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| 1 | A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents显示文摘A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-1,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher efficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed. | DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe | 2013 | Science China Chemistry2013，56，7： | 8 |
| 2 | Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains. | WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe | 2012 | Science China Chemistry2012，55，10： | 7 |
| 3 | On social computing research collaboration patterns: a social network perspective显示文摘社会计算的领域超过十年以前出现了。在最后十年期间,从许多学科的研究人员仔细一直在协作增加社会计算研究的生长。这篇论文瞄准识别关键研究人员和机构,并且在这个领域里检验合作模式。我们在不同层次采用合作作家身分网络分析从 1998 ~ 2011 在社会计算学习 6 543 份出版物的文献的信息。这篇论文在社会计算和罐头给当前的研究的一张快照在社会计算提供起始的指导给新研究人员。 | Tao WANG Qingpeng ZHANG Zhong LIU Wenli LIU Ding WEN | 2012 | Frontiers of Computer Science2012，6，1： | 3 |
| 4 | The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population显示文摘MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activity.As telomerase activity has been reported to be related to life-span,we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere.To test this hypothesis,we collected 446 unrelated pericentenarian individuals(age≥90,mean 94.45±3.45 years)and 332 normal controls(age 22-53,mean 35.0±12.0 years)from Dujiangyan,Sichuan,China.We typed the MNS16A polymorphism in both groups,and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test.There was no significant difference between the peri-centenarian and control groups.Thus,the MNS16A polymorphism in TERT might not influence human life-span,at least in the Han Chinese population studied here. | LIU LiNa WANG ChengYe LU Xiang XIAO FuHui WANG HuaWei YANG LiQin XU LiangYou KONG QingPeng | 2014 | Science China(Life Sciences)2014，57，10： | 1 |
| 5 | Differentiation of Reprogrammed Mouse Cardiac Fibroblasts into Functional Cardiomyocytes显示文摘 | Bo Jiang Hongyan Dong Qingpeng Li Yong Yu Zhifeng Zhang Yazhou Zhang Gang Wang Zhongming Zhang | 2013 | Cell Biochemistry and Biophysics2013，，2： | 1 |
| 6 | The Chinese ‘‘HumanFlesh’’ Web:the first decade and beyond显示文摘Human flesh search(HFS), a Web-enabled crowdsourcing phenomenon, originated in China a decade ago. In this article, we present the first comprehensive empirical analysis of HFS, focusing on the scope of HFS activities, the patterns of HFS crowd collaboration process, and the characteristics of HFS participant networks. A survey of HFS participants was conducted to provide an in-depth understanding of the HFS community and various factors that motivate these participants to contribute. This article also advocates a new stream of Web science and social computing research that will be important in predicting the future growth and use of the World Wide Web. | Fei-Yue Wang Daniel Zeng Qingpeng Zhang James A. Hendler Jianping Cao | 2014 | Chinese Science Bulletin2014，59，26： | 1 |
| 7 | The advantages of penehyclidine hydrochloride over atropine in acute organophosphorus pesticide poisoning:A meta-analysis显示文摘Background:Penehyclidine hydrochloride(PHC)has been used for many years as an anticholinergic drug for the treatment of acute organophosphorus pesticide poisoning(AOPP).The purpose of this meta-analysis was to explore whether PHC has advantages over atropine in the use of anticholinergic drugs in AOPP.Methods:We searched Scopus,Embase,Cochrane,PubMed,ProQuest,Ovid,Web of Science,China Science and Technology Journal Database(VIP),Duxiu,Chinese Biomedical literature(CBM),WanFang,and Chinese National Knowledge Infrastructure(CNKI),from inception to March 2022.After all qualified randomized controlled trials(RCTs)were included,we conducted quality evaluation,data extraction,and statistical analysis.Statistics using risk ratios(RR),weighted mean difference(WMD),and standard mean difference(SMD).Results:Our meta-analysis included 20,797 subjects from 240 studies across 242 different hospitals in China.Compared with the atropine group,the PHC group showed decreased mortality rate(RR=0.20,95%confidence