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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 3 | phosphorus speciation and sorption- desorption characteristics in heavily manured soils 显示文摘 | Dan Z X Ramberg C F Toth J D | 2009 | Soil Science Society of America2009，73，： | 1 |
| 4 | Improved assessment of mass concrete dams using acoustic travel time tomography :part Ⅰ -theory 显示文摘 | LEONARD J B WILLIAM F K DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 5 | Improved assessment of mass concrete dams using acoustic travel time tomography: part Ⅱ-applieation显示文摘 | WILLIAM F K LEONARD J B DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 6 | Cinehonain Ib isolated from Eriobotryajaponica induces insulin secretion in vitro and in vivo 显示文摘 | Qa'dan F Verspohl E J Nahrstedt A | 2009 | J Ethnopharmacol2009，124，2： | 1 |
| 7 | The ring-opening polymerization of D,L-lactide in the melt initiated with tetra- phenyltin 显示文摘 | KOHN F E WAN DEN BERG J W A DAN DE RIDDER G | 1984 | Journal of Applied Polymer Science1984，29，12： | 1 |
| 8 | Corrosion behavior of the Mg65Cu25Gd10 bulk amorphous alloys 显示文摘 | QIN F X BAE G T DAN Z H LEE H KIM N J | 2007 | Mater Sci Eng A2007，，： | 1 |
| 9 | Induction of systemic resistance against Fusarium wilt of radish by lippolysac-charides of Pseudomonas fluorescens显示文摘 | LEEMAN M VAN PELT J A DAN Ouden F M | 1995 | Phytopathology1995，85，9： | 1 |
| 10 | Resistance to azoxystrobin in Aternaria isolates from pistachio in California 显示文摘 | Ma Z H Dan F Themis J M | 2003 | Pesticide Biochemistry and Physiology2003，，66： | 1 |
| 11 | Leaf nitrogen: phosphorus stoichiometry across Chinese grassland biomes显示文摘 | He J S Wang L lynn Dan F B | 2007 | Oecologia2007，155，2： | 1 |
| 12 | Resurrection of uric acid as a causal risk factor in essential hypertension 显示文摘 | Richard J J Dan I F Jaime H A | 2005 | Hypertension2005，45，1： | 1 |
| 13 | Fetal chlorpyrifos expo- sure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood 显示文摘 | Qiao Dan Seidler F J Tate CA | 2003 | Environ Health Perspect2003，111，4： | 1 |
| 14 | Synthesis of Amorphous ZnSnO3 Hollow Nanoboxes and Their Lithium Storage Properties 显示文摘 | Dan J F Hou S C Chen S G | 2014 | Mater Lett2014，122，5： | 1 |
| 15 | Chemical oxygen demand determination in environment waters by mixed- acid digestion and single sweep polarography显示文摘 | DAN D Z DOU F L XIU D J | 2000 | Analytica Chimica Acta2000，420，1： | 1 |
| 16 | Soilless media : Practices make profit显示文摘 | Shannen F Ron A Dan J | 1998 | Greenhouse Grower1998，9，： | 1 |
| 17 | Synthesis,surface properties and oil solubilisation capacity of cationic gemini surfactants显示文摘 | DAN TH ENGBERTS J B F N KARTHAUSER J | 1996 | Colloids Surface A1996，118，： | 1 |
| 18 | Leaf nitrogen:phosphorus stoichiometry across Chinese grassland biomes显示文摘 | He J S Wang L lynn Dan F B | 2007 | Oecologia2007，155，2： | 1 |
| 19 | Subtenon’s depot corticosteroid injections in patients with a history of corticosteroid-induced intraocular pressure elevation显示文摘 | Darrin S Levin Dennis P Han Sundeep Dev William J Wirostko William F Mieler Thomas B Connor Varghese George Dan Eastwood | 2002 | American Journal of Ophthalmology2002，，2： | 1 |
| 20 | Novel magnetic porous carbon spheres derived from chelating resin as a heterogeneous Fenton catalyst for the removal of methylene blue from aqueous solution 显示文摘 | Ma J J Zhou L C Dan W F | 2015 | Journal of Colloid and Interface Science2015，446，： | 1 |
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