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| 1 | Exploring Seasonal and Circadian Rhythms in Structural Traits of Field Maize from LiDAR Time Series显示文摘Plant growth rhythm in structural traits is important for better understanding plant response to the ever-changing environment.Terrestrial laser scanning(TLS)is a well-suited tool to study structural rhythm under field conditions.Recent studies have used TLS to describe the structural rhythm of trees,but no consistent patterns have been drawn.Meanwhile,whether TLS can capture structural rhythm in crops is unclear.Here,we aim to explore the seasonal and circadian rhythms in maize structural traits at both the plant and leaf levels from time-series TLS.The seasonal rhythm was studied using TLS data collected at four key growth periods,including jointing,bell-mouthed,heading,and maturity periods.Circadian rhythms were explored by using TLS data acquired around every 2 hours in a whole day under standard and cold stress conditions.Results showed that TLS can quantify the seasonal and circadian rhythm in structural traits at both plant and leaf levels.(1)Leaf inclination angle decreased significantly between the jointing stage and bell-mouthed stage.Leaf azimuth was stable after the jointing stage.(2)Some individual-level structural rhythms(e.g.,azimuth and projected leaf area/PLA)were consistent with leaf-level structural rhythms.(3)The circadian rhythms of some traits(e.g.,PLA)were not consistent under standard and cold stress conditions.(4)Environmental factors showed better correlations with leaf traits under cold stress than standard conditions.Temperature was the most important factor that significantly correlated with all leaf traits except leaf azimuth.This study highlights the potential of time-series TLS in studying outdoor agricultural chronobiology. | Shichao Jin Yanjun Su Yongguang Zhang Shilin Song Qing Li Zhonghua Liu Qin Ma Yan Ge LingLi Liu Yanfeng Ding Frédéric Baret Qinghua Guo | 2021 | Plant Phenomics2021，3，1： | 5 |
| 2 | Hot deformation behavior of a spray-deposited AZ31 magnesium alloy显示文摘The flow stress behavior of an as-spray-deposited AZ31 magnesium alloy with fine grains was investigated by means of compression tests with a Gleeble 1500 thermal mechanical simulator at isothermal constant strain rates of 0.01, 0.1, 1.0, and 10 s-1; the testing temperatures ranged from 623 to 723 K. It is demonstrated that a linear equation can be fitted between the Zemer-Hollomon parameter Z and stress in a double-log scale. The effect of deformation parameters on the behavior of recrystallization was analyzed. Dynamic recrystallization (DRX) generally occurs at a higher temperature and at a lower strain rate. The constitutive equation of the spray-deposited AZ31 magnesium alloy is presented by calculating the deformation activation energy (199.8 kJ·mol-1). The as-spray-formed AZ31 alloy is easier for DRX nucleation at elevated temperatures due to the fine grain, which provides a large amount of nucleation sites and a high-diffusivity path for the atom. | LI Yongbing CHEN Yunbo CUI Hua DING Jie ZUO Lingli ZHANG Jishan | 2009 | Rare Metals2009，28，1： | 2 |
| 3 | C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death显示文摘Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular processes.To understand the cellular effect of lysosome damage,we screened natural smallmolecule compounds that induce iysosomal abnormality using Caenorhabditis elegans (C.elegans)as a model system.A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D)were identified that caused lysosome enlargement in C.elegans macrophage-like cells.Intriguingly,these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway.In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage,leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling,but not RIP1 or RIP3 signaling.These findings suggest that lysosomedamaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders. | Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua Tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang Gao Xiaojiang Hao Chonglin Yang | 2018 | Protein & Cell2018，9，12： | 2 |
| 4 | Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma显示文摘Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation damage.To this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC therapy.Here,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for NPC.Such nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking core.Taking advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of CDDP.When they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy agents.By means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC. | Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan Jun Shen Ruibing Wang Jinshan Guo Yue Pan | 2021 | Bioactive Materials2021，6，12： | 1 |