intervals[CI]:0.16–0.25,P<0.001),hospitalization time(WMD=-3.89,95%CI:-4.37 to-3.41,P<0.001),overall incidence rate of complications(RR=0.35,95%CI:0.28–0.43,P<0.001),overall incidence of adverse reactions(RR=0.19,95%CI:0.17–0.22,P<0.001),total symptom disappearance time(SMD=-2.13,95%CI:-2.35 to-1.90,P<0.001),time for cholinesterase activity to return to normal value 50–60%(SMD=-1.87,95%CI:-2.03 to-1.70,P<0.001),coma time(WMD=-5.57,95%CI:-7.20 to-3.95,P<0.001),and mechanical ventilation time(WMD=-2.16,95%CI:-2.79 to-1.53,P<0.001).Conclusion:PHC has several advantages over atropine as an anticholinergic drug in AOPP. | Siyao Zeng Lei Ma Lishan Yang Xiaodong Hu Cheng Wang Xinxin Guo Yi Li Yi Gou Yao Zhang Shengming Li Shaotong Zhang Xiaoxuan Wu Meihong Li Jing Lei Bingqian Li Chengfei Bi Like Ma Qingpeng Luo | 2023 | Journal of Intensive Medicine2023，3，2： | 0 |
| 8 | Adaptively temporal graph convolution model for epidemic prediction of multiple age groups显示文摘Introduction:Multivariate time series prediction of infectious diseases is significant to public health,and the deep learning method has attracted increasing attention in this research field.Material and methods:An adaptively temporal graph convolution(ATGCN)model,which leams the contact patterns of multiple age groups in a graph-based approach,was proposed for COVID-19 and influenza prediction.We compared ATGCN with autoregressive models,deep sequence learning models,and experience-based ATGCN models in short-term and long-term prediction tasks.Results:Results showed that the ATGCN model performed better than the autoregressive models and the deep sequence learning models on two datasets in both short-term(12.5%and 10%improvements on RMSE)and longterm(12.4%and 5%improvements on RMSE)prediction tasks.And the RMSE of ATGCN predictions fluctuated least in different age groups of COVID-19(0.029±0.003)and influenza(0.059±0.008).Compared with the Ones-ATGCN model or the Pre-ATGCN model,the ATGCN model was more robust in performance,with RMSE of 0.0293 and 0.06 on two datasets when horizon is one.Discussion:Our research indicates a broad application prospect of deep learning in the field of infectious disease prediction.Transmission characteristics and domain knowledge of infectious diseases should be further applied to the design of deep learning models and feature selection.Conclusion:The ATGCN model addressed the multivariate time series forecasting in a graph-based deep learning approach and achieved robust prediction on the confirmed cases of multiple age groups,indicating its great potentials for exploring the implicit interactions of multivariate variables. | Yuejiao Wang Dajun Daniel Zeng Qingpeng Zhang Pengfei Zhao Xiaoli Wang Quanyi Wang Yin Luo Zhidong Cao | 2022 | Fundamental Research2022，2，2： | 0 |
| 9 | Electro-chemo-mechanical design of polymer matrix in composited LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode endows solid-state batteries with superior performance显示文摘Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathode material has been widely concerned due to its high voltage,high specific capacity and excellent rate performance,which is considered as one of the most promising cathode materials for the next generation of high-energy-density solid-state lithium batteries.However,serious electro-chemo-mechanical degradation of Nickel-rich cathode during cycling,especially at a high voltage(over 4.5 V),constrains their large-scale application.Here,using the multiphysical simulation,highly-conductive polymer matrix with spontaneous stress-buffering effect was uncovered theoretically for reinforcing the electrochemical performance of composited NCM81 1 cathode through the visualization of uniform concentration distribution of Li-ion coupled with improved stress field inside NCM811 cathode.Thereupon,polyacrylonitrile(PAN) and soft polyvinylidene fluoride(PVDF) were selected as the polymer matrix to fabricate the composited NCM811 cathode(PVDFPAN@NCM811) for improving the electrochemical performance of the solid-state NMC811|Li full cells,which can maintain high capacity over 146.2 mA h