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| 1 | CsPrx25,a class III peroxidase in Citrus sinensis,confers resistance to citrus bacterial canker through the maintenance of ROS homeostasis and cell wall lignification显示文摘Citrus bacterial canker(CBC)results from Xanthomonas citri subsp.citri(Xcc)infection and poses a grave threat to citrus production.Class III peroxidases(CIII Prxs)are key proteins to the environmental adaptation of citrus plants to a range of exogenous pathogens,but the role of CIII Prxs during plant resistance to CBC is poorly defined.Herein,we explored the role of CsPrx25 and its contribution to plant defenses in molecular detail.Based on the expression analysis,CsPrx25 was identified as an apoplast-localized protein that is differentially regulated by Xcc infection,salicylic acid,and methyl jasmone acid in the CBC-susceptible variety Wanjincheng(C.sinensis)and the CBC-resistant variety Calamondin(C.madurensis).Transgenic Wanjincheng plants overexpressing CsPrx25 were generated,and these transgenic plants exhibited significantly increased CBC resistance compared with the WT plants.In addition,the CsPrx25-overexpressing plants displayed altered reactive oxygen species(ROS)homeostasis accompanied by enhanced H_(2)O_(2) levels,which led to stronger hypersensitivity responses during Xcc infection.Moreover,the overexpression of CsPrx25 enhanced lignification as an apoplastic barrier for Xcc infection.Taken together,the results highlight how CsPrx25-mediated ROS homeostasis reconstruction and cell wall lignification can enhance the resistance of sweet orange to CBC. | Qiang Li Xiujuan Qin Jingjing Qi Wanfu Dou Christophe Dunand Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 5 |
| 2 | Multi-scale validation strategy for satellite albedo products and its uncertainty analysis显示文摘Coarse-resolution satellite albedo products are important for climate change and energy balance research because of their capability to characterize the spatiotemporal patterns of land surface parameters at both the regional and global scales. The accuracy of coarse-resolution products is usually assessed via comparison with in situ measurements. The key issue in the comparison of remote sensing observations with in situ measurements is scaling and uncertainty. This paper presents a strategy for validating 1-km-resolution remote sensing albedo products using field measurements and high-resolution remote sensing observations. Field measurements were collected to calibrate the high-resolution(30 m) albedo products derived from HJ-1a/b images. Then, the calibrated high-resolution albedo maps were resampled(i.e., upscaled) to assess the accuracy of the coarse-resolution albedo products. The samples of field measurements and high-resolution pixels are based on an uncertainty analysis. Two types of coarse-resolution albedo datasets, from global land surface satellite(GLASS) and moderate-resolution imaging spectroradiometer(MODIS), are validated over the middle reaches of the Heihe River in China. The results indicate that the upscaled HJ(Huan Jing means environment in Chinese and this refers to a satellite constellation designed for environment and disaster monitoring by China) albedo, which was calibrated using field measurements, can provide accurate reference values for validating coarse-resolution satellite albedo products. However, the uncertainties in the upscaled HJ albedo should be estimated, and pixels with large uncertainties should be excluded from the validation process. | PENG JingJing LIU Qiang WEN JianGuang LIU QinHuo TANG Yong WANG LiZhao DOU BaoCheng YOU DongQin SUN ChangKui ZHAO XiaoJie FENG YouBin SHI Jian | 2015 | Science China Earth Sciences2015，58，4： | 5 |