| 5 | Par- allel multi source view maintenance显示文摘 | ZHANG Xin DING Lingli RUNDENSTEINER E A | 2004 | The VLDB Journal2004，13，1： | 1 |
| 6 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 7 | Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid-and choline acetyltransferase-positive neurons显示文摘This study examined the isolation and differentiation of dorsal root ganglion progenitor cells for therapeutic use in neurodegenerative diseases. Rat embryonic dorsal root ganglia progenitors were isolated and purified using the differential adhesion method combined with cytosine arabinoside treatment. After culture in serum-free medium supplemented with B27, basic fibroblast growth factor and epidermal growth factor, these cells remained viable and survived for more than 18 months in vitro. Most cells differentiated to neurons that were immunoreactive for gamma-aminobutyric acid and choline acetyltransferase as detected by immunohistochemical staining. In addition, nerve growth factor and neurotrophic tyrosine kinase receptor expression were also observed in dorsal root ganglion progenitors and differentiated cells. K252a, an inhibitor that blocks nerve growth factor-induced signaling, inhibited cell survival, suggesting the possible existence of a nerve growth factor autocrine loop in these proliferating cells. | Lingli Yu Yindi Ding Ambre Spencer Ji Ma Ruisheng Lu Brian B.Rudkin Chonggang Yuan | 2012 | Neural Regeneration Research2012，7，7： | 1 |
| 8 | Amino acid variation analysis of surface spike glycoprotein at 614 in SARS-CoV-2 strains显示文摘As severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to disperse globally with worrisome speed,identifying amino acid variations in the virus could help to understand the characteristics of it.Here,we studied 489 SARS-CoV-2 genomes obtained from 32 countries from the Nextstrain database and performed phylogenetic tree analysis by clade,country,and genotype of the surface spike glycoprotein(S protein)at site 614.We found that virus strains from China's Mainland were mostly distributed in Clade B and Clade undefined in the phylogenetic tree,with very few found in Clade A.In contrast,Clades A2(one case)and A2a(112 cases)predominantly contained strains from European regions.Moreover,Clades A2 and A2a differed significantly from those of China's Mainland in age of infected population(P Z 0.0071,mean age 40.24 to 46.66),although such differences did not exist between the US and China's Mainland.Further analysis demonstrated that the variation of the Sprotein at site 614(QHD43416.1:p.614D>G)was a characteristic of stains in Clades A2 and A2a.Importantly,this variation was predicted to have neutral or benign effects on the function of the S protein.In addition,global quality estimates and 3D protein structures tended to be different between the two S proteins.In summary,we identified different genomic epidemiology among SARS-CoV-2 strains in different clades,especially in an amino acid variation of the S protein at 614,revealing potential viral genome divergence in SARS-CoV-2 strains. | Canhui Cao Liang Huang Kui Liu Ke Ma Yuan Tian Yu Qin Haiyin Sun Wencheng Ding Lingli Gui Peng Wu | 2020 | Genes & Diseases2020，7，4： | 0 |
| 9 | Research on the Comprehensive Demodulation of Gear Tooth Crack Early Fault显示文摘The component of gear vibration signal is very complex,when a localized tooth defect such as a tooth crack is pre- sent,the engagement of the cracked tooth will induce an impulsive change with comparatively low energy to the gear mesh signal and the background noise.This paper presents a new comprehensive demodulation method which combined with amplitude envelop demodulation and phase demodulation to extract gear crack early fault.A mathematical model of gear vibration signal contain crack fault is put forward.Simulation results based on this model show that the new comprehensive demodulation method is more effective in finding fault and judging fault level then conventional single amplitude demodulation at present. | CUI Lingli DING Fang GAO Lixin ZHANG Jianyu (College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 10 | Remote Monitoring and Diagnosis System