g^(-1)after 200 cycles at a high voltage of 4.5 V.Suggestively,designing a multifunctional polymer matrix with high ionic conductivity and mechanical property can buffer the stress and maintain the integrity of the structure,which can be regarded as the door-opening avenue to realize the high electrochemical performance of Ni-rich cathode for solidstate batteries. | Haolong Jiang Xieyu Xu Qingpeng Guo Hui Wang Jiayi Zheng Yuhao Zhu Huize Jiang Olesya O.Kapitanova Valentyn S.Volkov Jialin Wang Yaqi Chen Yongjing Wang Yu Han Chunman Zheng Kai Xie Shizhao Xiong Yangyang Liu Xingxing Jiao | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 10 | Reinforced interface endows the lithium anode with stable cycle at high-temperature of 80℃显示文摘Embracing ultrahigh theoretical capacity of 3860 mA h g^(-1)and the lowest reduction potential of-3.04 V(versus standard hydrogen electrode),lithium(Li) is considered as the 'holy grail' material for pursuing higher energy density,of which application has been challenged due to the unstable interface caused by the non-uniform electrodeposition as well as high chemical activity.Operating at higher temperature can be recommended to uniform electrodeposition of Li metal.Nevertheless,the intrinsic side-reaction between Li metal anode and electrolyte is inevitably aggravated and thus fosters the failure of Li metal anode rapidly with uneven electrodeposition.Here,a kind of temperature-tolerated ionic liquid(1-methyl-3-ethylimidazole bis(fluorosulfo nyl)imide/lithium bis(trifluoromethylsulfo nyl)imide,EF/LT)based electrolyte that matrixed with poly(vinylidene fluoride-hexafluoropropylene) was designed to maintain the interfacial stabilization of Li metal due to the weak interfacial reaction and uniform electrodeposition at high temperature of 80℃.It is the matter that the 660-h cycle with lower polarization is achieved with EF/LT-based electrolyte at temperature of 80 ℃ and the full cell embraces outstanding cyclic performance,without capacity fading within 100 cycles.Delighting,a door for practical application of Li metal anode for higher energy density as the carbon neutrality progresses in the blooming human society has been opened gradually. | Yuhao Zhu Xieyu Xu Qingpeng Guo Yu Han Haolong Jiang Huize Jiang Hui Wang Pavel V.Evdokimov Olesya O.Kapitanova Valentyn S.Volkov Yongjing Wang Shizhao Xiong Chunman Zheng Kai Xie Xingxing Jiao Yangyang Liu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 11 | Allocation patterns of nonstructural carbohydrates in response to CO_(2)elevation and nitrogen deposition in Cunninghamia lanceolata saplings显示文摘Stored nonstructural carbohydrates(NSC)indicate a balance between photosynthetic carbon(C)assimilation and growth investment or loss through respiration and root exudation.They play an important role in plant function and whole-plant level C cycling.CO_(2)elevation and nitrogen(N)deposition,which are two major environmental issues worldwide,aff ect plant photosynthetic C assimilation and C release in forest ecosystems.However,information regarding the eff ect of CO_(2)elevation and N deposition on NSC storage in diff erent organs remains limited,especially regarding the trade-off between growth and NSC reserves.Therefore,here we analyzed the variations in the NSC storage in diff erent organs of Chinese fi r(Cunninghamia lanceolata)under CO_(2)elevation and N addition and found that NSC concentrations and contents in all organs of Chinese fi r saplings increased remarkably under CO_(2)elevation.However,N addition induced diff erential accumulation of NSC among various organs.Specifi cally,N addition decreased the NSC concentrations of needles,branches,stems,and fi ne roots,but increased the NSC contents of branches and coarse roots.The increase in the NSC contents of roots was more pronounced than that in the NSC content of aboveground organs under CO_(2)elevation.The role of N addition in the increase in the structural biomass of aboveground organs was greater than that in the increase in the structural biomass of roots.This result indicated that a diff erent tradeoff between growth and NSC