| 3 | CitGVD:a comprehensive database of citrus genomic variations显示文摘Citrus is one of the most important commercial fruit crops worldwide.With the vast genomic data currently available for citrus fruit,genetic relationships,and molecular markers can be assessed for the development of molecular breeding and genomic selection strategies.In this study,to permit the ease of access to these data,a web-based database,the citrus genomic variation database(CitGVD,http://gffzz1758061741e3440ch0w6f6cvxubu96nux.ffgz.tsg.suse.edu.cn/home)was developed as the first citrusspecific comprehensive database dedicated to genome-wide variations including single nucleotide polymorphisms(SNPs)and insertions/deletions(INDELs).The current version(V1.0.0)of CitGVD is an open-access resource centered on 1,493,258,964 high-quality genomic variations and 84 phenotypes of 346 organisms curated from in-house projects and public resources.CitGVD integrates closely related information on genomic variation annotations,related gene annotations,and details regarding the organisms,incorporating a variety of built-in tools for data accession and analysis.As an example,CitGWAS can be used for genome-wide association studies(GWASs)with SNPs and phenotypic data,while CitEVOL can be used for genetic structure analysis.These features make CitGVD a comprehensive web portal and bioinformatics platform for citrus-related studies.It also provides a model for analyzing genome-wide variations for a wide range of crop varieties. | Qiang Li Jingjing Qi Xiujuan Qin Wanfu Dou Tiangang Lei Anhua Hu Ruirui Jia Guojin Jiang Xiuping Zou Qin Long Lanzhen Xu Aihong Peng Lixiao Yao Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 4 |
| 4 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 5 | Clinical study inpatient-reported outcomes after binocular implantation of aspheric intraocular lens of different negative spherical aberrations显示文摘Objective: To compare patient-reported outcomes after implantation of the ZA9003 intraocular lens(IOLs), or the MCX11 ASP IOLs or the spherical IOLs(HQ-201HEP). Methods: Prospective nonrandomized controlled trial was used. A total of 105 patients(210 eyes) were divided into three groups according to the type of IOLs: ZA9003(35 patients, 70 eyes), MCX11 ASP(35 patients, 70 eyes) or HQ-201HEP(35 patients, 70 eyes). The main outcome was scores of Catquest nine-item short-form questionnaire. Additional outcome was best corrected visual acuities, spherical aberration(SA) and total higher-order aberrations(HOAs). Results: The global score was significantly lower in the spherical IOL group than the aspherical IOL group of-020 μm SA(P < 0.05) and the aspherical IOL group of-027 μm SA(P < 0.05), and no significant difference was found in the global score between the aspherical IOL group of-020 μm SA than the aspherical IOL group of-027 μm SA(P > 0.05). Significant differences were also found in question 2, question 5, question 6 and question 8 between the spherical IOLs and the aspherical IOLs. Conclusion: Implantation of an aspherical IOL could improve vision-related quality of life compared with a spherical IOL. However, there were no statistically significant differences in vision-related quality of life between aspheric IOLs with different negative spherical aberrations. | Ze-Quan Xu Xu-Hua Song Wen-Zhe Li Yan Dou Qiang Wu | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 3 |
| 6 | Rapid Urban Land Expansion in Earthquake-Prone Areas of China显示文摘A timely understanding of urban expansion in earthquake-prone areas is crucial for earthquake risk assessment and urban planning for earthquake mitigation.However, a comprehensive evaluation of urban expansion in earthquake-prone areas is lacking in China, especially in the context of rapid urbanization. Based on time series urban land data and seismic ground-motion parameter zonation maps, this study analyzed urban expansion in the most seismically hazardous areas(MSHAs) of China from1992 to 2015 on the national, regional, and city scales. The results show that urban land area in the MSHAs expanded by 6767 km^2 from 1992 to 2015, with a gain of 350%.Specifically, the increase in urban land area of small cities in the MSHAs of western China during this