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| 1 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | Two-and three-electrode impedance spectroscopic studies of graphite electrode in the first lithiation显示文摘The first lithiation of graphite electrode was investigated by electrochemical impedance spectroscopy (EIS) and scanning electron microscope (SEM) in a two-electrode button cell and a three-electrode glass cell. The results demonstrate that the study of the variation of EIS feature of the graphite electrode in the two-electrode button cell with electrode polarization potential decreasing in the first lithiation cannot be used to investigate the formation mechanism of the solid electrolyte interphase (SEI) film. However, the formation and growth process of the SEI film can be acquired by investigating the variation of EIS features of the graphite electrode in the three-electrode glass cell with the decrease of electrode po-larization potential in the first lithiation. Moreover, the results also point out that the SEI film on graph-ite electrode is mainly formed between 1.0 and 0.6 V in the first lithiation. | ZHUANG QuanChao TIAN LeiLei WEI GuoZhen DONG QuanFeng SUN ShiGang | 2009 | Chinese Science Bulletin2009，54，15： | 4 |
| 3 | Spatial Identification of Housing Vacancy in China显示文摘The housing vacancy rate(HVR)is an important index in assessing the healthiness of residential real estate market.In China,it is hardly to take advantage of the basic data of real estate information due to the opaque of those data.In this paper,the HVR is estimated to two scales.At the grid level,urban area ratio was calculated by nighttime images after eliminating outliers of nighttime images and night light intensity of non-residential pixels in mixed pixels by a proposed modified optimal threshold method,and built-up areas in each pixel were extracted from the land-cover data.Then,the HVR is calculated by comparing the light intensity of specific grid with the light intensity of full occupancy rate regions.At the administrative scale,the GCI(‘ghost city’index)is constructed by calculating the ratio of the total light radiation intensity of a city to the total construction land area of the city.The overall spatial differentiation pattern of the vacant houses in the national prefecture level administrative regions is analyzed.The following conclusions were drawn:vacant housing is rare in certain eastern coastal cities and regions in China with relatively fast economic development.Cities based on exhausted resources,some mountainous cities,and cities with relatively backward economic development more typically showed high levels of housing vacancy.The GCI of prefecture-level administrative units gradually declined from north to south,whereas the east-west distribution showed a parabolic shape.As city level decreased,the GCI registered a gradual upward trend.China’s urban housing vacancy can be divided into five categories:industry or resources driven,government planned,epitaxy expansionary,environmental constraint and speculative activate by combining the spatial distribution of housing vacancy with the factors of natural environment,social economic development level,and population density into consideration. | PAN Jinghu DONG Leilei | 2021 | Chinese Geographical Science2021，31，2： | 2 |
| 4 | Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Xinyu Zhou Jianjun Chen Qi Li Gaoping Ren Guoen Yao Ming Liu Qiang Dong Jìng Guo Leilei Li Jing Guo Peng Xie | 2012 | Stroke2012，，11： | 2 |
| 5 | CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients显示文摘 | Chen Leilei Chan Tim Hon Man Yuan Yun-Fei Hu Liang Huang Jun Ma Stephanie Wang Jian Dong Sui-Sui Tang Kwan Ho Xie Dan Li Yan Guan Xin-Yuan | 2010 | Journal of Clinical Investigation2010，，4： | 2 |
| 6 | Expression profiles of seven glutathione S-transferase ( GST ) genes from Venerupis philippinarum exposed to heavy metals and benzopyrene显示文摘 | Linbao Zhang Lihua Qiu Huifeng Wu Xiaoli Liu Liping You Dong Pei Leilei Chen Qing Wang Jianmin Zhao | 2011 | Comparative Biochemistry and Physiology Part C2011，，3： | 1 |
| 7 | Sex-dependent neurofunctional predictors of long-term maintenance of visual word learning显示文摘 | Qi Dong Leilei Mei Gui Xue Chuansheng Chen Tian Li Feng Xue Shizhi Huang | 2007 | Neuroscience Letters2007，，2： | 1 |