for High-speed Wire Rolling Mills显示文摘Traditional fault diagnosis systems of rolling mills mostly use single machine monitoring net,which leads the re- al-time data running only in the enterprise locally and can not monitor and manage the high-speed wire rolling mills between units, workshops and factories concentratedly.A new-type structure of remote diagnosis system for high-speed wire rolling mills is pre- sented in this paper.The signal processing,computer network and remote diagnosis etc techniques are used to predictive maintenance manage the rolling mills units in this system.The new structure reinforced the remote feedback function,made up the existing fault diagnosis systems’ insufficiency in the extension and the function,promoted resource sharing and avoided the repeat develop- ment.The remote diagnosis example shows that the system can monitor and diagnose the fault information of remote machine timely and effectively. | CUI Lingli ZHANG Jianyu DING Fang GAO Lixin WANG Dapeng (College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 11 | Fiber-specific increase of carotenoid content promotes cotton fiber elongation by increasing abscisic acid and ethylene biosynthesis显示文摘Cotton fiber is a raw material for the global textile industry and fiber quality is essential to its industrial application.Carotenoids are plant secondary metabolites that may serve as dietary components,regulate light harvesting,and scavenge reactive oxygen species.Although carotenoids accumulate predominantly in rapidly elongating cotton fibers,their roles in cotton fiber development remain poorly understood.In this study,a fiber-specific promoter proSCFP was applied to drive the expression of GhOR1Del,a positive regulator of carotenoid accumulation,to upregulate the carotenoid level in cotton fiber in planta.Fiber length,strength,and fineness were increased in proSCFP:GhOR1Del transgenic cotton and abscisic acid(ABA)and ethylene contents were increased in elongating fibers.The ABA downstream regulator GhbZIP27a stimulated the expression of the ethylene synthase gene GhACO3 by binding to its promoter,suggesting that ABA promoted fiber elongation by increasing ethylene production.These findings suggest the involvement of carotenoids and ABA signaling in promoting cotton fiber elongation and provide a strategy for improving cotton fiber quality. | Jianyan Zeng Dan Yao Ming Luo Lingli Ding Yi Wang Xingying Yan Shu’e Ye Chuannan Wang Yiping Wu Jingyi Zhang Yaohua Li Lingfang Ran Yonglu Dai Yang Chen Fanlong Wang Hanyan Lai Nian Liu Nianjuan Fang Yan Pei Yuehua Xiao | 2023 | The Crop Journal2023，11，3： | 0 |
| 12 | Diagnosis of Gearbox Typical Fault in Rolling Mills Based on the Wavelet Packets Technology显示文摘The early impulse fault diagnosis of the gearbox in rolling mills is often difficult and labour intensive because the gearbox of that high speed machine is multi-shafting transmission system,in which many gearsets and rolling bears work together at the same time and there are much complex frequency structure and various disturb.A new time-frequency method based on the wavelet packets technique was developed and used to extract the impact feature from signals collected from faulty data of one rolling mills gearbox.The method improves the signal to noise ration so that results obtained using this method represents features with fine resolution in both low-frequency and the high frequency bands.The results of analysis indicate the validity and the practicability of the method proposed here. | CUI Lingli GAO Lixin ZHANG Jianyu DING Fang College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China, | 2006 | 武汉理工大学学报2006，28，S3： | 0 |
| 13 | Target Resistance of Eleusine indica to Glyphosate显示文摘[Objectives]This study was conducted to detect the evolution of resistance to glyphosate in Eleusine indica.[Methods]In the previous study,glyphosate-resistant population T2-4 was screened out from E.indica populations in sugarcane fields in Guangxi.In this study,we determined the resistance index of T2-4 by whole plant bioactivity assay and further explored the molecular biological mechanism of resistance.