period was the fastest, 6.24 times greater than that at the national level. In terms of spatial patterns, the urban land patches in the MSHAs in 2015 were more fragmented than those in 1992 on all scales. The percentage of change in the number of patches and the landscape shape index of the urban land patches of small cities in the MSHAs of western China were the highest across all cities. Therefore, we believe that special attention should be paid to the cities in the MSHAs that exhibit the most rapid increases in both urban land area and fragmentation, especially the small cities in western China. It is imperative to integrate earthquake mitigation into the urban planning of these cities. | Qingxu Huang Shiting Meng Chunyang He Yinyin Dou Qiang Zhang | 2019 | International Journal of Disaster Risk Science2019，10，1： | 3 |
| 7 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 8 | CsWAKL08,a pathogen-induced wall-associated receptor-like kinase in sweet orange,confers resistance to citrus bacterial canker via ROS control and JA signaling显示文摘Citrus bacterial canker(CBC)is a disease resulting from Xanthomonas citri subsp.citri(Xcc)infection and poses a grave threat to citrus production worldwide.Wall-associated receptor-like kinases(WAKLs)are proteins with a central role in resisting a range of fungal and bacterial diseases.The roles of WAKLs in the context of CBC resistance,however,remain unclear.Here,we explored the role of CsWAKL08,which confers resistance to CBC,and we additionally analyzed the molecular mechanisms of CsWAKL08-mediated CBC resistance.Based on systematic annotation and induced expression analysis of the CsWAKL family in Citrus sinensis,CsWAKL08 was identified as a candidate that can be upregulated by Xcc infection in the CBC-resistant variety.CsWAKL08 can also be induced by the phytohormones salicylic acid(SA)and methyl jasmonic acid(MeJA)and spans the plasma membrane.Overexpression of CsWAKL08 resulted in strong CBC resistance in transgenic sweet oranges,whereas silencing of CsWAKL08 resulted in susceptibility to CBC.The peroxidase(POD)and superoxide dismutase(SOD)activities were significantly enhanced in the CsWAKL08-overexpressing plants compared to the control plants,thereby mediating reactive oxygen species(ROS)homeostasis in the transgenic plants.Moreover,the JA levels and the expression of JA biosynthesis and JA responsive genes were substantially elevated in the CsWAKL08 overexpression plants relative to the controls upon Xcc infection.Based on these findings,we conclude that the wall-associated receptor-like kinase CsWAKL08 positively regulates CBC resistance through a mechanism involving ROS control and JA signaling.These results further highlight the importance of this kinase family in plant pathogen resistance. | Qiang Li Anhua Hu Jingjing Qi Wanfu Dou Xiujuan Qin Xiuping Zou Lanzhen Xu Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 3 |
| 9 | Targeting of anti-microbial proteins to the hyphal surface amplifies protection of crop plants against Phytophthora pathogens显示文摘Phytophthora pathogens are a persistent threat to the world's commercially important agricultural crops,including potato and soybean.Current strategies aim at reducing crop losses rely mostly on disease-resistance breeding and chemical pesticides,which can be frequently overcome by the rapid adaptive evolution of pathogens.Transgenic crops with intrinsic disease resista nee offer a promising alternative and con tinue to be developed.Here,we explored Phytophthora-derived PI3P(phosphatidylinositol 3-phosphate)as a novel control target,using proteins that bind this lipid to direct secreted anti-microbial peptides and proteins(AMPs)to the surface of Phytophthora pathogens.In transgenic Nicotiana benthamiana,soybean,and potato plants,significantly enhanced resistance to different pathogen isolates was achieved by expression of two AMPs(GAFP1 or GAFP3 from the Chinese medicinal herb Gastrodia elata)fused with a PI3P-specific