| 8 | Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge显示文摘 | Linbao Zhang Xiaoli Liu Leilei Chen Liping You Dong Pei Ming Cong Jianmin Zhao Chenghua Li Dongyan Liu Junbao Yu Huifeng Wu | 2011 | Fish and Shellfish Immunology2011，，6： | 1 |
| 9 | Reconstructing avascular necrotic femoral head through a bioactiveβ-TCP system:From design to application显示文摘A variety of techniques have been used for treating avascular necrosis of the femoral head(ANFH),but have frequently failed.In this study,we proposed aβ-TCP system for the treatment of ANFH by boosting revascularization and bone regeneration.The angio-conductive properties and concurrent osteogenesis of the highly interconnected porousβ-TCP scaffold were revealed and quantified through an in vivo model that simulated the ischemic environment of ANFH.Mechanical test and finite element analysis showed that the mechanical loss caused by tissue necrosis and surgery was immediately partially compensated after implantation,and the strength of the operated femoral head was adaptively increased and eventually returned to normal bone,along with continuous material degradation and bone regeneration.For translational application,we further conducted a multi-center open-label clinical trial to assess the efficacy of theβ-TCP system in treating ANFH.Two hundred fourteen patients with 246 hips were enrolled for evaluation,and 82.1%of the operated hips survived at a 42.79-month median follow-up.The imaging results,hip function,and pain scores were dramatically improved compared to preoperative levels.ARCO stage II disease outperformed stage III in terms of clinical effectiveness.Thus,bio-adaptive reconstruction using theβ-TCP system is a promising hip-preserving strategy for the treatment of ANFH. | Yajie Lu Xiantao Chen Xiao Lu Changning Sun Minghui Li Guojing Chen Zuoyao Long Yuan Gao Haoqiang Zhang Mengquan Huang Chuanlei Ji Hongbin Fan Dong Liu Yuewen Hao Hong Wang Leilei Zhang Hongmei Zhang Jianxi Lu Zhen Wang Jing Li | 2023 | Bioactive Materials2023，，10： | 1 |
| 10 | Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge显示文摘 | Linbao Zhang Xiaoli Liu Leilei Chen Liping You Dong Pei Ming Cong Jianmin Zhao Chenghua Li Dongyan Liu Junbao Yu Huifeng Wu | 2011 | Fish and Shellfish Immunology2011，，6： | 1 |
| 11 | A retrospective study of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing neutropenia during definitive concurrent chemoradiotherapy in patients with esophageal squamous carcinoma显示文摘Objective:To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)for preventive or delayed treatment in neutropenia,completion rate of concurrent chemoradiotherapy and hospitalization rate in patients with esophageal squamous carcinoma during definitive concurrent chemoradiotherapy.Methods:A total of 70 patients with esophageal squamous carcinoma in Peking University Cancer Hospital from January 2019 to December 2020,who received PEG-rhG-CSF during concurrent chemoradiotherapy,were enrolled in this retrospective analysis.There were 32 patients in the preventive group,and 38 patients in the delayed group.The incidence of neutropenia,completion rate of concurrent chemoradiotherapy and neutropeniarelated hospitalization rate were compared between PEG-rhG-CSF preventive group and delayed group.Results:The incidence of severe neutropenia(Grades 3–4)in all patients was 31.4%.Comparison between preventive group and delayed group showed that the incidence of severe neutropenia was 6.3%and 39.4%(χ^(2)=10.428,P=0.001),respectively.In preventive group,the incidence of severe neutropenia was 3.7%and 20.0%,respectively,for primary prevention and secondary prevention of PEG-rhG-CSF(χ^(2)=12.321,P=0.001).The completion rate of concurrent chemoradiotherapy was 93.8%in the preventive group and 63.2%in the delayed group(χ^(2)=9.220,P=0.002).The incidence of treatment interruption was 25.7%in the whole group,12.5%in the preventive group and 36.8%in the delayed group(χ^(2)=5.389,P=0.020).Seven patients(7/70,10.0%)were hospitalized and treated with intravenous antibiotics for neutropenia,including 1 in the preventive group and 6 in the delayed group(P=0.078).Conclusions:Prophylactic use of PEG-rhG-CSF during concurrent chemoradiotherapy for patients with esophageal squamous carcinoma can effectively reduce the incidence of neutropenia,ensure the safety of treatment,and improve the completion rate of concurrent chemoradiotherapy. | Xin Dong Wei Deng Leilei Jiang Dan Yang Huiming Yu Dongming Li Anhui Shi Rong Yu Weihu Wang | 2022 | Radiation Medicine and Protection2022，3，2： | 1 |
