： | 8 |
| 3 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 4 | The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on real-time endoscopic assessment of the histology of diminutive colorectal polyps显示文摘 | Douglas K. Rex Charles Kahi Michael O’Brien T.R. Levin Heiko Pohl Amit Rastogi Larry Burgart Tom Imperiale Uri Ladabaum Jonathan Cohen David A. Lieberman | 2011 | Gastrointestinal Endoscopy2011，，3： | 7 |
| 5 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 4 |
| 6 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 7 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 8 | Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System显示文摘 | Paul S. Adler Barbara Goldoftas David I. Levine | 1999 | Organization Science1999，，1： | 3 |
| 9 | Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21显示文摘 | Vincent M. Aita Xiao Huan Liang V.V.V.S. Murty David L. Pincus Weiping Yu Eftihia Cayanis Sergei Kalachikov T.Conrad Gilliam Beth Levine | 1999 | Genomics1999，，1： | 3 |
| 10 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 11 | The approximation power of moving least-squares显示文摘 | David Levin | 1998 | Mathematics of Computation1998，，224： | 2 |
| 12 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 13 | High Detection Rates of Colorectal Neoplasia by Stool DNA Testing With a Novel Digital Melt Curve Assay显示文摘 | Hongzhi Zou William R. Taylor Jonathan J. Harrington Fareeda Taher Nazer Hussain Xiaoming Cao Charles L. Loprinzi Theodore R. Levine Douglas K. Rex Dennis Ahnen Kandice L. Knigge Peter Lance Xuan Jiang David I. Smith David A. Ahlquist | 2009 | Gastroenterology2009，，2： | 2 |
| 14 | Hydrogen production by Clostridium thermocellum 27405 from cellulosic biomass substrates 显示文摘 | David B Levin Rumana Islam Nazim Cicek | 2006 | Int J Hydrogen Energy2006，31，11： | 1 |
| 15 | Natriuretic Peptide显示文摘 | Elis R Levin David G | 1998 | N Engl J Med1998，339，： | 1 |
| 16 | Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation显示文摘 | Anthony Stallion Tzuyung D. Kou Samir Q. Latifi Kelly A. Miller Beverly B. Dahms David L. Dudgeon Alan D. Levine | 2005 | Journal of Pediatric Surgery2005，，3： | 1 |
| 17 | An introduction to the minimally invasive osteosynthesis of intra-articular calcaneal fractures显示文摘 | David S. Levine David L. Helfet | 2001 | Injury2001，，： | 1 |
| 18 | Intratheeal fentanyl with small-dose dilute bupivacaine: better anesthesia without prolonging recovery 显示文摘 | Ben David B Solomon E Levin H | 1997 | Anesth Analg1997，85，3： | 1 |
| 19 | Adult chronic rhinosinusitis: Definitions, diagnosis, epidemiology, and pathophysiology显示文摘 | Michael S. Benninger Berrylin J. Ferguson James A. Hadley Daniel L. Hamilos Michael Jacobs David W. Kennedy Donald C. Lanza Bradley F. Marple J.David Osguthorpe James A. Stankiewicz Jack Anon James Denneny Ivor Emanuel Howard Levine | 2003 | Otolaryngology - Head and Neck Surgery2003，，3： | 1 |
| 20 | Lenalidomide enhances anti-myeloma cellular immunity显示文摘 | Katarina Luptakova Jacalyn Rosenblatt Brett Glotzbecker Heidi Mills Dina Stroopinsky Turner Kufe Baldev Vasir Jon Arnason Dimitri Tzachanis Jeffrey I. Zwicker Robin M. Joyce James D. Levine Kenneth C. Anderson Donald Kufe David Avigan | 2013 | Cancer Immunology, Immunotherapy2013，，： | 1 |
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