binding domain(FYVE).Using the soybean pathogen P.sojae as an example,we demonstrated that the FYVE domain could boost the activities of GAFPs in multiple independent assays,including those performed in vitro,in vivo,and in planta.Mutational analysis of P.sojae PI3K1 and PI3K2 genes of this pathogen confirmed that the enhanced activities of the targeted GAFPs were correlated with PI3P levels in the pathogen.Collectively,our study provides a new strategy that could be used to confer resistance not only to Phytophthora pathogens in many plants but also potentially to many other kinds of plant pathogens with unique targets. | Yang Zhou Kun Yang Qiang Yan Xiaodan Wang Ming Cheng Jierui Si Xue Xue Danyu Shen Maofeng Jing Brett M.Tyler Daolong Dou | 2021 | Molecular Plant2021，14，8： | 2 |
| 10 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 11 | Process optimization of a closed-chamber distillation system for the recovery of FLiNaK molten salt显示文摘Low-pressure distillation has been proposed as a suitable technique for the recovery of carrier salt from molten salt reactor spent fuel.A closed-chamber distillation system,in which the pump is stopped and pressureinduced salt distillation is performed,was arranged for fluoride salt treatment.A stair-step optimization process was demonstrated to improve the recovery efficiency by up to 99%.The pressure change curve was feasible for estimating the distillation process,and a method for displaying the pressure value online in order to determine the endpoint was also developed.The decontamination factor of Nd in the condensate salt was deduced to be greater than 100 with 1 wt%NdF3–FLiNaK distillation.The optimal conditions developed in this study showed a high recovery ratio for the fluoride carrier salt and a high separation efficiency for rare earth products. | Jun-Xia Geng Yang Yang Hai-Ying Fu Yan Luo Qiang Dou Qing-Nuan Li | 2021 | Nuclear Science and Techniques2021，32，1： | 2 |
| 12 | A total synthesis of mycalisine A显示文摘在这份报纸,我们报导自然地发生的 pyrrolo 的全部的合成[2,3-d ] 嘧啶 nucleoside, mycalisine A。我们的合成策略把 d 木糖用作开始的材料和 Vorbr | Yan-Hui Dou Hai-Xin Ding Ru-Chun Yang Wei Li Qiang Xiao | 2013 | Chinese Chemical Letters2013，24，5： | 1 |
| 13 | Effect of pimelic acid on the crystalliza- tion, morphology and mechanical properties of polypropylene / wollastonite composites显示文摘 | Meng Mingrui Dou Qiang | 2008 | Materials Science and Engineering A2008，492，12： | 1 |
| 14 | Combined Cloud: A Mixture of Voluntary Cloud and Reserved Instance Marketplace显示文摘自愿的云是云计算的一个新范例。它与一些好预备的云一起提供一种其他的选择。然而,在不明确的时间跨越那参加者份额他们在自愿的云的计算资源,有一些,质问问题,即,变化,在能力下面并且低利益。在这份报纸,体系结构首先基于 Bittorrent 协议被建议。在这体系结构,资源能从保留的例子市场被保留或请求并且能在一个短圆与更低的价格被存取。实际上,这些资源能填满不适当的资源在自愿的云分享并且减轻变化和在能力下面问题。然后,每个节点的差错率被用来评估它的分享的时间的无常。由利用一个线性预言模型,它被被用于评估系统的计算能力的一个分发函数启用。而且,费用优化问题被调查,一个计算方法被介绍在自愿的云解决低利益的问题。最后,系统表演被模拟的二个集合验证。并且试验性的结果为资源保留优化显示出我们的计算方法的有效性。 | Wei Shen Wan-Chun Dou Fan Wu Shaojie Tang Qiang Ni | 2016 | Journal of Computer Science & Technology2016，31，6： | 1 |
| 15 | Effect of Metallic Salts of Malonic Acid on the Formation of β Crystalline Form in Isotactic Polypropylene显示文摘 | Qiang Dou Qu-Liang Lu Huai-Dong Li | 2008 | Journal of Macromolecular Science, Part B2008，，5： | 1 |
| 16 | Directed migration of human neural progenitor cells to interleukin-1βis promoted by chemokines stromal cell-derived factor-1 and monocyte chemotactic factor-1 in mouse brains显示文摘Background:Neurogenesis,including the proliferation,migration and differentiation of neural progenitor cells(NPCs),is impaired in HIV-1 associated dementia(HAD).We previously demonstrated HIV-1-infected macrophages(HIV-MDM)regulate stromal cell-derived factor 1(SDF-1)production in astrocytes through Interleukin-1β(IL-1β).Chemokines are known to induce NPC migration;however,it remains unclear how chemokines produced in inflammation regulate NPC migration.Methods:The secretion of SDF-1 and Monocyte chemotactic preotein-1(MCP-1)in astrocytes upon IL-1βstimulation was measured by ELISA assay.Human