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| 1 | Biofeedback therapy for chronic pelvic pain syndrome显示文摘Aim: To evaluate the efficacy of biofeedback therapy in patients with chronic pelvic pain syndrome(CPPS). Methods: From November 2001 to April 2002, patients visiting the Urological Outpatient Clinic of this Hospital were evaluated by means of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI)and classified by the NIH classification standard. Sixty-two patients of CPPS category Ⅲ were involved in this study. All patients had been treated by conventional approaches such as antibiotics and alpha-blockers for more than half a year without any improvement. The expressed prostatic secretion results were as follows: WBC 5 to 9/high power field, lipid +-+++ and bacterial culture negative. Their NIH-CPSI were 12-40. All the 62 cases complained of micturitional irritation (frequency, urgency, splitted stream and sense of residual urine), 32 cases, of pain or discomfort at the testicular, penile, scrotal, pelvic or rectal region and 13 cases, of white secretion-dripping. The patients were treated by the Urostym Biofeedback equipment (Laborie Co., Canada) 5 times a week for 2 weeks with a stimulus intensity of 15 mA-23 mA and duration of 20 minutes. Results: Sixty patients were significantly improved or cured, while no significant improvement in the remaining 2. No apparent side effect was observed. The NIH-CPSI dropped to 6 to 14 with an average reduction of 21 (P<0.01). In the 60 improved cases, pain was relieved after 2-3treatment courses and other symptoms disappeared after 4-5 courses. Conclusion: Biofeedback therapy is a safe and effective treatment for CPPS. Large randomized clinical trials are needed to confirm its efficacy and to explore the mechanism of action. ( Asian J Androl 2003 Jun; 5:155-158 ) | Zhang-Qun YE, Dan CAI, Ru-Zhu LAN, Guang-Hui DU, Xiao-Yi YUAN, Zhong CHEN, Yang-Zhi MA, You-Ming HU, Gui-Yun ZENGDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China | 2003 | Asian Journal of Andrology2003，5，2： | 25 |
| 2 | Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity显示文摘感觉神经原被不同发信号的网络和接受特征区分。因此,感觉神经原类型能被连接基于 transcriptome 的神经原与感觉显型打字定义。这里,我们分类老鼠的 somatosensory 神经原由高范围的单个房间的定序 RNA 的背面的根中心(DRG )(10 950 ±1 218 基因每神经原) 并且神经原基于尺寸的层次聚类。而且,对皮肤的刺激作出回应的单个 DRG 神经原被记录用一在里面 vivo 整个房间的补丁夹钳技术并且由神经原类型分类基因标记。小直径 DRG 神经原被分类进低阀值的 mechanoreceptor 的一种类型和 mechanoheat nociceptors (MHN ) 的五种类型。每 MHN 类型进一步被分成二种子类型。大 DRG 神经原被分成四种类型,包括表示联系 BAI1 的蛋白质 2-like 的 neurexophilin 1 快车 MHN 和机械 nociceptors (MN ) 1 (Baiap2l1 ) 。表示 trafficking 蛋白质粒子建筑群 3-like 和 Baiap2l1 显著的 MN 的 Mechanoreceptors 各被细分进二种子类型。这些结果为编目 somatosensory 神经原和他们的 transcriptome 数据库提供一个新系统。 | Chang-Lin Li Kai-Cheng Li Dan Wu Yan Chen Hao Luo Jing-Rong Zhao Sa-Shuang Wang Ming-Ming Sun Ying-Jin Lu Yan-Qing Zhong Xu-Ye Hu Rui Hou Bei-Bei Zhou Lan Bao Hua-Sheng Xiao Xu Zhang | 2016 | Cell Research2016，26，1： | 21 |
| 3 | Comparison between Bilateral and Unilateral Sudden Sensorineural Hearing Loss显示文摘 | Dan Bing Da-Yong Wang Lan Lan Li-Dong Zhao Zi-Fang Yin Lan Yu Guo-Hui Chen Jing Guan Qiu-Ju Wang | 2018 | Chinese Medical Journal2018，，3： | 12 |
| 4 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 5 | Herbal medicine Yin Zhi Huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole显示文摘瞄准:探索在殷·智·胡昂(YZH ) 和 omeprazole 之间的潜在的相互作用, CYP3A4 和 CYP2C19 的底层。方法:十八个健康志愿者包括 6 CYP2C19 *1 /*1, 6 CYP2C19 *1 /*2 和 6 CYP2C19 *2 /*2 在 2 阶段被注册,使随机化,转线路临床的试用。在每个阶段,志愿者收到了安慰剂或 10 mL YZH 口头的液体,为 14 d 3 倍每日。然后,所有病人口头上地拿了 20 mg omeprazole 囊。血样品在 omeprazole 管理以后被收集直到 12 h。omeprazole 和它的代谢物的血浆集中被 HPLC 与紫外察觉确定。结果:在 YZH 的治疗的 14 d 以后,血浆 omeprazole 显著地减少了,那些显著地 omeprazole 砜和 5-hydroxyomeprazole 增加了。在从到无穷的时间 0 的血浆集中时间曲线下面的区域的比率(到到 omeprazole 砜的 omeprazole 的 5-hydroxyomprazole 和那些的 omeprazole 的 AUC (0无穷)在 CYP2C19 *1 / *1 由64.80%+/-12.51%( P=0.001 )和63.31%+/-18.45%( P=0.004 )减少了,57.98%+/-14.80%( P=0.002 )和在 CYP2C19 *1 / *2 或 *3 的54.87%+/-18.42%( P=0.003 ),和37.74%+/-16.07%( P=0.004 )和在 CYP2C19 *2 / *2 的45.16%+/-15.54%( P=0.003 )分别地。到在 CYP2C19 *1 /*1 和 CYP2C19 *1 /*2 或 *3 的 5-hydroxyomprazole 的 omeprazole 的 AUC (0 无穷) 比率的减少比在 CYP2C19 *2 /*2 (P=0.047 和 P=0.009 ) 的那些大。结论:YZH 导致催化 CYP3A4 的 sulfoxidation 和在血浆 omeprazole 集中导致减少的 omeprazole 的 CYP2C19 依赖的 hydroxylation。 | Lan FAN Guo WANG Lian-sheng WANG Yao CHEN Wei ZHANG Yuan-fei HUANG Rui-xue HUANG Dong-li HU Dan WANG Hong-hao ZHOU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 10 |
