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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | An intracellular toxic protein (Xin) isolated from Xenorhabdus nematophilus strain BJ显示文摘An intracellular toxic protein, designated Xin and with remarkable inhibitory effect on growth of Helicoverpa armigera, was isolated from X. Nematophilus strain BJ by ion exchange chromatography and hydrophobic interaction chromatography. After placing neonates on the artificial diet containing Xin at concentration of 0 or 3.48μg/g for 7 days, the average weight of insects was 23.50mg and 0.55mg, respectively. The activity of Xin was lost by heating, freeze-drying, digestion with proteases or urea. The Xin molecular weight, over kD, was determined by gel filtration on Superose 12, and there were six component proteins analyzed by SDS-PAGE. The results show that Xin is a high molecular protein complex inhibiting growth of insect pest. | PAN Yinghong , JIAN Heng , ZHANG Jie , LIU Zheng, CHEN Zhongyi , YANG Xiufen, YANG Huaiwen and HUANG Dafang( State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100094, China Institute of Biocontrol Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China Institute of Biotechnology Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 9 |
| 3 | Characterization of ornidazole metabolites in human bile after intraveneous doses by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry显示文摘Ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry(UPLC/Q-TOF MS)was used to characterize ornidazole metabolites in human bile after intravenous doses.A liquid chromatography tandem mass spectrometry(LC–MS/MS)assay was developed for the determination of the bile level of ornidazole.Bile samples,collected from four patients with T-tube drainage after biliary tract surgery,were prepared by protein precipitation with acetonitrile before analysis.A total of 12 metabolites,including 10 novel metabolites,were detected and characterized.The metabolites of ornidazole in human bile were the products of hydrochloride(HCl)elimination,oxidative dechlorination,hydroxylation,sulfation,diastereoisomeric glucuronation,and substitution of NO_(2) or Cl atom by cysteine or N-acetylcysteine,and oxidative dechlorination followed by further carboxylation.The bile levels of ornidazole at 12 h after multiple intravenous infusions were well above its minimal inhibitory concentration for common strains of anaerobic bacteria. | Jiangbo Du Pan Deng Xiaoyan Chen Haidong Wang Tiangeng You Dafang Zhong | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 5 |
| 4 | Determination of ginsenoside compound K in human plasma by liquid chromatography–tandem mass spectrometry of lithium adducts显示文摘Ginsenoside compound K(GCK), the main metabolite of protopanaxadiol constituents of Panax ginseng, easily produces alkali metal adduct ions during mass spectrometry particularly with lithium. Accordingly, we have developed a rapid and sensitive liquid chromatography–tandem mass spectrometric method for analysis of GCK in human plasma based on formation of a lithium adduct. The analyte and paclitaxel(internal standard) were extracted from 50 m L human plasma using methyl tertbutyl ether. Chromatographic separation was performed on a Phenomenex Gemini C18 column(50 mm 2.0 mm; 5 μm) using stepwise gradient elution with acetonitrile–water and 0.2 mmol/L lithium carbonate at a flow rate of 0.5 m L/min. Detection was performed in the positive ion mode using multiple reaction monitoring of the transitions at m/z 629-449 for the GCK-lithium adduct and m/z 860-292 for the adduct of paclitaxel. The assay was linear in the concentration range 1.00–1000 ng/m L(r^2>40.9988)with intra- and inter-day precision of ±8.4% and accuracy in the range of 4.8% to 6.5%. Recovery,stability and matrix effects were all satisfactory. The method was successfully applied to a pharmacokinetic study involving administration of a single GCK 50 mg tablet to healthy Chinese volunteers. | Yunhui Chen Youming Lu Yong Yang Xiaoyan Chen Liang Zhu Dafang Zhong | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 3 |
| 5 | The Association Between Epoxide Hydrolase Genetic Variant and Effectiveness of Nicotine Replacement Therapy in a Han Chinese Population显示文摘Dear Editor,Nicotine is a psychoactive alkaloid that is thought to play a key role in addiction to commercial tobacco products[1]and cotinine is its primary metabolite[2].Pharmacological treatment,such as nicotine replacement therapy(NRT),is a valid solution to this problem.Tobacco smoke contains many carcinogens such as nitrosamines[i.e.,nicotinederived nitrosamine ketone(NNK)and N-nitrosonornicotine(NNN)],and | Fan Wang Yanlong Liu Song Guo Dafang Chen Hongqiang Sun | 2016 | Neuroscience Bulletin2016，32，6： | 2 |
| 6 | Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance显示文摘 | Hui Wang Zejun Huang Qi Chen Zhijin Zhang Hongbo Zhang Yanming Wu Dafang Huang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，2： | 1 |