NPCs were injected parallel along with IL-1β,SDF-1 or MCP-1 intracranially into basal ganglion 1 mm apart in SCID mice,and immunofluorescent staining was used to study the survival and migration of injected human NPCs.Results:SDF-1 and MCP-1 are secreted by astrocytes upon IL-1βstimulation in a time-dependent manner.Injected human NPCs survived in SCID mice and migrated towards sites of IL-1β,SDF-1 and MCP-1 injection.Conclusions:In conclusion,chemokines SDF-1 or MCP-1 secreted by astrocytes in the presence of IL-1βinjection are attractive to NPCs injected into SCID mouse brains,suggesting that SDF-1 and MCP-1 play important roles in NPC migration during neuroinflammation. | Yumei Wu Qiang Chen Hui Peng Huanyu Dou You Zhou Yunlong Huang Jialin C Zheng | 2012 | Translational Neurodegeneration2012，1，1： | 1 |
| 17 | Prediction of SO2 removal efficiency for wet Flue Gas Desulfurization显示文摘 | Binlin Dou Weiguo Pan Qiang Jin | 2009 | Energy Conversion and Management2009，，50： | 1 |
| 18 | Optimized Tension for AZ31B Thin Sheets Rolled with On-Line Heating Rolling显示文摘On-line heating rolling mill which could efficiently preheat sheet and apply tensile force on both ends of the sheet along rolling direction(RD)was used to investigate the effect of tension on mechanical behavior and shape quality of magnesium sheets.For revealing the infl uence mechanism,many analysis techniques including optical microscope,electron backscattered diffraction,macrotexture and transmission electron microscope were performed.The shape defect,edge wave,could be eliminated under higher tension along RD,which was attributed to more uniform distribution of microstructure and microstrain.Nevertheless,it is undesirable that the forward tensile force exceeds 3 kN in present work because the strength decreased for high recrystallization level when the tensile force is beyond this value.Furthermore,the main deformation mode was still slip during rolling process despite of accompanying twining,e.g.,double twins,but more prismatic slip activated when tensile force exceeds 3 kN.The distribution of shear bands was affected by the applied tensile force that they appear as'V'shape along RD at a low forward or backward tensile force,while they appear as reticulate shape under applied tensile force of 5 kN. | Biquan Xiao Jiangfeng Song Hua Zhao Aitao Tang Qiang Liu Bin Jiang Shitao Dou Fusheng Pan | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，2： | 1 |
| 19 | Synthesis of aqueous CdTe quantum dots embedded silica nanoparticles and their applications as fluorescence probes显示文摘 | Wang Chao Ma Qiang Dou Wenchao | 2009 | Talanta2009，77，： | 1 |
| 20 | Study of Imidazolium Ionic Liquids:Temperature-dependent Fluorescence and Molecular Dynamics Simulation显示文摘The steady-state fluorescence spectra and molecular dynamics simulations were explored to investigate the temperature dependent organization in some imidazolium ionic liquids:1-butyl-3-methylimidazolium hexafluo-rophosphate([bmim][PF6]),1-ethyl-3-methylimidazolium ethylsulfate([emim][EtSO4]) and 1-butyl-3-methylimida-zolium tetrafluoroborate([bmim][BF4]).The pure room temperature ionic liquids(ILs) exhibit a large red shift at more than an excitation wavelength of around 340 nm,which demonstrates the heterogeneous nature of the liquids.Furthermore,the fluorescence spectra of the ionic liquids were found to be temperature-dependent.The emission intensity gradually decreased with increasing temperature for the neat ionic liquids and the mixed solutions of [bmim][BF4]-H2O,which was the special phenomena induced by not only the local structure but also the viscosity.The molecular dynamics simulation further confirms that the structures of ionic liquids are sensitive to the surroun-ding environment because of the aggregation degree of ILs. | FU Hai-ying ZHU Guang-lai WU Guo-zhong SHA Mao-lin DOU Qiang | 2011 | Chemical Research in Chinese Universities2011，27，4： | 1 |
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