| 6 | Numerical simulation of land subsidence and verification of its character for an iron mine using sublevel caving显示文摘Combined with a digital bored photography system and in-situ statistics concerning the joints and fissures of both ore-body and surrounding rock,a 2D discrete model was constructed using UDEC.The stress field and displacement field changes of different sublevel stoping systems were also studied.Changes in the overlying rock strata settlement pattern has been analyzed and validated by in-situ monitoring data.The results show that:in the caving process,there exists an obvious delay and jump for the overlying rock strata displacement over time,and a stable arch can be formed in the process of caving,which leads to hidden goafs.Disturbed by the mining activity,a stress increase occurred in both the hanging wall and the foot wall,demonstrating a hump-shaped distribution pattern.From the comparison between simulation results and in-situ monitoring results,land subsidence shows a slow-development,suddenfailure,slow-development cycle pattern,which leads eventually to a stable state.This pattern validates the existence of balanced arch and hidden goafs. | Cao Shuai Song Weidong Deng Dan Lei Yuankun Lan Jianqiang | 2016 | International Journal of Mining Science and Technology2016，26，2： | 9 |
| 7 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain显示文摘Peripheral nerve injury could lead to chronic neuropathic pain.Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.Gene expression profiles of dorsal root ganglia(DRG)in neuropathic pain condition have been studied.However,little is known about transcriptomic changes in individual DRG neurons after peripheral nerve injury. | Kaikai Wang Sashuang Wang Yan Chen Dan Wu Xinyu Hu Yingjin Lu Liping Wang Lan Bao Changlin Li Xu Zhang | 2021 | Cell Research2021，31，8： | 5 |
| 8 | Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation显示文摘36 methyltransferase SETD2 经常是的 histone H3 离氨酸在各种各样的癌症变异,包括白血病。然而,没有任何功能的模型在 tumorigenesis 在造血作用或 SETD2 变化的原因的角色显示出 SETD2 的贡献。在这研究,用一个有条件的 Setd2 猛烈老鼠模型,我们证明那 Setd2 缺乏扭曲造血的区别并且减少 multipotent 祖先的数字;尽管 phenotypic 的数字在删除 Setd2 的老鼠的造血的干细胞(HSC ) 包括连续 BM 移植,未改变的、功能的试金表明 HSC 的自强和竞争力被损害。有趣地,通过一个潜伏时期,删除 Setd2 的 HSC 能获得能力克服生长劣势并且最后产生 myelodysplastic 症候群特征的造血的恶意。删除 Setd2 的造血的干细胞(HSPC ) 的基因表示侧面部分类似于 Dnmt3a/Tet2 双猛烈 HSPC 的,显示出 erythroid 抄写因素的激活 Klf1 相关的小径,哪个戏在造血的恶意的转变的一个重要角色。Setd2 缺乏也在 HSC 导致 DNA 复制应力,由激活的 E2F 基因思考了规章的网络和 ribonucleotide reductase 子单元 Rrm2b 的镇压表示,导致增长和房间周期畸形和 genomic 不稳定性,允许 synergistically 贡献 tumorigenesis 的第二等的变化的累积。因此,我们的结果证明 Setd2 为 HSC 自强被要求,并且提供在 tumorigenesis 支持 Setd2 缺乏的原因的角色的证据。内在的机制将推进我们癌症的 epigenetic 规定的理解并且提供潜在的新治疗学的目标。 | Yuan-Liang Zhang Jie-Wen Sun Yin-Yin Xie Yan Zhou Ping Liu Jia-Chun Song Chun-Hui Xu Lan Wang Dan Liu Ai-Ning Xu Zhu Chen Sai-Juan Chen Xiao-Jian Sun Qiu-Hua Huang | 2018 | Cell Research2018，28，4： | 5 |
| 9 | Evolution of urban black and odorous water:The characteristics of microbial community and driving-factors显示文摘Urban black blooms that are primarily caused by organic carbon are deleterious environmental problems.However,detailed studies on the microbial characteristics that form urban black blooms are lacking.In this study,we observed the composition,diversity,and function of bacterial community in the overlying water and sediments during the occurrence and remediation of urban black blooms using high-throughput 16S rRNA gene amplicon sequencing analysis.First,we found that pivotal consortia in the overlying water increased significantly during the formation of black blooms,including the genera Acidovorax,Brevundimonas,Pusillimonas,and Burkholderiales involved in the degradation of