[Results]The resistance index of T2-4 was 112,and it is thus a highly resistant population.Amino acid mutations were found at positions 102,106 and 381 in the EPSPS sequence of T2-4,containing at least a triple mutation allele in Thr-102-Ile,Pro-106-Ser and Pro-381-Leu and a double mutation allele in Pro-106-Ser and Pro-381-Leu.qPCR was used to determine the EPSPS gene copy number and expression in resistant plants of T2-4.EPSPS gene copy number and expression both increased,with 8.3-fold higher copy number and 2.7-fold higher expression than the sensitive population.Therefore,the resistance of T2-4 to glyphosate was mainly caused by multiple target mechanisms including mutation of EPSPS gene,copy number increase and expression increase,and the resistance of E.indica to glyphosate needs our high attention.[Conclusions]At present,the level of resistance to glyphosate is very high in the sugarcane fields of Guangxi,and it is necessary to take a variety of weed control measures to solve the problem of glyphosate resistance. | Tao ZHANG Siquan LUO Lingli BAI Hongyuan KUANG Chenzhong JIN Yanhui WANG Jingbo LI Bin SUN Zijuan DING | 2022 | Agricultural Biotechnology2022，11，6： | 0 |
| 14 | Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways显示文摘Fractures have an extraordinarily negative impact on individuals'quality of life and functional status.Nonunion or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new bone.The use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion. | Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu | 2024 | Genes & Diseases2024，11，1： | 0 |
| 15 | Core-shell structured Ru-Ni@SiO_2: Active for partial oxidation of methane with tunable H_2/CO ratio显示文摘This study demonstrated that a Ru-Ni bimetallic core-shell catalyst(0.6%Ru-Ni)@Si O_2with a proper surface Ru concentration is superior in achieving better catalytic activity and tunable H_2/CO ratio at a comparatively lower reaction temperature(700°C).Compared to the impregnation method,the hydrothermal approach leads to a highly uniform Ru distribution throughout the core particles.Uniform Ru distribution would result in a proper surface Ru concentration as well as more direct Ru-Ni interaction,accounting for better catalyst performance.Enriched surface Ru species hinders surface carbon deposition,but also declines overall activity and H_2/CO ratio,meanwhile likely enhances Ni oxidation to certain degree under the applied reaction conditions.Over the current(m%Ru-Ni)@Si O_2catalyst,the formation of fibrous carbon species is suppressed,which accounts for good stability of catalyst within a TOS of 10 h. | Yixuan Dou Yijun Pang Lingli Gu Yifan Ding Wu Jiang Xinzhen Feng Weijie Ji Chak-Tong Au | 2018 | Journal of Energy Chemistry2018，27，3： | 0 |
| 16 | Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions显示文摘Hepatitis E virus(HEV)infection can cause severe complications and high mortality,particularly in pregnant women,organ transplant recipients,individuals with pre-existing liver disease and immunosuppressed patients.However,there are still unmet needs for treating chronic HEV infections.Herein,we screened a best-in-class drug repurposing library consisting of 262 drugs/compounds.Upon screening,we identified vidofludimus calcium and pyrazofurin as novel anti-HEV entities.Vidofludimus calcium is the next-generation dihydroorotate dehydrogenase(DHODH)inhibitor in the phase 3 pipeline to treat autoimmune diseases or SARS-CoV-2 infection.Pyrazofurin selectively targets uridine monophosphate synthetase(UMPS).Their anti-HEV effects were further investigated in a range of cell culture models and human liver organoids models with wild type HEV strains and ribavirin treatment failure-associated HEV strains.Encouragingly,both drugs exhibited a sizeable therapeutic window against HEV.For instance,the IC50 value of vidofludimus calcium is 4.6–7.6-fold lower than the current therapeutic doses in patients.Mechanistically,their anti-HEV mode of action depends on the blockage of pyrimidine synthesis.Notably,two drugs robustly inhibited ribavirin treatment failure-associated HEV mutants(Y1320H,G1634R).Their combination with IFN-αresulted in synergistic antiviral activity.In conclusion,we identified vidofludimus calcium and pyrazofurin as potent candidates for the treatment of HEV infections.Based on their antiviral potency,and also the favorable safety profile identified in clinical studies,our study supports the initiation of clinical studies to repurpose these drugs for treating chronic hepatitis E. | Hongbo Guo Dan Liu Kuan Liu Yao Hou Chunyang Li Qiudi Li Xiaohui Ding Monique M.A.Verstegen Jikai Zhang Lingli Wang Yibo Ding Renxian Tang Xiucheng Pan Kuiyang Zheng Luc J.Wvan der Laan Qiuwei Pan Wenshi Wang | 2024 | Virologica Sinica2024，39，1： | 0 |
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