| 12 | Investigation of the block toppling evolution of a layered model slope by centrifuge test and discrete element modeling显示文摘Primary toppling usually occurs in layered rock slopes with large anti-dip angles.In this paper,the block toppling evolution was explored using a large-scale centrifuge system.Each block column in the layered model slope was made of cement mortar.Some artificial cracks perpendicular to the block column were prefabricated.Strain gages,displacement gages,and high-speed camera measurements were employed to monitor the deformation and failure processes of the model slope.The centrifuge test results show that the block toppling evolution can be divided into seven stages,i.e.layer compression,formation of major tensile crack,reverse bending of the block column,closure of major tensile crack,strong bending of the block column,formation of failure zone,and complete failure.Block toppling is characterized by sudden large deformation and occurs in stages.The wedge-shaped cracks in the model incline towards the slope.Experimental observations show that block toppling is mainly caused by bending failure rather than by shear failure.The tensile strength also plays a key factor in the evolution of block toppling.The simulation results from discrete element method(DEM)is in line with the testing results.Tensile stress exists at the backside of rock column during toppling deformation.Stress concentration results in the fragmented rock column and its degree is the most significant at the slope toe. | Leilei Jin Hongkai Dong Fei Ye Yufeng Wei Jianfeng Liu Changkui Wang | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，1： | 0 |
| 13 | Identification of the candidate gene controlling tiller angle in common wheat through genome-wide association study and linkage analysis显示文摘Wheat tiller angle(TA)is an important agronomic trait that contributes to grain production by affecting plant architecture.It also plays a crucial role in high-yield wheat breeding.An association panel and a recombinant inbred line(RIL)population were used to map quantitative trait loci(QTL)for TA.Results showed that 470 significant SNPs with 10.4%–28.8%phenotypic variance explained(PVE)were detected in four replicates by a genome-wide association study(GWAS).Haplotype analysis showed that the TA_Hap_4B1 locus on chromosome 4B was a major QTL to regulate wheat TA.Ten QTL were totally detected by linkage mapping with the RIL population,and QTA.hau-4B.1 identified in six environments with the PVE of 7.88%–18.82%was a major and stable QTL.A combined analysis demonstrated that both TA_Hap_4B1 and QTA.hau-4B.1 were co-located on the same region.Moreover,QTA.hau-4B.1 was confirmed by bulked segregant RNA-Seq(BSR-Seq)analysis.Phenotypic analysis showed that QTA.hau-4B.1was also closely related to yield traits.Furthermore,Traes CS4B02G049700 was considered as a candidate gene through analysis of gene sequence and expression.This study can be potentially used in cloning key genes modulating wheat tillering and provides valuable genetic resources for improvement of wheat plant architecture. | Lei Zhao Canguan Wang Tongzhu Wang Jinyuan Liu Qi Qiao Yulu Yang Pengyu Hu Leilei Zhang Simin Zhao Daiying Chen Yan Ren Ning Zhang Zhongdong Dong Feng Chen | 2023 | The Crop Journal2023，11，3： | 0 |
| 14 | miR-126 mitigates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the ERK1/2 and Bcl-2 pathways显示文摘Human bone marrow mesenchymal stem cells(hBMMSCs)are a promising cell source for bone engineering owing to their high potential to differentiate into osteoblasts.The objective of the present study is to assess microRNA-126(miR-126)and examine its effects on the osteogenic differentiation of hBMMSCs.In this study,we investigate the role of miR-126 in the progression of osteogenic differentiation(OD)as well as the apoptosis and inflammation of hBMMSCs during OD induction.OD is induced in hBMMSCs,and matrix mineralization along with other ODassociated markers are evaluated by Alizarin Red S(AR)staining and quantitative PCR(qPCR).Gain-and loss-offunction studies are performed to demonstrate the role of miR-126 in the OD of hBMMSCs.Flow cytometry and qPCR-based cytokine expression studies are performed to investigate the effect of miR-126 on the apoptosis and inflammation of hBMMSCs.The results indicate that miR-126 