refractory organics,as well as the genera Desulfovibrio,Dechloromonas,and Rhizobium related to the production of black and odorous substances.An RDA analysis revealed that chemical oxygen demand,dissolved oxygen,and oxidation reduction potential were related to the changes in microbial community composition.Furthermore,aeration was found to accelerate the removal of ammonia nitrogen and enhance the function of microbial community by stimulating the growth of order Planktomycetes during the remediation of black blooms,but aeration substantially damaged the microbial diversity and richness.Therefore,the health of the aquatic ecosystem should be comprehensively considered when aeration is applied to restore polluted waterbodies.Notably,we observed a large number of pathogenic bacteria in urban black blooms,which emphasizes the importance of treating domestic sewage so that it is harmless.Together,these findings provide new insights and a basis to prevent and manage urban black blooms. | Dan Zhang Huilan Yang Shuhuan Lan Chen Wang Xudong Li Yunxiao Xing Hua Yue Qiulin Li Ling Wang Yifei Xie | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 10 | VqMAPKKK38 is essential for stilbene accumulation in grapevine显示文摘Vitis species,including grapevine,produce a class of secondary metabolites called stilbenes that are important for plant disease resistance and can have positive effects on human health.Mitogen-activated protein kinase(MAPK)signaling cascades not only play key roles in plant defense responses but also contribute to stilbene biosynthesis in grapevine.MAPKKKs function at the upper level of the MAPK network and initiate signaling through this pathway.In this study,a Raf-like MAPKKK gene,VqMAPKKK38,was identified and functionally characterized from the Chinese wild grapevine V.quinquangularis accession‘Danfeng-2’.We observed that VqMAPKKK38 transcript levels were elevated by powdery mildew infection,high salinity conditions and chilling stresses,as well as in response to treatments by the hormones salicylic acid(SA),methyl jasmonate(MeJA),ethylene(Eth)and abscisic acid(ABA).In addition,based on both transient overexpression and gene suppression of VqMAPKKK38 in grapevine leaves,we found that VqMAPKKK38 positively regulates stilbene synthase transcription and stilbene accumulation probably by mediating the activation of the transcription factor MYB14.In addition,both hydrogen peroxide(H2O2)and calcium influx activated VqMAPKKK38 expression and stilbene biosynthesis,which suggests that VqMAPKKK38 may be involved in the calcium signaling and ROS signaling pathways. | Yuntong Jiao Dan Wang Lan Wang Changyue Jiang Yuejin Wang | 2017 | Horticulture Research2017，4，1： | 4 |
| 11 | Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice显示文摘Cognitive impairment is the main clinical manifestation of Alzheimer's disease(AD),and amyloid-β(AB)deposition and senile plaques are the characteristic neuropathological hallmarks in AD brains.This study aimed to explore the effect and mechanism of tetrahydroxy stilbene glucoside(TSG)on cognitive function in APP/PS 1 mice during long-term administration.Here,we treated APP/PS1 model mice of AD with different doses of TSG(50 mg/kg and 100 mg/kg)for 5 to 17 months by gavage,and we further observed whether TSG could ameliorate the cognitive decline in APP/PS1 mice using behavioral tests,and investigated the possible mechanisms by immunohistochemistry and Western blotting.Our results showed that TSG treatment rescued the spatial and non-spatial learning and memory impairments of APP/PS1 mice at Morris water maze test and novel object recognition test.Furthermore,Aβ40/42 deposition in the cortex and hippocampus of APP/PS1 mice treated with TSG was significantly reduced compared to the wild type mice using the immunohistochemical technique.Finally,Western blotting showed that TSG primarily decreased the APP expression to avoid the Aβplaque deposition in the cortex and hippocampus of mice.These results reveal the beneficial effects of TSG in APP/PSI-AD mice,which may be associated with the reduction of Aβdeposits in the brain. | Dan GAO Chen CHEN Rui HUANG Cui-cui YANG Bei-bei MLAO Lin LI Lan ZHANG | 2021 | Current Medical Science2021，41，2： | 3 |
