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| 1 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 2 | Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding 显示文摘 | Eason Donna D Shepherd Alexander T | 1999 | Biochimica et Biophysica Acta ( BBA )/Gene Structure and Expression1999，1446，12： | 1 |
| 3 | Pathophysiology of ischemia -reperfusion injury显示文摘 | Donna L Carden D Neil G | 2000 | J Pathol2000，190，3： | 1 |
| 4 | Pharmaceutical psychology显示文摘 | Donna D | 1979 | Am J Pharm Educ1979，43，： | 1 |
| 5 | Assay of set of all sudan azodye( I, II, III, IV, and Para-Red) contaminating agents by liquid chromatography-tandem mass spectrometry and isotope dilution methodlogy显示文摘 | MAZZO'Iq?I F DONNA L D MAIUOLO L | 2007 | Journal of Agricultural and Food Chemistry2007，56，： | 1 |
| 6 | Pharmaceutical psychology 显示文摘 | Donna D | 1979 | Am J Pharm Educ1979，43，： | 1 |
| 7 | Unrelated umbilical cord blood transplantation in adult patients显示文摘 | Gwynn D Long Mary Laughlin Bella Madan Joanne Kurtzberg Cristina Gasparetto Ashley Morris David Rizzieri Clayton Smith James Vredenburgh Edward C Halperin Gloria Broadwater Donna Niedzwiecki Nelson J Chao | 2003 | Biology of Blood and Marrow Transplantation2003，，： | 1 |
| 8 | Cancer proteomics: flom signaling networks to tumor markers显示文摘 | Richard J S Donna S D | 2001 | Trends in Biotechnology2001，19，10： | 1 |
| 9 | Silica aerogels with enhanced durability, 30-nm mean pore-size, and improved immersibility in liquids 显示文摘 | Erik M L Michael S D Donna M E | 2004 | Non-CrystaUine Solids2004，350，： | 1 |
| 10 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 11 | Pathophysiology of ischaemia-reperfusion injury显示文摘 | Donna L Carden and D Neil Granger | 2000 | J Pathaol2000，190，： | 1 |
| 12 | Effects of post harvest storage and dormancy status on ABA content,metabolism,and expression of genes involved in ABA biosynthesis and metabolism in potato tuber tissues显示文摘 | Luis D B Donna K Linda H | | 0，，45： | 1 |
| 13 | Characterization of Cryptosporidium meleagridis of human origin passaged through different host species显示文摘 | DONNA E AKIYOSHI D | 2003 | Infection and Immunity2003，71，： | 1 |
| 14 | Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease显示文摘AIM To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODS The thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease(IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy recipients.RESULTS Complete blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the timeof sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer(NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T(MAIT) cells, invariant natural killer T(i NKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells(Tregs) or na?ve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iN KT and MAIT cells than healthy controls. CONCLUSION Thiopurine use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients. | James D Lord Donna M Shows | 2017 | World Journal of Gastroenterology2017，23，18： | 1 |
| 15 | Pharmaceutical psychology 显示文摘 | | 1979 | Am J Pharm Educ1979，43，： | 1 |
| 16 | Synthesis and biological activities of substituted glycyrrhetic acids显示文摘 | John S Baran Donna D Langford Chi-Dean Liang | 1974 | Journal of Medicinal Chemistry1974，17，2： | 1 |
| 17 | Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons显示文摘 | Robert D Barber Donna E | 2000 | J Neurosci2000，20，10： | 1 |
| 18 | Pathophysiology of ischemixreperfusion Injury显示文摘 | DONNA L GRMIGER D N | 2000 | J Pathol2000，190，3： | 1 |
| 19 | The Hazards of Moist Toilet Paper Allergy to the Preservative Methylchloroisothiazolinone/Methylisothiazolinone显示文摘 | Kevin H Gardner Mark D P Davis MD Donna M Richardson RN | 2010 | ARCH D ER-MATOL2010，8，： | 1 |
| 20 | Integration of primary health care services: perceptions of Australian-primary care interface显示文摘 | Donna M S Doris Y David D et ol | 2002 | Evaluation and Program Planning2002，25，1： | 1 |
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