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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Polymer-layered silicate nanocomposites: preparation, properties and uses of a new class of materials [Review]显示文摘 | Alexandre M Dubois P | | 0，，： | 2 |
| 3 | Diffusion measurements in intracranial hematomas: implications for MR imaging of acute stroke 显示文摘 | DuBois P Singer MB | 2000 | Am J Neuroradiol2000，21，7： | 1 |
| 4 | Cloning and characterization of a growth factor-inducible eyclooxygenase gene from rat intestinal epithelial cells 显示文摘 | DuBois RN Tsujii M Bishop P | 1994 | Am J Physiol1994，266，51： | 1 |
| 5 | 查看详情显示文摘 | Renoncourt A Bauduin P Nicholl E Touraud D Verbavatz J.M Dubois M Drechsler M Kunz W | | 0，，： | 1 |
| 6 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois K A Gilles J K Hamilton P A | 1956 | Anal Chem1956，28，3： | 1 |
| 7 | Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9) 显示文摘 | VAN DEN STEEN P E DUBOIS B NELISSEN I | 2002 | Crit Rev Biochem Mol Biol2002，37，6： | 1 |
| 8 | 查看详情显示文摘 | Dubois P Jéròme R Teyssié P | | 0，，： | 1 |
| 9 | Variations in insti- tutional infrastructure, physician specialization and experi- ence and outcome in ovarian cancer: asystematic review 显示文摘 | DuBois A Rochon J P fisterer J | 2009 | Gynecol Oncol2009，112，2： | 1 |
| 10 | Trypanosomes Expressing a Mosaic Variant Surface Glycopmtein Coat Escape Early Detection by the Immune System显示文摘 | Dubois M E Demick K P Mansfield J M | 2005 | Infection Immunity2005，73，5： | 1 |
| 11 | 4-Dimethylaminopyridine-based organoactivation: from simple esterification to lac tide ring-opening 'living' polymerization显示文摘 | COULEMBIER 0 DUBOIS P | 2012 | Journal of Polymer Science Part A: Polymer Chemistry2012，50，： | 1 |
| 12 | Tourism/leisure greenhouse gas emissions forecasts for 2050: factors for change in France 显示文摘 | Dubois G Ceron J P | 2006 | Journal of Suatainable Tourism2006，14，2： | 1 |
| 13 | Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double -blind placebo -controlled muhicenter study 显示文摘 | Fourrier F Dubois D Pronnier P | 2005 | Crit Care Med2005，33，8： | 1 |
| 14 | Efficacy of chemical and fluorescent protein markers in studying plant colonization by endophytic non pathogenic Fusarium oxys- porum isolates显示文摘 | PAPARU P MACLEOD A DUBOIS T | 2009 | Biological Control2009，54，： | 1 |
| 15 | High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy 显示文摘 | Gross D A Graff Dubois S Opolon P | 2004 | J Clin Invest2004，113，3： | 1 |
| 16 | Evaluation of the Grey-level Co-occurrences Matrix Method for Land-cover Classification Using SPOT显示文摘 | Marceau D J Howarth P J Dubois J M | 1990 | IEEE Transactions on Geoscience and Remote Sensing1990，28，： | 1 |
| 17 | Constitutive expression of TGF-beta, interleukin-6 and interleukin-8 by tumor cells as a major component of immune escape in human ovarian carcinoma显示文摘 | Toutirais O Chartier P Dubois D | 2003 | Eur Cytokine Netw2003，14，4： | 1 |
| 18 | Polymer-layered silicate nano- composites: preparation, properties and uses of a new class of materials显示文摘 | Alexandre M Dubois P | 2000 | Materials Science and Engineering: R : Reports2000，28，12： | 1 |
| 19 | The Market for Luxury Goods : Income Versus Culture 显示文摘 | Dubois B Duquesne P | 1993 | European Journal of Marketing1993，27，： | 1 |
| 20 | Constitutive ex- pression of TGF-btal ,interleukin-6 and interleukin-8 by tumor ceils as a major component of immune escape in human ovarian earcinoma显示文摘 | Toutirais O Chartier P Dubois D | 2003 | Eur Cytokine N etw2003，14，4： | 1 |
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