| 12 | Surface Oxygen Injection in Tin Disulfide Nanosheets for Efficient CO_(2) Electroreduction to Formate and Syngas显示文摘Surface chemistry modification represents a promising strategy to tailor the adsorption and activation of reaction intermediates for enhancing activity.Herein,we designed a surface oxygen-injection strategy to tune the electronic structure of SnS_(2) nanosheets,which showed effectively enhanced electrocatalytic activity and selectivity of CO_(2) reduction to formate and syngas(CO and H_(2)).The oxygen-injection SnS_(2) nanosheets exhibit a remarkable Faradaic efficiency of 91.6%for carbonaceous products with a current density of 24.1 mA cm^(−2) at−0.9 V vs RHE,including 83.2%for formate production and 16.5%for syngas with the CO/H_(2) ratio of 1:1.By operando X-ray absorption spectroscopy,we unravel the in situ surface oxygen doping into the matrix during reaction,thereby optimizing the Sn local electronic states.Operando synchrotron radiation infrared spectroscopy along with theoretical calculations further reveals that the surface oxygen doping facilitated the CO_(2) activation and enhanced the affinity for HCOO*species.This result demonstrates the potential strategy of surface oxygen injection for the rational design of advanced catalysts for CO_(2) electroreduction. | Tao Chen Tong Liu Tao Ding Beibei Pang Lan Wang Xiaokang Liu Xinyi Shen Sicong Wang Dan Wu Dong Liu Linlin Cao Qiquan Luo Wei Zhang Wenkun Zhu Tao Yao | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 13 | Heterostructured CoFe@N-doped carbon porous polyhedron for efficient microwave absorption显示文摘The synthesis of wide bandwidth,thin thickness,and high performance microwave absorbing materials has become a hot topic of current research.Metal-organic frameworks with heterojunctions and porous structures are considered as suitable candidates to meet these characteristics.Herein,heterogeneous CoFe@N-doped porous carbon polyhedron composites were successfully synthesized via Fe^(2+)to replace Co in zeolite imidazole frame-67.The dielectric properties of composites were enhanced by the replacement of Fe^(2+),and the synergistic effect of dielectric loss and magnetic loss was realized.The petal-like lamellar structure increases the travel of electromagnetic(EM)waves,and the formation of porous structures improves impedance matching.Specifically,a reflection loss of−67.30 dB was obtained at a thickness of 2.88 mm,and an ultrabroad wide effective absorption bandwidth of 8.40 GHz was obtained,covering most of the X-band(8–12 GHz)and the whole Ku-band(12–18 GHz).The radar cross section(RCS)reduction value can reach 29.4 dB·m^(2),which means that the radar detector has a smaller probability of detecting targets.This work describes the unique advantages of metal ion replacement metal-organic frameworks derived materials in structural design,impedance matching,and performance adjustment,and provides a new reference for the field of electromagnetic wave absorption. | Dan Wu Yiqun Wang Shuanglin Deng Di Lan Zhongning Xiang Qinchuan He | 2023 | Nano Research2023，16，2： | 2 |
| 14 | MicroRNA bta-miR-365-3p inhibits proliferation but promotes differentiation of primary bovine myoblasts by targeting the activin A receptor type Ⅰ显示文摘Background: MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts.Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs. Skeletal muscles express a plethora of microRNA genes that regulate muscle development and function by controlling the expression of protein-coding target genes. To expand our understanding of the role of microRNA, specifically btamiR-365-3 p, in muscle biology, we investigated its functions in regulating primary bovine myoblast proliferation and differentiation.Results: Firstly, we found that bta-miR-365-3 p was predominantly expressed in skeletal muscle and heart tissue in Chinese Qinchuan beef cattle. Quantitative PCR and western blotting results showed that overexpression of btamiR-365-3 p significantly reduced the expression levels of cyclin D1(CCND1), cyclin dependent kinase 2(CDK2) and proliferating cell nuclear antigen(PCNA) but stimulated the expression levels of muscle differentiation markers, i.e.,MYOD1, MYOG at both mRNA and protein level. Moreover, downregulation of bta-miR-365-3 p increased the expression of CCND1, CDK2 and PCNA but decreased the expression of MYOD1 and MYOG at both mRNA and protein levels. Furthermore, flow cytometry, EdU proliferation assays and immunostaining results showed that increased levels of bta-miR-365-3 p suppressed cell proliferation but promoted myotube formation, whereas decreased levels of bta-miR-365-3 p resulted in the opposite consequences. Finally, we identified that activin A receptor type I(ACVR1) could be a direct target of bta-miR-365-3 p. It was demonstrated that bta-miR-365-3 p can bind to the 3'UTR of ACVR1 gene to regulate its expression based on dual luciferase gene reporter assays.Consistently, knock-down of ACVR1 was associated with decreased expressions of CDK2, CCND1 and PCNA but increased expression of MYOG and MYOD1 both at mRNA and protein level.Conclusion: Collectively, these data suggested that bta-miR-365-3 p represses proliferation but promotes differentiation of bovine myoblasts through several biological mechanisms involving downregulation of ACVR1. | Dan Hao Xiaogang Wang Xiao Wang Bo Thomsen Yu Yang Xianyong Lan Yongzhen Huang Hong Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 2 |
| 15 | Genome-wide analysis reveals selection for Chinese Rongchang pigs显示文摘Livestock have undergone domestication and consequently strong selective pressure on genes or genomic regions that control desirable traits. To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total of about 170 Gb of DNA sequence data with about 6.4-fold coverage for each of six female individuals. By combining these data with the publically available genome data of 10 Asian wild boars,we identified 449 protein-coding genes with selection signatures in Rongchang pigs, which are mainly involved in growth and hormone binding, nervous system development, and drug metabolism. The accelerated evolution of these genes may contribute to the dramatic phenotypic differences between Rongchang pigs and Chinese wild boars. This study illustrated how domestication and subsequent artificial selection have shaped patterns of genetic variation in Rongchang pigs and provides valuable genetic resources that can enhance the use of pigs in agricultural production and biomedical studies. | Lei CHEN Shilin TIAN Long JIN Zongyi GUO Dan ZHU Lan JING Tiandong CHE Qianzi TANG Siqing CHEN Liang ZHANG Tinghuan ZHANG Zuohua LIU Jinyong WANG Mingzhou LI | 2017 | Frontiers of Agricultural Science and Engineering2017，4，3： | 2 |
| 16 | Pulmonary aspergillosis, mucormycosis, and actinomycosis co-infection presenting as a cavitary lesion in a patient with diabetes显示文摘To the Editor: Mucormycosis and aspergillosis are opportunistic fungal infections that can lead to life-threatening complications.[1,2] Pulmonary actinomycosis is a rare infection which is commonly confused with other lung diseases.[3] Co-infection with these three pathogens in the same host is rare. Here, we report a unique case of a cavitary lesion with aspergillosis, mucormycosis, and actinomycosis co-infection. | Lan Lin Dan Xue Ting-Yan Lin Ying-Xiao Wu Yi-Ting Jiang Li-Min Chen | 2019 | Chinese Medical Journal2019，，20： | 2 |