expression is downregulated during the OD of hBMMSCs.Gain-and loss-of function assays reveal that miR-126 upregulation inhibits the differentiation of hBMMSCs into osteoblasts,whereas the downregulation of miR-126 promotes hBMMSC differentiation,as assessed by the determination of osteogenic genes and alkaline phosphatase activity.Furthermore,the miR-126 level is positively correlated with the production of inflammatory cytokines and apoptotic cell death.Additionally,our results suggest that miR-126 negatively regulates not only B-cell lymphoma 2(Bcl-2)expression but also the phosphorylation of extracellular signal-regulated protein kinase(ERK)1/2.Moreover,restoring ERK1/2 activity and upregulating Bcl-2 expression counteract the miR-126-mediated suppression of OD in hBMMSCs by promoting inflammation and apoptosis,respectively.Overall,our findings suggest a novel molecular mechanism relevant to the differentiation of hBMMSCs into osteoblasts,which can potentially facilitate bone formation by counteracting miR-126-mediated suppression of ERK1/2 activity and Bcl-2 expression. | Ying Zhang Yiping Dong Qiushi Wei Zhikun Zhuang Youwen Liu Qiang Yuan Wei He Zhenhao Jing Jitian Li Peifeng Li Leilei Zhang Zhinan Hong Ning Zhang Haibin Wang Wuyin Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 15 | Geology,Geochemistry and Re-Os Age of the Qiaoxiahala Deposit in NW China:Evidence of an Overprinted Fe(-Cu/Au)Deposit显示文摘Overprinting of an earlier formed deposit may obscure the nature of the deposit and hinder our understanding of regional metallogeny.The Qiaoxiahala Fe(-Cu/Au)deposit in eastern Junggar,NW China,is characterized by magnetite mineralization later replaced by sulfide minerals such as chalcopyrite.To reveal the genesis of Qiaoxiahala,we conducted Re-Os dating on post-magnetite molybdenite separated from chalcopyrite and rare earth elements(REEs)for basal-tic volcanic rock,magnetite,chalcopyrite and diorite.An isochron age of 377±7 Ma was obtained together with a weighted mean age of 375±3 Ma,which is indistinguishable from mineralization ages determined in previous studies.Rare earth element(REE)data for basaltic volcanic rocks hosting the ore are comparable to that of the magnetite,while the REE signatures of chalcopyrite from the Cu ore and local intrusive diorite share a similar pattern.These suggest that two distinct fluid sources are responsible for the deposition of Fe and Cu in the Qiaoxiahala deposit.According to these experimental results,we consider that the iron mineralization in Qiaoxiahala is the result of fluid exsolution from basaltic volcanism which was further overprinted by fluids that deposited copper and gold,which may have been sourced from nearby dioritic intrusions. | Zhongjiang Zang Wei Liu Leilei Dong | 2021 | Journal of Earth Science2021，32，1： | 0 |
| 16 | Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells显示文摘The estrogen receptor(ER)-related factor(ERRF)was previously reported as a novel modulator of breast cancer(Su et al.,2012).Its expression was upregulated in breast cancer,and increased ERRF expression was significantly associated with ER and/or progesterone receptor(PR)positivity and human epidermal growth factor receptor 2(HER2)negativity(Su et al.,2012).In addition,ERRF was necessary for ER-positive breast cancer cells to form tumors | Ang Luo Dan Su Xuan Zhang Leilei Qi Liya Fu Jin-Tang Dong | 2016 | Journal of Genetics and Genomics2016，43，9： | 0 |
| 17 | The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype显示文摘Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a natural process associated with tissue repair. A large number of apoptotic bodies (ABs), a type of extracellular vesicle, are produced during apoptosis, and this is associated with a reduction in inflammation. However, the functions of apoptotic bodies remain largely unknown. In this study, we investigated the role of M2-Mφs-derived apoptotic bodies (M2-ABs) in regulating the M1/M2 balance of macrophages in a mouse model of OA. Our data show that M2-ABs can be targeted for uptake by M1-Mφs, and this reprograms M1-to-M2 phenotypes within 24 h. The M2-ABs significantly ameliorated the severity of OA, alleviated the M1-mediated pro-inflammatory environment, and inhibited chondrocyte apoptosis in mice. RNA-seq revealed that M2-ABs were enriched with miR-21–5p, a microRNA that is negatively correlated with articular cartilage