storage occurred to alleviate resource limitations under CO_(2)elevation and N addition and highlights the importance of separating biomass into structural biomass and NSC reserves when investigating the eff ects of environmental change on biomass allocation. | Wenhui Zheng Renshan Li Qingpeng Yang Weidong Zhang Ke Huang Xin Guan Longchi Chen Xin Yu Qingkui Wang Silong Wang | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 12 | Molecular Cloning and Expression Analysis of zm NAC Transcription Factor Gene显示文摘In order to study NAC transcription factor gene in maize(Zea mays), a completed c NAC encoding the NAC-like gene homologue named as Zm NAC was cloned from the maize inbred line Zheng 58 using a pair of specific primers, which were designed to cover the full coding region according to the reported NAC gene family. The length of the sequences was 953 bp.The deduced amino acid sequences analysis showed that the sequence contained the complete coding region of a typical NAC gene, including a complete open reading frame which was 939 bp. The study analyzed the expression patterns of NAC transcript gene induced in various PEG(polyethylene glycol) simulated drought condition. Real-time PCR indicated that maize NAC gene can be induced in various PEG to abiotic stress responses, it could express constitutively to adopt the drought condition in short time, and the higher drought, the more early expression, which indicated that NAC transcript gene could be involved in the regulation of the defense response. | Rong ZHOU Yanwei WANG Jinbao PAN Qingpeng SUN Yihong JI Min LU Jun HAN Zhangjie NAN Yongkun YU | 2016 | Agricultural Science & Technology2016，17，2： | 0 |
| 13 | Stereoselective synthesis of the 3,6-branched Fuziα-glucans up to 15-mer via a one-pot and convergent glycosylation strategy显示文摘A family of the 3,6-branched Fuziα-glucans including the pentasaccharide repeating unit as well as its di-and trimers were efficiently achieved via a one-pot and convergent glycosylation strategy.All the protectedα-glucans up to 15-mer were assembled with high yields and excellentα-stereoselectivity,which was secured by the synergisticα-directing effects of the Tol SCl/Ag OTf promotion system and the stericβ-facial shielding of bulky saccharide residues linked at the 6-O-position of glucosyl donors.Moreover,the 3,6-branched architecture of glycosyl donor was revealed to be more favorable for theα-selective glucosidation of primary hydroxyl group,especially in the case of large oligosaccharide acceptor.The structurally well-defined syntheticα-glucans would be useful for various biological studies. | Qingpeng Zhao Shihao Zhou Yue Wang Xiaoyu Yang Youhui Meng Yanxin Zhang Jian Gao | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 14 | Short-Term Visual Experience Leads to Potentiation of Spontaneous Activity in Mouse Superior Colliculus显示文摘Spontaneous activity in the brain maintains an internal structured pattern that reflects the external environment,which is essential for processing information and developing perception and cognition.An essential prerequisite of spontaneous activity for perception is the ability to reverberate external information,such as by potentiation.Yet its role in the processing of potentiation in mouse superior colliculus(SC)neurons is less studied.Here,we used electrophysiological recording,optogenetics,and drug infusion methods to investigate the mechanism of potentiation in SC neurons.We found that visual experience potentiated SC neurons several minutes later in different developmental stages,and the similarity between spontaneous and visually-evoked activity increased with age.Before eye-opening,activation of retinal ganglion cells that expressed ChR2 also induced the potentiation of spontaneous activity in the mouse SC.Potentiation was dependenton stimulus number and showed feature selectivity for direction and orientation.Optogenetic activation of parvalbumin neurons in the SC attenuated the potentiation induced by visual experience.Furthermore,potentiation in SC neurons was blocked by inhibiting the glutamate transporter GLT1.These results indicated that the potentiation induced by a visual stimulus might play a key role in shaping the internal representation of the environment,and serves as a carrier for short-term memory consolidation. | Qingpeng Yu Hang Fu Gang Wang Jiayi Zhang Biao Yan | 2021 | Neuroscience Bulletin2021，37，3： | 0 |