| 17 | Phosphate limitation increases coenzyme Q10 production in industrial Rhodobacter sphaeroides HY01显示文摘Coenzyme Q10(CoQ10)is an important component of the respiratory chain in humans and some bacteria.As a high-value-added nutraceutical antioxidant,CoQ10 has excellent capacity to prevent cardiovascular disease.The content of CoQ10 in the industrial Rhodobacter sphaeroides HY01 is hundreds of folds higher than normal physiological levels.In this study,we found that overexpression or optimization of the synthetic pathway failed CoQ10 overproduction in the HY01 strain.Moreover,under phosphate-limited conditions(decreased phosphate or in the absence of inorganic phosphate addition),CoQ10 production increased significantly by 12%to220 mg/L,biomass decreased by 12%,and the CoQ10 productivity of unit cells increased by 27%.In subsequent fed-batch fermentation,CoQ10 production reached 272 mg/L in the shake-flask fermentation and 1.95 g/L in a 100-L bioreactor under phosphate limitation.Furthermore,to understand the mechanism associated with CoQ10 overproduction under phosphate-limited conditions,the comparatve transcriptome analysis was performed.These results indicated that phosphate limitation combined with glucose fed-batch fermentation represented an effective strategy for CoQ10 production in the HY01.Phosphate limitation induced a pleiotropic effect on cell metabolism,and that improved CoQ10 biosynthesis efficiency was possibly related to the disturbance of energy metabolism and redox potential. | Lu Zhang Leshi Liu Ke-Feng Wang Lan Xu Liming Zhou Weishan Wang Chuan Li Zheng Xu Tong Shi Haihong Chen Yuanhang Li Hui Xu XiuLiang Yang Zhichun Zhu Biqin Chen Dan Li Guanghuang Zhan Si-Liang Zhang Li-Xin Zhang Gao-Yi Tan | 2019 | Synthetic and Systems Biotechnology2019，4，4： | 2 |
| 18 | A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling显示文摘Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. In this study, we established a high-profile compounds library and certificated a novel compound named N-(N-pyrrolidylacetyl)-9-(4-bromobenzyl)-1,3,4,9-tetrahydro-β-carboline (YF-452), which remarkably inhibited the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity invitro. Rat thoracic aorta ring assay indicated that YF-452 significantly blocked the formation of microvascular exvivo. In addition, YF-452 inhibited angiogenesis in chick chorioallantoic membrane (CAM) and mouse corneal micropocket assays. Moreover, YF-452 remarkably suppressed tumor growth in xenografts mice model. Furthermore, investigation of molecular mechanism revealed that YF-452 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. These results indicate that YF-452 inhibits angiogenesis and may be a potential antiangiogenic drug candidate for cancer therapy. | Yongrui Liu Yuan He Feifei Yang Xiaonan Cong Jinhua Wang Shihong Peng Dan Gao Weifang Wang Liping Lan Xuexiang Ying Mingyao Liu Yihua Chen Zhengfang Yi | 2017 | Science China(Life Sciences)2017，60，2： | 2 |
| 19 | Micro-RNA: A New Kind of Gene Regulators显示文摘A group of small RNA molecules, distinct from but related to siRNAs (small interference RNAs) have been identified in avariety of organisms. These small RNAs, called microRNAs (miRNAs), are endogenously encoded approximately 20-24 ntlong single-stranded RNAs. They are generally expressed in a highly tissue- or developmental-stage-specific fashion andare post-transcriptional regulator of gene expression in animals and plants. This article summarizes the character, mechanismand analysis method about miRNAs. The current view that miRNAs represent a newly discovered, hidden layer of generegulation has resulted in high interest among researchers in the discovery of miRNAs, their targets, expression mechanismof action and analysis methods. | WU Dan HU Lan | 2006 | Agricultural Sciences in China2006，5，1： | 2 |
| 20 | Step Motor Control System显示文摘All kinds of step motors and servomotors are widely used in CSR control system, such as many vacuum valves control that set on the HIRFL-CSR; all kinds of electric switches and knobs of ECR Ion Source; equipment of CSR Beam Diagnostics and a lot of large equipment like Inside Gun Toroid and Collector Toroid of HIRFL. A typical control system include up to 32 16-I/O Control boards, and each 16-I/O Control board can control 4 motors at the same time (including 8 Limit Switches). | Zhang Shuocheng, Wang Dan, Qiao Weimin and Jing Lan | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 2 |
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