degeneration. Inhibiting the function of miR-21–5p in M1-Mφs significantly reduced M2-ABs-guided M1-to-M2 reprogramming following in vitro cell transfection. Together, these results suggest that M2-derived apoptotic bodies can prevent articular cartilage damage and improve gait abnormalities in OA mice by reversing the inflammatory response caused by M1 macrophages. The mechanism underlying these findings may be related to miR-21-5p-regulated inhibition of inflammatory factors. The application of M2-ABs may represent a novel cell therapy, and could provide a valuable strategy for the treatment of OA and/or chronic inflammation. | Leilei Qin Jianye Yang Xudong Su Xilan li Yiting Lei Lili Dong Hong Chen Cheng Chen Chen Zhao Huan Zhang Jun Deng Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 18 | Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands显示文摘Progesterone(Pg)/progesterone receptor(PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified.Using in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland development driven by Pg/PR signaling. Postnatal deletion of Zfhx3 in mouse mammary epithelial cells attenuated side-branching morphogenesis and alveologenesis. These effects were undetectable in the absence of Pg/PR signaling. During the estrus cycle, Zfhx3 expression corresponded to that of Pg, being at the highest level at the diestrus stage; Zfhx3 deletion inhibited mammary gland branching more potently at diestrus than estrus stage. Loss of Zfhx3 not only attenuated the expansion of stem/progenitor cells driven by Pg/PR signaling, but also impaired the function of Pg/PR signaling in the transcriptional activation of multiple genes. In addition, Pg/PR signaling significantly expanded PR-and Zfhx3-positive epithelial cells, and induced the physical association of ZFHX3 with PR. These findings establish Zfhx3 as an integral transcription factor of Pg/PR signaling in driving side-branching and alveologenesis during mammary gland development. | Gui Ma Ang Gao Yinan Yang Yuan He Xi Zhang Baotong Zhang Zhiqian Zhang Mei Li Xing Fu Dan Zhao Rui Wu Leilei Qi Qingxia Hu Juan Li Liya Fu Zhengmao Zhu Jin-Tang Dong | 2019 | Journal of Genetics and Genomics2019，46，3： | 0 |
| 19 | Prolonged Mantle Modification beneath the North China Craton:Evidence from Contrasting Mafic Dykes in Jiaodong Peninsula显示文摘The nature of lithosphere mantle beneath North China Craton(NCC) has been changed during the Mesozoic.We investigated the mafic dykes in Jiaodong to put constraint on the origin of them and reveal the mantle evolution of the NCC.Zircons from Kunyushan and Nansu mafic dykes give concordia U-Pb ages of 114.9 and 52.8 Ma,respectively.The Kunyushan mafic dyke has high MgO(~8.0 wt.%) and Cr(>380 ppm) but lower FeO(<10 wt.%) contents.Large ion lithophile elements(LILE) are enriched compared to primitive mantle.The εHf(t) values of zircons are between-15.0 and-20.1.All these geochemical data imply an old and enriched lithosphere mantle source.In contrast,the Nansu mafic dyke has lower concentrations of Mg O(<7.0 wt.%) and Cr(200 ppm–230 ppm) but higher FeO(>11 wt.%) contents.The LILE and light rare earth elements(LREE) are not so strongly enriched relative to the mafic dyke from Kunyushan but display slight enrichment compared to the primitive mantle.Positive zircon εHf(t) values are obtained(from +11.7 to +19.5,with one outlier of +3.4).It is suggested that the Nansu dyke sourced from an enriched MORB mantle and was generated by fluid flux melting. | Leilei Dong Zhiming Yang Mingchun Song | 2023 | Journal of Earth Science2023，34，4： | 0 |
| 20 | Exhumation of the Late Cretaceous Ore-forming Porphyries in Zhongdian Area,Northwestern Yunnan:Evidence from Fission Track Analysis显示文摘Objective The Zhongdian area,Yunnan Province,is located in the southern of the Yidun Island arc belt in the TethysHimalayan metallogenic area,and is one of the important copper polymetallic mineral resource bases in China.Based on the previous studies(Liu et al.,2014),this paper discusses the Late Cretaceous tectono-thermal events in Zhongdian,to reconstruct the framework of their evolution and to restore the uplift history of representative ore-forming porphyries. | LIU Xuelong YANG Zhiming LU Yingxiang ZHANG Na DONG Leilei JIAO Qianqian CHEN Jianhang YANG Fucheng | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 0 |
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