| 7 | Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearum显示文摘 | Hongbo Zhang Dabing Zhang Jia Chen Yuhong Yang Zejun Huang Dafang Huang Xue-Chen Wang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 8 | Absorption and enterohepatic circulation of baicalin in rats显示文摘 | Jie Xing Xiaoyan Chen Dafang Zhong | 2005 | Life Sciences2005，78，2： | 1 |
| 9 | The ethylene-, jasmonate-, abscisic acid- and NaCl-responsive tomato transcription factor JERF1 modulates expression of GCC box-containing genes and salt tolerance in tobacco显示文摘 | Haiwen Zhang Zejun Huang Bingyan Xie Qi Chen Xin Tian Xiulin Zhang Hongbo Zhang Xiangyang Lu Dafang Huang Rongfeng Huang | 2004 | Planta2004，，2： | 1 |
| 10 | Absorption and enterohepatic circulation of baicalin in rats 显示文摘 | Xing Jie Chen Xiaoyan Zhong Dafang | 2005 | Life Sci2005，78，2： | 1 |
| 11 | Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance显示文摘 | Hui Wang Zejun Huang Qi Chen Zhijin Zhang Hongbo Zhang Yanming Wu Dafang Huang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，2： | 1 |
| 12 | Development of a dissolution medium for nimodipine tablets based on bioavailability evaluation显示文摘 | He Zhonggui Zhong Dafang Chen Xiaoyan | 2004 | European journal of pharmaceutical sciences2004，21，4： | 1 |
| 13 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 14 | Land Use Change and Driving Forces in Guangzhou City during 1996- 2012显示文摘Based on the statistical data of land use change,from the perspective of sustainable use,we use literature inquiry,statistical analysis,GIS spatial analysis and dynamic degree model of land use,to analyze the land use change characteristics,land use amount and spatial distribution characteristics in Guangzhou City during 1996- 2012,and further elaborate the driving forces of land use change to get the basic law of land use change in Guangzhou City. The results show that the construction land was rapidly expanded,causing a significant reduction in arable land( from 129286 ha in 1996 to 84567 ha in 2012); in construction land,the land for residential,industrial and mining use and transportation land dramatically increased,and the single dynamic degree of transportation land was close to 7. 1%. In comparison with other developed cities,it is found that economic factors and policy factors are important factors affecting land use change in Guangzhou City,and the growth rate of economic density of land was high in Tianhe District and Yuexiu District. From the perspective of sustainable use,the future land use in Guangzhou City needs to better coordinate the relationship between various types of land,between socio-economic development and coordinated land use development,between environmental protection and land development and utilization. Through a series of land consolidation activities,it is necessary to strengthen the protection of farmland,improve the intensive and economical use of construction land,improve the ecological environment,and coordinate development of urban and rural areas,to ultimately achieve sustainable land use in Guangzhou City. | Yiying YAO Dafang WU Yanyan LIU Yihua LIU Qixian CHEN Haolong CHEN Jiaxin WU Jialiang ZHONG | 2015 | Asian Agricultural Research2015，7，9： | 1 |
| 15 | HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China显示文摘 | Zhaohui Li Dafang Chen Chunfeng Zhang Yong Li Bangwei Cao Tao Ning Yiming Zhao Weicheng You Yang Ke | 2005 | Immunogenetics2005，，11： | 1 |
| 16 | Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of ALS显示文摘 | Chen Dafang Shen Li Wang Liping | 2007 | ALS2007，8，2： | 1 |
| 17 | Pharmacokinetics of Loratadine and its metabolite descarboethoxyloratadine in healthy Chinese subjects显示文摘 | Zhang Yifan Chen Xiaoyan Zhong Dafang | 2003 | Acta Pharmacol Sin2003，24，7： | 1 |
| 18 | Choline Transporters in Human Lung Adenocarcinoma: Expression and Functional Implications显示文摘然而,胆碱是为房间幸存和增长的必要营养素胆碱运输 ers 的表示和功能很好没在癌症被识别。在这研究,我们检测了 mRNA 和器官的阳离子 transporter 的蛋白质表示 OCT3,肉毒碱 / 阳离子运输 ers OCTN1 和 OCTN2,和在人的肺腺癌房间的像运输的 proteinCTL1 衬里的胆碱 A549, H1299 和 SPC-A-1.Their 表示模式是进一步的在 25 人的主要腺癌纸巾证实了。在这些房间线的胆碱举起被 CTL1 禁止者显著地堵住,但是仅仅部分在房间增长上由 10 月或这些禁止者的 OCTNinhibitors.The 功效禁止了密切与他们堵住胆碱运输的能力被相关。在这些运输 ers 的本国的表示下面,全部的胆碱举起被特定的 PI3K/AKT 禁止者显著地堵住。这些结果在人的肺腺癌的房间增长描述胆碱运输 ers 和他们的相关功能的表示,因此提供潜在的“胆碱饥饿”通过指向胆碱运输 ers 的癌症干扰的策略,特别 CTL1。 | Tao WANG Jinjun LI Fei CHEN Yingjun ZHAO Xianghuo HE Dafang WAN Jianren GU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 1 |
| 19 | The ethylene-, jasmonate-, abscisic acid- and NaCl-responsive tomato transcription factor JERF1 modulates expression of GCC box-containing genes and salt tolerance in tobacco显示文摘 | Haiwen Zhang Zejun Huang Bingyan Xie Qi Chen Xin Tian Xiulin Zhang Hongbo Zhang Xiangyang Lu Dafang Huang Rongfeng Huang | 2004 | Planta2004，，2： | 1 |
| 20 | Stereoselective pharmacokinetics of propafenone and its major metabolites in healthy Chinese volunteers 显示文摘 | Xiaoyan Chen Dafang Zhong Henning Blume | 2000 | European Journal of Pharmaceutical Sciences2000，，1： | 1 |
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