| 15 | GaN metal-oxide-semiconductor field-effect transistors on AIGaN/GaN heterostructure with recessed gate显示文摘 | Qingpeng WANG Jin-Ping AO Pangpang WANG Ying JIANG Liuan LI Kazuya KAWAHARADA Yang LIU | 2015 | Frontiers of Materials Science2015，9，2： | 0 |
| 16 | An Open Invitation to Join the International Brugada Electrocardiographic Indices Registry显示文摘Background:The Brugada Electrocardiographic Indices Registry is a comprehensive data registry composed of patients with Brugada patterns on the electrocardiogram(ECG).The aim is to test the hypotheses that(i)ECG indices combining both depolarization and repolarization abnormalities can better predict spontaneous ventricular arrhythmias than existing ECG markers in Brugada syndrome and(ii)that serial ECG measurements will provide additional information for risk stratifi cation,especially in asymptomatic patients.Methods:Patients with both Brugada pattern ECGs and Brugada syndrome are eligible for inclusion in this registry.Baseline characteristics and ECG variables refl ecting depolarization and repolarization will be determined.The primary outcome is spontaneous ventricular tachycardia/ventricular fi brillation or sudden cardiac death.Secondary outcomes are inducible ventricular tachycardia/ventricular fi brillation and syncope.Results:As of November 15,2019,39 investigators from 32 cities in 18 countries had joined this registry.As of December 15,2019,1383 cases had been enrolled.Conclusions:The Brugada Electrocardiographic Indices Registry will evaluate the disease life course,risk factors,and prognosis in a large series of Brugada patients.It will therefore provide insights for improving risk stratification. | Gary Tse Sharen Lee Xuan Jiang Dong Chang Yunfei Gu Zhengrong Huang Xintao Li Qunshan Wang Shaoying Zeng Guoliang Li Dan Hu Jiandong Zhou Qingpeng Zhang Gan-Xin Yan Yunlong Xia Fang Zhou Liu Tong Liu | 2020 | Cardiovascular Innovations and Applications2020，，1： | 0 |
| 17 | PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma显示文摘Small-cell lung cancer(SCLC)is a highly malignant cancer with characteristics of rapid growth,abundant angiogenesis,and early distant metastasis that accounts for about 15%of lung cancers.With the wide application of low-dose computed tomography screening in recent years,the incidence of early limited-stage SCLC has increased dramatically. | Chengming Liu Zhanyu Wang Qingpeng Zeng Sufei Zheng Xiaoli Feng Qi Xue Nan Sun Jie He | 2023 | Genes & Diseases2023，10，1： | 0 |
| 18 | Primary Malignant Giant Cell Tumor of Bone:A Case Report显示文摘Primary malignant giant cell tumor of bone is clinically rare,lack of specificity,and often misdiagnosed.Currently,related literature about this tumor remains scarce.One case of primary malignant giant cell tumor of bone was diagnosed and treated in our hospital,and the treatment effect was satisfactory.There was no recurrence or metastasis in 2 years of followup.The report is as follows. | Guojun Zhou Sen Li Zhibin Li Qingpeng Deng Peng Wang Xiaowen Sang | 2021 | Proceedings of Anticancer Research2021，5，4： | 0 |
| 19 | Bioinformatic Analysis of zm ERECTA-LIKE2Gene from Zea mays显示文摘Zm ERECTA-LIKE2 sequences were isolated according to the Zea mays genome. The study indicates that zm ERECTALIKE2 is composed of 2 410 nucleotides and encodes a receptor-like kinase which consists of 774 amino acids by biological analysis. The results show that zm ERECTA-LIKE2 protein contains 13 domains of leucine-rich repeats and belongs to the PKclike family, it is a liposoluble protein, with a conserved transmembrane region. | Wencheng JIA Yihong JI Yanyan ZHANG Jinbao PAN Yongkun YU Min LU Jun HAN Zhanjie NAN Weixiang WANG Liyu SHI Ye WANG Qingpeng SUN | 2016 | Agricultural Science & Technology2016，17，1： | 0 |
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